With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.
General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgOTf (0.0513 g, 0.2 mmol) into the reaction flask. After stirring for 18 h and then filtrating, the filtrate was slow evaporated at ambient temperature. 8 days later, colorless block-shaped crystals were obtained. Yield: 39.2percent (0.0935 g). Anal. Calc. for(C63H52AgF3O4P4S): C, 63.38; H, 4.36; N, 0. Found: C, 63.26; H,4.32; N, 0percent. IR (cm-1, KBr pellets): 3467br, 3055m, 1968w,1660m, 1587m, 1564m, 1482s, 1461s, 1435vs, 1280vs, 1253vs,1223s, 1160s, 1097s, 1069m, 1029vs, 999m, 877w, 798m, 746s,724m, 694vs, 636s, 572w, 512s, 473m, 448w, 421w. 1H NMR(600 MHz, CDCl3): 2.90 (d, 4H, dppe), 6.66?7.28 (m, 48H, Ph). 31P{1H} NMR (243 MHz, CD3Cl): 5.1 (br, d, JAg?P = 364.5 Hz, dppe),5.3 (dt, J19F?P = 211.4 Hz, dppe), 10.1 (2d, J19F?P = 102.1 Hz, DPEphos),11.3 (2d, J19F?P = 116.7 Hz, DPEphos), 11.5 (dd, J109Ag?P = 245.4 Hz,J107Ag?P = 235.7 Hz, DPEphos)., 166330-10-5
The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate