131274-22-1, Name is Tri-tert-butylphosphonium tetrafluoroborate, molecular formula is C12H28BF4P, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 131274-22-1, category: chiral-phosphine-ligands
The invention discloses an asymmetric synthesis method of galanthamine and lycoramine. According to the asymmetric synthesis method, the iodide of cheap and easily available raw material isovanillin and easily prepared 4-triethylsilyl-3-butyne-1-amidogen are taken as raw materials, a coumarone compound can be produced by virtue of a palladium catalytic Larock cyclization reaction after the nitrogen atom is protected by virtue of reductive amination, next, an optical pure key intermediate can be obtained at the ee value of 94% by virtue of the asymmetric michael addition of p-methyl vinyl ketone under the catalysis of critical metal Sc(OTf)3 and oxynitride ligands after the coumarone compound is transformed into a coumaranone structure, and the intermediate is subjected to the asymmetric adol reaction induced chirally by a substrate and subsequent selective reduction of lithium tri-sec-butylborohydride so that optically pure galanthamine and lycoramine can be obtained. The asymmetric synthesis method has the advantages of shorter synthesis route and higher efficiency.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: chiral-phosphine-ligands. In my other articles, you can also check out more blogs about 131274-22-1
Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate