Tag: M.W:500-600

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC?Cu(I) complexes 1?3 were synthesized by the following route: a solution of imidazolium salt (0.4mmol), copper powder (0.032g, 0.5mmol) and POP (0.22g, 0.4mmol) was reacted in CH3CN (5mL) at 60¡ãC for 24h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. The addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. The product was recrystallized with ethanol., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Xu, Shengxian; Wang, Jinglan; Liu, Shaobo; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Molecular Structure; vol. 1153; (2018); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Add 20mg tricine and 5mg TPPTS to the penicillin vial.Add 0.2 mL of physiological saline to dissolve it. Add 25mug SnCl2¡¤2H2O,Then add 10 muL of DMF solution (1 mg/mL) containing ligand HYNICPBB and 0.5 mL of freshly rinsed 99mTcO4-solution.Reaction at 100 C for 30 min,That is, the 99mTc (HYNICPBB) (tricine/TPPTS) complex of the present invention is obtained.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Normal University; Zhang Junbo; Song Xiaoqing; Gan Qianqian; Zhang Xuran; Wang Xuebin; Tang Zhigang; Lu Jie; Zhang Zhanbin; (7 pag.)CN110078768; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: To suspension of sodium dithiocarbamate 2a-f (0.5 mmol) inCH3OH (10 mL) was added a solution of K2PtCl4 (0.210 g,0.50 mmol) in H2O (10 mL). The reaction mixture wasstirred for 30 min. Next, a solution of dppf (0.28 g, 0.50 mmol)in CH2Cl2 (10 mL) was slowly added to the above mixtureand stirred for 24 h. KPF6 (0.46 g, 2.5 mmol) was addedand the mixture was stirred for another 8 h. The solvent wasthen evaporated, and dichloromethane was added to theresidue and the mixture washed with water. The organicphases were dried over anhydrous Na2SO4. The crude productwas purified by chromatography (eluent: CH2Cl2/CH3OH, 50:1, v/v) to give complexes 3a-f.3a: yellow solid, 0.30 g (Yield: 58%). 1H NMR (500MHz, CDCl3): delta 7.64 (m, 7H, -PhH), 7.56 (t, J = 6.8 Hz,5H, -PhH), 7.48 (t, J = 6.9 Hz, 8H, -PhH), 4.57 (s, 4H,-CpH), 4.38 (d, J = 1.7 Hz, 4H, -CpH), 3.54 (t, J = 7.2 Hz,4H, -NCH2-, -NCH2-), 1.20 (t, J = 7.2 Hz, 6H, -CH2CH3,-CH2CH3). 13C NMR (125 MHz, CDCl3): delta 133.94, 133.89,133.85, 132.29, 129.48, 128.99, 128.94, 128.90, 76.18,74.45, 44.67, 12.39. 31P NMR (200 MHz, CDCl3): delta 15.94,-144.30 (m). ESI-MS(+): m/z found 843.1473 [M-Fe-PF6]+,897.0880 [M-PF6]+, calcd for C39H38F6FeNP3PtS21042.0560.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Xu, Shou De; Wu, Xiang Hua; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 437 – 442;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Under argon protection,Add to 50mLSchlenk bottle1 ¡¤ 56 mmol of (SO3Na) 3-R6,4.73 mmol of [CH3 (EO)4N+H=C(N (CH3) 2)2] [CH3SO3-] and 1 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours,Filtration and removal of the filtrate under reduced pressure gave an orange-yellow viscous liquid in 91% yield.

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

A mixture of CuI (0.0379g, 0.2mmol), POP (0.1080g, 0.2mmol) and C16H6N6 (0.0565g, 0.2mmol) were dissolved in a mixture of CH2Cl2 (5ml) and CH3OH (5ml), stirred for 6h and filtered. Yellow crystals of 4 were obtained from the filtrate after standing at room temperature for several days. Yield: 85percent. Anal. Calc. for C52H34CuIN6OP2: C, 61.71; H, 3.36; N, 8.31. Found: C, 60.97.11; H, 3.88; N, 7.70percent. IR (cm?1): 3399m, 3050w, 1585w, 1512w, 1461m, 1433m, 1372s, 1259m, 1209s, 1095m, 997w, 873w, 804w, 748s, 697s, 619w, 512s, 425m. 1H NMR (600MHz, CDCl3, 298K) delta, ppm: 7.1?7.4 (m, overlap with the solvent peak signal, C16H6N6-aromatic ring, pop-aromatic ring), 8.6 (d, 2H, C16H6N6-aromatic ring), 8.0 (d, 2H, C16H6N6-aromatic ring)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Yan-Ru; Yu, Xiao; Lin, Sen; Jin, Qiong-Hua; Yang, Yu-Ping; Liu, Min; Li, Zhong-Feng; Zhang, Cun-Lin; Xin, Xiu-Lan; Polyhedron; vol. 138; (2017); p. 46 – 56;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The complex Ru(OAc)2(CO)(PPh3)2 (200.5 mg, 0.26 mmol, 1 equiv) suspended in 5 mL of toluene, was reacted with the ligand dppf (167.3 mg, 0.26 mmol, 1 equiv). After stirring at 1 10 ¡ãC for 2 h, the solution was concentrated to about 1 mL and the complex was precipitated by addition of 10 mL n-heptane, filtered, washed 3 times with 4 mL of n-heptane, 3 times with 3 mL of ethyl ether and dried under reduced pressure. Yield: 139.6 mg (67percent) determined to be a mixture of 3 isomers in a ratio of 7/2/1 at -70 ¡ãC, the mixture is interchanging at room temperature. Anal. Calcd (percent) for C39H34FeO5P2Ru: C, 58.44; H, 4.28; Found: C, 58.10; H, 4.60. 1H NMR (200 MHz, CDCI3, 25 ¡ãC) delta 7.95 – 7.14 (m broad, 20 H), 4.68 – 4.24 (m broad, 8H), 1 .56 (s broad, 6H). 13C NMR (50 MHz, CD2CI2, 25 ¡ãC) delta 134.9 – 133.1 (m), 130.7 (d, J = 16.0 Hz), 129.1 – 127.2 (m), 75.5 (d, J = 36.2 Hz), 73.1 , 72.6, 24.2 (s, broad). 13C NMR (50 MHz, CD2CI2, -70 ¡ãC) delta 203.07 (t, J = 16.5 Hz), 182.69 (s), 181 .93 (s), 134.64 (dd, J = 22.9, 9.9 Hz), 132.95 (d, J = 9.7 Hz), 132.24 – 130.81 (m), 129.84 (s), 127.92 – 126.43 (m), 78.20 – 76.66 (m), 75.95 (d, J = 5.4 Hz), 75.53 – 74.02 (m), 72.71 (s), 71 .80 (d, J = 6.1 Hz), 71 .14 (d, J = 5.4 Hz), 25.40 (s), 24.47 (d, J = 4.8 Hz). 31P NMR (81 MHz, CD2CI2, 25 ¡ãC) delta 50.8 (s broad). 31P NMR (81 MHz, CD2CI2, -70 ¡ãC) delta 53.1 (d, J = 27.1 Hz, 10percent), 52.0 (d, J = 26.7 Hz, 23percent), 49.8 (d, J = 30.4 Hz), 45.4 (d, J = 30.4 Hz, 67percent), 43.5 (d, J = 26.8 Hz, 10percent). IR (cm-1): 1974, 1613.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITA’ DEGLI STUDI DI UDINE; INNOVATION FACTORY S.R.L.; BARATTA, Walter; BALDINO, Salvatore; GIBOULOT, Steven; (76 pag.)WO2017/134618; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC?Cu(I) complexes 1?3 were synthesized by the following route: a solution of imidazolium salt (0.4mmol), copper powder (0.032g, 0.5mmol) and POP (0.22g, 0.4mmol) was reacted in CH3CN (5mL) at 60¡ãC for 24h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. The addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. The product was recrystallized with ethanol. [Cu(Ph-BenIm-Py)](PF6), 1. The product was a white powder. Yield: 0.30g, 72percent. 1H NMR (400MHz, DMSO-d6): delta 8.41 (dd, J=20.0, 8.3Hz, 2H), 8.14 (dd, J=15.2, 6.0Hz, 2H), 7.55?7.46 (m, 2H), 7.44?7.31 (m, 8H), 7.27?7.19 (m, 10H), 7.14?6.99 (m, 8H), 6.94 (d, J=7.7Hz, 5H), 6.84 (d, J=7.4Hz, 2H), 6.62 (d, J=3.3Hz, 2H), 5.31 (s, 2H). 13C NMR (101MHz, DMSO-d6). delta 157.54, 150.39, 149.33, 147.58, 141.75, 140.09, 135.23, 134.89, 134.51, 133.67, 132.96, 132.17, 131.58, 131.03, 129.55, 129.15, 128.37, 127.92, 127.57, 126.99, 125.87, 125.23, 124.19, 123.72, 122.98, 121.72, 121.16, 119.69, 114.23, 113.30, 112.59, 111.41, 51.87.31P NMR (162MHz, DMSO-d6): delta?8.95 (s),?143.45 (quint). HRMS (m/z, ESI+): calcd. For C55H43CuN3OP2 ([M]+) 886.2177; found 886.2169. Anal. Calcd. For C55H43CuF6N3OP3 (1032.41): C 63.99, H 4.20, N 4.07; found: C 63.77, H 4.11, N 3.98., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Xu, Shengxian; Wang, Jinglan; Liu, Shaobo; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Molecular Structure; vol. 1153; (2018); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The complex RuCl2(CO)(dmf)(PPh3)2 (199.3 mg, 0.25 mmol, 1 equiv) suspended in 5 mL of toluene, was reacted with the ligand dppf (141 .3 mg, 0.25 mmol, 1 equiv). After stirring the mixture at 110 ¡ãC for 2 h, the obtained solution was concentrated to about 1 mL, 10 mL n-heptane were added and the suspension was stirred at room temperature for 1 h. The precipitate was filtered, the obtained solid was washed 3 times with 4 mL of n-heptane, 3 times with 3 mL of ethyl ether and dried under reduced pressure. Yield: 99.5 mg (39percent). Anal. Calcd (percent) for C35H28CI2FeOP2Ru: C, 55.73; H, 3.74 Found: C, 55.41 ; H, 3.33. 31 P NMR (81 MHz, CD2CI2) delta 53.6 (d, J = 27.2 Hz), 46.6 (d, J = 26.8 Hz). IR (cm-1): 1979.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITA’ DEGLI STUDI DI UDINE; INNOVATION FACTORY S.R.L.; BARATTA, Walter; BALDINO, Salvatore; GIBOULOT, Steven; (76 pag.)WO2017/134618; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, General Procedure 1. A solution of BrettPhos (1.5 eq) and aryl bromide (6.0 eq) in THF (15 mL mmol-1) was added to a vial containing (COD)Pd(CH2TMS)2 (1.0 eq). The resulting yellow solution was stirred for 48 h and then layered with twice the volume of pentane and left standing. After 24 h, the resulting solid was filtered off, washed with pentane and dried under vacuum. Preparation of (BrettPhos)Pd(2-Me,4-CF3C6H3)(Br). According to general procedure 1, (COD)Pd(CH2TMS)2 (144 mg, 0.37 mmol) was reacted with BrettPhos (300 mg, 0.56 mmol) and 2-methyl-4-trifluoromethylbromobenzene (531 mg, 2.22 mmol) in 6 mL THF to afford 218 mg (247 mummol, 67%) of the desired complex as a white powder. 31P-NMR (162 MHz, CDCl3): delta=43.9 ppm. 19F-NMR (376 MHz): delta=-62.1 ppm. 1H (500 MHz, CDCl3): complex spectrum, shown in FIG. 9.

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Massachusetts Institute of Technology; US2011/15401; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Under argon protection,Add to 50mLSchlenk bottle1 ¡¤ 56 mmol of (SO3Na+)3-R6, 4¡¤73 mmol of [CH3 (EO)16N+(n-C6H13) = C(N(CH3) 2) 2] [CH3SO3-] and 10 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours,The filtrate was filtered and the acetonitrile was removed under reduced pressure to give an orange-yellow viscous liquid in 95% yield.

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate