Tag: M.W:300-400

819867-21-5,819867-21-5, Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-([1,2,4]triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of acetylene derivative (21.6 g, 52 mmol) and 3-bromo-[1,2,4]triazolo[4,3-b]pyridine (10.3 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 80 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity, yielding the desired product (10.2 g, 37%).

819867-21-5 Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 67475893, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, A mixture of NBD-Cl (400 mg, 2 mmol) and 2-(methylamino) ethan-1-ol (200 mL, 2.5 mmol) was dissolved in20 mL CH2Cl2, and then DIPEA (430 mL, 2.5 mmol) was added. Thereaction mixture and stirred at room temperature for 2 h. Themixture was washed by water (3 25 mL) and brine, and dried byNa2SO4. After removing the solvent under reduced pressure, theresidue was purified by silica gel column chromatography to give ared solid 3a (138 mg, 29%). 1H NMR (400 MHz, MeOD) d 8.54 (d,J 9.1 Hz, 1H), 6.44 (d, J 9.1 Hz, 1H), 4.33 (s, 2H), 3.95 (t, J 5.5 Hz,2H), 3.62 (s, 3H). 2-(Diphenylphosphanyl) benzoic acid (123 mg,0.41 mmol), EDC (84 mg, 0.44 mmol) and DMAP (54 mg,0.44 mmol) were dissolved by CH2Cl2, and then 3a (80 mg,0.34 mmol) was added. The mixture was stirred at room temperatureunder nitrogen protection overnight. After removing thesolvent under reduced pressure, the resulting residue was purifiedby silica gel column chromatography with CH2Cl2 to get an orangefoam 3 (146 mg, 87%). 1H NMR (400 MHz, CDCl3) d 8.36 (d,J 8.9 Hz, 1H), 7.78 (s, 1H), 7.34 (dt, J 10.8, 6.1 Hz, 8H), 7.21 (dd,J 10.4, 4.9 Hz, 4H), 6.91 (s, 1H), 6.04 (d, J 9.0 Hz, 1H), 4.52 (t,J 5.3 Hz, 2H), 4.37 (s, 2H), 3.35 (s, 3H). 13C NMR (101 MHz, CDCl3)d 166.4, 145.42 (s), 144.7, 140.97 (s), 140.7, 137.5, 135.2, 134.6, 134.0,133.8,133.3,133.1,132.6,130.5,128.9,128.6,128.4,123.2,102.0, 62.2,54.2, 41.9. 31P NMR (162 MHz, DMSO-d6) d 4.37. HRMS (ESI): m/z[MH] calcd. for C28H24N4O5P: 527.1479; found: 527.1488.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Dejun; Kang, Xueying; Gao, Yasi; Zhu, Jiqin; Yi, Long; Xi, Zhen; Tetrahedron; vol. 75; 7; (2019); p. 888 – 893;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Into a 1 L three-neck round-bottom flask equipped with a 250 mL addition funnel, a reflux condenser and a nitrogen inlet, 70 g of recrystallized tri(4-methoxyphenyl)phosphorus and 300 mL of dry THF were added. To the solution, 2.8 g of thin lithium pieces were added at 25 C. under nitrogen with stirring. LiP(4-OMe-Ph)2 was immediately formed in the solution, and the solution turned to a deep reddish yellow color while a large amount of heat was generated. The temperature of the solution was elevated slowly to 55 C. for 1 hour, and the solution was cooled again to 25 C. for 2 hours with stirring. The formed 4-methoxyphenyllithium was decomposed by dropwise adding 18.5 g of distilled and purified t-butylchloride for 45 min. The transparent reddish yellow solution was boiled for 5 min, and then cooled again to -4 C.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; SK GLOBAL CHEMICAL CO., LTD.; SK INNOVATION CO., LTD.; US2012/130086; (2012); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

819867-21-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.819867-21-5,Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Potassium 3-((2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenylcarbamoyl)phenyl)ethynyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carboxylate Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of acetylene derivative (21.6 g, 52 mmol) and ethyl 3-bromo[1,2,4]triazolo[4,3-b]pyridine-7-carboxylate (14.0 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 130 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity. The obtained product is dissolved in dry DMSO (50 ml). Water (1 ml) and potassium tert-butylate (0.6 g) are added and the mixture is stirred for 4 h. The desired product is purified on an ion exchange resin (15.1 g, 47%).

As the paragraph descriping shows that 819867-21-5 is playing an increasingly important role.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: Under N2 atmosphere, NaOAc (4.0 equiv), PPh3 1a (0.5 mmol), PdCl2 (10.0 mol %), AgOOCCF3 (5.0 equiv), CH3CN (2.0 mL) and methyl acrylate 2a (0.6 mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60 C for 24 h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under N2 atmosphere, NaOAc (4.0?equiv), PPh3 1a (0.5?mmol), PdCl2 (10.0?mol?percent), AgOOCCF3 (5.0?equiv), CH3CN (2.0?mL) and methyl acrylate 2a (0.6?mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60?¡ãC for 24?h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Nitrophenylacetylene (0.077 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuBr2 (0.022 g, 0.1 mmol),Di-tert-butyl peroxide (0.45 g, 3 mmol),Reacts with acetone (2 mL) at 50oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 65%)., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Using PHEMA-TX-1 as catalyst, the tris(4-methoxyphenyl)phosphane(1a) was transformed into tris(4-methoxyphenyl)phosphineoxide (2a) (Scheme 6). Typically, 1a (352 mg, 1.0 mmol), PHEMA-TX-1(0.52 mg, 0.001 mmol, 19 muL stock solution prepared by dissolving 56 mg PHEMA-TX-1 in 2.0 mL of DMF), CH3OH (30 mL) were addedinto to a 100 mL round bottom flask equipped with a magnetic stirrer.The reaction was triggered by irradiation of a 23W house hold lamp at room temperature under air atmosphere. The photocatalytic reaction was monitored by TLC (eluent: petroleum ether/ethyl acetate=20/1)and finished after 8 h. The solution was concentrated under vacuum and the mixture was again dissolved in 5 mL of ethyl acetate (EA). ThePHEMA-TX-1 was precipitated in EA and recovered for the second cycle of photocatalytic reaction. The NMR yield of 2a in the first cycle was 99% as determined by 1H NMR analysis of the crude reaction mixtureusing dibromomethane as internal standard. Subsequently, using the recovered PHEMA-TX-1 as catalyst, the following cycles of reactionswere performed using the same procedure as above. The result wasshown in Scheme 6. 1H NMR (400 MHz, CDCl3) delta 7.57 (dd, J=9.4,9.4 Hz, 6H), 6.95 (d, J=8.0 Hz, 6H), 3.83 (s, 9H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ding, Aishun; Chen, Yang; Wang, Guowei; Zhang, Yaopeng; Hu, Jianhua; Guo, Hao; Polymer; vol. 174; (2019); p. 101 – 108;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

4-fluorophenylacetylene (0.060 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuSCN (0.012 g, 0.1 mmol),Tert-butyl alcohol peroxide (0.45 mL, 3 mmol) and toluene (2 mL),90oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 82%)., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

2-Trifluoromethylphenylacetylene (0.085 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuI2 (0.032 g, 0.1 mmol),Tert-butyl alcohol peroxide (0.45 mL, 3 mmol),And ethanol (2 mL),60oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 77%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate