With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.
cis-RuC12(slMes)(t-butylvinylidene)(Ph2P(OMe)), cis-C777v: trans-C 71 9v (5.0 g, 7.0 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed CH2C12 was added (40 mL). Phosphinite Ph2P(OMe) (2.26 g, 10.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The reaction was stirred under N2 for 60 mm at ambient temperature (20 – 25 C) yielding a yellow crystalline solid. The crude material was filtered, washed with heptanes and dried under high vacuum to provide a crude yellow solid (3.6 g). The crude yellow solid (1.6 g) was dissolved in degassed CH2C12 (2000 mL) and filtered through Celite. The filtrate was concentrated under high vacuum and the resulting solid was recrystallized in CH2C12/heptanes. The crystals were filtered and washed with heptanes and dried under high vacuum to yield a yellow solid. Yield: 1.3g. ?H NMR (400 IVIHz, CD2C12, ppm): oe 7.46 -7.41 (m, 1H), 7.39- 7.28 (m, 5H), 7.18 – 7.14 (m, 3H), 7.000 (s, 1H), 6.95 (s, 1H), 6.90 – 6.85 (m, 2H), 6.64 (s, 1H), 4.06 – 3.85 (m, 4H), 3.35 (d, J= 11 Hz, 3H), 2.80 (s, 3H), 2.77 (s, 3H) 2.40 (s, 6H), 2.33 (s, 3H), 2.09 (s, 3H), 1.93 (d, J= 5 Hz, 1H), 0.33 (s, 9H). 3?P NIVIR (161.8 IVIHz, C6D6, ppm): oe 135.15 (s)., 4020-99-9
The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate