Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

3-Amino-2-naphthol (0.159 g, 1.0 mmol), 2-(diphenylphosphino)benzoic acid (0.306 g,1.0 mmol) and p-toluene sulfonic acid (0.190 g, 1.0 mmol) were added to toluene (30 mL).The mixture was heated to 150C for 15 hr under nitrogen. The progress of reaction wasmonitored by TLC. After the reaction mixture cooled, the solution was extracted withwater, and the organic solution was evaporated. Then the crude intermediate in 10 mLdichloromethane were stirred in a round-bottom flask, and then H2O2 (1.2 mL, 10 mmol,30percent) was slowly added into the mixture while stirring at room temperature. The organic layer was separated and washed with water. The extract was evaporated to dryness affordinga pale yellow solid. The residue was dissolved in CHCl3 and added to methanol in orderto get solid precipitate. The crude product was purified by column chromatography withCHCl3: ethyl acetate (5:1) eluent to afford pale yellow solid (0.222 g, yield 50percent)., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Kim, Ik-Hwan; Kang, Eunguk; Kim, Dong-Eun; Shin, Hoon-Kyu; Lee, Burm-Jong; Molecular Crystals and Liquid Crystals; vol. 597; 1; (2014); p. 88 – 94;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a round bottom flask were added 2-(diphenylphosphino)benzoic acid (17.94 mg, 0.058 mmol) and 3 mL of DMF. To the solution were added 1-O-(N,N’,N,N’tetramethyluronium)azabenzotriazoloxy hexafluorophosphate (26.73 mg, 0.070 mmol), 1-hydroxyazabenzotriazole (9.56 mg, 0.070 mmol), and diisopropylethylamine (45.4 mg, 0.0612 mL). After stirring the reaction mixture for 7 minutes, N-alpha-(6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl)lysine methyl ester hydrochloride (35.2 mg, 0.070 mmol) dissolved in 4 ml of DMF was added to the above mixture. The reaction mixture was stirred for 2 hours. The solvent was removed in vacuo and the resulting crude oil was subjected to HPLC purification using the method described above. The collected fractions were combined, and were lyophilized to give the product as a pale yellow solid. The yield was 29 mg (66percent) after HPLC purification., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Patent; Liu, Shuang; US2005/8575; (2005); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, (2R)-(4E)-5-(5-Isopropoxy-3-pyridyl)-4-penten-2-ol A mixture of 5-bromo-3-isopropoxypyridine (10.26 g, 47.50 mmol), (2R)-4-penten-2-ol (4.91 g, 57.00 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (578 mg, 1.90 mmol), triethylamine (28.46 mL, 204.25 mmol), and acetonitrile (30 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (8.92 g, 85.0%).

The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Targacept, Inc.; US6218383; (2001); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4R,9aR)-6-(2-Ethoxycarbonyl-vinyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester To a solution of 1.0 g (2.71 mmol) (4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester (Example 5, intermediate b) and 0.36 ml (3.25 mmol) ethyl acrylate in 30 ml toluene were added 0.67 g (8.15 mmol) sodium acetate, 82.6 mg (0.27 mmol) tri(o-tolyl)phosphine and 0.04 mg (0.1 mmol) allylpalladium chloride dimer. The reaction mixture was heated under reflux for 20 h, then poured into saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic phase was washed with 10% aqueous citric acid solution and brine, dried over magnesium sulfate, filtered and evaporated. The crude product was purified by column chromatography on silica gel (0.032-0.063 mm) with n-hexane:ethyl acetate (9: 1) as eluant to afford the desired compound as a yellow solid (91.2%). ISP-MS: m/e=388.3 ([M+H+])

6163-58-2, The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Adams, David Reginald; Bentley, Jonathan Mark; Blench, Toby Jonathan; Hebeisen, Paul; Monck, Nathaniel Julius Thomas; Richter, Hans; Roever, Stephan; Roffey, Jonathan Richard Anthony; Taylor, Sven; US2003/207888; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13885-09-1,2-(Diphenylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

General procedure: To a solution of [Fe2(CO)6(m-SCH2CH2S)] (0.037 g, 0.1 mmol) and tris(4-methylphenyl)-phosphine (0.032 g, 0.1 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO2H2O(0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for1 h and then the solvent was reduced on a rotary evaporator. The residue was subjectedto TLC using CH2Cl2/petroleum ether1:5 (v/v) as eluent. From the main redband, 0.054 g (83%) of 2 was obtained as a red solid., 13885-09-1

As the paragraph descriping shows that 13885-09-1 is playing an increasingly important role.

Reference£º
Article; Yan, Lin; He, Jiao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 72; 15; (2019); p. 2531 – 2543;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

247940-06-3, 2-(Dicyclohexylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 76 3-[2-(2,4-Dichloro-Phenyl)-Ethoxy]-4-Methoxy-N-(1-Phenyl-piperidin-4-Ylmethyl)-Benzamide A mixture of 100 mg (0.2 mmol) 3-[2-(2,4-Dichloro-phenyl)-ethoxy]-4-methoxy-N-piperidin-4-ylmethyl-benzamide, 50 mg (0.32 mmol) Bromobenzene, 70 mg sodium-t-butoxide in 5 ml dioxane were purged with argon for 10 min. Then 37 mg of 2-(Dicyclohexylphosphino)biphenyl and 20 mg Pd2(dba)3 were added under argon and the mixture refluxed overnight. The residue was taken up in 3 ml saturated NaHCO3 solution and filtered through a chem elut cartridge by elution with ethyl acetate. Subsequent removal of the solvent under reduced pressure and purification by preparative HPLC (C18 reverse phase column, elution with a H2O/MeCN gradient with 0.5% TFA) the fractions containing the product were evaporated and lyophilised.

247940-06-3, The synthetic route of 247940-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Example 3 Synthesis of TMPO The following is an exemplary procedure for the synthesis of tris(4-methoxyphenyl)phosphine oxide (TMPO, VI) as depicted in . Into a 100 mL three-necked flask equipped with a magnetic stir bar and nitrogen inlet and outlet were placed tris(4-methoxyphenyl)phosphine (TMP, V) (3.0 g, 8.5 mmol) and acetone (30 mL). A mixture of water (2 mL) and H2O2 (35%, 1 mL, 9 mmol) was added slowly. After the mixture had been stirred at room temperature for 1 hour, the acetone was evaporated, and methylene chloride (50 mL) was added. The organic phase was washed with a saturated NaCl solution (35 mL) three times with the aid of a separatory funnel. The organic layer was then dried over anhydrous sodium sulfate. Finally, the solvent was removed via rotary evaporation to afford 3.0 g (95%) of a white solid, m.p. 144.7-145.4 C. MS (m/e): 368 (M+). Anal. Calcd. for C21H21O4P: C, 68.47%; H, 5.75%; P, 8.41%. Found: C, 68.42%; H, 5.72%; P, 8.11%. FT-IR (KBr, cm-1): 3068, 3026, 2959, 2837, 1597, 1569, 1503, 1468, 1289, 1254, 1179, 1121, 1019, 803, 671, 543. 1H-NMR (CDCl3, delta in ppm): 3.84 (s, 6H, CH3), 6.94-6.97 (dd, 6H, Ar-H), 7.54-7.60 (dd, 6H, Ar-H). 13C-NMR (DMSO-d6, delta in ppm): 55.29, 114.08, 114.21, 124.19, 125.28, 133.21, 133.32, 161.79, 161.82.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; The United States of America as represented by the Secretary of The Air Force; Tan, Loon-Seng; Wang, David Huabin; US8546614; (2013); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

A mixture of [{(mu-SCH2)2CH2}Fe2(CO)6] (0.193 g, 0.5 mM), P(PhOMe-p)3 (0.211 g, 0.6 mM), and Me3NO¡¤2H2O (0.056 g, 0.5 mM) was dissolved in MeCN (15 mL) and was stirred at room temperature for 2 h to give a black-red solution. The solvent was removed on a rotary evaporator and the residue was subjected to preparative TLC separation using CH2Cl2/petroleum ether (v/v = 1 : 5) as eluent. From the main red band, 1 (0.241 g, 68%) was obtained as a red solid. M.p.: 180-181 C. Anal. Calcd for C29H27Fe2O8PS2: C, 49.04; H, 3.83%. Found: C, 48.93; H, 3.99%. IR (KBr disk, cm-1): nuC?O 2041 (vs), 1985 (vs), 1979 (vs), 1958 (vs), 1930 (vs). 1H NMR (400 MHz, CDCl3, TMS, ppm): 7.58 (t, 3JHH = 3JHP = 7.6 Hz, 6H, PhH), 6.93 (d, 3JHH = 7.6 Hz, 6H, PhH), 3.84 (s, 9H, OCH3), 1.78-1.72 (m, 2H, SCHaHe), 1.54-1.48 (m, 4H, SCHaHe and CH2). 13C{1H} NMR (100.6 MHz, CDCl3, TMS, ppm): 213.92 (d, 2JPC = 12.0 Hz, PFeCO), 209.83 (s, FeCO), 160.97 (s, ipso-PhCOMe), 134.97 (d, 2JPC = 12.3 Hz, o-PhCH), 127.55 (d, 1JPC = 44.8 Hz, ipso-PhCP), 114.00 (d, 3JPC = 10.5 Hz, m-PhCH), 55.37 (s, OCH3), 30.02 (s, CH2), 22.29 (s, SCH2). 31P{1H} NMR (161.9 MHz, CDCl3, 85% H3PO4, ppm): 60.26 (s).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Pei-Hua; Li, Xin-Hang; Liu, Yun-Feng; Liu, Ya-Qing; Journal of Coordination Chemistry; vol. 67; 5; (2014); p. 766 – 778;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(6) (Tri(m-tolyl)phosphine-kappaP)(1-(4-fluorobenzoyl)-3-(N-methylphenyl) thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.163?g (0.564?mmol) 1-(4-fluorobenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 192-194?¡ãC. FTIR (cm-1); 3142(w), 2998(w), 2879(w), 1617(m), 1509(s), 1422(s), 1362(w), 1310(w), 1244(w), 1192(w), 1090(m), 1064(w), 1020(w), 990(w), 940(m), 916(s), 864(s), 780(s), 746(s), 690(s), 619(w). H NMR (300?MHz, CDCl3) delta 2.30 [(s, 9H, 3(-CH3)],3.59 (s, 3H, N-CH3), 6.86-8.41 (m, 21H, ArH); 13C NMR (75.5?MHz, CDCl3) delta 21.3 (3C), 42.2 (C), 114.7 & 114.9 (2C, d, 13C-19F, 2J?=?19.7?Hz), 127.0 (C), 127.6 (C), 127.8 (C), 127.9 (C), 128.4 (C), 129.3 (C), 132.0 (C), 132.7 & 132.9 (2C, d, 13C-19F, 3J?=?10.6?Hz), 135.3 &137.9 (1C, d, 13C-19F, 1J?=?272.0?Hz), 135.4(C), 137.8 (C), 145.5 (C), 168.7 (C), 171.0 (1C, C=O), 173.8 (1C, C=S); 31P NMR (121.5?MHz, CDCl3) delta 34.80; Anal. Calc. for C36H33ClFN2OPPdS (Mol. mass: 733.57) C, 58.94; H, 4.53; N, 3.82; S, 4.37. Found: C, 58.99; H, 4.58; N, 3.89; S, 4.42.

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4.3.29 methyl 2-phenyl-5-(3-methylphenyl)oxazole-4-carboxylate ;(4i) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 117 mg (80percent). 1H NMR (300 MHz, CDCl3) delta 2.44 (s, 3H), 3.97 (s, 3H), 7.27 (d, J=7.7 Hz, 1H), 7.38 (t, J=7.7 Hz, 1H), 7.46-7.49 (m, 3H), 7.93-7.96 (m, 2H), 8.13-8.17 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 161.7, 158.7, 154.5, 137.2, 130.2, 130.1, 127.9, 127.8, 127.4, 126.9, 125.9, 125.4, 124.8, 51.4, 20.6 ppm., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate