Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29949-84-6,Tris(3-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78%).2

29949-84-6, The synthetic route of 29949-84-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid. IR (KBr disk, cm?1): nuC?O 2052 (vs), 1983 (vs), 1976 (vs), 1937 (vs). 1H NMR (500MHz, CDCl3): 7.55?7.50 (m, 6H, PhH), 7.14 (t, J=8Hz, 6H, PhH), 1.93 (d, J=7Hz, 2H, SCH2), 1.19 (d, J=8Hz, 2H, SCH2) ppm. 31P{1H} NMR (200MHz, CDCl3, 85percent H3PO4): 61.45 (s) ppm. 13C{1H} NMR (125MHz, CDCl3): 214.52 (d, JP-C=8.4Hz, PFeCO), 209.66 (FeCO), 164.92, 162.91 (dd, JP-C=1.4Hz, JF-C=251.7Hz, p-PhC), 135.13, 134.03 (dd, JP-C=8.4Hz, JF-C=13.1Hz, o-PhC), 131.67, 131.34 (dd, JP-C=40.7Hz, JF-C=3.4Hz, i-PhC), 116.21, 116.05 (dd, JP-C=10.6Hz, JF-C=21Hz, m-PhC), 34.88 (d, JP-C=2.9Hz, SCH2) ppm. Anal. Calc. for C25H16F3Fe2O5PS2: C, 45.48; H, 2.44. Found: C, 45.54; H, 2.56., 18437-78-0

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 4-methoxycarbonylphenylacetylene to the reaction flask(0.080 g, 0.5 mmol), dinaphthylphosphoric acid(0.30 g, 1 mmol), CuBr (0.014 g, 0.1 mmol),Di-tert-butyl peroxide (0.30 g, 2 mmol),Reacts with water (2 mL) at 80oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 75%)., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Complex 1 was synthesized by the simultaneous and dropwise addition of tris-(4-fluorophenyl)phosphine(0.316 g, 1 mmol) in acetone and sodium 4-benzylpiperazine-1-carbodithioate (0.274 g, 1 mmol)in methanol to a methanolic suspension of palladium(II) chloride (0.177 g, 1 mmol). The reaction mixturewas refluxed for 5 h with constant stirring. The resulting orange-colored solution was filtered androtary evaporated to obtained orange solid (scheme 1). It was dried and re-dissolved in chloroform,and on slow evaporation needle-like crystals were obtained. Complexes 2 and 3 were synthesized bythe same method (scheme 1). Complex 1: Yield: 0.50 g (65percent), M.p. 198 ¡ãC. Mol. Wt: 709.47: Anal. Cald (found) for C30H27ClF3N2PPdS2:C, 50.78 (50.71); H, 3.84 (3.83); N, 3.95 (3.92); S, 9.04 (9.00): IR (4000?200 cm?1): 1492 v(C?N); 1010 v(CSSsym);378 v(Pd?S); 303 v(Pd?Cl); 245 v(Pd-P). 1H NMR {CDCl3, 300 MHz, delta (ppm)}: 3.40 (s, 2H, H4), 3.56 (t, 4H,H2, H2?, 3J1H, 1H = 5.1 Hz), 2.27 (t, 4H, H3, H3?, 3J1H, 1H = 5.1 Hz), 7.28?7.40 (m, 17H, H6, H6?, H7, H7?,H8, Hb, Hb?,Hc, Hc?). 13C NMR {CDCl3, 75 MHz, delta (ppm)}: 205.4 (C1); 51.8 (C2, C2?), 46.8 (C3, C3?); 62.5 (C4), 136.8 (C5),129.1 (C6, C6?), 128.2 (C7, C7?), 127.6 (C8), 163.2 (Ca), 115.9 (Cb, Cb?); 124.8 (Cc, Cc?), 165.7 (Cd).

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Zia-ur-Rehman; Journal of Coordination Chemistry; vol. 69; 20; (2016); p. 2999 – 3009;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

Into a 100 mL three-necked flask equipped with a magnetic stir bar and nitrogen inlet and outlet were placed commercially available tris(4-methoxyphenyl)phosphine ((12a), 3.0 g, 8.5 mmol) and acetone (30 mL). A mixture of water (2 mL) and H2O2 (35%, 1 mL, 9 mmol) was added slowly. After the mixture was stirred at room temperature for 1 h, acetone was evaporated and methylene chloride (50 mL) was added. The organic phase was washed with a saturated NaCl solution (35 mL) three times. The organic layer was dried over sodium sulfate. The solvent was removed under vacuum to afford 3.0 g (95%) of a white solid, m.p. 144.7-145.4 C. (lit. 143-144 C.). MS (m/e): 368 (M+). Anal. Calcd. for C21H21O4P: C, 68.47%; H, 5.75%; P, 8.41%. Found: C, 68.42%; H, 5.72%; P, 8.11%. FT-IR (KBr, cm-1): 3068, 3026, 2959, 2837, 1597, 1569, 1503, 1468, 1289, 1254, 1179, 1121, 1019, 803, 671, 543. 1H-NMR (CDCl3, 8 in ppm): 3.84 (s, 6H, CH3), 6.94-6.97 (dd, 6H, Ar-H), 7.54-7.60 (dd, 6H, Ar-H). 13C-NMR (DMSO-d6, delta in ppm): 55.29, 114.08, 114.21, 124.19, 125.28, 133.21, 133.32, 161.79, 161.822

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; The United States of America as represented by the Secretary of the Air Force; Tan, Loon-Seng; Wang, David Huabin; (19 pag.)US10294255; (2019); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: PR3 and NH4PF6 were added to a solution of fac-[RuCl3(NO)(P?N)] (1) in MeOH (5 mL) and the resulting orange suspensionwas refluxed for 3 h, except for the P(p-Me-C6H4)3 system whenreaction occurred at r.t. After being cooled to room temperature,the resulting yellow suspensions of complexes 3?5 were filteredto give a yellow solid that was washed with H2O (2 5 mL), MeOH(2 5 mL) and Et2O (2 5 mL), and then dried in vacuo. In the caseof complex 2, the reaction generated a clear yellow solution; thesolvent was removed in vacuo to give a yellow residue that wasthen largely dissolved in CH2Cl2 (5 mL), and the mixture wasfiltered through Celite. Addition of n-hexane (15 mL) yielded a yellowsolid that was then treated as described above. The mer, transisomerof 1 [6,7] could also be used as the precursor for synthesesusing the same methodology, which gave similar product yields., 18437-78-0

As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; da Silva, Juliana P.; Fagundes, Francisco D.; Back, Davi F.; Ellena, Javier; James, Brian R.; de Araujo, Marcio P.; Inorganica Chimica Acta; vol. 454; (2017); p. 40 – 45;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Compound 1 (90mg, 0.25mmol) and tris(4-methoxyphenyl)phosphine (2, 113mg, 0.32mmol) in acetonitrile (anhydrous, 15mL) were added into a three-necked flask under a stream of nitrogen. After reflux at 100C for 20h and concentrated, the compound Fe-4 (brownish red solid, 65mg, 41%) was obtained via a silica gel chromatography (dichloromethane/methane=20/1, v/v). The chemical purity of compound Fe-4 was >95% by HPLC analysis. 1H NMR (400MHz, CDCl3) delta 7.66-7.61 (m, 6H, CH-Ph), 7.13-7.11 (m, 6H, CH-Ph), 4.72 (s, 2H, CH-Cp), 4.44 (s, 2H, CH-Cp), 4.12 (s, 5H, Cp-Fe), 3.86 (s, 9H, PhOCH3), 3.43 (s, 2H, O=C-CH2), 2.68 (s, 2H, CH2-P), 1.70-1.50 (m, 6H, CH2-CH2-CH2). 13C NMR (100MHz, CDCl3) delta 204.70, 164.61, 135.54, 116.27, 109.09, 78.93, 72.36, 69.89, 69.42, 55.74, 39.28, 30.20, 23.97, 23.52, 22.74.31P NMR (400MHz, CDCl3) delta 22.15. HRMS (+TOF MS): m/z calculated for C37H40FeO4P+ [M]+ 635.2008, found 635.2008.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Xiaoyan; Chen, Shuting; Liu, Zelan; Zhao, Zuoquan; Lu, Jie; Journal of Organometallic Chemistry; vol. 871; (2018); p. 28 – 35;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred and degassed solution of [Fe(h5-Cp)(CO)2I] (1 mmol)in dry acetone (30 mL) PR3 (1 mmol) was added. The reactionmixture was then irradiated under UV light (125 W) for 3e7 h (seebelow). The precipitate was separated by cannula-filtration and thesolvent was evaporated under vacuum. The residue was twicerecrystallized from dry dichloromethane/n-hexane and dark greenproducts are obtained.[Fe(h5-Cp)(CO)(PPh3)

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Pilon, Adhan; Girio, Patricia; Nogueira, Guilherme; Avecilla, Fernando; Adams, Harry; Lorenzo, Julia; Garcia, M. Helena; Valente, Andreia; Journal of Organometallic Chemistry; vol. 852; (2017); p. 34 – 42;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, 2-(Diphenylphosphanyl)benzoic acid (0.50 g, 1.63 mmol) and 4-dimethylaminopyridine (DMAP, 20 mg, 0.163 mmol) were dissolved in CH2Cl2 (10 mL). Ethanol (0.29 mL, 4.89 mmol) was added, and the solution was placed under Ar(g) and cooled to 0¡ã C. N,N’-Diisopropylcarbodiimide (DIC, 0.25 mL, 1.63 mmol) was added dropwise, and the resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography, eluting with 10percent EtOAc(ethylacetate)/hexanes, to give phosphine 1a as a pale yellow solid (0.44 g, 1.32 mmol, 81percent yield). 2-(Diphenylphosphanyl)benzoic acid was purchased from Sigma-Aldrich (St. Louis, Mo.).Data for 1a: 1H NMR (400 MHz, CDCl3) delta=8.07 (m, 1H, Ar.), 7.44-7.25 (m, 12H, Ar.), 6.93 (m, 1H, Ar.), 4.22 (q, 2H, J=7.1 Hz, OCH2CH3), 1.21 (t, 3H, J=7.1 Hz, OCH2CH3). 13C NMR (100 MHz, CDCl3, 31P-coupled; 1H-decoupled, observed signals) delta=166.9, 140.8, 140.0, 138.1, 137.9, 134.8, 134.6, 134.3, 134.0, 133.8, 131.8, 130.6, 128.6, 128.5, 128.4, 128.2, 61.2, 14.0. 31P NMR (162 MHz, CDCl3) delta=-4.0. HRMS (ESI+) m/z calculated for (C21H20O2P)+ 335.1196, measured 335.1208.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Patent; Raines, Ronald Thaddeus; Myers, Eddie Leonard; US2010/125132; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.8 (1R,2S)-1-Phenyl-2-(pivalamido)propyl 2-(diphenylphosphinyl)benzoate 9d fx17 Purified by flash column chromatography (80/20, hexanes/EtOAc) to yield 0.256 g (20percent) of product as a yellow oil. [alpha]D23 = -12.7 (c 0.694, CHCl3). 1H NMR (500 MHz, CDCl3): delta 0.86 (d, J = 6.9 Hz, 3H), 1.04 (s, 9H), 4.35-4.41 (m, 1H), 6.00 (s, 1H), 6.02 (d, J = 3.7 Hz, 1H), 6.90-6.93 (m,1H), 7.14-7.26 (m, 16H), 7.31-7.39 (m, 3H), 8.04-8.07 (m, 1H). 13C NMR (100 MHz, CDCl3): delta 14.75, 27.58, 38.67, 49.00, 79.18, 126.62, 127.92, 128.38, 128.57, 128.63, 128.68, 128.73, 128.87, 130.90, 130.94, 132.31, 133.47, 133.66, 133.81, 133.96, 134.17, 134.79, 134.89, 135.00, 137.48, 137.58, 137.69, 139.58, 139.84, 166.33, 177.80. 31P NMR (162 MHz, CDCl3): delta -5.24. IR v (Nujol): 1717, 1652, 1398, 1378, 1251, 746, 697 cm-1. ESI HRMS for C33H34NO3P: calcd (M+H+) 524.2355; found 524.2353.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate