Tag: M.W:400-500

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

The experimental multi-tooth phosphine coordination silver complex double emitting dye synthesis method according to the following steps:1 mmol of multidentate phosphine ligand, 1 mmol of AgI, 5 ml of DCM were mixed and reacted at 40 C. for 10 hours. The mixture was spin-dried and purified by column chromatography with DCM and PE to obtain a multidentate phosphine coordination silver complex.Wherein the ratio of multidentate phosphine ligand to AgI is 1: 1.The volume ratio of DCM to PE in the mixed solvent of DCM and PE is 1:20.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; Heilongjiang University; Xu Hui; Zhang Jing; Han Chunmiao; (47 pag.)CN106833010; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, tBuXPhos (232 mg, 0.546 mmol) was added inone portion at -78C to a solution of ketone 1 (192 mg, 0.546mmol) in CH2Cl2 (5mL) and the resulting slurry allowed to warmto r.t. while it was stirred. The solvent was then removed undervacuum and the crude product washed with MeOH to afford 7as a white solid (321 mg, 76%).

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Article; Ines, Blanca; Holle, Sigrid; Bock, Dominique A.; Alcarazo, Manuel; Synlett; vol. 25; 11; (2014); p. 1539 – 1541;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

787618-22-8,787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Palladium reagents were synthesized following the scheme of Figure 14 for generalprocedure A. In a nitrogen-filled glovebox, an oven-dried scintillation vial (1 0 mL), whichwas equipped with a magnetic stir bar and fitted with a Teflon screwcap septum, vascharged with RuPhos (2.5 equiv), a dihaloaryl compound (1 equiv) and cydohexane (1.2mL). Solid [(1,5-COD)Pd(CH2Si:Me3)] (2.5 equiv) was added rapidly in one portion and theresulting solution vvas stirred for 16 hat Jt. After this time, pentane (3 mL) was added andthe resulting mixture vas placed into a -20 C freezer for 3 h. The vial was then takenoutside of the glove box, and the resulting precipitate was filtered, washed with pentane (3 X3 mL), and dried under reduced pressure to afford the oxidative addition complex (Figure14)

As the paragraph descriping shows that 787618-22-8 is playing an increasingly important role.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; BUCHWALD, Stephen, L.; PENTELUTE, Bradley, L.; ZHANG, Chi; (170 pag.)WO2017/151910; (2017); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

General procedure: Synthesis of the phosphine oxidesThe phosphine oxides were synthesized by oxidation ofthe corresponding phosphines. Calculated amounts of H2O2(30%) were added slowly to the vigorously stirred THF solutionof the respective phosphine. Stirring was maintainedat room temperature for 2 h. After evaporation of THF, theresidue was treated with acetone-ethyl acetate to obtain therespective phosphine oxide product as a precipitate. The precipitatesthus obtained were filtered off and dried in a vacuum.All melting points were above 360 C with decomposition. OPPO: 1H NMR (250 MHz, CDCl3): d = 7:19 (m, 8H,Phen-H), 7.35 (m, 12H, Phen-H), 7.57 (t, 2H, Phen-H), 7.75(m, 2H, Phen-H). – MS (EI): m=z = 478. Yield 82%.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Pietraszkiewicz, Marek; Mal, Suraj; Pietraszkiewicz, Oksana; Gorski, Krzysztof; Chelwani, Nitin; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 69; 2; (2014); p. 239 – 247;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon atmosphere, 20 mL of dry acetonitrile was added to silver(I) bromide (170 mg , 0.904 mmol) and 1,2-bis(diphenylphosphino)benzene (404 mg, 0.904 mmol), and the mixture was stirred at room temperature for one hour and then heated to reflux for seven hours. The reaction solution was allowed to reach room temperature, concentrated, and filtrated after being suspended in 9 mL of chloroform. The filtrated matter was subjected to thermal recrystallization from acetonitrile-chloroform and dried to obtain 399 mg of the colorless crystal complex. Under argon atmosphere, 3 mL of dry dichloromethane was added to the above obtained complex (80.0 mg, 0.0631 mmol) and triphenylphosphine (33.1 mg, 0.126 mmol), and the mixture was stirred at 40C for 10 minutes. The reaction solution was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 108 mg of the complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (3). The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 7.48-7.17 (m, 31H), 7.07-7.03 (m, 8H); 13C NMR (75 MHz, CDCl3) delta 134.8 (t, J = 2.4 Hz), 134.6-134.2 (m), 130.2-130.0 (m), 129.7 (br), 129.0 (br), 128.9 (br), 128.7-128.6 (m); 31P NMR (122 MHz, CDCl3) delta 8.1 (br, W1/2 = 87 Hz) , -14.8 (br, W1/2 = 340 Hz). The result of DART-MS measurement for the obtained complex is provided below. DART-MS (M/Z): found; 815.16. calcd; 815.13 (M-Br)+. Based on the DART-MS measurement of the obtained complex, it was confirmed that the obtained complex contained the following structure.

13991-08-7, The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10119] In a schlenk flask provided with a teflon closure, a solution of Os(tetradentate ligand)(DMSO)2 (200 mg, 0.2 64 mmol) in THF (10 mL) was treated with 1,2-bis(diphe- nylphosphino)benzene (118 mg, 0.264 mmol). The resulting mixture was stirred at 100 C. for 60 hours to produce a yellow solution. Afier cooling at room temperature (.-22 C.), the solvent was removed in vacuo. After extraction with dichioromethane, the solid was filtered off and the solution was evaporated to dryness. Addition of 5 mL of acetonitrile caused precipitation of a yellow solid that was washed with thrther portions of acetonitrile (2×5 mL) and subsequently with diethyl ether (3×5 mL). The yellow solid was dried in vacuo. Yield: 215mg (68%). IR (cm?): v(C=C) 1570 (w). ?H NMR (500 MHz, CD2C12, 298 K): oe 8.00 (dd, JHH=7.0,JHH=1.5, 1H, CH), 7.63 (t, JHH=8.0, 2H, CH), 7.58 (m, 1H,CH), 7.53-7.50 (m, 3H, CH), 7.38 (d, 1H, CH), 7.35(d, H-H=, 1H, CH), 7.29-7.25 (m, 8H, CH), 7.16-7.14 (m,3H, CH), 7.08-7.00 (m, 3H, CH), 6.95-6.88 (m, 6H, CH),6.79-6.76 (m, 3H, CH), 6.73 (t, H-H=, 1H, CH), 6.63 (dt,JHH=1.0, JHH=7.2, 1H, CH), 6.59 (dt, JHH=1.0, JHH=7.0,1H, CH), 6.39-6.35 (m, 3H, CH), 6.30 (t, 6.30 (t, JHH=8.5,2H, CH), 5.80-5.74 (m, 1H, -CH2—-), 4.32-4.28 (m, 2H,-CH2-), 3.86-3.80 (m, 1H, -CH2-). ?3C{?H} NMR(125.68 MHz, CD2C12, 298 K): oe 210.9 (t, J=4.3, NCN),187.4 (dd, J,=7.9, J,=79.7, NCN), 158.1 (t, J=6.4,Os-C Ph), 153.9 (dd, J=12.5, J=55.5, Os-C Ph),151.7 (d J=3.2, Cq), 149.4 (d, J=3.8, Cq), 148.6 (dd,J=47.2, J=34.2, Cq), 144.9 (dd, J=41.9, J=36.3,Cq), 143.7 (d, J=5.4, Cq), 143.5 (d, J=5.4, CH), 142.3(s, CH), 138.3 (d, J=3.6, Cq), 137.2 (d, J=28.8, Cq),137.0, 136.7 (both s, Cq), 136.2 (d, J=9.7, CH), 133.8 (d,J=11.9, CH), 133.5 (dJ=3.3, Cq), 132.8 (d, J=14.8,CH), 132.3 (d, J,=1 .9, Cq), 132.2 (d, J=10.3, CH), 131.9(dd, J=6.9, J=31.8, Cq), 131.7 (d, J=13.9, CH),130.0 (d, j=9.3, CH), 129.6 (d, j=3.9, CH), 129.2,129.0 (both s, CH), 128.9 (d, J=3.6, CH), 128.3 (s, CH),127.9 (d, J=9.0, CH), 127.5, 127.4 (both s, CH), 127.2 (d,J=8.7, CH), 126.4 (d, J=8.4, CH), 123.3, 122.7, 122.5,122.0, 121.7,121.1, 120.4,119.3, 112.3,111.2, 111.1, 110.6,109.7, 107.3 (all s, CH), 47.5 (s, -CH2-), 45.0 (d, J=3.5,-CH2—-). 3?P{?H} NMR (121.4 MHz, CD2C12, 298 K): oe32.1 (d, j=s?s), 18.7 (d, J=5.5).

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Universal Display Corporation; TSAI, Jui-Yi; XIA, Chuanjun; ESTERUELAS, Miguel A.; ALABAU, Roberto G.; OLIVAN, Montserrat; ONATE, Enrique; (89 pag.)US2016/240799; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Example 558 52 mg of tert-butyl 5-hydroxy-1H-indole-1-carboxylate, 79 mg of tripotassium phosphate, 4.7 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 6.8 mg of tris(dibenzylideneacetone)dipalladium(0) were added to 1.4 mL of toluene solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 2 hours and 30 minutes. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain tert-butyl 5-(3-(benzamido)-4-(tert-butoxycarbonyl)phenoxy)-1H-indole-1-carboxylate.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

A toluene solution (20mL) of 1 (22mg, 0.043mmol) and dppb (18mg, 0.043mmol) was refluxed under a nitrogen atmosphere for 27 h. The solvent was removed under reduced pressure and the residue was chromatographed by TLC on silica gel. Elution with cyclohexane/CH2Cl2 (4:1 v/v) developed two bands. The faster band was unreacted 1 (2mg) while the slower moving band afforded [Fe2(CO)5{mu,kappa2-C6H4PPh(C6H4)PPh2}(mu-PFu2)] (7) (20mg, 66%) as red crystals after recrystallization from hexane/CH2Cl2 at 4C. Spectral data for 7: Anal. Calcd for C39H29Fe2O7P3: C, 57.52; H, 3.60. Found: C, 57.62; H, 3.88%. IR (nu(CO), CH2Cl2): 2023 s, 1983 vs, 1945 w cm-1. 1H NMR (CDCl3): delta 5.72-5.63 (m, 1H, Fu), 6.08 (m, 1H, Fu), 6.20 (m, 1H, Fu), 6.29 (m, 2H, Fu), 6.31 (m, 1H, Fu), 6.53-6.41 (m, 2H, Ph), 6.83-6.80 (m, 3H, Ph), 7.18-7.10 (m, 5H, Ph), 7.48-7.30 (m, 9H, Ph), 7.96-7.62 (m, 4H, Ph). 31P{1H} NMR (CDCl3): delta 138.7 (dd, J=54, 30Hz), 90.5 (t, J=55Hz), 82.7 (dd, J=50, 30Hz)., 13991-08-7

As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Rahaman, Ahibur; Alam, Fakir Rafiqul; Ghosh, Shishir; Tocher, Derek A.; Haukka, Matti; Kabir, Shariff E.; Nordlander, Ebbe; Hogarth, Graeme; Journal of Organometallic Chemistry; vol. 751; (2014); p. 326 – 335;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

Under argon atmosphere, silver(I) iodide (235 mg, 1.00 mmol) and 50 mL of the solution of 1,2-bis(diphenylphosphino)benzene (447 mg, 1.00 mmol) in acetonitrile were mixed and the mixture was heated to reflux with stirring for seven hours. The reaction solution was allowed to reach room temperature and the precipitated colorless crystal was filtrated. The obtained filtrated matter was washed with acetonitrile and dried to obtain 531 mg of the complex. The mixture of this complex (49.7 mg) and triphenylphosphine (19.2 mg, 0.0730 mmol) was dissolved in 3 mL of dichloromethane, and the resulting solution was stirred for 30 minutes at room temperature. The reaction solution was concentrated, subjected to recrystallization by slow diffusion of chloroform-diethylether, and dried to provide 30.9 mg of the colorless solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-1, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (3). [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 7.44-7.14 (m, 31H), 7.03 (t, J= 7.2 Hz, 8H); 13C NMR (75 MHz, CDCl3) delta 141.2 (t, J= 22.7 Hz), 134.5 (t, J= 3.0 Hz), 134.2-134.0 (m), 133.3 (d, J= 22.2 Hz), 132.2 (t, J= 10.9 Hz), 129.6 (s), 129.3 (s), 128.5 (d, J= 9.0 Hz), 128.2 (t, J= 4.5 Hz); 31P NMR (122 MHz, CDCl3) delta 3.7 (br, W1/2=159 Hz), -14.8 (br, W1/2 = 450 Hz). The result of DART-MS measurement of the obtained complex is provided below. DART-MS (M/Z): found; 815.16. calcd; 815.13 (M-I)+. Based on the DART-MS measurement of the obtained complex, it was confirmed that the obtained complex contained the following structure.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon atmosphere, 25 mL of dry acetonitrile was added to silver(I) chloride (150 mg, 1.04 mmol) and 1,2-bis(diphenylphosphino)benzene (467 mg, 1.04 mmol), and the mixture was stirred at room temperature for one hour, followed by reflux for five hours. The reaction solution was allowed to reach room temperature, concentrated, and filtrated after being suspended in 7 mL of chloroform. The filtrated matter was subjected to thermal recrystallization from acetonitrile-chloroform and dried to obtain 258 mg of the colorless crystal complex. Under argon atmosphere, 3 mL of dry dichloromethane was added to the above obtained complex (80.0 mg, 0.0678 mmol) and triphenylphosphine (35.6 mg, 0.136 mmol), and the mixture was stirred at 40C for 10 minutes. The reaction solution was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 107 mg of the colorless crystal complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (3). [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 7.48-7.17 (m, 31H), 7.06 (t, J = 7.0 Hz, 8H); 13C NMR (75 MHz, CDCl3) delta 134.9-134.8 (m), 134.5 (br), 134.4-134.1 (m), 130.1 (br), 129.7 (br), 129.8-129.7 (m), 129.0 (br), 128.9 (br), 128.8-128.7 (m); 31P NMR (122 MHz, CDCl3) delta 9.1 (br, W1/2 = 66 Hz), -14.8 (br, W1/2 = 390 Hz). The result of DART-MS measurement for the obtained complex is provided below. DART-MS (M/Z): found; 815.16. calcd; 815.13 (M-C1)+. Based on the DART-MS measurement of the obtained complex, it was confirmed that the obtained complex contained the following structure.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate