Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In a 1000 ml reaction flask was charged with 99.5 g (0.46 mol)Diphenylmethoxyphosphine (purity ? 99.5%) and 109.7 g(0.64 mol) of m-methoxybenzyl chloride (content of ? 99.2%), heated to 58 C with stirring, and incubated at this temperature for 8 hours, The end of Paul to cool to 15 C, directly into the next step reaction., 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; Suzhou Chengche Pharmaceutical & Chemical Co., Ltd; Xia, Qiujing; (6 pag.)CN105541565; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 0.32 g (1.61 mmol) of the compound [1], 0.47 g (1.61 mmol) of 2- (diphenylphosphino) benzaldehyde, 1.5 g (1.61 mmol) of Amberlyst 15 (0.11 g), 15 mL of toluene were added, and the mixture was allowed to react at 80 ¡ã C. for 8 hours. The reaction solution was filtered, and the filtrate was evaporated under reduced pressure to give 0.61 g (yield: 80percent) of the target compound (hereinafter referred to as the compound [3]) represented by the following formula [3].

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsui Chemicals; Ishii, Seiichi; Ichikawa, Shinichiro; Fujita, Otomo Toshinori; (49 pag.)JP2018/162230; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A hexane solution (30 mL) of 4 (20 mg, 0.23 mmol) and PTh3 (10 mg, 0.035 mmol) was heated to reflux for 1 h during, during which time the color of the solution changed from pale yellow to orange. The solvent was then removed under reduced pressure and the residue was subjected to TLC on silica gel. Elution with hexane/CH2Cl2 (7:3, v/v) developed only one band that corresponded to 5 (16 mg, 61%)., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uddin, Md Miaz; Begum, Noorjahan; Ghosh, Shishir; Sarker, Jagodish C.; Tocher, Derek A.; Hogarth, Graeme; Richmond, Michael G.; Nordlander, Ebbe; Kabir, Shariff E.; Journal of Organometallic Chemistry; vol. 812; (2016); p. 197 – 206;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4559-70-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: Under an argon atmosphere, the carbonyl compounds (0.24 mmol, 1.2 eq), TsNHNH2 (0.252 mmol, 1.26 eq) and anhydrous dioxane (2.0 mL) were successively added to a flame-dried Schlenk flask. The reaction was heated at 60 ?C with stirring for 30 minutes. After the solution cooled down to room temperature diphenyl phosphine oxide 1a (0.20 mmol, 1.0 eq), K2CO3 (0.60 mmol, 3.0 eq), and CuI (0.02 mmol, 10 mol %) were sequentially added to the system. The mixture was stirred to reflux. When the reaction was considered complete, as determined by TLC analysis, the reaction mixture was cooled to room temperature. Water was added to the mixture and extracted with ethyl acetate twice. The combined organic phase was washed with brine and dried over Na2SO4. The concentrated residue was purified by column chromatography over silica gel using petroleum ether/ethyl acetate (1:1) as eluent to get the product.

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Zi-Sheng; Zhou, Zhao-Zhao; Hua, Hui-Liang; Duan, Xin-Hua; Luo, Jian-Yi; Wang, Jia; Zhou, Ping-Xin; Liang, Yong-Min; Tetrahedron; vol. 69; 3; (2013); p. 1065 – 1068;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,6-Bis(chloromethyl)-3-hydroxypyridine hydrochloride (5) (0.20 g, 0.88 mmol) was added to a solution of tris(2-thienyl)phosphine (0.98 g, 3.50 mmol) in acetonitrile (40 mL) and the mixture was refluxed for 48 h. Then, the solvent was evaporated in vacuo, the dry residue was dissolved in chloro- form and washed with water. The aqueous filtrate was dried in vacuo, and recrystallized from acetone. The yield was 0.10 g (15%), a white crystalline compound, m.p. 176-178 C. 1H NMR (DMSO-d6), d: 5.00 (d, 2 H, CH2P, J = 15.3 Hz); 5.11 (d, 2 H, CH2P, J = 15.7 Hz); 7.10, 7.34 (AB-system, 2 H, PyH, J = 8.4 Hz); 7.47-7.49 (m, 3 H, P(2-thien)3); 7.51-7.53 (m, 3 H, P(2-thien)3); 7.89 (dd, 3 H, P(2-thien)3, J1= 8.3 Hz, J2= 3.6 Hz); 7.97 (dd, 3 H, P(2-thien)3, J1= 8.3 Hz, J2= 3.6 Hz); 8.47-8.50 (m, 6 H, P(2-thien)3); 11.33 (s, 1 H, OH). 13C NMR (DMSO-d6), d: 20.92 (s, CH2P); 25.93 (d, CH2P, J = 54.4 Hz); 119.25 (d, Cthien, J = 86.5 Hz); 123.89 (s, CPyr); 124.71 (s, CPyr); 129.64 (d, Cthien, J = 13.4 Hz); 131.00 (d, Cthien, J = 10.1 Hz); 133.74 (d, Cthien, J = 10.2 Hz); 135.23 (d, Cthien, J = 2.1 Hz); 137.02 (s, CPyr); 138.01 (CPyr); 139.45 (d, Cthien, J = 12.7 Hz); 153.09 (t, CPyr, J = 5.1 Hz). 31P NMR (DMSO-d6), d: 4.07; 4.31. HRMS, found: m/z 340.4863 [M – 3 Cl – H]2+. C31H26NOP2S6Cl2. Calculat- ed: [M – 3 Cl – H] = 340.4863., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Shtyrlin; Vafina; Pugachev; Khaziev; Nikitina; Zeldi; Iksanova; Shtyrlin, Yu. G.; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 537 – 545; Izv. Akad. Nauk, Ser. Khim.; 2; (2016); p. 537 – 545,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

As shown in Figure 1 between the Wittig reagent methoxy benzyl diphenyl phosphorusoxychloride synthetic route.In 1000 ml by adding reaction bottle 108g (0.5mol) diphenyl methoxy phosphorus (? 99.5% purity) and 86g (0.5mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 8 hours, heat insulating end cooling to 10 C, directly enters the reaction of the next.

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Taicang Kastem New Material Co., Ltd; Li, Ruiqing; (5 pag.)CN105503951; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: 2-Chloromethylbenzothiazole (1) (0.183 g, 0.001 mol) andpotassium iodide (KI) (0.166 g, 0.001 mol) were taken intoa round bottomed flask containing 20 mL of THF. Thereaction mixture was stirred for 3 h at 40C. After completionof the reaction as checked by TLC, cooled the reactionmass to RT and then filtered to remove the salt (KCl),resulted in iodo compound, 2-(iodomethyl) benzo[d]thiazole(2). The filtrate was transferred into a flask and sodiumazide (NaN3) (0.065 g, 0.001 mol) was added. The reactionmixture was stirred at 25-30C for 3 h to form an intermediate,2-azidomethylbenzothiazole (3). The reaction mixturewas filtered to remove the salt, NaI, and filtrate was takenfor the next step.Triphenylphosphine (4a) (0.262 g, 0.001mol) was added to 3under N2 atmosphere. The reaction mixture was stirred at 65-70C for 4 h and the progress of the reaction was monitored byTLC using ethylacetate: n-hexane (2:3) as an eluent. After completionof the reaction, the solvent was removed from the reactionmixture in a rotaevaporator to get the crude product and itwas purified by column chromatography using ethylacetate:nhexane(1:4) to obtain pure product, N-(1,3-Benzothiazol-2-ylmethyl)-N-(1,1,1-triphenyl-lambda5-phosphanylidene) amine (5a).The same procedure was adopted for the synthesis of remainingtitle compounds and the physical data of these compounds aresummarized in Table 1., 607-01-2

Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Madhava; Subramanyam; Thaslim Basha; Jawahar Babu; Naga Raju; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 16 – 21;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, General procedure: General procedures for the synthesis of 2-6: To a solution of 1 (0.2mmol) and monophosphines (0.2mmol) in MeCN, a solution of Me3NO¡¤2H2O (0.2mmol) in MeCN was added. The mixture was stirred at room temperature for 1h (Scheme 3 ). Then the solvent was removed on a rotary evaporator and the residue was subjected to TLC by using CH2Cl2/ petroleum ether as eluent. From the main red band, 2-6 were obtained as red solids with high yields, varying from 67% to 96%. Although complex 2 was reported in the literature [14], we prepared it by a different method and further studied its electrochemical and photochemical properties

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Li, Rui-Xia; Liu, Xu-Feng; Liu, Ting; Yin, Yi-Bing; Zhou, Ying; Mei, Shun-Kang; Yan, Jing; Electrochimica Acta; vol. 237; (2017); p. 207 – 216;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, Under argon a solution of 2-(ethylthio)ethanamine (0.36 g, 3.44 mmol) in THF (3 ml) is added to a solution of 2-(diphenylphosphino)benzaldehyde (1.00 g, 3.44 mmol) in THF (10 ml). After stirring for 12 h at 72 ¡ãC the reaction mixture is cooled to 0 ¡ãC, DCM (3 ml) is added and the solvents are evaporated under vacuo. SNP-ligand N-(2- (diphenylphosphino)benzylidene)-2-(ethylthio)ethan-amine is obtained as an orange solid (1.20 g, 92percent). Analytical data: 1H-NMR (400 MHz, CDCl3): 8.92 (d, 7=4.80, 1H), 8.00 (m, 1H), 7.41 (m, 1H), 7.38-7.28 (m, 11H), 6.91 (m, 1H), 3.70 (dt, 7=1.26, 7.07, 2H), 2.62 (t, 7=7.33, 2H), 2.50 (q, 7=7.33, 2H), 1.23 (t, 7=7.33, 3H). 13C-NMR (400 MHz, CDCl3): 161.12, 139.67, 137.93, 136.96, 136.87, 134.42, 133.77, 130.74, 129.28, 129.01, 128.13, 61.64, 32.56, 26.49, 15.28. 31P-NMR (500 MHz, CDCl3): -13.55 (s, IP). GC/MS: 377 (6percent, M+), 348 (54percent, [M-29]+), 288 (100percent), 226 (20percent), 208 (14percent), 183 (28percent), 165 (14percent), 107 (11percent), 89 (34percent), 61 (14percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GIVAUDAN SA; GEISSER, Roger Wilhelm; OETIKER, Juerg Daniel; SCHROeDER, Fridtjof; WO2015/110515; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate