Tag: M.W:300-400

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 20 mL methanolic suspension of palladium(II) chloride (0.177 g,1 mmol) in a round bottom three-neck flask was added tris(4-fluorophenyl)phosphine (0.316 g, 1 mmol) solution in acetone (20 mL) and sodium 4-(3-methoxyphenyl)piperazine-1-carbodithioate (0.290 g, 1 mmol) solution in methanol (30 mL) in a dropwise manner.The reaction mixture was refluxed for 6 h with constant stirring. The formed greenish precipitate was separated by filtration (scheme 1). This precipitate was re-dissolved in acetone, and on slow evaporation, needle crystals were obtained.Yield: (0.470 g, 60percent), m.p. 250 ¡ãC. Mol. Wt: 745.48: Anal. Calcd C30H27ClF3N2OPPdS2: C, 49.62 (49.65); H, 3.72 (3.68); N, 3.86 (3.80); S, 8.82 (8.79): IR(4000?200 cm?1): 1584 nu(C?N); 1002 nu(CSSsym); 250 nu(Pd?S); 338 nu(Pd?Cl); 218 nu(Pd?P):1H NMR (CDCl3,300 MHz) delta (ppm): 3.81 (s, 3H, H10), 3.89 (t, 4H, H3, H3?, 3J1H,1H = 4.8 Hz), 4.06 (t, 4H, H2, H2?, 3J1H,1H = 5.1 Hz), 6.44 (s, 1H, H5), 6.45 (d, 1H, H9,3J1H,1H = 2.4 Hz), 6.52 (dd, 1H, H8, 3J1H,1H = 2.4, 2.7 Hz), 6.54 (d, 1H, H7, 3J1H,1H = 2.4 Hz), 7.14?7.73 (m, 12H, H12, H12?, H13, H13?). 13C NMR (CDCl3, 75 MHz) delta (ppm): 46.5 (C3, C3?), 48.9 (C2, C2?), 55.3 (C10), 103.6 (C5), 105.9 (C7), 109.6 (C9),116.0 (C12), 125.3 (C13), 130.2 (C8), 151.4 (C4), 160.7 (C6), 163.2 (C11), 165.7 (C14),206.2 (C1). 31P NMR (121.49 MHz, CDCl3) delta (ppm): 24.36.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Naseer, Muhammad Moazzam; Abbasi, Rashda; Mazhar, Kehkashan; Tahir, Muhammad Nawaz; Awan, Iqra Zubair; Zia-Ur-Rehman; Journal of Coordination Chemistry; vol. 68; 14; (2015); p. 2539 – 2551;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-49-3,2′-(Di-tert-butylphosphino)-N,N-dimethyl-[1,1′-biphenyl]-2-amine,as a common compound, the synthetic route is as follows.

Bis[3-(1-naphthyl)-1H-inden-7-yl] ether Under an argon atmosphere, to a mixture of 5.50 g (15.6 mmol) of 4-bromo-1-(1-naphthyl)-2,3-dihydro-1H-inden-1-yl methyl ether, 4.00 g (15.5 mmol) of 3-(1-naphthyl)-1H-inden-7-ol, 6.60 g (31.1 mmol) of K3PO4, and 150 ml of toluene, a mixture of 183 mg (0.32 mmol) of Pd(dba)2 and 212 mg (0.62 mmol) of N-{2′-[di(tert-butyl)phosphino][1,1′-biphenyl]-2-yl}-N,N-dimethylamine was added. The resulting mixture was stirred for 8 hours at 100 C. Then, 300 ml of water was added, the organic layer was separated, and the aqueous layer was extracted with 3*75 ml of CH2Cl2. The combined extract was dried over Na2SO4 and evaporated to dryness. The crude 1-(1-methoxy-4-{[1-methoxy-1-(1-naphthyl)-2,3-dihydro-1H-inden-4-yl]oxy}-2,3-dihydro-1H-inden-1-yl)naphthalene was purified using a short colunm with Silica Gel 60 (40-63 mum, d 50 mm, 170 mm, eluant: CH2Cl2). This product was demethoxylated in a mixture of 170 ml of 16 M HCl and 170 ml of methanol for 7 hours at reflux. The crude product was extracted with 3*150 ml of CH2Cl2. The combined extract was washed with 2*100 ml of water, dried over K2CO3, and evaporated to dryness. The analytically pure product was obtained by flash chromatography on Silica Gel 60 (40-63 mum, d 35 mm, 1300 mm, eluant: hexanes-CH2Cl2=5:1). Yield, 2.65 g (34%) of a white solid., 224311-49-3

As the paragraph descriping shows that 224311-49-3 is playing an increasingly important role.

Reference£º
Patent; Voskoboynikov, Alexander Z.; Izmer, Vyatcheslav V.; Asachenko, Andrey F.; Nikulin, Mikhail V.; Ryabov, Alexey N.; Lebedev, Artyom Y.; Coker, Catalina L.; Canich, Jo Ann M.; US2007/135597; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 3 N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-pyridine-2-carboxamide 10.26 g (37.5 mmol) of 2-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine (content: 99.5 percent, prepared according to Example 1), 6.25 g (56.2 mmol) of 4-fluoroaniline, 4.37 g (41.3 mmol) of sodium carbonate, 26.3 mg (37.5 mumol) of dichlorobis(triphenylphosphine)palladium(II) and 0.40 g (1.125 mmol) of tris(4-methoxyphenyl)phosphine (IV, R8 =R9 =R10 =methoxy) in 37.5 ml of xylene were placed in an autoclave at room temperature. The autoclave was flushed with inert gas, a carbon monoxide pressure of 5 bar was then applied and the mixture was heated to 150 C. The CO pressure was raised to 18 bar and the mixture was stirred for 21 hours at 150 C. After cooling to room temperature and depressurization, 50 ml of xylene and 50 ml of water were added to the reaction mixture, which was filtered. The aqueous phase was extracted with 25 ml of xylene and the combined organic phases were washed with 30 ml of water. Neither unconverted educt nor by-products were detectable by GC in the xylene phase. After distillation of the solvent, the crude product (15.83 g) was obtained in the form of a yellow solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;; ; Patent; Lonza AG; US5892032; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

819867-21-5,819867-21-5, Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-((1H-benzimidazol-1-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of iododerivative (26.9 g, 52 mmol) and 1-ethynyl-1H-benzimidazole (7.4 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 80 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity, yielding the desired product (13 g, 47%).

As the paragraph descriping shows that 819867-21-5 is playing an increasingly important role.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

A mixture of 12-bromododecanoic acid (302 mg, 1.08 mmol) and tris(4-methoxyphenyl)phosphine (400 mg, 1.14 mmol) in degassed MeCN (5 mL) under N2 was heated at 80 00 for 3 d. On cooling the solvent was removed in vacuo and the resultingresidue purified by column chromatography eluting with 0-10% MeOH in DCM to give (11-carboxyundecyl)tris(4-methoxyphenyl)phosphonium bromide (545 mg, 80%) as a white solid.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; NOVINTUM BIOTECHNOLOGY GMBH; SPAREY, Tim; RATCLIFFE, Andrew; COCHRANE, Edward; STEVENSON, Brett; HALLETT, David; LAGASSE, Franz; LASSALLE, Gilbert; FROIDBISE, Alexandre; (106 pag.)WO2018/193113; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

A solution of (mu3-S)FeCo2(CO)9 (0.069 g, 0.15 mmol) and tris(4-fluorophenyl)phosphane(0.063 g, 0.2 mmol) in CH2Cl2 (10 mL) was added to a solution of Me3NO2H2O (0.022 g,0.2 mmol) and stirred at room temperature for 1 h. The solvent was reduced in vacuo andthe residue was subjected to TLC separation using CH2Cl2:petroleum ether = 1:5 (v/v) aseluent. From the first main brown band, 1 (0.039 g, 35percent) was obtained as a black solid. Fromthe second main brown band, 2 (0.040 g, 26percent) was obtained as a black solid. 1: IR (CH2Cl2,cm?1): nuC?O 2082 (vs), 2039 (vs), 2017 (vs), 1982 (s). 1H NMR (500 MHz, CDCl3): 7.427.38 (m,6H, PhH), 7.14 (t, J = 7.5 Hz, 6H, PhH) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4): 47.30 (s)ppm. 13C{1H} NMR (125 MHz, CDCl3): 164.22 (d, JP-F = 251.6 Hz, p-PhC), 135.31, 135.21 (dd,JP-C = 12.6 Hz, JP-F = 8.6 Hz, o-PhC), 129.83 (d, JP-C = 44.9 Hz, i-PhC), 116.28, 116.11 (dd,JP-C = 11.4 Hz, JP-F = 21.1 Hz, m-PhC) ppm. Anal. Calcd for C26H12Co2F3FeO8PS: C, 41.85; H, 1.62.Found: C, 41.77; H, 1.98percent. 2: IR (CH2Cl2, cm?1): nuC?O 2047 (s), 2013 (vs), 1984 (s). 1H NMR(500 MHz, CDCl3): 7.42, 7.11 (2s, 24H, PhH) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85percent H3PO4):44.89 (s) ppm. Anal. Calcd for C43H24Co2F6FeO7P2S: C, 49.93; H, 2.34. Found: C, 49.81; H, 2.22percent., 18437-78-0

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Peng; Liu, Xu-Feng; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 70; 17; (2017); p. 3080 – 3094;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(7) (Tri(m-tolyl)phosphine-kappaP)(1-(2,4-dichlorobenzoyl)-3-(N-methylphenyl)thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.192?g (0.564?mmol) 1-(2,4-dichlorobenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 215-217?¡ãC. FTIR (cm-1); 3139(w), 2996(w), 2882(w), 1622(m), 1512(s), 1420(s), 1368(w), 1318(w), 1242(w), 1189(w), 1095(m), 1061(w), 1018(w), 988(w), 934(m), 910(s), 860(s), 784(s), 744(s), 692(s), 614(w). H NMR (300?MHz, CDCl3) delta 2.36 [(s, 9H, 3(-CH3)], 3.59 (s, 3H, N-CH3), 6.84-8.40 (m, 20H, ArH); 13C NMR (75.5?MHz, CDCl3) delta 21.6 (3C), 42.2 (C), 114.6 (C), 114.9 (C), 124.6 (C), 125.4 (C), 127.2 (2C), 127.5 (C),128.8 & 128.9 (d, 3C,13C-31P, 2J?=?12.0?Hz), 129.1(C), 129.3 (3C), 132.7 & 132.8 (d, 3C, 13C-31P, 3J?=?9.0?Hz), 134.7 & 134.9 (d, 3C, 13C-31P, 2J?=?11.5?Hz), 141.3 (3C), 151.1 (3C), 171.3 (1C, C=O), 173.9 (1C, C=S); 31P NMR (121.5?MHz, CDCl3) delta 32.87; Anal. Calc. for C36H32Cl3N2OPPdS (Mol. mass: 784.47) C, 55.12; H, 4.11; N, 3.57; S, 4.09. Found: C, 54.91; H, 3.99; N, 3.59; S, 4.03., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: Into a round bottom flask was added (dichloroiodo)benzene (2, 0.15 mmol, 1.02 equiv), DCM (0.25 mL, 0.6M), and to this was added excess ethanol (0.1 mL, 10 equiv), followed by the secondary phosphine oxide (0.15 mmol, 1.0 equiv,). The reaction mixture was stirred at room temperature for the indicated length of time, then concentrated in vacuo and purified by column chromatography., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Eljo, Jasmin; Murphy, Graham K.; Tetrahedron Letters; vol. 59; 31; (2018); p. 2965 – 2969;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, Example One N-(5-Vinyl-pyridin-2-yl)-acetamide. A solution of of N-(5-bromo-pyridin-2-yl)-acetamide (4.30 g, 20 mmol) in acetonitrile (15 ml) and triethylamine (5.04 ml) was treated with palladium acetate (45 mg, 0.2 mmol) and tri-o-tolylphosphine (203 mg, 0.66 mmol). The mixture was placed in a pressure reactor under 50 psig of ethylene pressure and heated at 85C for 66 hours. The reaction mixture was cooled, vented, and partitioned between phosphate buffer (0.1 M, pH 6.6) and ethyl acetate. The aqueous phase was extracted with ethyl acetate twice more. The combined ethyl acetate extracts were washed with additional phosphate buffer, brine and dried over sodium sulfate. The extracts were filtered and evaporated to afford 2.06 g (63%) of the title product as a flaky crystalline residue. Recrystallization from ethyl acetate/cyclohexane gave colorless flakes. mp 120 – 121 C 1H NMR (CDCl3): delta = 8.55 (br, 1 H); 8.24 (d, 1 H); 8.15 (d, 1 H); 7.76 (d of d, 1H); 6.64 (d of d, 1 H); 5.73 (d, 1 H); 5.28 (d, 1 H); 2.19 (s, 3 H). MS (Cl): m/z= 163 (M+H+).

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; EP887079; (1998); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, The 1a? (439 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed in vacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-(benztriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol), followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 6 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried overNa2SO4. The solvent was removed in vacuo to afford the crude product as a colourless oil, which was purified by flash chromatography (20percent EtOAc in hexanes) yielding the precat. 1a as a white solid (514 mg, 82percent). Mp. 93?95 ¡ãC [alpha]D30 = +20.8 (c 1.20, CH2Cl2); 1H NMR (400 MHz, CDCl3): delta = 7.63?7.61 (m, 2 H), 7.38?7.18 (m, 15 H), 7.12?6.98 (m, 8 H), 6.71 (d, J = 8.0 Hz, 1 H), 5.08 (dd, J = 11.2, 3.6 Hz, 1 H), 4.53 (dd, J = 8.4, 5.6 Hz, 1 H), 3.68 (d, J =11.2, 1 H), 2.12 (s, 6 H), 2.12?2.04 (m, 1 H), 0.84 (d, J = 7.2 Hz, 3 H), 0.82 (d, J = 7.2 Hz, 3H); 13C NMR (100 MHz, CDCl3): delta (C-P coupling not removed) = 171.1, 168.7, 141.2, 141.0, 140.5, 137.6, 137.5, 137.4, 136.6, 136.4, 134.5, 133.9, 133.8, 133.7, 132.1, 130.3, 129.7, 128.7, 128.6, 128.5, 128.5, 128.4, 127.9, 127.7, 127.7, 127.5, 127.5, 126.9, 73.2, 58.5, 54.8, 40.5, 31.8, 19.1, 18.0; 31P NMR (162 MHz, CDCl3) delta = ? 10.2; HRMS (ESI): calcd. for C40H43N3O2P [M+H]+ 628.3093, found 628.3095.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zheng, Xiaojun; Deng, Qifu; Hou, Qinglin; Zhang, Kaiqiang; Wen, Pushan; Hu, Shunqin; Wang, Haifei; Synthesis; vol. 50; 12; (2018); p. 2347 – 2358;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate