Tag: M.W:300-400

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N,N’-Dicyclohexylcarbodiimide (163 mg, 0.79 mmol) and 4-dimethylaminopyridine (5 mg, 0.039 mmol) were added to a solution of 2-(diphenylphosphino)benzoic acid (220.0 mg, 0.72 mmol) in anhydrous CH2Cl2 (30 mL) under argon with stirring at room temperature. After 30 min, fluorescein monomethyl ether (249 mg, 0.72 mmol) was added and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and cold acetone was added to dissolve the crude product. The insoluble urea by-product was removed by filtration. The filtrate was concentrated and the residue was purified by silica gel column chromatography (EtOAc /pet.ether=1:2) to provide 1 as a pale yellow solid (280 mg, 61percent)., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Miao, Zhengrui; Reisz, Julie A.; Mitroka, Susan M.; Pan, Jia; Xian, Ming; King, S. Bruce; Bioorganic and Medicinal Chemistry Letters; vol. 25; 1; (2015); p. 16 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 4-trifluoromethylphenylacetylene to the reaction flask(0.085 g, 0.5 mmol), dinaphthylphosphoric acid(0.30 g, 1 mmol), CuI2 (0.032 g, 0.1 mmol),Phenylisopropyl hydroperoxide (0.46 g, 3 mmol),And N,N-dimethylformamide (2 mL),70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 82%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, (3) Ethyl (2E)-3-[4-(1-{4-[(1E)-3-ethoxy-3-oxo-1-propenyl]phenyl}-5-methyl-1H-pyrrol-2-yl)phenyl]-2-propenoate A solution of 1,2-bis(4-bromophenyl)-5-methyl-1H-pyrrole (2.00 g, 5.115 mmol), ethyl acrylate (1.39 ml, 12.8 mmol), tris(2-methylphenyl)phosphine (125 mg, 0.410 mmol), palladium acetate (23.0 mg, 0.102 mmol) and triethylamine (1.78 ml, 12.8 mmol) in DMF (4 ml) was stirred at 100 C. for 18 hours under nitrogen atmospheric current. The obtained mixture was poured into water and extracted with ethyl acetate. The extract was colleted and washed with water and dried over magnesium sulfate anhydride, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=85:15) to give the object compound as a solid. 2.00 g (yield: 91.3%) 1H-NMR (CDCl3) delta; 1.27-1.38 (6H, m), 2.16 (3H, s), 4.21-4.33 (4H, m), 6.12 (1H, d, J=3.4 Hz), 6.28-6.48 (3H, m), 7.04 (2H, d, J=8.4 Hz), 7.17 (2H, d, J=8.4 Hz), 7.30 (2H, d, J=8.4 Hz), 7.52-7.73 (4H, m). IR (KBr) cm-1; 2980, 1713, 1636, 1603, 1514, 1310, 1267, 1204, 1179, 1040, 982, 839, 768, 731.

The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Matsumoto, Takahiro; Katayama, Nozomi; Mabuchi, Hiroshi; US2003/144338; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

151.2 mg (0.5 mmol) of di(naphthalen-1-yl)phosphine oxide, 147.1 mg (0.5 mmol) 4-phenylmethylene-2,6-di-tert-butyl-2,5-cyclohexadien-1-one, 0.025 mmol of cesium carbonate was added to a Schlenk tube under nitrogen, and added under nitrogen. 1.0 mL of acetonitrile was stirred at 40 C for 6 hours. After the reaction is completed, it is purified by column chromatography and the target product ((3,5-di-tert-butyl-4-hydroxyphenyl)(phenyl)methyl)bis(1-naphthyl)phosphorus oxide The isolated yield was 83%., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Hunan Institute of Science and Technology; Xiong Biquan; Wang Gang; Xu Weifeng; Tang Kewen; (9 pag.)CN109456362; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under a N2 atmosphere, phosphine ligand (2 mmol) (L) was added to a stirred solution of Co2(CO)8 (1 mmol) in tetrahydrofuran or toluene (10 mL). The reaction mixture was stirred for 1 h under CO bubbling at 50 ¡ãC. The organic solvent was evaporated under reduced pressure. The resulting solid was washed several times with diethyl ether and pentane, finally dried under vacuum to give the desired complex., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Ame?zquita-Valencia, Manuel; Rami?rez-Garavito, Ricardo; Toscano, Rube?n A.; Cabrera; Catalysis Communications; vol. 33; (2013); p. 29 – 33;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

Under inert gas protection, 344 mg of Fe2S2(CO)6 (1 mmol) and 20 mL of tetrahydrofuran solvent were added to the flask containing the stirring magnets.A dark red solution was obtained, and the obtained solution was cooled to -78 ¡ã C with a liquid nitrogen bath, and 2 mL of a lithium triethylborohydride (1M in THF) solution was slowly added under stirring.After reacting for 15 min, 0.18 mL of trifluoroacetic acid (2.2 mmol) was added and the reaction was continued for 15 min.Add 304 mg of P(C6H4-3-CH3)3 (1.0 mmol), stir at room temperature for 3 h, then add 630 mg of I-4-C6H4N(CH2Cl)2 (2 mmol) and 0.28 mL of triethylamine.The reaction was stirred at room temperature for 12 h. The tetrahydrofuran solvent was removed by rotary evaporation, and the residue was extracted with dichloromethane.Then, thin layer chromatography was carried out using a developing solvent of dichloromethane/petroleum ether in a volume ratio of 1:6, and the main ribbon was collected to obtain a model 3.

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; He Jiao; Wu Yu; Xie Ying; Jiang Jin; Sun Yanchun; Wang Zheng; Zou Like; Xie Bin; Gao Fan; Mu Chao; (11 pag.)CN109232665; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: Complex 1a (24 mg, 0.03 mmol) and appropriate triarylphosphine(0.06 mmol) were suspended in 5ml of acetone, andthe reaction mixture was ultrasonicated for 2 h. The resulting suspensionwas evaporate to dryness and the dry residue was chromatographedon Silica (eluent dichloromethane: methanol = 4: 1)to afford yellow-orange solid of 2a-d.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Zhukovsky, Daniil D.; Sizov, Vladimir V.; Starova, Galina L.; Tunik, Sergey P.; Grachova, Elena V.; Journal of Organometallic Chemistry; vol. 867; (2018); p. 367 – 374;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29949-84-6,Tris(3-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

EXAMPLE 81 7-(3-Methoxyphenyl)-1-(4-methylpiperazin-1-yl)naphthalene A mixture of 3-methoxy-1-bromobenzene (0.089 mL, 0.71 mmol), 7-trimethylstannyl-1-(4-methylpiperazin-1-yl)naphthalene (0.25 g, 0.64 mmol), bis(acetonitrile) palladium chloride (0.0085 g, 0.032 mmol), tri(3-methoxyphenyl)phosphine (0.023 g, 0.064 mmol), and butylated hydroxytoluene (BHT, about 0.001 g, antioxidant) in dimethyl formamide (12 mL) was warned to 110 C. for 2 hours. The reaction was cooled to room temperature and diluted with 1N aqueous lithium chloride (25 mL) and 1 N sodium hydroxide (2 mL); then extracted with ether (3X). The combined ether layer was washed with 1N aqueous lithium chloride and brine. The organic phase was dried over calcium sulfate and concentrated. The residue was purified by flash chromatography on silica gel (1*2.5 inches). Elution proceeded as follows: 75% ethyl acetate/hexane, 200 mL, nil; 2% methanol/ethyl acetate 200 mL and 10% methanol/ethyl acetate, 200 mL, 0.084 g of an oil. This oil was further purified by kugelrohr distillation (1 mm Hg). The distillation proceeded as follows: 110-130 C., 0.014 g of a mixture of the title product and 7-methyl-1-(4-methylpiperazin-1-yl)naphthalene: 200-220 C., 0.062 g (23%) of the title compound as a yellow oil: 1 H NMR delta 8.43 (incompletely resolved dd, J=1.2Hz, 1 h), 7.90 (d, J=9 Hz, 1 H), 7.74 (dd, J=2, 8.5 Hz, 1 H), 7.58 (d, J=8 Hz, 1 H), 7.43 (sym m, 2 H), 7.34 (dt, J=1.5, 7.5 Hz, 1 H), 7.29 (5, J=2 Hz, 1 H), 7.14 (dd, J=1, 7.5 Hz, 1 H), 6.96 (ddd, J=1,2.5, 8 Hz, 1H), 3.92 (s, 3 H) 3.20 (br s, 4 H), 2.75 (br s, 4 H), 2.44 (s, 3 H). The product was dissolved in chloroform and HCl gas was bubbled through the solution to form the hydrochloride salt. Concentration of this solution to about 1 mL. at the boil and addition of about 1 mL of ether caused the white crystalline product to precipitate. The hydrochloride salt weighted 0.057 g: mp 236-238 C. Analysis calculated for C22 H24 N2 O*HCl: C, 71.63; H, 6.83; N, 7.59. Found: C, 71.31; H, 6.92; N, 7.59.

29949-84-6, 29949-84-6 Tris(3-methoxyphenyl)phosphine 141534, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US5597826; (1997); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2mmol NaOH (0.080g) is dissolved in 10ml of methanol and 2mmol of carbon disulfide (CS2) (0.150g, 120mul, density=1.266g/ml) is then added. The clear solution is then added to a 10ml acetonitrile solution which contains 0.5mmol AgNO3 (0.085g) and 1mmol tri-aryl-phosphines (tpp: 0.262g (1), 0.304g, tptp and tmtp: 0.304g (2 and 3)). The mixture was stirred for 3h at 0¡ãC and the resulting yellow solution was filtered off. Colorless crystals of 1?3 suitable for X-ray analysis were grown from slow evaporation of the solution after 2days., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Article; Banti, Christina N.; Kourkoumelis, Nikolaos; Tsiafoulis, Constantinos G.; Skoulika, Stavroula; Hadjikakou, Sotiris K.; Polyhedron; vol. 121; (2017); p. 115 – 122;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: To a solution of [Fe2(CO)6{mu-SCH(CH3)CH(CH3)S}] (0.040 g, 0.10 mmol) and tris(4-fluorophenyl)phosphine (0.032 g, 0.10 mmol) in CH2Cl2 (5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h, and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 2:5 (v/v) as eluent.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lin, Hui-Min; Wang, Ling-Hui; Liu, Xu-Feng; Liu, Xing-Hai; Jiang, Zhong-Qing; Transition Metal Chemistry; vol. 45; 1; (2020); p. 47 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate