Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 8 N-(4-Fluorophenyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide The procedure was as described in Example 4. 4.92 g of crude product was obtained in the form of a light yellow solid from 3.47 g (12.5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine, 2.08 g (18.7 mmol) of 4-fluoroaniline, 1.46 g (13.8 mmol) of sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 0.13 g (375 mumol) of tris(4-methoxyphenyl)phosphine in 12.5 ml of xylene after 21 hours at 150 C. under a CO pressure of 19 bar (GC: complete conversion). It was purified by recrystallization from methylcyclohexane. The yield was 3.97 g (84.4 percent) of light beige crystals. Other data concerning the product was: M.p.: 138-139 C. 1 H NMR (CDCl3): delta=3.85 (s, 3H); 6.41 (s, 1H); 7.06 (m, 2H); 7.29 (d, J=8.1 Hz, 1H); 7.59 (m, 2H); 8.05 (t, J=8.1 Hz, 1H); 8.14 (d, J=8.1 Hz, 1H); 9.28 (bs,1H).

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Lonza AG; US5892032; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under inert gas protection conditions,To a flask equipped with a stirring magnet, 344 mg of Fe2S2(CO)6 (1 mmol) and 30 mL of tetrahydrofuran solvent were added.A dark red solution was obtained, and the resulting solution was cooled to -78 ¡ã C with a liquid nitrogen bath.2.1 mL of lithium triethylborohydride (1M in THF) solution was slowly added under stirring.After reacting for 15 min, 0.2 mL of trifluoroacetic acid (2.5 mmol) was added and the reaction was continued for 15 min.Add 348 mg of P(C6H4-4-F)3 (1.1 mmol), stir at room temperature for 3 h before adding788 mg of I-4-C6H4N(CH2Cl)2 (2.5 mmol) and 0.3 mL of triethylamine were stirred at room temperature for 12 h.The solvent of tetrahydrofuran was removed by rotary distillation, and the residue was extracted with dichloromethane, and then subjected to thin-layer chromatography using a solvent of dichloromethane/petroleum ether ratio of 1:5 to collect a main color band to obtain a model 2 .

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; He Jiao; Wu Yu; Xie Ying; Jiang Jin; Sun Yanchun; Wang Zheng; Zou Like; Xie Bin; Gao Fan; Mu Chao; (11 pag.)CN109232665; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Solution of di(1-naphthyl)phosphine oxide (0.1 g) in chloroform (5 mL) was refluxed in air for 2 h. Then the solvent was distilled under reduced pressure and residue was dried in vacuum. Di(1-naphthyl)phosphinic acid was prepared in near quantitative yield. White powder, mp 198-201 C, FT-IR (KBr): 3055, 3008, 2955, 2922, 2854, 2632, 2289, 1955, 1646, 1619, 1591, 1568, 1505, 1456, 1432, 1382, 1334, 1212, 1178, 1152, 1025, 995, 951, 833, 800, 773, 753, 680, 566, 526, 479. 1H NMR (CDCl3): 9.58 (br, 1H, OH), 8.48 (d, J 8.5 Hz, 2H, H8), 8.16 (dd, J 16.3 and 7.2 Hz, 2H, H2), 7.92 (d, J 8.4 Hz, 2H, H4), 7.79 (d, J 8.1 Hz, 2H, H5), 7.40-7.36 (m, 4H, H6,7), 7.29 (t, J 7.7 Hz, 2H, H3). 13C NMR (CDCl3): 133.5 (d, J 11 Hz, C9), 133.4 (d, J 11 Hz, C8), 133.3 (d, J 2 Hz, C7), 132.7 (d, J 11 Hz, C10), 128.9 (d, J 137 Hz, C1), 128.7 (C4), 127.1 (C5), 126.6 (d, J 5 Hz, C3), 126.1 (C6), 124.5 (d, J 15 Hz, C2). 31P NMR (CDCl3): 37.3 ppm. MS m/z calcd for C20H15O2P: MS (M+ 315)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kuimov, Vladimir A.; Matveeva, Elena A.; Khutsishvili, Spartak S.; Vakul’skaya, Tamara I.; Sinegovskaya, Lidiya M.; Malysheva, Svetlana F.; Gusarova, Nina K.; Trofimov, Boris A.; Tetrahedron; vol. 73; 32; (2017); p. 4723 – 4729;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29949-84-6,Tris(3-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

29949-84-6, As the paragraph descriping shows that 29949-84-6 is playing an increasingly important role.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13885-09-1,2-(Diphenylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

A solution of CuI (0.019 g, 0.1 mmol) in CH3CN(5 mL) wasadded to a stirred solution of 2,2?-Bipy (0.016 g, 0.1 mmol)and 2-(Dpp)bp (0.034 g, 0.1 mmol) in CH3CN(5 mL). Themixture was stirred for 10 min, with no visible precipitation.After filtration, the clear filtrate was set aside for evaporationin air. Orange block crystals of complex 4 were obtainedafter several hours. Yield: 43.4 mg (63.4percent, based on Cu).Anal. Calc. for 4 C34H27N2P1Cu1I1:C, 59.63; H, 3.94; N,4.09. Found (percent): C, 59.64; H, 3.92; N, 3.98. IR (KBr pellet,cm?1): 3430sh, 3054vw, 1610m, 1431s, 1146w, 1103w,770, 699.

13885-09-1, As the paragraph descriping shows that 13885-09-1 is playing an increasingly important role.

Reference£º
Article; Chen, Di; Chai, Wen-Xiang; Song, Li; Transition Metal Chemistry; vol. 43; 6; (2018); p. 517 – 527;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compounds 1d? was prepared according to the reported procedures.2 The 1d? (320 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed invacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-benztriazole-1-N,N,N?,N?-tetraethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol),followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 18 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried over Na2SO4. The solvent was removed in vacuo to afford the crude product as colourless oil, which was purified by flash chromatography (15percent EtOAc in hexanes) yielding the precat 1d (356 mg, 70percent), 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Zhou, Zhipeng; Zheng, Xiaojun; Liu, Jialin; Li, Jinlei; Wen, Pushan; Wang, Haifei; Synlett; vol. 28; 8; (2017); p. 999 – 1003;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, 2-(Diphenylphosphanyl)benzoic acid (0.50 g, 1.63 mmol) and DMAP (20 mg, 0.163 mmol) were dissolved in CH2Cl2 (10 mL). Ethanethiol (EtSH, 0.35 mL, 4.89 mmol) was added, and the solution was placed under Ar(g) and cooled to 0¡ã C. DIC (0.25 mL, 1.63 mmol) was added dropwise, and the resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography, eluting with 10percent EtOAc/hexanes, to give phosphine 1b as a pale yellow solid (0.43 g, 1.22 mmol, 75percent yield).Data for 1b: 1H NMR (400 MHz, CDCl3) delta=8.02 (m, 1H, Ar.), 7.45-7.24 (m, 12H, Ar.), 6.99 (m, 1H, Ar.), 2.98 (q, 2H, J=7.4 Hz, SCH2CH3), 1.22 (t, 3H, J=7.4 Hz, SCH2CH3). 13C NMR (100 MHz, CDCl3, 31P-coupled; 1H-decoupled, observed signals) delta=192.7, 141.9, 141.7, 138.0, 137.8, 137.7, 134.6, 134.0, 133.8, 131.7, 128.9, 128.6, 128.4, 128.4, 128.3, 24.0, 14.6. 31P NMR (162 MHz, CDCl3) delta=-5.8. HRMS (ESI+) m/z calculated for (C21H20OPS)+ 351.0968, measured 351.0953.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Raines, Ronald Thaddeus; Myers, Eddie Leonard; US2010/125132; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add in the reaction bottle4-phenylbutyne (0.065 g, 0.5 mmol), dinaphthyl phosphorus (0.30 g, 1 mmol),Cu(SCN)2 (0.0179 g, 0.1 mmol), tert-butyl peroxide (0.30 mL, 2 mmol) and water (2 mL),60oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 85%)., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

240417-00-9, 2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

CH2Cl2 (25 ml) was added to a Schlenk flask containing the 2-(N,N-dimethlamino)-2′-(diphenylphosphino)biphenyl (2.00 g, 5.2 mmol) and (DME)NiBr2 (1.30 g, 4.2 mmol) in a dry box. A green solution formed immediately upon mixing. This solution was stirred for 20 hours. Then, it was filtered and recrystallized from CH2Cl2/pentane. The product was washed three times with an additional 15 ml of pentane and dried for 1 hour under vacuum. A green powder was isolated in 69.3% yield. The product was soluble in CH2Cl2. 1H NMR indicates that it is paramagnetic. Anal. Calcd for (C26H24NPBr2Ni) : C, 52.03% ; H, 4.08% ; N, 2.33% ; P, 5.16%. Found: C, 1.20% ; H, 4.24% ; N, 2.14% ; P, 5.29%.

240417-00-9, As the paragraph descriping shows that 240417-00-9 is playing an increasingly important role.

Reference£º
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2004/37837; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

TfOCH2CF2H (0.257 g, 1.2 mmol) was reacted with tris (m-tolyl) phosphine (0.365 g, 1.2 mmol) The reaction was stirred at 120 ¡ã C for 6 h, The resulting solid was then treated with ether, Toluene, N-hexane or petroleum ether, filter, And then pump dry, The product (E)-[(3-CH3C6H4)3PCHCHP(3-CH3C6H4)3][OTf]2 (white solid, 0.447g,0.48mmol) Yield: 80percent., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Patent; Wuhan University of Technology; Zhang, Chengpan; Wang, Shimeng; Dongh, Tao; Han, Jiabin; (10 pag.)CN105017320; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate