Tag: M.W:400-500

787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

787618-22-8, [Step 4] tert-Butyl 7-methyl-8-(4-methylpiperazin-1-yl)-5-oxo-1,5-dihydro-2H-chromeno[3,4-c]pyridine-3(4H)-carboxylate To a suspension of tert-butyl 7-methyl-5-oxo-8-{[(trifluoromethyl) sulfonyl]oxy}-1,5-dihydro-2H-chromeno[3,4-c]pyridine-3(4H)-carboxylate (5.60 g) in toluene (100 ml), cesium carbonate (5.91 g), chloro-(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium (II)-methyl-t-butyl ether adduct (250 mg), 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (141 mg) and 1-methylpiperazine (3.33 ml) were added. The reaction solution was stirred in a nitrogen atmosphere at 110 C. for 8 hours while heating. The reaction solution was diluted with chloroform and a small volume of methanol and filtered with Celite. The reaction solution, to which water and saturated saline were added, was extracted with chloroform and a small volume of methanol. The organic layer was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (1-10% methanol/chloroform) to obtain the title compound (4.59 g) as a solid. 1H-NMR (CDCl3) delta: 7.36 (1H, d, J=8.5 Hz), 6.99 (1H, d, J=8.5 Hz), 4.40 (2H, s), 3.72 (2H, t, J=5.8 Hz), 3.02 (4H, t, J=4.6 Hz), 2.88-2.82 (2H, m), 2.66-2.57 (2H, m), 2.38 (6H, s), 1.66-1.59 (2H, m), 1.49 (9H, s). MS (ESI/APCI) m/z: 414 [M+H]+

787618-22-8 Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine 121592071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; Ota, Masahiro; Inoue, Hidekazu; Kawai, Junya; Ohki, Hitoshi; Toki, Tadashi; (25 pag.)US2019/284198; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

Example 7A N-(2-Fluoro-4-nitrophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-4-amine 50 mg (0.19 mmol) of 1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-4-amine, 61 mg (0.23 mmol) of 2-fluoro-1-iodo-4-nitrobenzene and 26 mg (0.27 mmol) of sodium tert-butoxide are initially charged in 1 ml of toluene. The mixture is degassed. 8.7 mg (0.01 mmol) of tris(dibenzylideneacetone)dipalladium and 9.1 mg (0.02 mmol of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine are then added. The mixture is heated in a sealed vessel at 120 C. overnight. The mixture is then filtered through an Extrelut cartridge (mobile phase: dichloromethane/methanol 10:1) and purified by preparative HPLC. Yield: 38 mg (50% of theory) LC-MS (Method 3): Rt=2.73 min. MS (ESI pos.): m/z=403 [M+H]+. 1H-NMR (DMSO-d6, 300 MHz): delta=-0.09 (s, 9H), 0.82 (t, 2H), 3.52 (t, 2H), 5.60 (s, 2H), 6.50 (d, 1H), 6.84 (d, 1H), 7.37 (t, 1H), 7.50 (d, 1H), 8.04 (dd, 1H), 8.13 (d, 1H), 8.17 (dd, 1H), 9.33 (s, 1H).

The synthetic route of 564483-18-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657408-07-6,Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.,657408-07-6

To an argon degassed and dried flask was added (2S,3S)-2-amino-N-(2-fluoro-4-iodo-phenyl)-3-phenyl-butyramide (796 mg, 1.99 mmol), zinc cyanide (352 mg, 2.99 mmol), tetrakis-triphenylphosphine palladium (0) (116 mg, 0.1 mmol) and dry tetrahydrofuran (4 mL). After heating at 80 C. for 8 hours there was no reaction. To the cooled mixture was added 2-dicylohexylphosphino-2′-6′-dimethoxybiphenyl (42 mg, 0.1 mmol) and the reaction mixture heated again to 80 C. for 90 minutes, again no reaction occurred. To the cooled mix was added triethylamine (840 mul, 5.99 mmol) and the reaction mixture heated at 80 C. for 2 hours, again no reaction occurred. To the cooled mix was added 2-dicylohexylphosphino-2′-6′-dimethoxybiphenyl (84 mg, 0.2 mmol) and still no reaction occurred after 2 hours at 85 C. To the cooled mix was added rac-2-2′-bis(diphenylphosphino)-1-1’binaphthyl (125.6 mg, 0.2 mmol) and dry toluene (2 mL). After heating at 85 C. for 40 hours the reaction mix was dissolved in ethyl acetate (50 mL) and washed with 1.5 N aqueous potassium hydrogen sulfate solution, saturated aqueous sodium bicarbonate solution and the aqueous layers were back extracted with ethyl acetate (2¡Á50 mL). The combined organic layers were dried over sodium sulfate and concentrated. The crude residue was purified by chromatography over silica gel gradient eluted from 5 to 15% v/v ethyl acetate in hexanes to give (2S,3S)-2-amino-N-(4-cyano-2-fluoro-phenyl)-3-phenyl-butyramide as a yellow residue after concentration of the product containing fractions (120 mg, 20.2% yield). HRMS: Obs Mass (M+H+), 531.2035. Calcd. Mass, 531.2038 for C29H28FN4O5+.

As the paragraph descriping shows that 657408-07-6 is playing an increasingly important role.

Reference£º
Patent; Niu, Huifeng; US2008/207563; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of CuCl (19.6mg, 0.2mmol) and dppb (89.3mg, 0.2mmol) with an excess of batho (66.5mg, 0.2mmol) were dissolved in CH2Cl2 (5mL) and 17 CH3OH (5mL) solution, stirred at room temperature for 6h. The insoluble residues were removed by filtration, and the filtrate was evaporated slowly at room temperature to yield yellow crystalline products. Yield: 80%. Anal. Calc. for C54H40ClCuN2P2: C, 73.83; H, 4.59; N, 3.19. Found: C, 73.62; H, 4.73; N, 3.06%. IR (KBr disc, cm-1): 3652m, 3279w, 3049w, 1962w, 1614m, 1555m, 1514w, 1481m, 1433w, 1410w, 1384w, 1226m, 1095s, 1025w, 865s, 836m, 769s, 745s, 696vs, 663w, 628w, 529s, 484s. 1H NMR (600MHz, CDCl3, 298K) delta 8.39ppm (d, 2H), 8.06ppm (d, 2H), 7.74ppm (d, 2H), 7.69ppm (m, 4H), 7.63ppm (m, 10H), 7.41-7.31ppm (m, 20H); 1P NMR (400MHz, CDCl3, 298K) delta -2.62ppm.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Yu, Xiao; Fan, Weiwei; Wang, Guo; Lin, Sen; Li, Zhongfeng; Liu, Min; Yang, Yuping; Xin, Xiulan; Jin, Qionghua; Polyhedron; vol. 157; (2019); p. 301 – 309;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

657408-07-6, Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,657408-07-6

Step 2 To a 500 mL round flask was added 3-(2,6-dichlorophenyl)-6,7-dimethylimidazo[1,2-f]phenanthridine (2.4 g, 6.1 mmol), phenylboronic acid (3.74 g, 30 mmol), Pd2(dba)3 (1.1 g, 1.2 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (S-Phos, 1.97 g, 4.8 mmol), potassium phosphate tribasic (7.64 g, 36 mmol), and 100 mL of toluene. The reaction was heated to reflux and stirred under a nitrogen atmosphere for 12 hours. After cooling, the mixture was purified by a silica gel column. Yield of 3-(2,6-diphenylphenyl)-6,7-dimethylimidazo[1,2-f]phenanthridine was 0.9 g.

657408-07-6 Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 11269872, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Universal Display Corporation; EP2243785; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6737-42-4, Accurate weighing1,3-bis(diphenylphosphino)propane (0.1237 g, 0.3 mmol), potassium acetate (0.1325 g,1.35 mmol) was added to a 25 mL Schlenk reaction flask followed by 2-methylbromobenzene (128 muL, 0.9 mmol), solventIt was dimethyl sulfoxide (2 mL) and reacted at 60 C for 24 h. After completion of the reaction, it was extracted with ethyl acetate/water and dried over anhydrous sodium sulfate.The organic phase was removed under reduced pressure. EtOAc (EtOAc/EtOAc)80%.

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

42.5 mg mesityl -Cu and 3ml of Toluene were added to 46.3(0.23 mmol) of 7-TpIn and 103.7mg (0.23 mmol) of dppb in a glove box. It formsa yellow solution. It was dried in vacuum, dissolved in dichloromethane and coatedwith a layer of hexane. It forms yellow crystals. Under UV (356nm), these emitlight in a strong yellow. Yield: 68%.

13991-08-7, The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon atmosphere, 1,2-bis(diphenylphosphino)benzene (34.6 mg, 0.0776 mmol) was added to 5 mL of the solution of silver(I) tetrafluoroborate (15.1 mg, 0.0776 mmol) in dichloromethane, and the mixture was stirred at room temperature for 30 minutes. Then, 2,9-dichloro-1,10-phenanthroline (23.2 mg, 0.0931 mmol) was added to the reaction solution, which was heated to reflux with stirring for two hours. The reaction solution was filtrated, and the filtrate was concentrated, subjected to recrystallization by slow diffusion of dichloromethane-ether, and dried to provide 46.0 mg of the yellow solid complex. [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 8.80 (d, J = 8.1 Hz, 2H), 8.24 (s, 2H), 8.15 (d, J = 8.1 Hz, 2H), 7.62-7.51 (m, 4H), 7.39-7.29 (m, 20H); 31P NMR (122 MHz, CDCl3) delta -4.4 (d, J (31P-107Ag, 109Ag) = 325, 373 Hz). The composition of the obtained complex was determined according to the same method as in Example 15. The present complex corresponds to the above composition formula (5).

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

564483-19-8, Example 16 3-(3-tert-Butyl-5-phenoxy-phenyl)-1H-pyridin-2-one (I-45) step 1-A mixture of 3-(3-bromo-5-tert-butyl-phenyl)-2-methoxy-pyridine (123 mg, 0.384 mmol), phenol (46 mg, 0.489 mmol), Pd(OAc)2 (4.1 mg, 0.018 mmol), 2-di-tert-butylphosphino-2′,4′,6′-tri-isopropyl-1,1′-biphenyl (9.9 mg, 0.023 mmol) and K3PO4 (167 0.787 mmol)) in a Schlenk flask was purged with argon before toluene (5 mL) was added. The reaction under an argon atmosphere was heated overnight at 115 C. The reaction was cooled to RT, filtered through CELITE, and the filtrate was concentrated. The crude residue was purified by SiO2 chromatography eluding with an EtOAc/hexane gradient (0 to 2% EtOAc) to afford 40 mg (41%) of 3-(3-tert-butyl-5-phenoxy-phenyl)-2-methoxy-pyridine (124). step 2-A solution of 124 (52 mg, 0.157 mmol), 48% HBr (50 L, 0.436 mmol) and HOAc (3 mL) in sealed tube was heated at 70 C. overnight. The reaction mixture was cooled to RT, carefully poured into a cold saturated aqueous NaHCO3 and then extracted with EtOAc. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated. The crude residue was purified on a preparative SiO2 TLC plate developed with 66% EtOAc/hexanes to afford 48 mg (96%) of I-45 as a foam.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; Roche Palo Alto LLC; US2010/21423; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: In a nitrogen-filled glovebox, phosphine ligand (0.21 mmol,1.00 eq.) and [(1,5-cyclooctadiene) Pd(CH2TMS)2] (80 mg,0.21 mmol, 1.00 eq.) were suspended in pentane (5.0 mL). The reaction mixture was stirred vigorously at room temperature, duringwhich time a solid precipitated from solution. After 48 h, thenon-homogenous mixture was filtered though a sintered glass frit.The filter cake was washed with pentane (10.0 mL) to yield thedesired complex. 9: Yellow-green solid (Yield: 106 mg, 79%). IR (neat): 2931,2850, 1580, 1456, 1419, 1376, 1359, 1293, 1252, 1170, 1155,1087, 1044, 1013, 929, 870, 851, 798, 746, 715 cm1.

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lee, Hong Geun; Milner, Phillip J.; Colvin, Michael T.; Andreas, Loren; Buchwald, Stephen L.; Inorganica Chimica Acta; vol. 422; (2014); p. 188 – 192;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate