Month: November 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: Ligand 7 (263.3mg, 0.50mmol) [or 10 (249.3mg, 0.50mmol)] was dissolved in 10mL of anhydrous toluene and cooled to 0C. After the addition of P(NMe2)3 or P(NEt2)3 (0.65mmol), the resulting solution mixture was stirred at 0C for 10min. Next, the reaction mixture was gently warmed to 110C for 6h, and then filtered, concentrated, and purified by preparative TLC on silica gel plates to give the pure product 8a-b [or 11a-b]. Characterization data of new ligand 8a: Yield: 80%; mp: 46-48C. [alpha]D20=+352 (c 0.2, CHCl3). 1H NMR (400MHz, CDCl3) delta 8.12 (s, 2H), 7.92 (dd, J=18.9, 13.6Hz, 2H), 7.50 (t, J=8.5Hz, 4H), 7.44-7.21 (m, 12H), 4.90 (dd, J=27.3, 13.3Hz, 4H), 4.80-4.68 (m, 4H), 2.43-2.28 (m, 6H). 13C NMR (100MHz, CDCl3) delta 147.6, 147.5, 138.4, 138.3, 132.4, 132.0, 131.0, 130.6, 130.5, 130.3, 128.6, 128.5, 128.4, 128.3, 127.8, 127.7, 127.6, 127.5, 126.9, 126.8, 125.8, 125.7, 124.9, 124.7, 124.0, 123.9, 122.7, 73.1, 72.8, 68.12, 68.10, 67.7, 35.6, 35.4. 31P NMR (162MHz, CDCl3) delta 148.62. IR(KBr) nu 3056, 2968, 2963, 2857, 1450, 1350, 1108, 1018, 900, 742, 965cm-1. HRMS (ESI) m/z: Calcd for C38H34NO4P [M+H]+: 600.2304 found: 600.2306, 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Wenxian; Wang, Tao; Zhao, Ruijuan; Xie, Huanping; Liu, Lantao; Tetrahedron Asymmetry; vol. 27; 4-5; (2016); p. 157 – 162;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

General procedure: To a CH2Cl2 solution of [Cp*Ir(S2C2B10H10)] (B or C) (107mg, 0.2mmol) PR3 (0.2mmol) was added and the mixture was stirred for 10minat ambient temperature. The resulting yellow solution was evaporated in vacuo and the residue was washed with hexanes to give B1-B4, C1-C4, respectively. Single crystals suitable for X-ray analysis were obtained by slow evaporation of a CH2Cl2/hexane solution. (Note: for the preparation of B4 and C4, slight excess of PMe3 was added.)

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zou, Wenli; Zhang, Xiaolei; Dai, Humin; Yan, Hong; Cremer, Dieter; Kraka, Elfi; Journal of Organometallic Chemistry; vol. 865; (2018); p. 114 – 127;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1.0 mmol of [Cu(CH3CN)4]BF4 and2.0 mmol of PPh3 were dissolved in 10 mL of CH2Cl2. The mixture was refluxed for 30 min at room temperature. Then 1.0 mmol of Phen was added. The mixture was refluxed for another half hour.The solvent was removed by rotary evaporation. The crude product was further purified by recrystallization from the mixed solvent of tetrahydrofuran/ether. Yield: 85percent., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Kai; Zhang, Dong; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 124; (2014); p. 341 – 348;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: D1 (0.12 g, 0.4 mmol), copper powder (0.032 g, 0.5 mmol), and POP (0.22 g, 0.4 mmol) werereacted in CH3CN (5 mL) at 60 ¡ãC for 24 h. The resulting mixture was filtered through a plugof Celite and concentrated to 1 mL. Addition of Et2O (10 mL) to the filtrate afforded a paleyellow precipitate, which was collected, washed with Et2O, and recrystallized with ethanol., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Liu, Shaobo; Xu, Shengxian; Wang, Jinglan; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Coordination Chemistry; vol. 70; 4; (2017); p. 584 – 599;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The reactions were run in a CEM Corp. MARS microwave fitted with a fiber optic temperature probe and a port on top for a reflux condenser.1 mmol of Mo(CO)6 and dppe (0.425 g, 1.1 mmol) were combined with 20 mL of 1-propanol in a two-neck 100 mL RB flask. To this mixture was added NaBH4 (0.128 g, 3.3 mmol). The flaskwas placed in themicrowave and a reflux condenser attached through a hole in the top of the microwave. The mixture was sparged with nitrogen. The mixture was heated under nitrogen at 400 W for 1.5 min to reach reflux temperature. Once the reflux temperature was reached the microwave power was reduced and the temperature maintained for 18 min. The mixture was cooled to room temperature and 2?4 mL of water was added to the reaction to dissolve excess NaBH4 and promote product precipitation. The reaction was cooled ?10 ¡ãC for several hours. The light yellow complex was filtered in air and washed with 2¡Á5 mL of petroleum ether/diethyl ether(1:1) mixture resulting in 580 mg of Mo(CO)4dppe after drying, a 95percent yield.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Birdwhistell, Kurt R.; Schulz, Brian E.; Dizon, Paula M.; Inorganic Chemistry Communications; vol. 26; (2012); p. 69 – 71;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6163-58-2,Tri-o-tolylphosphine,as a common compound, the synthetic route is as follows.

(2R)-(4E)-5-(5-Isopropoxy-3-pyridyl)-4-penten-2-ol A mixture of 5-isopropoxy-3-bromopyridine (10.26 g, 47.50 mmol), (2R)-4-penten-2-ol (4.91 g, 57.00 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (578 mg, 1.90 mmol), triethylamine (28.46 mL, 204.25 mmol), and acetonitrile (30 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (8.92 g, 85.0%).

6163-58-2, As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; Caldwell, William S.; Dull, Gary M.; Bhatti, Balwinder S.; Hadimani, Srishailkumar B.; Park, Haeil; Wagner, Jared M.; Crooks, Peter A.; Lippiello, Patrick M.; Bencherif, Merouane; US2003/125345; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below.

13689-19-5, As the paragraph descriping shows that 13689-19-5 is playing an increasingly important role.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: PR3 and NH4PF6 were added to a solution of fac-[RuCl3(NO)(P?N)] (1) in MeOH (5 mL) and the resulting orange suspensionwas refluxed for 3 h, except for the P(p-Me-C6H4)3 system whenreaction occurred at r.t. After being cooled to room temperature,the resulting yellow suspensions of complexes 3?5 were filteredto give a yellow solid that was washed with H2O (2 5 mL), MeOH(2 5 mL) and Et2O (2 5 mL), and then dried in vacuo. In the caseof complex 2, the reaction generated a clear yellow solution; thesolvent was removed in vacuo to give a yellow residue that wasthen largely dissolved in CH2Cl2 (5 mL), and the mixture wasfiltered through Celite. Addition of n-hexane (15 mL) yielded a yellowsolid that was then treated as described above. The mer, transisomerof 1 [6,7] could also be used as the precursor for synthesesusing the same methodology, which gave similar product yields., 18437-78-0

The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; da Silva, Juliana P.; Fagundes, Francisco D.; Back, Davi F.; Ellena, Javier; James, Brian R.; de Araujo, Marcio P.; Inorganica Chimica Acta; vol. 454; (2017); p. 40 – 45;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 1,8-bis(diphenylphosphino)naphthalenedioxide (64.5 mg) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (25.3 mg, 0.130 mmol) in dry dichloromethane, and the mixture was heated to reflux with stirring for one hour. Then, 2-dimethylamino-2′-(diphenylphosphino)biphenyl (49.6 mg, 0.130 mmol) was added to the reaction solution, which was heated to reflux for another one hour. The obtained brown suspension was filtrated, and the filtrate was concentrated and the residue was dissolved in chloroform followed by slow diffusion of diethylether. The precipitate was isolated by filtration, and the filtrated matter was subjected to vacuum drying, thereby providing 101 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-1, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (1).

240417-00-9, As the paragraph descriping shows that 240417-00-9 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

1.1 Preparation of N,N’-Di-(o-tolyl)-1,4-phenylenediamine To a 5 L round-bottomed 3-neck flask, equipped with reflux condenser, nitrogen inlet and exhaust, mechanical stirrer (equipped with PTFE stirrer rod, guide and stirrer blade) and a powder addition funnel, was added the 1,4-phenylenediamine (77.85 g, 0.720 mol, 1.0 eq.) and 2-bromotoluene (270.87 g, 1.584 mol, 2.2 eq.) and toluene (1500 mL). The resulting mixture was stirred for 10 mins, then degassed by sparging with nitrogen gas for 1 hour. The palladium(II) acetate (3.60 g, 0.1 eq.) and 1,1′-diphenylphosphinoferrocene (dppf) (8.88 g, 0.1 eq.) were then added and the mixture stirred under nitrogen for 15 mins. Sodium tert-butoxide (207.36 g, 2.16 mol, 3.0 eq.) was then charged as a solid. The mixture was heated to reflux and maintained at this temperature for 16 hours. GCMS after this time indicated complete reaction. The mixture was allowed to cool to room temperature and poured into a mixture of ice-water (1000 mL) and diethyl ether (500 mL). The phases were separated and the organic phase passed through celite (200 g). The filtrates were concentrated to dryness in vacuo and the crude product triturated from methanol. The product was recovered by filtration and the cake washed with methanol (2*250 mL). The solid product was then dried for 24 hours at 40¡ã C. in vacuo. The product was afforded as a pale white solid, 132.17 g, 65percent. NMR and GCMS data are consistent with the required structure., 12150-46-8

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Patent; Merck Patent GmbH; US2008/217605; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate