With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6163-58-2,Tri-o-tolylphosphine,as a common compound, the synthetic route is as follows.
(2R)-(4E)-5-(5-Isopropoxy-3-pyridyl)-4-penten-2-ol A mixture of 5-isopropoxy-3-bromopyridine (10.26 g, 47.50 mmol), (2R)-4-penten-2-ol (4.91 g, 57.00 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (578 mg, 1.90 mmol), triethylamine (28.46 mL, 204.25 mmol), and acetonitrile (30 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (8.92 g, 85.0%).
6163-58-2, As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.
Reference£º
Patent; Caldwell, William S.; Dull, Gary M.; Bhatti, Balwinder S.; Hadimani, Srishailkumar B.; Park, Haeil; Wagner, Jared M.; Crooks, Peter A.; Lippiello, Patrick M.; Bencherif, Merouane; US2003/125345; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate