Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

Triphenylphosphonium bromide 2b (16.81 g, 49.0 mmol), and xylene (50 mL) were added into flask A (250 mL) with an inlet connected to a nitrogen balloon. To flask B (500 mL, three-necked) with an inlet connected to the flask A, (2-diphenylphosphino)benzoic acid 2e (10.00 g, 32.6 mmol), and MTBE (200 mL) were added. The flask A was heated in an oil-bath at 130 ¡ãC, and the generated HBr1 was introduced through a glass tube into the flask B under stirring by purging nitrogen. After solid 2b was completely disappeared, the reaction mixture in the flask B was filtered,and the white solids were washed with MTBE (80 mL ¡Á 2) and hexane (60 mL ¡Á 3). The solids were collected and dried in vacuo to afford (2-carboxyphenyl)diphenylphosphonium bromide 2d (11.21 g) in 89percent yield., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Huang, Wenhua; Xu, Ning; Synthetic Communications; vol. 47; 22; (2017); p. 2133 – 2138;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13885-09-1,2-(Diphenylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

1.453 g of 2-diphenylphosphine-biphenyl, 1.404 g of 2-iodoanisole, 122.5 mg of cymene dichloride dimer, and 78.7 mg of N-Ac-beta-alanine were added to the reactor. 1.536 g of cesium acetate and 2 mL of toluene, the reaction temperature was controlled at 120 ¡ã C for 18 hours, then cooled to room temperature, filtered through celite and distilled under reduced pressure to give 1.76 g of product.95percent.

13885-09-1, 13885-09-1 2-(Diphenylphosphino)biphenyl 12976978, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Hubei University; Liu Yuejin; Li Jiawei; Wang Liangneng; Zeng Minghua; (9 pag.)CN109400646; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13885-09-1, 2-(Diphenylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of CuI (0.019 g, 0.1 mmol) in CH3CN(5 mL) wasadded to a stirred solution of 1,10-phenanthroline (0.018 g,0.1 mmol) and 2-(Dpp)bp (0.034 g, 0.1 mmol) in EtOAc(5 mL). The mixture was stirred for 5 min and then the precipitatewas filtered off. The resultant clear solution was setaside for evaporation in air. Orange block crystals of complex1 were obtained after 1 day and red crystals of complex2 were obtained the next day. These two different productswere separated manually under a microscope. Yield: 20.0 mg(28.2percent, based on Cu) for 1 and 24.4 mg (27.1percent, based onCu) for 2. Anal. Calc. for 1 C36H27N2P1Cu1I1:C, 60.98; H,3.81; N, 3.95. Found (percent): C, 61.04; H, 3.81; N, 3.88. IR(KBr pellet, cm?1): 3446sh, 3004s, 1789m, 1639m, 1550s,1448m, 1209w, 1120m, 716m; for 2 C36H27N2P1Cu2I2:C,48.07; H, 3.03; N, 3.12. Found (percent): C, 48.14; H, 3.04; N,3.04. IR (KBr pellet, cm?1): 3522sh, 3004s, 1639w, 1461m,1221s, 930s, 868s.

13885-09-1, 13885-09-1 2-(Diphenylphosphino)biphenyl 12976978, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Di; Chai, Wen-Xiang; Song, Li; Transition Metal Chemistry; vol. 43; 6; (2018); p. 517 – 527;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Into a round bottom flask was added (dichloroiodo)benzene (2, 0.15 mmol, 1.02 equiv), DCM (0.25 mL, 0.6M), and to this was added excess ethanol (0.1 mL, 10 equiv), followed by the secondary phosphine oxide (0.15 mmol, 1.0 equiv,). The reaction mixture was stirred at room temperature for the indicated length of time, then concentrated in vacuo and purified by column chromatography., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Eljo, Jasmin; Murphy, Graham K.; Tetrahedron Letters; vol. 59; 31; (2018); p. 2965 – 2969;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

To a solution of P(3-Me-C6H4)3 (1.98 g, 6.50 mmol) in toluene (20 mL), a solution of 3c (1.51gm, 5.90 mmol) in toluene (10 mL) was added via cannula. After 4 hours, the clear yellow solution was evaporated to afford a yellow residue. The yellow residue was washed with a mixture of 1:3 toluene-hexanes (4 x 12 mL), yielding a yellow oil. The yellow oil was washed with ether (10 mL) to give white solid 8 (1.8 g, 60percent). 1H NMR (CDCl3): delta 7.71 (s, 1H, 6-CH of -C6H3SO3-), 7.68 (s, 3H, 2-CH of (3-CH3-C6H4)3P=NH-), 7.55 (m, 3H, 5-CH of (3-CH3-C6H4)3P=NH-), 7.32 (s, 3H, 4-CH and 6-CH of (3-CH3-C6H4)3P=NH-), 6.85 (d, J = 8.4, 1H, 4-CH of -C6H3SO3-), 6.39 (d, J = 8.4, 1H, 3-CH of -C6H3SO3-), 3.90 (t, 2H, CH of CH2CH2CH3), 2.35 (s, 9H, 3-CH3 of (3-CH3-C6H4)3P=NH-), 2.19 (s, 3H, J = 6.8, 5-CH3 of – CH3C6H3SO3-), 1.52 (m, 2H, CH of CH2CH2CH3), 0.78 (t, 3H, J = 7.4, CH of CH2CH2CH3). 31P NMR (CDCl3): delta 2.7. 13C NMR (CDCl3): delta 148.9, 138.4 (d, JPC = 11.6), 134.6, 133.1 (d, JPC = 9.3), 132.5 (d, JPC = 3.1), 131.5 (d, JPC = 2.3), 130.5 (d, JPC = 10.0), 129.8 (d, JPC = 2.3), 128.4 (d, JPC = 13.2), 126.5 (d, JPC = 24), 124.6, 122.5 (d, JPC = 10.8), 71.1, 22.4, 21.5, 20.2, 10.1. Anal. Calcd for C31H34NO3PS: C, 70.03; H, 6.45; N, 2.63. Found: C, 69.89; H, 6.32; N, 2.52., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Burns, Christopher T.; Shang, Suisheng; Thapa, Rajesh; Mashuta, Mark S.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4832 – 4835;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Weigh 0.2 mmol of (E)-1,3-diphenylpropene, 0.3 mmol of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone into a 15 mL pressure-resistant reaction tube and add magnetic stirring. The mixture was reacted with 2 mL of nitromethane at room temperature for 5 min, monitored by TLC, and then reacted with 0.4 mmol of bis(naphthalen-1-yl)phosphine oxide for 6 h. After completion of the reaction, it was extracted with 20 ml of sodium sulfite solution, 10 mL of ethyl acetate, dried over anhydrous sodium sulfate at 20 C for 10 minutes and filtered, and finally distilled under reduced pressure at -0.09 MPa at 40 C to remove organics. The product (E)-(1,3-diphenylallyl)bis(naphthalen-1-yl)phosphine oxide was obtained as a solvent in a yield of 96%., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Guangdong University of Technology; Wen Chunxiao; Chen Qian; Wang Xiaofeng; Yu Guodian; Huo Yanping; Zhang Kun; (15 pag.)CN108774263; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, Thus, crotonaldehyde was treated with HCN in the presence of an (R)-oxynitrilase readily obtained from grinding and scouring of bitter almonds,18 which gave the (R)-cyanohydrin with high levels of enantioselectivity (>96percent ee).19 Subjecting to the conditions of a Pinner reaction furnished the ethyl ester 20 (Scheme 6).20 The reduction with lithium aluminum hydride led to diol 21 and subsequent silylation furnished the silylether 22 on a multigram scale.21 Applying the standard Steglich esterification protocol22 with ortho-diphenylphosphanylbenzoic acid (o-DPPBA)23 provided o-DPPB-ester (R)-(+)-6 quantitatively. Crystallization of this product improved the enantiopurity to greater than 99percent ee. In order to obtain the requested (S)-enantiomer of 6 one could apply a corresponding (S)-oxynitrilase. However, such enzymes are far more difficult to access.24 Hence, we looked at a Mitsunobu inversion protocol, which ideally would use o-DPPBA itself as the nucleophile.25 Since o-DPPBA is both a carboxylic acid and a phosphine we expected this to be a non trivial reaction because the reagent triphenylphosphine as well as o-DPPBA may react with the azodicarboxylate electrophile. Interestingly, we observed a clean Mitsunobu reaction of the allylic alcohol 22 with o-DPPBA to furnish the corresponding (S)-(-)-enantiomer of o-DPPB-ester 6 in good yield (81percent). After recrystallization (S)-(-)-6 was obtained in >99percent enantiopurity.

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Albert-Ludwigs-Universitat Freiburg; US2011/282075; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78percent).2

6224-63-1, The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of complex 1 (0.245 g, 0.5 mmol) in MeCN (15 mL) was added the decarbonylation reagent Me3NO¡¤2H2O (0.056 g, 0.5 mmol). The mixture was stirred at room temperature for 10 min and then PPh3 (0.131 g, 0.5 mmol) was added. The resulting mixture was stirred for additional 2 h to give a dark red solution. Solvents were removed under vacuum and the residue was subjected to TLC using CH2Cl2/petroleum ether (v/v = 1:20) as the eluent. From the main red band, complex 2 (0.152 g, 42percent) was obtained as a dark red solid.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Yu-Long; He, Jiao; Wei, Juan; Wei, Jian; Mu, Chao; Wu, Yu; Xie, Bin; Zou, Li-Ke; Wang, Zheng; Wu, Mei-Li; Li, Han-Min; Gao, Fan; Zhao, Pei-Hua; Polyhedron; vol. 137; (2017); p. 325 – 331;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

DCM-OH was obtained following the previous method [48], andthen DCM-P was synthesized as outlined in Scheme 2. DCM-OH (50 mg,0.16 mmol) and 2-(diphenylphosphino)benzoic acid (161.7 mg,0.528 mmol) were dissolved in dichloromethane, then 4-(dimethylamino)-pyridinium-4-toluene sulfonate (141.3 mg, 0.48 mmol) and N,N?-diisopropylcarbodiimide (60.6 mg, 0.48 mmol) were added. The reactionsystem was stirred at room temperature for 5 h under argon protection.After the reaction was over, the mixture was extracted withdichloromethane for 3 times. The organic layer was combined and driedwith anhydrous Na2SO4, and then the solvent was evaporated in vacuo.The residual was purified by silica gel chromatography with EA/PE toget the desired product DCM-P (40 mg, 0.067 mmol), and the yield was42%. 1H NMR (400 MHz, d6-DMSO, ppm): delta 8.74 (d, J=8.1 Hz, 1H), delta8.25 (dd, J1=8.1 Hz, J2=4.0 Hz, 1H), delta 7.96-7.92 (m, 1H), delta 7.79 (d,J=12.1 Hz, 3H), delta 7.74 (s, 1H), delta 7.65-7.59 (m, 3H), delta 7.54 (d,J=16.2 Hz, 2H), delta 7.42-7.40 (m, 5H), delta 7.25-7.21 (m, 4H), delta 7.09 (d,J=8.1 Hz, 2H), delta 7.06 (d, J=8.1 Hz, 1H), delta 6.94-6.90 (m, 1H); 13CNMR (100 MHz, d6-DMSO, ppm): delta 170.79, 165.10, 158.40, 153.50,152.52, 152.04, 140.78, 140.50, 137.91, 137.65, 137.53, 135.98,134.13, 133.92, 133.41, 131.90, 131.59, 129.81, 129.51, 129.30,129.23, 126.70, 125.16, 122.84, 122.80, 120.47, 119.57, 117.58,116.23, 61.05, 60.21; HRMS (ESI, m/z): [M + H]+ calcd forC39H26N2O3P: 601.1675, Found: 601.1676 (Figure S1)., 17261-28-8

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Tianlin; Chai, Yun; Chen, Shuhan; Yang, Guichun; Lu, Cuifen; Nie, Junqi; Ma, Chao; Chen, Zuxing; Sun, Qi; Zhang, Yuexing; Ren, Jun; Wang, Feiyi; Zhu, Wei-Hong; Dyes and Pigments; vol. 166; (2019); p. 260 – 265;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate