Tag: M.W:400-500

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

787618-22-8, General procedure: Representative procedure for the preparation of rPdtoptionally substituted (Ri?), allyl)(liqand)(X) complexes: A dry Schlenk tube is charged with the ligand (4.74 mmol) and [(optionally substituted (Ri2)m- allyl)PdCI]2 (2.36 mmol). The tube is evacuated and backfilled with nitrogen a total of three times. 10 mL of anhydrous solvent (such as THF or toluene) is added and the mixture is stirred at room temperature for a period of time (e.g . 20 minutes). Pentane (5 mL) or hexanes is added to fully precipitate the product. The product is collected by vacuum filtration, washed (3 x 10 mL of pentane, or hexanes) and dried under vacuum

The synthetic route of 787618-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Several ml of toluene were condensed into evacuated ampoule containing the mixture of 5mg (1 eq) of (CO)2Rh(SQ) and 1.1 eq of corresponding diphos under intensive cooling by liquid N2. Solution was quickly brought to room temperature with shaking and placed into EPR cavity immediately. All of reactions were carried out without isolation of the products.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Kozhanov; Bubnov; Teplova; Abakumov; Cherkasov; Journal of Molecular Structure; vol. 1147; (2017); p. 541 – 548;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-18-7, Example 412 55 mg of 2-nitroaniline, 0.17 g of cesium carbonate, 2.4 mg of tris(dibenzylideneacetone)dipalladium(0), 1.2 mg of palladium acetate and 6.3 mg of 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl were added to 2.0 mL of toluene solution containing 0.10 g of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 4 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 1:1] to obtain 94 mg of tert-butyl 2-(benzamido)-4-(2-nitroanilino)benzoate as yellow solid. 1H-NMR (CDCl3) delta: 1.64 (9H, s), 6.90-6.96 (2H, m), 7.50-7.60 (4H, m), 7.66 (1H, dd, J = 8.5, 1.2 Hz), 8.02 (1H, d, J = 8.5 Hz), 8.02-8.08 (2H, m), 8.22 (1H, dd, J = 8.7, 1.6 Hz), 8.94 (1H, d, J = 2.2 Hz), 9.53 (1H, s), 12.33 (1H, s).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Example 526 29 mg of 3,5-difluorophenol, 79 mg of tripotassium phosphate, 4.7 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 6.8 mg of tris(dibenzylideneacetone)dipalladium(0) were added to 1.4 mL of toluene solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 3 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain 71 mg of tert-butyl 2-(benzamido)-4-(3,5-difluorophenoxy)benzoate as colorless oil. 1H-NMR (CDCl3) delta: 1.64 (9H, s), 6.56-6.63 (3H, m), 6.73 (1H, dd, J = 8.8, 2.4 Hz), 7.50-7.60 (3H, m), 8.01-8.07 (3H, m), 8.70 (1H, d, J = 2.4 Hz), 12.34 (1H, s).

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, (2) A suspension of the compound obtained in (1) (107 g), ethyl 1H-pyrazole-4-carboxylic acid (59.22 g), tripotassium phosphate (112.14 g), 2-di-t-butylphosphino-2′,4′,6′-triisopropyl biphenyl (11.22 g) and tris(dibenzylideneacetone)dipalladium(0) (8.06 g) in t-butyl alcohol (1173 mL) was stirred under nitrogen atmosphere for 4 hours at 90 C. The reaction mixture was added with water and filtered, and the resulting crystals were washed with methanol. The crystals were then dissolved in chloroform, and NH-silica gel (300 mL), silica gel (300 mL) and sodium sulfate (200 g) were added, followed by filtration to remove the insoluble material. The filtrate was concentrated under reduced pressure, the residue was added with methanol. The resulting crystals were corrected by filtration to yield ethyl 1-[7-methoxy-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylate (99.62 g, 69% yield) as colorless crystals. MS (ESI) m/z: 409 [M+H]+.

564483-19-8 Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine 11618717, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei; US2015/239889; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

Example 7 (EX 7) (0136) IrCl3(THT)3 (150 mg, 0.27 mmol) was placed in a round-bottom flask, (0137) (119 mg, 0.27 mmol), 15 ml decalin, and 15 ml dimethylformamide were subsequently added thereto to obtain the first mixture. The first mixture was heated under reflux and under a nitrogen atmosphere for a period of 6 hours. After the reaction was completed and the temperature was cooled down to room temperature, decalin in the first mixture was removed by reduced pressure distillation. Thereafter, (0138) (51 mg, 0.27 mmol) and 15 ml dimethylformamide were sequentially added to the first mixture, from which decalin was removed, to obtain a second mixture. The second mixture was heated under reflux and under a nitrogen atmosphere for a second reaction period of 12 hours. After the reaction was completed and the temperature was reduced to room temperature, dimethylformamide in the second mixture was removed by reduced pressure distillation to obtain a solid. The solid was washed using diethyl ether to obtain an intermediate product (400 mg, 70% yield).

13991-08-7, The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Liao, Jia-Ling; US8957208; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

564483-18-7, Example 430 Production of N-{3-[(2-anilinoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide A mixture of N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (100 mg, 0.242 mmol), iodobenzene (32 mul, 0.290 mmol), tris(dibenzylideneacetone)dipalladium (0) (11 mg, 24.2 mumol), dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (23 mg, 48.4 mumol), sodium tert-butoxide (34 mg, 0.362 mmol) and toluene (2 mL) was stirred under an argon atmosphere with heating at 80 C. for 5 hr. After the reaction mixture was allowed to cool to room temperature, saturated aqueous sodium hydrogencarbonate solution was added to the mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=0/100?50/50) to give the title compound (19 mg, 16%) as a pale-green powder. 1H-NMR (DMSO-d6, 300 MHz) delta 6.78 (1H, t, J=7.3 Hz), 6.96-7.07 (2H, m), 7.18-7.25 (2H, m), 7.36-7.50 (3H, m), 7.65-7.72 (3H, m), 7.79 (1H, t, J=7.6 Hz), 7.98 (2H, d, J=9.2 Hz), 8.18-8.32 (2H, m), 8.91 (1H, s), 10.58 (1H, s).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

32.6mg mesityl -Cu and 3ml of toluene were added to 34.6mg (0.18mmol) of 8-PyQ and 79.5mg (0.18 mmol) of dppb in a glove box. It forms a dark Redsolution. This was filtered and coated with n-hexane layer. it forms redcrystals. under UV (356nm), they emit a strong red. the solution in the sameway emits a strong red. Yield: 70%.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

19845-69-3, 1,6-Bis(diphenylphosphino)hexane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dppb (59.4mg, 97%, 0.15mmol) was added to a DCM solution (10mL) of (C14H9C?CAu)n (119.4mg, 0.30mmol) with stirring at room temperature, then the solution was kept stirring for 1h. After filtration, addition of ethyl ether to the concentrated solution gave the product as brown powder (yield 100.8mg, 55%).

19845-69-3, 19845-69-3 1,6-Bis(diphenylphosphino)hexane 2754312, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Chen, Jing; Huang, Miao-Miao; Shi, Yanhui; Li, Xiu-Ling; Journal of Organometallic Chemistry; vol. 834; (2017); p. 58 – 63;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

19845-69-3, 1,6-Bis(diphenylphosphino)hexane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the dimeric complex [Pd(mu-Cl)(Cl)(NHC)]2(0.10 mmol) and the appropriate diphosphine ligand (0.10 mmol) was dissolved in CH2Cl2 (5.0 mL) and stirred at ambient temperature overnight. The reaction mixture was filtered over Celite, the solvent was reduced under vacuum to about 1.0 mL and the yellow precipitate formed by careful addition of n-hexane (c.a. 10 mL). The yellow solid was then filtered off, washed with n-hexane, and dried under vacuum.

19845-69-3, As the paragraph descriping shows that 19845-69-3 is playing an increasingly important role.

Reference£º
Article; Yang, Jin; Li, Pinhua; Zhang, Yicheng; Wang, Lei; Journal of Organometallic Chemistry; vol. 766; (2014); p. 73 – 78;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate