Tag: M.W:500-600

Reference of 166330-10-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 166330-10-5, Name is (Oxybis(2,1-phenylene))bis(diphenylphosphine)

Four new heteroleptic copper(I) complexes bearing either 2-pyridyl-1,2,3-triazole (pytri) or the related triphenylamine (TPA) substituted (TPA-tripy) ligands and the ancillary ligands 6,6?-dimesityl-2,2?-bipyridine (diMesbpy) or bis[(2-diphenylphosphino)phenyl] ether (POP) were synthesized in good yields (75-95%). All the complexes were extensively characterized using nuclear magnetic resonance (NMR) spectroscopies and electrospray ionization mass spectrometry (ESIMS) and in the case of the two pytri compounds the solid state structures were determined via X-ray crystallography. The pytri complexes showed MLCT absorption bands which shift from 433 nm for the diMesbpy complex to 347 nm for POP. TPA-pytri complexes introduce an ILCT band resulting in improved visible absorption (376 nm, 26,400 M?1 cm?1 for [Cu(TPA-pytri)(diMesbpy)](PF6)). Emission from this ILCT state (470 nm, Phi = 0.08) was red-shifted compared to the free ligand with negligible effects from ancillary ligands. Band assignments were confirmed with resonance Raman spectroscopy and TD-DFT calculations.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene, molecular formula is C34H28FeP2. In a Article，once mentioned of 12150-46-8, Formula: C34H28FeP2

Addition of 1,1′-bis(diphenylphosphino)ferrocene (dppf) to an ‘activated mixture’ containing and Me3NO*2H2O in thf-MeOH (2:1) in the molar ratio 1.0:1.0:2.4 at 25 deg C gives in 34percent yield.The molecular structure was determined by X-ray diffraction analysis: monoclinic, space group P21/n, a = 13.646(1), b = 18.440(2), c = 17.850(4) Angstroem, beta = 97.69(1) deg, final R 0.030 for 3992 observations.It contains two tricarbonylrhenium(I) moieties bridged by dppf and two methoxo ligands.The cp-Fe-cp (cp = eta-C5H5) axis of dppf makes a projection of 53.5 deg onto the Re-Re axis.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 12150-46-8 is helpful to your research., Formula: C34H28FeP2

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 166330-10-5, Name is (Oxybis(2,1-phenylene))bis(diphenylphosphine), molecular formula is C36H28OP2. In a Review，once mentioned of 166330-10-5, Formula: C36H28OP2

Biginelli compounds are one of the most important heterocyclic systems that play an important role in medicinal chemistry. It has been proved that the biological activities of these compounds are dependent on the absolute configuration of the C4 atom of the heterocyclic ring, and thus the oxidative dehydrogenation reaction can affect their biological and pharmaceutical activities. In this review, the oxidation methods of various Biginelli compounds have been summarized with a focus on the conditions of the reactions, the proposed mechanisms, and the effect of the substituents on the reaction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Formula: C36H28OP2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 166330-10-5, in my other articles.

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Reference of 161265-03-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 161265-03-8, C39H32OP2. A document type is Article, introducing its new discovery.

(Chemical Equation Presented) Palladium-catalyzed arylation of sulfenate anions generated from beta-sulfinyl esters can take place under biphasic conditions. This hitherto unknown reaction provides a simple, mild, and efficient route to aryl sulfoxides in good yields. The development of a new pseudo-domino type I procedure involving a sulfinylation followed by a Mirozoki-Heck coupling is also described.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a Patent，once mentioned of 161265-03-8, category: chiral-phosphine-ligands

The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect. A pharmaceutical composition having a P2X3 and/or P2X2/3 receptor antagonistic effect comprising a compound of the formula (I): wherein ring A is substituted or unsubstituted 5 to 7-membered cycloalkane, substituted or unsubstituted 5 to 7-membered cycloalkene or the like; C is a carbon atom; -X- is -N(R16)- or the like; R16 is hydrogen, substituted or unsubstituted alkyl or the like; R7 is substituted or unsubstituted 5- or 6-membered heteroaryl, substituted or unsubstituted 6 to 10 membered aryl; Q1 and Q2 are each independently a carbon atom or a nitrogen atom; -L- is -O-, -S- or the like; R6 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or the like; R2 is hydrogen, hydroxy or the like, or its pharmaceutically acceptable salt or a solvate thereof.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 161265-03-8 is helpful to your research., category: chiral-phosphine-ligands

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Synthetic Route of 161265-03-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine)

The present invention is directed to novel compounds according to formulae (I) wherein R1, R2 , R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 12150-46-8, C34H28FeP2. A document type is Article, introducing its new discovery., category: chiral-phosphine-ligands

Reactions of PdCl2, LiCl, 4-R-N’-(mesitylidene)benzohydrazides (H2Ln; n = 1 and 2 for R = H and OMe, respectively) and NaOAc·3H2O in 1:2:1:1 mol ratio in methanol produce [Pd(HLn)Cl] (1 (n = 1) and 2 (n = 2)) in ?77% yields. Reactions of [Pd(HLn)Cl] (1 and 2) with PPh3 in 1:2 mol ratio in acetone provide [Pd(Ln)(PPh3)] (3 (n = 1) and 4 (n = 2)) in ?76% yields. Whereas, treatment of 2 mol equivalents of [Pd(HLn)Cl] (1 and 2) with 1 mol equivalent of 1,4-bis(diphenylphosphino)butane (dppb) in acetone affords the dinuclear [Pd2(mu-dppb)(Ln)2] (5 (n = 1) and 6 (n = 2)) in ?74% yields. Analogous reaction between [Pd(HL2)Cl] (2) and 1,1′-bis(diphenylphosphino)ferrocene (dppf) provides [Pd2(mu-dppf)(L2)2] (7) in 67% yield. Elemental (CHN) analysis, X-ray crystallographic and spectroscopic (IR, UV-Vis and NMR) measurements have been used to characterize all the complexes. In these complexes, the metal centers are in square-planar CNOCl or CNOP coordination geometry formed by the 6,5-membered fused chelate rings forming methylene-C, azomethine-N and amide- or amidate-O donor (HLn)- or (Ln)2- and the ancillary ligand chloride or phosphine. The spectroscopic properties of the complexes are consistent with the corresponding molecular structures established by X-ray crystallography.

Interested yet? Keep reading other articles of 12150-46-8!, category: chiral-phosphine-ligands

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Reference of 166330-10-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 166330-10-5, Name is (Oxybis(2,1-phenylene))bis(diphenylphosphine), molecular formula is C36H28OP2. In a Article，once mentioned of 166330-10-5

A new method for the rhodium-catalyzed regioselective C-C bond formation using terminal alkynes and 1,3-dicarbonyl compounds to achieve valuable branched alpha-allylated 1,3-dicarbonyl products is reported. With a Rh(I)/DPEphos/p-CF3-benzoic acid as the catalyst system, the desired products can be obtained in good to excellent yields and with perfect regioselectivity. A broad range of functional groups were tolerated, and first experimental insights of a plausible reaction mechanism were obtained.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 166330-10-5 is helpful to your research., Reference of 166330-10-5

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161265-03-8, Name is (9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine), molecular formula is C39H32OP2. In a Article，once mentioned of 161265-03-8, Recommanded Product: 161265-03-8

Palladium(II) dialkyl complexes have previously been studied for their formation of alkanes through reductive elimination. More recently, these complexes, especially L2Pd(CH2TMS)2 derived from Pd(COD)(CH2TMS)2, have found general use as palladium(0) precursors for stoichiometric formation of oxidative addition complexes through a two-electron reductive elimination/oxidative addition sequence. Herein, we report evidence for an alternative pathway, proceeding through single-electron elementary steps, when DPEPhosPd(CH2TMS)2 is treated with an alpha-bromo-alpha,alpha-difluoroacetamide. This new pathway does not take place through a palladium(0) intermediate, neither does it afford the expected oxidative addition complexes. Instead, stoichiometric amounts of carbon-centered alkyl radicals are formed, which can be trapped in high yields either by TEMPO or by an arene, leading to alpha-aryl-alpha,alpha-difluoroacetamides. The same overall transformation takes place under both thermal conditions (70 C) and irradiation with a household light bulb (at 30 C). It is also demonstrated that DPEPhosPdMe2, made in situ from Pd(TMEDA)Me2, displays a similar initial reactivity. Finally, electronically and structurally different alkyl bromides were evaluated as reaction partners.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: 161265-03-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 161265-03-8, in my other articles.

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application of 12150-46-8. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 12150-46-8, Name is 1,1-Bis(diphenylphosphino)ferrocene. In a document type is Article, introducing its new discovery.

The substitution chemistry of the complex [RuCl(PPh3)2{HB(pz)3}] (1) is reported. Treating 1 with the phosphines bis(diphenylphosphino)methane (dppm), 1,2-bis(diphenylphosphino)-ethane (dppe), or 1,1?-bis(diphenylphosphino)ferrocene (dppf) provides the complexes [RuCl-(dppm){HB(pz)3}] (2), [RuCl(dppe){HB(pz)3}] (3), or [RuCl(dppf){HB(pz)3}] (4), respectively. Reactions of 1 with pivaloisonitrile (CNCMe3) are solvent dependent: In neat dichloromethane or tetrahydrofuran the reaction of 1 with CNCMe3 provides the neutral complex [Ru(CNCMe3)Cl(PPh3)(HB(pz)3}] (5), while the salt [Ru(CNCMe3)(PPh3)2{HB(pz)3}]PF 6 (6· PF6) is obtained when the reaction is carried out in dichloromethane/methanol mixtures in the presence of NH4PF6. The reaction of 4 with CNCMe3 and NH4PF6 provides the salt [Ru-(CNCMe3)(dppf){HB(pz)3}]PF 6(7·PF6). The bis(isonitrile) salt [Ru(CNCMe3)2(PPh3){HB(pz)3}]-PF 6 (8·PF6) results from the reaction of 1, 5, or 6·PF6 with excess CNCMe3 in thf/methanol. The reaction of 1 with Na[S2CNMe2] provides the complex [Ru(S2CNMe2)(PPh3){HB(pz)3}] (9); however similar reaction of 1 or [Ru(NCMe)2(PPh3){HB(pz)3)]PF6 with Na[O2CH] failed to cleanly provide [Ru(O2CH)(PPh3){HB(pz)3}] (10), although this could be characterized spectroscopically. Rather, the ultimate product of these reactions was the hydrido complex [RuH(PPh3)2{HB(pz)3)] (11), which could also be obtained in high yield from the reaction of 1 with NaOMe. In a similar manner, reaction of 4 with methanolic NaOMe provided [RuH-(dppf){HB(pz)3}] (12). The reactions of 1 and 4 with alkynes are solvent dependent: Treating 1 with HC?CR (R = C6H4Me-4, CPh2OH) in thf provides, respectively, the vinylidene complex [RuCl(=C=CHC6H4Me-4)(PPh3){HB(pz)3}] (13) and the allenylidene complex [RuCl(=C= C=CPh2)(PPh3){HB(pz)3}] (14), while the reaction of 1 with HC?CC6H4Me-4 in a mixture of thf and methanol provides the alkynyl complex [Ru(C?CC6H4Me-4)(PPh3) 2{HB(pz)3}] (15). The reaction of 1 with HC?CCPh2OH in the presence of AgPF6 provides the allenylidene salt [Ru(=C=C=CPh2)(PPh3)2{HB(pz) 3}]PF6 (16·PF6), and similar treatment of 4 provides [Ru(=C=C=CPh2)(dppf){HB(pz)3}]PF6 (17·PF6). The reaction of 4 with HC?CC6H4Me-4 and AgPF6 provides the vinylidene salt [Ru(=C=CHC6H4Me-4)(dppf){HB(pz)3}]PF 6 (18·PF6), deprotonation of which (NaOMe) provides [Ru(C?CC6H4Me-4)(dppf){HB(pz)3}] (19). The allenylidene salt (16·PF6) with NaOMe provides the gamma-alkoxyalkynyl complex [Ru(C?CCPh2-OMe)(PPh3)2{HB(pz) 3}] (20). The complex [OsCl(PPh3)2{HB(pz)3}] (21) is obtained from the reaction of [OsCl2(PPh3)3] with K[HB(pz)3] and is converted by KOH in reluxing 2-methoxyethanol to the hydride complex [OsH(PPh3)2{HB(pz)3}] (22). The vinylidene complex 13 reacts with [Et2NH2][S2CNEt2] to provide the metallacyclic vinyl complex [Ru{C(=CHC6H4-Me-4)SC(NEt2)S}(PPh 3){HB(pz)3}] (23). Similarly the complex 14 and the salt 16·PF6 react with Na[S2CNMe2] to both provide the metallacyclic allenyl complex [Ru{C(=C=CPh2)SC-(NMe2)S}(PPh3){HB(Pz) 3}] (24). These reactions represent the first examples of the coupling of dithiocarbamates with vinylidene and allenylidene ligands. The complexes 5 and [RuCl-(CS)(PPh3){HB(Pz)3}] (25) and the salt (16·PF6) were characterized crystallographically.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate