Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 20 N-(2,2,2-Trifluoroethyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide Analogously to Example 14, 1.39 g (5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)-pyrazol-5-yloxy]pyridine, 0.75 g (7.57 mmol, 98 percent content) of 2,2,2-trifluoroethylamine, 0.80 g (7.55 mmol) of anhydrous sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 88 mg (0.25 mmol) of tris(4-methoxyphenyl)phosphine in 20 ml of methylcyclohexane were reacted under a CO pressure of 21 bar. The yield was 0.96 g (75.4 percent) of a white solid. The melting point was 135.8 to 136.3 C. (from methylcyclohexane). Other data concerning the product was: MS; m/z: 368 (M+); 242 (100 percent) 1 H NMR (CDCl3): delta=3.82 (s, 3H); 4.05 (m, 2H); 6.29 (s, 1H); 7.27 (dt, J=8.1/0.6 Hz, 1H); 7.64 (br. s, 1H); 8.01 (dd, J=7.3/0.5 Hz, 1H); 8.07 (d, J=7.3 Hz, 1H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, A mixture of DCMOH (156.2 mg, 0.5 mmol), 2-(diphenylphosphino)benzoic acid (183.8 mg, 0.6 mmol), N,N?-dicyclohexylcarbodiimide(288.9 mg, 1.4 mmol) and 4-dimethylaminopyridine (61.1 mg, 0.5 mmol) in anhydrousdichloromethane was stirred at room temperature for 12 h.The residue was filtrated, washed with brine, and extractedwith dichloromethane. The organic layer was dried overanhydrous Na2SO4 and concentrated. The residue was purifiedby silica gel chromatography with dichloromethane/methanol (15:1, v/v) to give DCMHNO as a brown solid(195 mg, 65%). 1H NMR (400 MHz, CDCl3) delta 8.91 (dd, J1=8.4 Hz, J2=1.2 Hz, 1H), 8.31-8.22 (m, 1H), 7.76-7.72 (m,1H), 7.63-7.52 (m, 4H), 7.50-7.42 (m, 3H), 7.41-7.27 (m,10H), 7.06-6.98 (m, 3H), 6.86 (s, 1H), 6.75 (d, J=15.9 Hz,1H). 13C NMR (101 MHz, CDCl3) delta 164.94, 157.26, 152.81,152.32, 152.21, 141.67, 141.39, 137.85, 137.55, 137.44,134.71, 134.52, 134.16, 133.95, 132.76, 132.28, 131.40,128.96, 128.86, 128.65, 128.58, 128.39, 126.02, 125.84,122.49, 118.79, 118.63, 117.84, 116.71, 115.62, 106.98,63.05. HRMS (MALDI-TOF): m/z: [M+K]+ calcd. forC39H25KN2O3P+: 639.1234; found: 639.1444. m.p.232-234 C.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Wang, Jianguo; Zhu, Wenping; Li, Chunbin; Zhang, Pengfei; Jiang, Guoyu; Niu, Guangle; Tang, Ben Zhong; Science China Chemistry; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TFFPP (0.0600 g, 0.189 mmol) was added to a solution of [AuCl(C4H8S)] (0.0146 g, 0.063 mmol) in dichloromethane (20 mL) at -80 ¡ãC and the reaction stirred for 3 h. The solvent was removed by purging nitrogen gas into the solution. The residue was then recrystallized from CH2Cl2/n-hexane mixture for seven days. Partial evaporation of the solvent provided quality crystals. Yield is 98percent. 1H NMR [delta (ppm)]: 7.2(m) and 7.6(m). 31P NMR [delta (ppm)]: 81.1.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Agbeworvi, George; Assefa, Zerihun; Sykora, Richard E.; Taylor, Jared; Crawford, Carlos; Journal of Molecular Structure; vol. 1108; (2016); p. 508 – 515;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

15929-43-8, Bis(4-(trifluoromethyl)phenyl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh 1a (51.2mg, 0.2mmol) and chiral amide 4d(12.6 mg, 0.02 mmol) in a round bottom flask containing a stir bar,Add 0.4 mL of dichloromethane to an ice bath at 0 C;Further taking bis(4-trifluoromethylphenyl)phosphine oxide (67.6 mg, 0.2 mmol)Dissolved in 0.4 mL of dichloromethane and injected into a reaction system of a round bottom flask by a peristaltic pump for 30 minutes. After the injection was completed, the reaction was monitored by TLC.After the reaction was completed, the reaction mixture was concentrated and purified by column chromatography (ethyl ether: ethyl acetate = 1:1) to afford product. The yield was 77% and the enantiomeric excess was 93%., 15929-43-8

The synthetic route of 15929-43-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangxi University; Jiang Jun; Gu Xiu; Yuan Hao; Wu Yi; (23 pag.)CN109096334; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: Triphenylphosphite (2.25g, 7.25mmol) was added portionwise to a stirred mixture of the corresponding amino acid methyl ester hydrochloride (7.15mmol), 2-(diphenylphosphanyl)benzoic acid (2.19g, 7.15mmol), and pyridine (30mL) at 100¡ãC under an argon atmosphere. The reaction mixture was stirred at this temperature for 6h. The excess of pyridine was removed under vacuum. The resulting residue was dissolved in chloroform, washed with water (3 times), saturated aqueous solution of NaHCO3 (3 times), and again with water (2 times). The organic layer was separated, dried over anhydrous Na2SO4, and evaporated to dryness. The resulting residue was purified by column chromatography on silica gel (eluent EtOAc?hexane (1:2)) to give ligands 5a,b as white crystalline solid. 4.2.4.1 Methyl (2R)-2-{[2-(diphenylphosphanyl)benzoyl]amino}-3-(methylsulfanyl)propanoate 5a Yield: 1.25 g (40percent). Mp: 105?108¡ãC. 31P{1H} (121.49 MHz, CDCl3): delta ?9.31 ppm. 1H NMR (400.13 MHz, CDCl3): delta 2.11 (s, 3H, SMe), 2.93 (d, 2H, CH2, 3JHH=5.0 Hz), 3.79 (s, 3H, OMe), 4.92 (dt, 1H, CH, 3JHH=7.6 Hz, 3JHH=5.0 Hz), 6.87 (br d, 1H, NH, 3JHH=7.6 Hz), 7.02 (ddd, 1H, H(C3), 3JHH=7.7 Hz, 3JHP=4.0 Hz, 4JHH=0.8 Hz), 7.29?7.39 (m, 11H, HAr), 7.43 (dt, 1H, H(C5), 3JHH=7.5 Hz, 4JHH=1.2 Hz), 7.70 (ddd, 1H, H(C6), 3JHH=7.5 Hz, 4JHP=3.8 Hz, 4JHH=1.2 Hz) ppm. 13C{1H} NMR (100.61 MHz, CDCl3): delta 16.33 (s, SMe), 36.45 (s, CH2S), 52.04 and 52.64 (both s, OMe and CH), 127.66 (d, C3, 2JCP=4.6 Hz), 128.53 (d, m-C in PPh, 3JCP=6.9 Hz), 128.58 (d, m-C in PPh, 3JCP=6.8 Hz), 128.62 (s, C4 or C5), 128.75 and 128.78 (both s, p-C in PPh2), 130.60 (s, C5 or C4), 133.79 (d, o-C in PPh, 2JCP=3.8 Hz), 133.99 (d, o-C in PPh, 2JCP=3.7 Hz), 134.45 (s, C6), 137.09 (d, C2, 1JCP=22.2 Hz), 137.28 (d, ipso-C in PPh, 1JCP=11.3 Hz), 137.33 (d, ipso-C in PPh, 1JCP=11.0 Hz), 140.15 (d, C1, 2JCP=24.3 Hz), 168.37 (s, C(O)NH), 171.26 (s, C(O)OMe) ppm. IR (KBr, nu/cm?1): 498(w), 518(w), 697(m), 749(s), 999(vw), 1027(vw), 1090(w), 1126(vw), 1159(w), 1176(w), 1214(m), 1258(w), 1311(w), 1434(m), 1459(w), 1479(w), 1520(br, m) (C(O)NH), 1560(vw), 1584(w), 1649(s) (nuC=O in C(O)NH), 1744(s) (nuC=O in C(O)OMe), 2850(vw), 2917(w), 2950(w), 3051(w), 3295(br, w) (nuNH). Anal. Calc. for C24H24NO3PS: C, 65.89; H, 5.53; N, 3.20. Found: C, 66.03; H, 5.49; N, 3.14percent.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Churusova, Svetlana G.; Aleksanyan, Diana V.; Rybalkina, Ekaterina Yu.; Nelyubina, Yulia V.; Peregudov, Alexander S.; Klemenkova, Zinaida S.; Kozlov, Vladimir A.; Polyhedron; vol. 143; (2018); p. 70 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.5 (1R,2S)-2-Benzamido-1-phenylpropyl 2-(diphenylphosphinyl)benzoate 9a fx14 Purified by recrystallization in CH2Cl2/hexanes to yield 0.702 g (71percent) of product as a white solid. [alpha]D23 = -5.9 (c 1.04, CHCl3). Mp = 77-81 ¡ãC. 1H NMR (400 MHz, CDCl3): delta 0.93 (d, J = 7.0 Hz, 3H), 4.64-4.71 (m, 1H), 6.22 (d, J = 2.9 Hz, 1H), 7.03-7.05 (m, 1H), 7.07 (dd, J = 8.8, 2.5 Hz, 1H), 7.20-7.49 (m, 20H), 7.83 (d, J = 8.3 Hz, 2H), 8.08 (m, 1H). 13C NMR (100 MHz, CDCl3): delta 14.45, 49.63, 79.55, 126.20, 127.28, 127.30, 127.99, 128.48, 128.50, 128.59, 128.66, 128.74, 128.93, 129.00, 130.92, 130.96, 131.38, 132.26, 133.34, 133.53, 133.97, 134.17, 134.63, 134.96, 135.44, 135.67, 137.02, 137.11, 137.15, 137.25, 137.39, 138.57, 138.80, 166.77, 167.03. 31P NMR (162 MHz, CDCl3): delta -5.64. IR v (cm-1, Nujol mull): 1722, 1627, 1247, 753, 695. ESI HRMS for C35H30NO3P: calcd (M+H) 544.2042; found 544.2042., 17261-28-8

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: The complexes were prepared according to the following method [14]: 1mmol of copper(I) bromide or copper(I) chloride is stirred in methanol until complete dissolution. Then, 2.1 mmol of the corresponding phosphine ligand was added. The mixture was stirred at 60¡ãC for 30min. under nitrogen atmosphere. A microcrystalline precipitate was obtained by concentration of the solution at reduced pressure. The solid product was dissolved in a dichloromethane/methanol mixture and the solution was gradually cooled to 4¡ãC to give an air stable and colorless crystalline solid suitable for X-ray single-crystal diffraction studies., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Espinoza, Sully; Arce, Pablo; San-Martn, Enrique; Lemus, Luis; Costamagna, Juan; Faras, Liliana; Rossi, Miriam; Caruso, Francesco; Guerrero, Juan; Polyhedron; vol. 85; (2015); p. 405 – 411;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

0.5 mmol of naphthyl diphenylphosphine oxide, 0.25 mmol of potassium carbonate and 0.75 mmol of methyl thiophenol were weighed into 10 mLThe flask was stirred at room temperature for 6 hours. After the reaction, the tetrahydrofuran solvent was removed using a rotary evaporator and the residue was dissolved in lmL of methylene chloride. The residue was purified by silica gel column chromatography to obtain Color transparent liquid, the yield was 87%., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong University of Technology; Yan Xinxing; Chen Qian; Wen Chunxiao; Zeng Jiekun; Huang Yulin; Wang Xiaofeng; Chen Ziming; Huo Yanping; Du Zhiyun; Zhang Kun; (29 pag.)CN106928272; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under Argon gas protection, add to the flask with stirrer344 mg of Fe2S2(CO)6 (1 mmol) and 15 mL of tetrahydrofuran solvent,A dark red solution was obtained and the resulting solution was cooled down to -78 ¡ãC in a liquid nitrogen bath.2 mL of lithium triethylborohydride (1M in THF) was added slowly with stirring.After 10 minutes of reaction, 0.18 mL of trifluoroacetic acid was added.After the reaction was continued for 15 minutes, 0.18 mL of formaldehyde solution (37percentwt) was added.The reaction was warmed to room temperature and stirred for 3 h before adding 320 mgP(C6H4-4-F)3 (1.0 mmol), stirring for 10 h at room temperature,The tetrahydrofuran solvent was removed by rotary evaporation and 15 mL of dichloromethane and 0.9 mL of concentrated sulfuric acid were added.Continue to stir the reaction for 18 h, add 15 mL of water, and separateDichloromethane in the organic layer was removed by rotary evaporation and the residue was extracted with dichloromethane.Thin layer chromatography was then performed using a developer having a dichloromethane/petroleum ether volume ratio of 1:3.The main band was collected to obtain the model 2 in a yield of 27percent.

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; Zou Like; Mu Chao; Deng Chenglong; Wu Yu; Zhao Peihua; Xie Bin; Luo Qiang; (10 pag.)CN106674288; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate