Tag: M.W:500-600

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

The resulting precursor P – 3 (4.8 g, 10 mmol, 1.0 equivalent), silver oxide (1.2 g, 5 mmol, 50percent yield), solvent acetonitrile 50 ml are sequentially added into a 100 ml flask, 50 ¡ãC light reaction 12 hours; filter, collecting the filtrate, dryness, a colorless solid. The solid with thecopperpowder (0.64 g, 10 mmol, 1.0 equivalent) as for 100 ml flask, add anhydrous non-oxygen second grade nitrile 50 ml, stirring at the room temperature reaction 5 hours; add ligand POP (4.3 g, 8 mmol, 80percent yield), stirring at the room temperature reaction 3 hours; filter, to remove the insoluble solid, collecting the filtrate, reduced pressure drying, be light green solid, that is the crude product. The crude product is dissolved inmethylenechloridesolvent, slow volatilization of the solvent, a large number of light yellow crystalline precipitation, filtration to obtain pure complex [(NHC – 3) Cu (POP)]+PF6-(8.1 G, 7.5 mmol), yield is 75percent., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Luoyang Normal College; Wang Zhiqiang; Zhang Zhiqiang; Xu Liancai; Sun Xiaojuan; Xu Chen; Li Hongmei; (21 pag.)CN104610285; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,1′-Bis(diphenylphosphino)ferrocene (dppf) (0.554 g, 1.0 mmol) was added to a solution of silver(I) cyanide (0.134 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture in dark at room temperature.The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h. Slowly, the colour of the solution changed from light orange to dark yellowish orange. The resulting solution was evaporated to dryness to give a yellowish orange solid which was then extracted with dichloromethane (20 mL). The addition of cyclohexane (250 mL) to this solution led to yellowish orange needle shaped diffraction quality crystals. These were separated and washed with hexane and dried. Yield: (1.116 g, 70 percent).Anal. Calc. for C77H68N3P4Ag3Fe2: C, 57.97; H, 4.27; N, 2.63. Found: C, 58.12; H, 4.45; N, 2.68. IR (cm-1, KBr): nu = 3440, 3052, 2926, 2136(CN), 1958, 1892, 1650, 1581, 1478, 1430, 1310, 1165, 1158, 1094, 1087, 1030, 898, 818, 742, 696, 630, 495. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K): 8.05e7.30 (m, 40H, Ph), 4.32(s, 8H, C5H4), 4.20 (s, 8H, C5H4). 31P{1H}: d 2.56 (sbr). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 266 (10,548), 460 (24,204). ESI-MS (m/z) :1594.1 (M+).

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Example 4 15 g of 2-chlorobenzonitrile, 14.8 g of p-tolueneboronic acid and 28.9 g of sodium carbonate together with 50 ml of p-xylene, 40 ml of DMSO and 10 ml of water are heated to 120 C. At 80 C., a mixture of 24.7 g of palladium acetate and 0.55 ml of 0.6 M aqueous TPPTS solution in 2.5 ml of DMSO is added. After the reaction is complete, the phases are separated. The aqueous phase is washed with 50 ml of xylene. The combined organic phases are washed with 20 ml of water and dried over sodium sulfate. The solvent is evaporated and the residue is crystallized from n-heptane. This gives 18.6 g (88%) of 4′-methylbiphenyl-2-carbonitrile having a melting point of 48-49 C.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Clariant GmbH; US2001/20104; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A reaction flask was charged with 1 , l’-bis(diphenylphosphino)ferrocene (1.84 g, 3.32 mmol), bis(l,5-cyclooctadiene)nickel (0.75 g, 2.80 mmol) and oxygen-free toluene (10 mL) under a nitrogen atmosphere in a glovebox. After stirring for 4 h at room temperature, hexanes (40 mL) were added to the reaction mixture. The reaction mixture was allowed to stand overnight, and then the solvents were decanted off and the orange-yellow solid remaining was washed with hexanes. The solid was dried under vacuum to give the title compound as an orange-yellow solid (1.86 g, 78percent yield). 31P NMR (benzene-^): delta 38.4 (s).

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2009/61991; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, mixing dimethyl sulfide gold chloride with a phosphine ligand BrettPhos in dichloromethane, stirring the reaction for 5 min at room temperature, filtering, and spinning, That is, the BrettPhosAuCl catalyst is obtained, and the ratio of the phosphine ligands BrettPhos, dimethyl sulfide, gold chloride, and dichloromethane is 1 mmol: 1 mmol: 1 mL;

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanyang Normal College; Li Ting; Li Bo; Yang Yuhan; Yang Ping; (9 pag.)CN109053654; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgOTf (0.0513 g, 0.2 mmol) into the reaction flask. After stirring for 18 h and then filtrating, the filtrate was slow evaporated at ambient temperature. 8 days later, colorless block-shaped crystals were obtained. Yield: 39.2percent (0.0935 g). Anal. Calc. for(C63H52AgF3O4P4S): C, 63.38; H, 4.36; N, 0. Found: C, 63.26; H,4.32; N, 0percent. IR (cm-1, KBr pellets): 3467br, 3055m, 1968w,1660m, 1587m, 1564m, 1482s, 1461s, 1435vs, 1280vs, 1253vs,1223s, 1160s, 1097s, 1069m, 1029vs, 999m, 877w, 798m, 746s,724m, 694vs, 636s, 572w, 512s, 473m, 448w, 421w. 1H NMR(600 MHz, CDCl3): 2.90 (d, 4H, dppe), 6.66?7.28 (m, 48H, Ph). 31P{1H} NMR (243 MHz, CD3Cl): 5.1 (br, d, JAg?P = 364.5 Hz, dppe),5.3 (dt, J19F?P = 211.4 Hz, dppe), 10.1 (2d, J19F?P = 102.1 Hz, DPEphos),11.3 (2d, J19F?P = 116.7 Hz, DPEphos), 11.5 (dd, J109Ag?P = 245.4 Hz,J107Ag?P = 235.7 Hz, DPEphos)., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: NHC-Cu(I) complexes 1-3 were synthesized by the following route:a solution of imidazolium salt (0.4 mmol), copper powder (0.032 g,0.5 mmol) and POP (0.22 g, 0.4 mmol) reacted in CH3CN (5 mL) at60 C for 24 h. The resulting mixture was filtered through a plug ofCelite and concentrated to ca. 1 mL. Addition of Et2O (10 ml) to thefiltrate afforded a pale yellow precipitate, which was collected andwashed with Et2O. And the productwas recrystallized with ethanol., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Jinglan; Liu, Shaobo; Xu, Shengxian; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Organometallic Chemistry; vol. 846; (2017); p. 351 – 359;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Cu(CH3CN)4]ClO4 (16.3 mg, 0.050 mmol) was added to a mixtureof ppipH (19.3 mg, 0.050 mmol) and POP (27.9 mg, 98%,0.050 mmol) in DCM under a stream of dry argon with a vacuum-line system and Schlenk techniques and the mixture was stirredfor 2 h at room temperature. After filtration, layering n-hexanecarefully onto the DCM filtrate produced orange-yellow crystals afew days later as 1aCH2Cl2. The orange-yellow product wasobtained in a 55.4% yield (32.4 mg) after being dried under aninfrared lamp. Mp: 200.9-201.7 C. 1H NMR (400 MHz, DMSO-d6,d, ppm): 14.67 (s, 1H, NH), 9.07 (d, J = 8.0 Hz, 2H), 8.87 (d,J = 4.4 Hz, 2H), 7.93 (s, br, 2H), 7.45 (td, J = 7.6 Hz, J0 = 1.2 Hz, 2H),7.32-7.18 (m, 14H), 7.10 (t, J = 7.6 Hz, 2H), 7.00-6.96 (m, 8H),6.65-6.62 (m, 2H). 31P NMR (400 MHz, DMSO-d6, d, ppm):11.22. Characteristic IR spectrum (KBr, cm1): 3144 s (NH),1097 s (ClO4). ESI-MS (m/z): 987.1493 [Cu(ppipH)(POP)]+ (Calc.987.1497)., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Liu, Xia; Shan, Yuyu; Xu, Jie; Zhang, Xia; Shang, Sitong; Li, Xiu-Ling; Polyhedron; vol. 164; (2019); p. 152 – 158;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: PyIm-Cu(I) complexes P1?P4 were synthesized by the following route: [Cu(CH3CN)4](PF6) (0.124g, 0.4mmol) and POP (0.216g, 0.4mmol) reacted in dichloromethane (15ml) at 25¡ãC for 2h. Then, the corresponding PyIm ligand (0.4mmol) was dissolved in the degassed dichloromethane solution and injected into the mixed solution for 2h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1ml. Addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. And the product was recrystallized with ethanol., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Wang, Jinglan; Chai, Chaoyang; Xu, Shengxian; Zhao, Feng; Xia, Hongying; Wang, Yibo; Inorganica Chimica Acta; vol. 484; (2019); p. 237 – 244;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

146960-90-9, 1,1′-Bis(dicyclohexylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,1′-Bis(dicyclohexylphosphino)ferrocene (dcpf) (0.578 g, 1.0 mmol) was added to a solution of silver(I) cyanide (0.134 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture at room temperature. The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h in dark. Slowly, the colour ofthe solution changed from light yellowish orange to dark yellowish orange colour. The resulting solution was evaporated to dryness to give a yellowish orange solid which was then extracted with dichloromethane (20 mL). The addition of diethyl ether (100 mL) to this solution led to yellow needle shaped diffraction quality crystals. These were separated and washed with hexane and dried. Yield: (0.846 g, 50 %). Anal. Calc. for C72H104N4P4Ag4Fe2: C, 51.06; H,6.15; N, 3.31. Found: C, 51.28; H, 6.34; N, 3.43. IR (cm-1, KBr): nu = 3401, 2926, 2852, 2368, 2345, 2129(CN), 1740, 1444, 1240, 1165, 1109, 1036, 850, 625, 480. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K):4.43 (s, 8H, C5H4), 4.18 (s, 8H, C5H4), 2.71-1.34 (m, 88H, Cy). 31P{1H}:delta 56.6 (sbr). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 272 (14,719), 478 (30,674). ESI-MS (m/z): 1692.8 (M+)., 146960-90-9

As the paragraph descriping shows that 146960-90-9 is playing an increasingly important role.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate