Tag: M.W:200-300

719-80-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

To a stirred solution of CsF (63 mg, 0.42 mmol) in anhydrous acetonitrile 1 mL was consecutively added 2,5 dimethyl-(o-trimethyl silyl)phenyl triflate (25 mg, 0.077 mmol) and ethoxydiphenylphosphine (60 mg, 0.31 mmol). Reaction mixture was allowed to stir at room temperature (30 C.) for 30 hrs. The reaction mixture was concentrated and directly loaded on silica gel column and purified by using solvent gradient of Pet. Ether: Ethyl Acetate (1:1) to yield a white solid phosphine oxide (19 mg, 81%). Reaction Time: 30 h; Rf: 0.3 (1:1 EtOAc:Pet Ether); White Solid; mp 157-159 C.; 19.0 mg, 81%; 1H NMR (400 MHz, CDCl3, TMS) delta 7.75-7.60 (m, 4H), 7.59-7.52 (m, 2H), 7.51-7.43 (m, 4H), 7.26-7.20 (m, 1H), 7.19-7.13 (m, 1H), 6.88 (d, J=14.4 Hz, 1H), 2.37 (s, 3H), 2.21 (s, 3H); 13C NMR (100 MHz, CDCl3, TMS) delta 140.0 (d, J=7.7 Hz), 134.7 (d, J=13.1 Hz), 133.9 (d, J=12.3 Hz), 132.9 (d, J=103.3 Hz), 132.8 (d, J=2.3 Hz), 131.9 (d, J=10.0 Hz), 131.8, 131.7 (d, J=3.1 Hz), 130.4 (d, J=103.3 Hz), 128.5 (d, J=11.6 Hz), 21.2 (d, J=4.6 Hz), 21.0; 31P NMR (162 MHz, CDCl3) delta 31.7; HRMS-ESI (m/z) calcd (C20H19OP+H)+: 307.1246 found: 307.1244

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Mhaske, Santosh Baburao; Dhokale, Ranjeet Ashokrao; US2015/210725; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Evren, Enes; Ozdemir, Ismail; Inorganica Chimica Acta; vol. 500; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 1000 ml by adding reaction bottle 95.2g (0.44mol) diphenylmethoxyphosphine and 77g (0.45mol) m-methoxybenzyl chloride making between, to elevate temperature under stirring condition 60 C, and in this temperature 12 hours, cooling to the end of the 20 C, directly enters the reaction of the next., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Chenghe Pharmaceutical & Chemical Co., Ltd.; Xia, Qiujing; (6 pag.)CN105541569; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: NMR titration experiments of the guests HPCy3+, N-tosyldiallylamine (7) and Cy3P=O withsulfocalixarenes 1 as hosts: The titration experiments were performed at least in duplicate using a standard?constant guest? method in 600-640 muL D2O with addition of 7-10 muL MeOD-d4 or 10 muL DMSO-d6as internal standard (deltaH (MeOD-d4) = 3.31 ppm; deltaH (DMSO-d6) = 2.50 ppm) at room temperature. AllH-atoms of the guests HPCy3+, N-tosyldiallylamine (7) and Cy3P=O were evaluated using MestRe-C [32]and MestReNova [33]. Kass and log K values of the receptors were obtained by analysising the course ofthe chemical shifts of the protons of the guest HPCy3+, N-tosyldiallylamine (7) and Cy3P=O using theprogram HypNMR2008 [34,35].

13689-19-5, As the paragraph descriping shows that 13689-19-5 is playing an increasingly important role.

Reference£º
Article; Tomasek, Jasmine; Sessler, Miriam; Groeger, Harald; Schatz, Juergen; Molecules; vol. 20; 10; (2015); p. 19130 – 19141;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Under nitrogen, a mixture of 1 (115 mg, 0.138 mmol) and ethyl diphenylphosphinite (600 muL, 2.78 mmol) in a 25 mL flask was heated for 30 min at 100 C. Toluene (2 mL) was then added and the mixture was heated at reflux for 2 h. The product mixture was purified by column chromatography (silica gel) using a non-polar eluent (EtOAc/CH2Cl2, 1:1) to remove by-products and then a polar mixture (EtOAc/MeOH, 9:1) to separate the product. The eluate was concentrated and dried under vacuum to give a white solid foam 2 (175 mg, 95%).1HNMR (400 MHz, CDCl3) delta 7.71-7.66 (m, 12H, Ar-H), 7.50-7.39 (m, 18H, Ar-H),7.04 (dd, 3JHH=7.9 Hz, 4JHP=1.7 Hz, 6H, Ar-H), 6.97 (d, 3JHH = 7.9 Hz, 6H, Ar-H), 4.08 (q, J = 7.1 Hz, 6H, -COCH2CH3),3.65 (d, 2JHP =13.7 Hz, 6H, CH2P(O)Ph2),3.18 (d, J = 15.7 Hz, 6H, ArCHaHb), 2.95 (s,6H, ArCH2-), 2.80 (d, J = 15.7 Hz, 6H, ArCHaHb), 1.18 (t, J = 7.1 Hz, 9H, -COCH2CH3); 13C NMR (100MHz, CDCl3) delta 176.5 (s, -C=O), 136.8 (d, 5JCP = 2.6 Hz, Ar-C), 135.8 (s, Ar-C), 132.6 (d, 1JCP= 97.6 Hz, Ar-C), 132.2 (d, 4JCP = 2.4 Hz, Ar-C), 131.6 (d, 3JCP = 9.2 Hz, Ar-C), 130.4 (d, 3JCP = 4.8 Hz, Ar-C), 130.1 (d, 4JCP = 2.4 Hz, Ar-C), 129.9 (d, 2JCP = 8.0 Hz, Ar-C), 128.9 (d, 2JCP = 11.6 Hz, Ar-C), 61.1, 56.1, 43.7, 40.3, 38.1 (d, 1JCP = 66.2 Hz, CH2P(O)Ph2), 14.1;31P NMR (162 MHz, CDCl3) delta 31.2; HRMS-FAB (NOBA) Calcdfor C84H82O9P3 (M+H+): m/z (rel intensity) 1330.5272 (12.1%),1330.5248 (1.7%), 1329.5239 (40.8%), 1329.5214 (1.8%), 1328.5205 (90.9%),1327.5172 (100.0%),Observed: m/z (relintensity) 1330.5010 (M+4, 16), 1329.5145 (M+3, 44), 1328.5295 (M+2,90),1327.5162 (M+H+, 100), 1277.3716 (11), Elemental analysis: Calcd forC84H81O9P3: C, 76.00; H, 6.15; O,10.85; P, 7.00, Observed: C, 75.78; H, 6.20.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lim, Dong Seob; Sahoo, Suban K.; Cho, Chan Sik; Kim, Yang; Choi, Heung-Jin; Tetrahedron Letters; vol. 56; 41; (2015); p. 5665 – 5669;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78%).2

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below., 13689-19-5

The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

The same general procedure was adopted for the synthesis of all the complexes. The lanthanide chloride and tricyclohexylphosphine oxide were dissolved in hot ethanol. Heating was continued for 1h and the solution was allowed to slowly evaporate at room temperature during which time crystalline material formed. The crystals were filtered, washed with cold ethanol and dried at the pump.

13689-19-5, 13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 67; (2014); p. 368 – 372;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

Solid silver thiocyanate (0.0478 g, 0.29 mmol) was added to the solution of cyclohexyldiphenylphosphine(0.3031 g, 1.13 mmol) in acetonitrile (100 mL). The reaction mixture was heatedunder reux for 16 h. The solution was ltered hot and the solvent was reduced to ~10 mL by means of evaporation. The solution was transferred to a small vial and it was left to crystallizefrom which small white cubic crystals were isolated (0.3002 g, 84%), m.p. 173-176 C.Anal. Calcd for C55H63AgNSP3: C, 68.04; H, 6.54; N, 1.44; S, 3.30%. Found: C, 68.35; H, 6.56; N,1.39; S, 3.37%. Solid FTIR (nu, in cm-1): 3047(w) nu(C-H)aromatic; 2934, 2851(m) nuasym(C-H); 2360,2341(w); 2050(m) nu(SCN); 1479, 1461, 1446, 1432(m) nu(C=C)aromatic; 1328, 1309; 1268; 1193,1182, 1155; 1096(m) nu(P-C); 1071, 1024, 998(s) delta(C-H); 916(w); 885, 851, 741, 732 697(m)delta(C-H)aromatic. 1H NMR (400 MHz, CDCl3) (delta, in ppm): 1.27 (m, 14H, cyclohexyl), 1.67 (m, 14H,aromatic); 2.30 (d, 3J(H-H) = 8.0 Hz, 3H, H1); 7.30 (m, 17H, H-aromatic), 7.44 (t, 3J(H-H) = 8.0 Hz,11H, H-aromatic). 13C{H} NMR (100 MHz, CDCl3) (delta, in ppm): 25.94 (C4, cyclohexyl); 26.75 (d,1J(P-C) = 12.5 Hz, C1, cyclohexyl); 29.30 (d, 2J(P-C) = 10.4 Hz, C2, cyclohexyl); 35.61 (C3,cyclohexyl); 128.60 (d, 2J(P-C) = 8.3 Hz, ortho C, phenyl); 129.606 (para C, phenyl); 133.16 (d,3J(P-C) = 5.5 Hz, meta C, phenyl); 133.67 (d, 1J(P-C) = 16.3 Hz, ipso C, phenyl). 31P{H} NMR(161 MHz, CDCl3) (delta, in ppm): 9.32. 1H NMR (400 MHz, (CD3)2SO) (delta, in ppm): 1.14 (m, 14H,cyclohexyl), 1.59 (d, 3J(H-H) = 10.8 Hz, 3H, H1); 7.40 (m, 17H, H-aromatic), 7.59 (t, 2J(H-H) = 8.0 Hz, 11H, H-aromatic). 13C{H} NMR (100 MHz, (CD3)2SO) (delta, in ppm): 25.46 (C4,cyclohexyl); 25.81 (d, 1J(P-C) = 12.7, C1, cyclohexyl); 28.74 (d, 2J(P-C)=10.9, C2, cyclohexyl);33.97 (d, 3J(P-C) = 8.4 Hz, C3, cyclohexyl); 128.60 (d, 2J(P-C) = 8.6 Hz, meta C, phenyl); 129.64(para C, phenyl); 132.96 (d, 3J(P-C) = 13.7 Hz, ortho C, phenyl); 133.47 (d, 1J(P-C) = 16.6, ipsoC, phenyl). 31P{H} NMR (161 MHz, (CD3)2SO) (delta, in ppm): 9.04.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The same general procedure was adopted for the synthesis of all the complexes. The lanthanide chloride and tricyclohexylphosphine oxide were dissolved in hot ethanol. Heating was continued for 1h and the solution was allowed to slowly evaporate at room temperature during which time crystalline material formed. The crystals were filtered, washed with cold ethanol and dried at the pump.

13689-19-5, The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 67; (2014); p. 368 – 372;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate