Electric Literature of 50777-76-9, An article , which mentions 50777-76-9, molecular formula is C19H15OP. The compound – 2-(Diphenylphosphino)benzaldehyde played an important role in people’s production and life.
The novel water-soluble chiral PNNP-type ligand for the enantioselective reduction of ketones in aqueous media
The condensation of o-(diphenylphosphino)benzaldehyde and (R,R)-1,2-diaminocyclohexane in dichloromethane gives a diiminodiphosphine ligand, which is reduced with excess NaBH4 in refluxing ethanol to afford the corresponding diaminodiphosphine ligand [(R,R)-C6P2(NH)2]. The novel water-soluble PNNP-type tetradentate diaminodiphosphine ligand [(R,R)-C6P2(NH)2(SO3Na)4] has been prepared by the sulfonation of the chiral ligand [(R,R)-C6P2(NH)2] and also characterized by IR, NMR and CD. The water-soluble iridium catalyst is generated in situ from [IrCl(COD)(Ph3P)] and water-soluble ligand [(R,R)-C6P2(NH)2(SO3Na)4] in a mixture solvent of 2-propanol and water. This water-soluble iridium catalytic system has been examined for asymmetric transfer hydrogenation of various aromatic ketones in aqueous media, giving the corresponding optically active alcohols in high yield and excellent enantioselectivity. Even those ketones having a great bulkiness of the alkyl group, such as isobutyrophenone, phenyl cyclohexyl and 1,1-diphenylacetone, are smoothly converted to optically active alcohols in up to 99% ee.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 50777-76-9, help many people in the next few years., Electric Literature of 50777-76-9
Reference£º
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate