Tag: M.W:200-300

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

224311-51-7, 2-(Di-tert-Butylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 600 mg of tert-butyl 3-bromo-5-cyano-1H-1-indazolecarboxylate produced in Production Example I-14-b in 9 ml tetrahydrofuran were added 21 mg of palladium(II) acetate, 57 mg of 2-(di-tert-butylphosphino)biphenyl, 357 mg of potassium fluoride and 498 mg of 2-benzo[b]thiopheneboronic acid, and the mixture was stirred at 50C for 1 hour. After removing the solvent by distillation, the residue was dissolved in 2 ml of methylene chloride. 4 ml of trifluoroacetic acid was added and the mixture was stirred at room temperature for one day. After removing the solvent by distillation, the residue was diluted with 50 ml of ethyl acetate. The mixture was sequentially washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated. The crude product was purified and separated by silica gel column chromatography (ethyl acetate:toluene = 1:19), to give 294 mg of the title compound as bright yellow crystals.1H-NMR (400 MHz, DMSO-D6) d 7.41 (2H, t, J = 7.8 Hz), 7.44 (2H, t, J = 7.8 Hz), 7.80 (2H, s), 7.91 (1H, d, J = 8.0 Hz), 8.01 (1H, d, J = 8.0 Hz), 8.41 (1H, s), 8.99 (1H, s), 13.88 (1H, s)., 224311-51-7

As the paragraph descriping shows that 224311-51-7 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; EP1380576; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Evren, Enes; Ozdemir, Ismail; Inorganica Chimica Acta; vol. 500; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

To a solution of the chloro derivative of pyridoxine 9 (1 equiv) in 30 ml of acetonitrile were added trisubstituted phosphine (1-5 equiv). The reaction mixture was refluxed for 7 h. Different workup procedures were used for preparation of phosphonium salts., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Pugachev, Mikhail V.; Shtyrlin, Nikita V.; Sapozhnikov, Sergey V.; Sysoeva, Lubov P.; Iksanova, Alfiya G.; Nikitina, Elena V.; Musin, Rashid Z.; Lodochnikova, Olga A.; Berdnikov, Eugeny A.; Shtyrlin, Yurii G.; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7330 – 7342;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

0.86 g (2.30×10″3 moles) of trichlorotris(tetrahydrofuran)vanadium [VCI3(THF)3], 20 ml of toluene and, subsequently, 2.40 g (9.0×10″3 moles) of dipheny(cyclohexyl)phosphine (P/V molar ratio = 4) were placed into a 100 ml tailed flask. The mixture obtained was left, under vigorous stirring, at room temperature, for 60 minutes and, then, heated under reflux for 1 hour. The suspension obtained was filtered in the hot (60C) and the fraction collected was concentrated, under vacuum, at room temperature. Subsequently, drop by drop, under stirring, about 50 ml of pentane were added, obtaining the precipitation of a dark powder. After about 3 hours, everything was filtered and the solid light blue/gray residue obtained was washed with pentane (50 ml) and dried, under vacuum, at room temperature, obtaining 1.30 g (conversion with respect to starting [VCI3(THF)3] = 81.4%) of complex VCI3(PCyPh2)2 (molecular weight = 693.97 gxmol”1). (0157) Elementary analysis [found (calculated)] C: 62.40% (62.31%); H: 6.30% (6.10%); CI: 15.50% (15.33%); P: 9.0% (8.93%); V: 7.20% (7.34%)

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Patent; VERSALIS S.P.A.; RICCI, Giovanni; LEONE, Giuseppe; SOMMAZZI, Anna; FORNI, Alessandra; MASI, Francesco; (110 pag.)WO2016/128812; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Ethyl diphenylphosphinite,0.87 g (0.0038 mol), was added dropwise to asolution of 1.25 g (0.0038 mol) of compound 21a in1 mL of diethyl ether on cooling to -5 to 5C. Themixture was left to stand for 24 h at room temperature,and the solvent and volatile components were removedunder reduced pressure. Yield 1.44 g (76.6%), colorlesscrystals, mp 146-148C (from isooctane). The spectralcharacteristics of samples of 23a synthesized bydifferent methods were identical.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gazizov; Ivanova, S. Yu.; Khairullin; Kirillina, Yu. S.; Gazizova; Russian Journal of General Chemistry; vol. 88; 11; (2018); p. 2243 – 2250; Zh. Obshch. Khim.; vol. 88; 11; (2018); p. 1761 – 1769,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13360-92-4,Phenoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

EXAMPLE 20 Diphenyl[1-(morpholinosulfonylamino)ethyl]phosphine oxide. EQU27 When a mixture of equimolar quantities of phenyl diphenylphosphinite, acetaldehyde, and morpholinosulfonylamine in chlorobenzene is treated by the procedure used in the preceding experiment, the product is a white solid, mp 215-217C., 31 P nmr (DMSO-d6) -30.9 ppm., 13360-92-4

The synthetic route of 13360-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Monsanto Company; US3954860; (1976); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

1. “A”REACTION. BENZYIDIPHENYLPHOSPHINE (APPROXIMATELY 1. 0 G or 3.6 mmol ; Strem CHEMICALS), IrCI3* nH2O (APPROXIMATELY 0.52 g or 1.7 mmol ; available from Johnson Matthey Inc. of West DEPTFORD, NEW Jersey), and ethoxyethanol (approximately 15 ml ; ALDRICH, degassed) can be stirred at approximately 130C for approximately 45 minutes under nitrogen. The yellow precipitate may be isolated by filtration and dried under vacuum to yield approximately 0.78 g of the intermediate product. 31P NMR (202 MHz, CD2CI2, 296 K): -38.83. 2. “B”reaction. The product from the A reaction (approximately 0.30 g) can be combined with the sodium salt of 2,4-pentanedione (approximately 0.59 g or 0.48 mmol ; prepared from the corresponding acid and sodium hydride (both from ALDRICH)) and 2-ethoxyethanol (approximately 15 mL; ALDRICH), and the contents can be stirred under nitrogen at approximately 130C for approximately one hour. The volatile components can then be removed in vacuo, and the product may be purified from the resulting crude off-white solid via silica gel flash chromatography with CH2CI2 as the eluting solvent. The product (approximately 35 mg) may be isolated as a white solid that exhibits blue luminescence under 254 and 365 nm illumination. 31P NMR (202 MHz, CD2CI2, 296 K): -5.28.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; E.I. du Pont de Nemours and Company; WO2004/16710; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, To a white suspension of P(CH2C6H5)Ph2 (2.08 g, 7.53 mmol) in toluene (20 mL) in a 300 mL Kjeldahl flask, added dropwise a yellow solution of 3c (1.83 g, 7.17 mmol) in toluene (20 mL) at 25 oC. The combined mixture became a clear yellow solution immediately. After stirring for 15 minutes effervescence was observed. The solution was stirred for 4 hours and it remained a clear yellow solution. Removal of the solvent under vacuum afforded a yellow viscous material which was redissolved with CH2Cl2 (20 mL). The resulting clear yellow solution was transferred via cannula over to a suspension of [PyH][BF4] (1.29 g, 7.17 mmol) in CH2Cl2 (20 mL). The Kjeldahl flask was rinsed with CH2Cl2 (2×20 mL) and the rinsing solution was transferred to the reaction flask via cannula. Pyridine (0.9 mL, 10.8 mmol) was added to the white suspension in CH2Cl2 and the reaction mixture was refluxed for 12 hours. After cooling the reaction to 25 oC, a clear yellow solution was observed and the volatiles were removed under vacuum. The resulting viscous residue was washed with diethyl ether (4 x 40 mL) to give a yellow gum. The gum was purified by column chromatography using silica gel (80 g) and CH2Cl2. The column was eluted with CH2Cl2 (200 mL), CH2Cl2-MeOH 98:2 (500 mL), CH2Cl2-MeOH 95:5 (500 mL), CH2Cl2-MeOH 90:10 (500 mL), and CH2Cl2-MeOH 80:20 (500 mL). The fractions (100 mL) were analyzed by UV-Vis, and those that contained the product were combined and dried under vacuum, affording white foam. The foam was treated with CH2Cl2 (100 mL) and diethyl ether (300 mL) to afford a white precipitate. Filtration of the precipitate followed by diethyl ether washes (40 mL) afforded 17 (2.17g, 66%) as a white powder. 1H NMR ((CD3)2SO): delta 9.66 (d, JPH = 10.4, 1H, -P=NH-), 7.97 (m, 4H, 2,6-CH of -(C6H5)2P=NH-), 7.82 (m, 2H, 4-CH of -(C6H5)2P=NH-), 7.70 (m, 4H, 3,5-CH of -(C6H5)2P=NH-), 7.54 (s, 1H, -CH of C6H3SO3), 7.20-7.28 (m, 3H, 2,6- and 4-CH of -C6H5CH2P=NH-), 7.10 (m, 3,5-CH of -C6H5CH2P=NH-), 6.91 (dd, J = 8.0, 1.6, 1H, 4-CH of -C6H3SO3-), 6.64 (d, J = 8.0, 1H, 3-CH of -C6H3SO3-), 5.00 (d, JPH = 14.0, -CH2P=NH-), 2.21 (s, 3H, 5-CH3 of -C6H3SO3-). 1H NMR (CD2Cl2): delta 9.68 (d, JPH = 10.4, 1H, -P=NH-), 7.71-7.85 (m, 7H, 6-CH of -C6H3SO3-, 3,5-CH of -(C6H5)2P=NH-, and 2,6-CH of -C6H5CH2P=NH-), 7.62 (, m, 4H, 2,6-CH of -C6H5CH2P=NH ), 7.28 (m, 1H, 4-CH of -C6H5CH2P=NH), 7.20 (t, J = 7.6, 3,5-CH of -C6H5CH2P=NH-), 6.96 (m, 2H, 4-CH of -(C6H5)2P=NH-), 6.79 (dd, J = 8.4, 2.0, 1H, 4-CH of -C6H3SO3-), 6.34 (d, J = 8.4, 1H, 3-CH of -C6H3SO3-), 4.27 (d, JPH = 14.0, -CH2P=NH-), 2.23 (s, 3H, 5-CH3 of -C6H3SO3-). 31P NMR ((CD3)2SO): delta 35.9. 31P NMR (CD2Cl2): delta 36.1. 13C NMR ((CD3)2SO): delta 137.0 (d, JPC = 7.8), 135.6 (d, JPC = 3.1, para-CH of -(C6H5)2P=NH-), 133.1 (d, JPC = 10.8, ortho-CH of -(C6H5)2P=NH-), 132.7, 132.4, 131.1, 131.0 (d, JPC = 3.1), 130.4 (d, , JPC = 10.8, meta-CH of -(C6H5)2P=NH-), 129.3 (d, JPC = 3.1), 128.5, 128.4, 128.0 (d, JPC = 10.0, ipso C of -C6H5CH2P=NH-), 120.5 (d, JPC = 96.8, ipso C of -(C6H5)2P=NH-), 119.5 (d, JPC = 3.9), 30.9 (d, JPC = 56.5, -CH2P=NH-), 20.5. Anal. Calcd for C26H24NO3PS: C, 67.66; H, 5.24; N, 3.03. Found: C, 67.86; H, 5.33; N, 2.91.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Burns, Christopher T.; Shang, Suisheng; Thapa, Rajesh; Mashuta, Mark S.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4832 – 4835;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate