Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

151 mg (0.5 mmol) of bis(1-naphthyl)phosphorus,115.5 mg (0.75 mmol) of 4,4-dimethoxy-2,5-cyclohexadien-1-one,0.05 mmol of water and 1.0 mL of toluene were placed in a Schlenk tube under nitrogen, and the reaction was stirred at 100 C for 12 hours. After completion of the reaction, it was purified by column chromatography, and the isolated yield was 64%., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Hunan Institute of Science and Technology; Xiong Biquan; Wang Gang; Tang Kewen; Xu Weifeng; (8 pag.)CN109096331; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

To azide 6 [8a,14] (436?mg, 0.832?mmol) in Et2O (2.1?mL) under argon atmosphere was added tris(4-methoxyphenyl)phosphine (293?mg, 0.832?mmol) at rt. Stirring was maintained at rt for 24?h and then pentane (2.0?mL) was added and the resultant thick precipitate was filtered. The precipitate was washed with pentane/Et2O 1:1 (1?mL) and dried in vacuo to obtain the title compound 1d as a colourless solid (630?mg, 90%). MP 168-170?C; [alpha]D24?=?-18.0 (c?=?0.59, CHCl3); 1H NMR (500?MHz, CDCl3) delta ppm 2.99 (br. s, 1H), 3.10 (br. s, 1H), 3.82 (s, 9H), 3.97-4.09 (m, 1H), 5.11 (br. s, 1H), 6.88 (d, J?=?5.5?Hz, 6H), 7.11-7.21 (m, 6H), 7.22-7.31 (m, 7H), 7.31-7.45 (m, 6H), 7.63 (s, 2H); 13C NMR (125?MHz, CDCl3) delta ppm 50.3, 55.0, 55.6, 59.9, 115.0 (d, JPC?=?11.4?Hz), 123.8 (q, JFC?=?272.8?Hz), 126.6, 126.9 (br. s), 128.1, 128.5, 128.8, 128.9 (br. s), 130.6 (q, JFC?=?32.4?Hz), 134.9 (JPC?=?11.5?Hz), 142.9, 163.7; 31P NMR (162?MHz, CDCl3) delta ppm 27.6 (br s); 19F NMR (376?MHz, CDCl3) delta ppm – 62.6; IR numax/cm-1 3027, 2963, 1624, 1594, 1499, 1471, 1388, 1258, 1118, 1028, 804, 700; HRMS (ESI+): calcd. for C45H40F6N3O3PS [M+H]+ 848.2505, found 848.2492.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Farley, Alistair J.M.; Jakubec, Pavol; Goldys, Anna M.; Dixon, Darren J.; Tetrahedron; vol. 74; 38; (2018); p. 5206 – 5212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(8) (Tri(m-tolyl)phosphine-kappaP)(1-(2-methylbenzoyl)-3-(N-methylphenyl)thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.161?g (0.564?mmol) 1-(2-methylbenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 164-165?¡ãC. FTIR (cm-1) 3089(w), 3002(w), 2880(w), 1638(m), 1508(s), 1419(s), 1279(w), 1249(w), 1193(w), 1165(w), 1092(w), 1066(w), 1020(s), 913(s), 859(s), 781(s), 690(s), 616(w); 1H NMR (300?MHz, CDCl3) delta 2.39 [(s, 9H, 3(-CH3)], 2.77 (s, 3H, Ar-CH3), 3.52 (s, 3H, N-CH3), 7.08-8.07 (m, 21H, ArH); 13C NMR (75.5?MHz, CDCl3) 21.6 (3C), 22.9 (C), 42.3 (C), 125.1 (C), 126.9 (1C), 127.7-127.9 (m, 3C), 128.5 (C), 129.3 (C), 130.5 (C), 131.9-132.1(m, 3C), 132.0 (C), 132.1 (C), 135.3 & 135.4 (d, 3C, 13C-31P, 2J?=?12.0?Hz), 137.6 & 137.8 (d, 3C, 13C-31P, 2J?=?11.5?Hz), 145.6(1C), 168.7 (1C, C=O), 173.3 (1C, C=S);31P NMR (121.5?MHz, CDCl3) delta 34.62; Anal. Calc. for C37H36ClN2OPPdS (Mol. mass: 729.61) C, 60.91; H, 4.97; N, 3.84; S, 4.39. Found: C, 60.83; H, 4.92; N, 3.85; S, 4.32., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Phosphine 1 (0.21 g, 0.69 mmol) was dissolved in Et2O (5 ml)and elemental sulfur or selenium (0.70 mmol) was added andresulted mixture stirred during 1 h at room temperature. Then themixture was filtered off and Et2O was removed to give the phosphinechalcogenide 3 and 4 as powders., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Sterkhova; Smirnov; Malysheva; Kuimov; Belogorlova; Journal of Molecular Structure; vol. 1197; (2019); p. 681 – 690;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4.3.31 methyl 2-phenyl-5-(4-fluorophenyl)oxazole-4-carboxylate (4k) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 89 mg (60percent). White solid, mp 140-142 ¡ãC; 1H NMR (300 MHz, CDCl3) delta 3.95 (s, 3H), 7.16 (t, J=8.7 Hz, 2H), 7.44-7.47 (m, 3H), 7.09-7.18 (m, 4H) ppm; 13C NMR (75 MHz, CDCl3) delta 164.4, 161.6, 161.0, 158.6, 153.3, 130.1, 129.6, 129.5, 127.8, 126.6, 125.7, 125.1, 122.2, 122.1, 114.7, 114.4, 51.3 ppm; IR (KBr) 2950, 2844, 1715, 1505, 1434, 1355, 1235, 1094, 1009, 844, 708 cm-1; HRMS (ESI) calcd for [C17H12FNO3+H]+ 298.0874, found 298.0876.

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

To a solution of 2-diphenylphosphinobenzoic acid (67 mg, 0.22 mmol) in dry CH2Cl2 (5 mL) under an argon atmosphere N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide (50 mg, 0.26 mmol), hydroxybenzotriazole (36 mg, 0.26 mmol), and (1R,5S)-(-)-cytisine (50 mg, 0.26 mmol) were added at room temperature. The mixture was stirred at room temperature for 24 h and then was directly subjected to flash column chromatography (silica gel, CH2Cl2/CH3OH = 50:1) to give 104 mg (99percent yield) of 3 as a white solid; m.p. 126-128 ¡ãC. [alpha]D20 = -198.4 (c 0.64, CHCl3). 1H NMR (600 MHz, CDCl3, 253 K): 1:0.9 mixture of rotamers; signals for B-chair conformer: delta = 7.40-7.38 (m, 2H, Har), 7.37-7.34 (m, 1H, 10-H), 7.35-7.33 (m, 2H, Har), 7.32-7.30 (m, 3H, Har), 7.24-7.21 (m, 1H, Har), 7.20-7.16 (m, 3H, Har), 7.10 (dt, JH,H = 7.5, 0.6 Hz, 1H, Har), 7.06-7.02 (m, 1H, Har), 6.61 (dd, JH,H = 9.1, 1.2 Hz, 1H, 9-H), 6.15 (ddd, JH,H = 7.6, 3.6, 0.7 Hz, 1H, Har), 5.88 (dd, JH,H = 6.8, 1.0 Hz, 1H, 11-H), 4.85 (d, JH,H = 12.4 Hz, 1H, 4-Heq), 4.26 (d, JH,H = 15.6 Hz, 1H, 6-H), 3.90 (dd, JH,H = 15.6, 6.4 Hz, 1H, 6-H), 3.32 (d, JH,H = 12.7 Hz, 1H, 2-Heq), 2.94 (d, JH,H = 12.4 Hz, 1H, 4-Hax), 2.87 (brs, 1H, 1-H), 2.76 (dd, JH,H = 12.7, 1.6 Hz, 1H, 2-Hax), 2.61 (brs, 1H, 5-H), 2.05-1.92 (m, 2H, 13-H) ppm; resolved signals for A-chair conformer: delta = 7.45-7.42 (m, 1H, Har), 7.06-7.02 (m, 1H, Har), 7.37-7.34 (m, 1H, 10-H), 6.94 (ddd, JH,H = 7.5, 3.3, 0.6 Hz, 1H, Har), 6.54 (dd, JH,H = 9.0, 1.1 Hz, 1H, 9-H), 6.19 (dd, JH,H = 6.8, 0.7 Hz, 1H, 11-H), 4.75 (d, JH,H = 12.8 Hz, 1H, 2-Heq), 4.11 (d, JH,H = 15.6 Hz, 1H, 6-H), 3.74 (dd, JH,H = 15.6, 6.0 Hz, 1H, 6-H), 3.50 (d, JH,H = 12.6 Hz, 1H, 4-Heq), 3.20 (brs, 1H, 1-H), 3.04 (dd, JH,H = 12.8, 1.9 Hz, 1H, 2-Hax), 2.98 (d, JH,H = 12.6 Hz, 1H, 4-Hax), 2.32 (brs, 1H, 5-H), 2.05-1.92 (m, 2H, 13-H) ppm. 13C NMR (150.9 MHz, CDCl3, 253 K): signals for B-chair conformer: delta = 170.15 (Cq, C=O, amide), 163.19 (Cq, C=O, lactam), 148.16 (CH, 12-C), 141.27 (d, J31P,13C = 33.7 Hz, Cq, Car), 138.61 (CH, 10-C), 135.82 (d, J31P,13C = 9.9 Hz, Cq, Car), 135.70 (d, J31P,13C = 9.4 Hz, Cq, Car), 134.26 (d, J31P,13C = 20.7 Hz, 2 CH, Car), 134.00 (CH, Car), 133.63 (Cq, CCO), 133.06 (d, J31P,13C = 18.8 Hz, 2 CH, Car), 129.96 (CH, Car), 129.09 (CH, Car),129.03 (CH, Car), 128.56 (d, J31P,13C = 6.8 Hz, 2 CH, Car), 128.53 (d, J31P,13C = 7.8 Hz, 2 CH, Car), 128.29 (CH, Car), 126.06 (d, J31P,13C = 7.5 Hz, 1 CH, Car), 117.66 (CH, 9-C), 105.61 (CH, 11-C), 53.13 (d, J31P,13C = 1.8 Hz, CH2, 2-C), 49.01 (CH2, 6-C), 47.22 (CH2, 4-C), 34.37 (CH, 1-C), 26.93 (CH, 5-C), 25.72 (CH2, 13-C) ppm; signals for A-chair conformer: delta = 170.21 (Cq, C=O, amide), 163.26 (Cq, C=O, lactam), 148.18 (CH, 12-C), 141.65 (d, J31P,13C = 33.9 Hz, Cq, Car), 139.50 (CH, 10-C), 135.52 (d, J31P,13C = 8.5 Hz, Cq, Car), 135.42 (d, J31P,13C = 8.9 Hz, Cq, Car), 134.04 (d, J31P,13C = 20.3 Hz, 2 CH, Car), 134.04 (CH, Car), 133.76 (Cq, CCO), 133.03 (d, J31P,13C = 18.8 Hz, 2 CH, Car), 129.96 (CH, Car), 128.87 (CH, Car), 128.55 (CH, Car), 128.49 (CH, Car), 128.31 (d, J31P,13C = 6.5 Hz, 2 CH, Car), 128.27 (d, J31P,13C = 6.3 Hz, 2 CH, Car), 126.23 (d, J31P,13C = 7.9 Hz, 1 CH, Car), 117.19 (CH, 9-C), 106.42 (CH, 11-C), 52.23 (d, J31P,13C = 2.2 Hz, CH2, 4-C), 48.47 (CH2, 6-C), 48.30 (CH2, 2-C), 34.17 (CH, 1-C), 27.26 (CH, 5-C), 25.86 (CH2, 13-C) ppm. 31P{1H} NMR (242.92 MHz, CDCl3, 253 K): signal for B-chair conformer: delta = -14.07 ppm; signal for A-chair conformer: delta = -13.75 ppm. IR (KBr): nu = 3050, 2925, 2854, 1657, 1639, 1580, 1546, 1434, 1424, 1306, 1243, 745, 673 cm-1. MS (ESI): m/z = 479 (100, [M + 1]+), 289 (63). C30H27N2O2P (478.52): calcd. C 75.30, H 5.69, N 5.85, found C 75.63, H 5.81, N 5.96., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Philipova, Irena; Stavrakov, Georgi; Vassilev, Nikolay; Nikolova, Rositsa; Shivachev, Boris; Dimitrov, Vladimir; Journal of Organometallic Chemistry; vol. 778; (2015); p. 10 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Under N2 atmosphere, NaOAc (4.0?equiv), PPh3 1a (0.5?mmol), PdCl2 (10.0?mol?percent), AgOOCCF3 (5.0?equiv), CH3CN (2.0?mL) and methyl acrylate 2a (0.6?mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60?¡ãC for 24?h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, N-(5-Vinyl-pyridin-2-yl)-acetamide . A solution of of N-(5-bromo-pyridin-2-yl)-acetamide (prepared as described in Preparation One, 4.30 g, 20 mmol) in acetonitrile (15 ml) and triethylamine (5.04 ml) was treated with palladium acetate (45 mg, 0.2 mmol) and tri-o-tolylphosphine (203 mg, 0.66 mmol). The mixture was placed in a pressure reactor under 50 psig of ethylene pressure and heated at 85 C for 66 hours. The reaction mixture was cooled, vented, and partitioned between phosphate buffer (0.1 M, pH 6.6) and ethyl acetate. The aqueous phase was extracted with ethyl acetate twice more. The combined ethyl acetate extracts were washed with additional phosphate buffer, brine and dried over sodium sulfate. The extracts were filtered and evaporated to afford 2.06 g (63%) of the title product as a flaky crystalline residue. Recrystallization from ethyl acetate/cyclohexane gave colorless flakes. mp 120 – 121 C 1H NMR (CDCl3): delta = 8.55 (br, 1 H); 8.24 (d, 1 H); 8.15 (d, 1 H); 7.76 (d of d, 1 H); 6.64 (d of d, 1 H); 5.73 (d, 1 H); 5.28 (d, 1 H); 2.19 (s, 3 H). MS (Cl): m/z =163 (M+H+).

6163-58-2 Tri-o-tolylphosphine 80271, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Products Inc.; EP920864; (1999); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: Complex 1 was synthesized by the simultaneous and dropwise addition of tris-(4-fluorophenyl)phosphine(0.316 g, 1 mmol) in acetone and sodium 4-benzylpiperazine-1-carbodithioate (0.274 g, 1 mmol)in methanol to a methanolic suspension of palladium(II) chloride (0.177 g, 1 mmol). The reaction mixturewas refluxed for 5 h with constant stirring. The resulting orange-colored solution was filtered androtary evaporated to obtained orange solid (scheme 1). It was dried and re-dissolved in chloroform,and on slow evaporation needle-like crystals were obtained. Complexes 2 and 3 were synthesized bythe same method (scheme 1).

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Zia-ur-Rehman; Journal of Coordination Chemistry; vol. 69; 20; (2016); p. 2999 – 3009;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate