Tag: M.W:400-500

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.657408-07-6, Name is Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine, molecular formula is C26H35O2P. In a Patent，once mentioned of 657408-07-6, category: chiral-phosphine-ligands

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer’s Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: chiral-phosphine-ligands, you can also check out more blogs about657408-07-6

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19845-69-3, Name is 1,6-Bis(diphenylphosphino)hexane, molecular formula is C30H32P2. In a Article，once mentioned of 19845-69-3, HPLC of Formula: C30H32P2

The new stable paramagnetic cations <(R'R2P)Cu(adcOR'')Cu(PR2R')2>(1+), adcOR” = azodicarboxylic ester, have been characterized by high-resolution EPR spectroscopy.Two equivalent copper centres within one molecule give rise to isotope combinations 63Cu/63Cu (47.9percent), 63Cu/65Cu (42.6percent) and 65Cu/65Cu (9.5percent); both isotopes have I = 3/2, but the nuclear magnetic moment is 7.1percent higher for 65Cu.A theoretical analysis of the hyperfine splitting pattern, including a stick spectrum and actual computer simulations, is given, and experimantal spectra could be sucessfully reproduced in this way.Factors favouring the detection of individual isotope combination lines, particularly in the outer special regions, are the small number of coupling nuclei (14N, 31P) in the ligands, the rather narrow EPR lines of these ligand-centred radical complexes and the relatively large isotropic copper coupling constants of ca. 1.6 mT.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C30H32P2, you can also check out more blogs about19845-69-3

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13991-08-7, Name is 1,2-Bis(diphenylphosphino)benzene, molecular formula is C30H24P2. In a Article，once mentioned of 13991-08-7, Recommanded Product: 13991-08-7

The cobalt(I) carbonyl complexes Y, Y2, and Y (L-L = ditertiary phosphine; Y = BF4, BPh4) have been obtained by treating alcoholic solutions of cobalt(II) salts containing weakly-coordinating anions and diphosphines with carbon monoxide under ambient conditions.The types of products formed depend on the steric properties of the ligand L-L.The stereochemistry and dynamic behaviour of the products in solution have been studied by variable-temperature 31P<1H> NMR spectroscopy.A possible mechanism is suggested for the carbonylation reactions, which were found to involve formation of the diphosphine oxides.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 13991-08-7, you can also check out more blogs about13991-08-7

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, Name is 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl, molecular formula is C33H49P, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 564483-18-7, Recommanded Product: 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl

A domino Rh- and Pd-catalyzed synthesis of dihydroquinolines is disclosed. Two metals and two ligands are placed in one reaction vessel along with the two reactive reagents to afford selective sequential coupling despite the potential for side reactions. In this report, we describe mechanistic investigations attempting to discern the catalyst-ligand interactions occurring in this domino reaction. Through these studies, the reactivity and relative catalyst ligand loadings were successfully tuned to efficiently access the heterocyclic products.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl. In my other articles, you can also check out more blogs about 564483-18-7

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Electric Literature of 13991-08-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 13991-08-7, Name is 1,2-Bis(diphenylphosphino)benzene

Abstract Reaction of 4-bromo-2-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol (BIPP), chelating diphosphine ligands and [Cu(MeCN)4]ClO4 afforded five mononuclear [Cu(BIPP)(PP)]ClO4 (PP = dppe, 1; dppp, 2; bdpp, 3; POP, 4; xantphos, 5) complexes with good phosphorescent emission in the solid state. All the complexes are characterized by elemental analyses, electrospray Ionization mass spectra, 1H and 31P NMR spectra and X-ray single crystallography. The photoluminescence quantum yields of complexes 1-5 are from less than 0.010 to 0.262 in the solid state under air atmosphere, which increase with the increasing rigidity of diphosphine ligands and the increasing strength of intermolecular and intramolecular pi?pi interactions. The aggregation-induced emission of complexes 4 and 5 at room temperature was investigated.

If you are hungry for even more, make sure to check my other article about 13991-08-7. Electric Literature of 13991-08-7

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13406-29-6, Name is Tris(4-(trifluoromethyl)phenyl)phosphine, molecular formula is C21H12F9P. In a Article，once mentioned of 13406-29-6, SDS of cas: 13406-29-6

Convenient synthesis of four new distorted octahedral ruthenium(II) complexes (1, 2, 3, 4) having general molecular formula [RuCl2LPAr3] (L = pyridine-based tridentate ligands not containing N-H bonds) is described. Their composition and structure were determined by elemental analysis and NMR spectra, and complexes 2 and 4 were also identified by X-ray single-crystal diffraction. All ruthenium(II) complexes exhibited good to excellent catalytic activity in the transfer hydrogenation of ketones. Among them, complex 4 achieved the highest final TOF value of 51600 h-1 for a high molar ratio of substrate to catalyst (2000:1).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 13406-29-6. In my other articles, you can also check out more blogs about 13406-29-6

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13991-08-7, Name is 1,2-Bis(diphenylphosphino)benzene, molecular formula is C30H24P2. In a Article，once mentioned of 13991-08-7, Recommanded Product: 1,2-Bis(diphenylphosphino)benzene

Iron-catalysed 1,2-acyl migration of tertiary alpha-azido ketones and 2-azido-1,3-dicarbonyl compounds provides a simple and atom-economical approach toward enamides and isoquinolones. This paper reports two catalyst systems for these transformations which employ iron(ii) complexes [Fe(dpbz)]Br2 (dpbz = 1,2-bis(diphenylphosphino)benzene) and FeBr2/Et3N, respectively. [Fe(dpbz)]Br2 was found to be highly effective at converting 2-azido-2,3-dihydro-1H-inden-1-ones to isoquinolones. The reagent combination of FeBr2/Et3N, on the other hand, exhibited a broader catalytic scope, owing to the beneficial effect of Et3N. This latter catalyst system enables 2-azido-2-methyl-1,3-dicarbonyl compounds to be converted to the corresponding enamides under mild conditions in good yields.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 1,2-Bis(diphenylphosphino)benzene, you can also check out more blogs about13991-08-7

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19845-69-3, Name is 1,6-Bis(diphenylphosphino)hexane, molecular formula is C30H32P2. In a Article，once mentioned of 19845-69-3, Safety of 1,6-Bis(diphenylphosphino)hexane

Reactions of [Re2(CO)10] with Me3NO and diphosphines [Ph2P(CH2)nPPh2, n=1-6] yield mixtures of the monodentate-coordinated diphosphine complexes [Re 2(CO)9(eta1-P-P)] (P-P=Ph 2P(CH2)nPPh2, n=1-6) (yields 5-40%) and bridged dimers [{Re2(CO)9}2(mu-P-P)] (5-50%). These complexes were isolated as either equatorial or axial isomers, or a mixture of two isomers. Reactions of the monodentate complexes with Me 3NO yield close-bridged complexes [Re2(CO) 8(mu-P-P)] and phosphine oxide complexes [Re2(CO) 9{P-P(O)}]. The structures of the close-bridged complexes 1 (n=3) and 2 (n=4), were determined by X-ray crystallography. The Re-Re bond in the close-bridged complex with the longest phosphine chain (n=6) is readily cleaved in CDCl3 to give the complex [{cis-ReCl(CO)4} 2(mu-dpph)] (3) as the product, the structure of which was also determined by X-ray crystallography.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 1,6-Bis(diphenylphosphino)hexane. In my other articles, you can also check out more blogs about 19845-69-3

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

In an article, published in an article, once mentioned the application of 13406-29-6, Name is Tris(4-(trifluoromethyl)phenyl)phosphine,molecular formula is C21H12F9P, is a conventional compound. this article was the specific content is as follows.Quality Control of: Tris(4-(trifluoromethyl)phenyl)phosphine

The Pt(ii) coordination chemistry of oligocationic ammoniomethyl- and neutral aminomethyl-substituted triarylphosphines (L) is described. Complexes of the type PtX2(L)2 (X = Cl, I) have been isolated and characterized. For the hexa-meta-ammoniomethyl-substituted ligands [1] 6+ and [2]6+, two ligands always occupy a trans-configuration with respect to each other in complexes of the type PtX 2(L)2, while for the tri-para-ammoniomethyl-substituted ligand [7]3+, the trans/cis ratio is dependent on the ionic strength of the solution. This behaviour was not observed for the neutral aminomethyl-substituted ligands. In the crystal structure of trans-[PtI 2(1)2]I12, the geometrical parameters of the phosphine ligand [1]6+ are very similar to those found in the analogous complex of the benchmark ligand PPh3, i.e. trans-PtI 2(PPh3)2, indicating that no significant increase in the steric congestion is present in the complex. Instead, the coordination chemistry of this class of phosphine ligands is dominated by repulsive Coulombic inter-ligand interactions.

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Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, Name is 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl, molecular formula is C33H49P, belongs to chiral-phosphine-ligands compound, is a common compound. In a patnet, once mentioned the new application about 564483-18-7, HPLC of Formula: C33H49P

Despite the dominant position of aromatic fluorophores, we report herein the design and synthesis of quinoidal fluorophores based on rarely emissive quinoidal bithiophene. Quinoidal bitheno[3,4-b]thiophene, QBTT-C6, consisting of cruciform-fused (E)-1,2-bis(5-hexylthiophen-2-yl)ethene and quinoidal bithiophene, shows a fluorescence quantum yield of 8.5%, 25-fold higher than that of the parent quinoidal QBT chromophore, but its maximum emission is at similar wavelengths. QBTT-Ar’s featuring intramolecular charge transfer can further shift the maximum emission into the near-infrared region. The intramolecular charge transfer is programmably enhanced by tuning the substituents on the aryl groups from the electron-withdrawing trifluoromethyl to the electron-donating methoxy groups. Unexpectedly, a positive relationship between intramolecular charge transfer and fluorescence quantum yield is observed; as a result, QBTT-FL gives an unprecedentedly high fluorescence quantum yield of up to 53.1% for quinoidal oligothiophenes. With detailed photophysical and theoretical investigations, we demonstrate that the nonradiative intersystem crossing (S1 ? T2) is significantly restrained in QBTT-Ar’s, which can be attributed to the faster reverse intersystem crossing (T2 ? S1) characteristic of a small activation energy. This work reveals the possibility for developing red/near-infrared fluorophores from the less explored quinoidal molecules because of their intrinsically narrow bandgaps.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C33H49P. In my other articles, you can also check out more blogs about 564483-18-7

Reference：
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate