Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

3-phenylpropyl-1-amine (344 ml;2.41 mmol) in 10 mL of toluene was added drop-wise to a mixtureof (2-(diphenylphosphino))-benzaldehyde (0.7 g; 2.41 mmol) andanhydrous magnesium sulfate (1.6 g) in toluene (10 mL). The reactionwas stirred under reflux for 3 h. Resulting in a light yellowmixture. After filtration a yellow oil was obtained upon eliminationof the solvent under reduced pressure. Twice the treatment withhexane (10 mL) resulted in a purification of the product, whichhowever did not crystallize. Yield: 97percent. 1H NMR (CDCl3, 298 K,300 MHz): d (ppm) 8.86 (d, J 4,65 Hz, 1H, HCN-), 7.98e7.94(m, 1H, aromatic), 7.38e7.04 (m, 17H, aromatic), 6,87-6,83 (m, 1H,aromatic), 3.48 (t, J 6.65 Hz, 2H, NCH2-), 2.44e2.39 (m, 2H,-CH2-Ph), 1.84e1.75 (m, 2H, -CH2-). 31P{1H} (CDCl3, 298 K):d (ppm)13.80. ESI-MS (CHCl3 after treatment of H2O2) m/z:424.2 [OPN3 H]., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wajda-Hermanowicz, Katarzyna; Kochel, Andrzej; Wrobel, Robert; Journal of Organometallic Chemistry; vol. 860; (2018); p. 30 – 48;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Accurately weighed ethyl diphenylphosphine (123 muL, 0.6 mmol),4-bromobiphenyl (0.1399 g, 0.6 mmol),Potassium monohydrogen phosphate (0.4050 g, 3 mmol) was added to a 25 mL Schlenk reaction flask, followed by solvent toluene (2 mL).The reaction was carried out at 50 C for 8 h.After the reaction was completed, it was extracted with ethyl acetate/water.The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated.Using petroleum ether/ethyl acetate as the eluent,Separated by silica gel column,The yield of the product was 50%., 607-01-2

As the paragraph descriping shows that 607-01-2 is playing an increasingly important role.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, Ethyl diphenylphosphinite (4.7 mL, 21.76 mmol) was combined with a solution of 2,6-bis(chloromethyl)pyridine (15.7g, 89.18 mmol) [13] in o-xylene (60 mL) under a nitrogen atmosphere, and the mixture was stirred (120 C, 2 h). After evaporation of solvent, the residue was purified by column chromatography (silica gel (230 g), CH2Cl2/MeOH, 100/0 to 97/3) leaving 1a as a white powder. Yield: 6.64 g, 89 %. Mp 118-120 C. Single crystals of 1a were obtained by slow evaporation of a CH2Cl2/Et2O (10/90) solution. 31P{1H} NMR (121.5 MHz, CDCl3): delta=30.5. 1H NMR (300 MHz, CDCl3): delta=7.75-7.69 (m, 4H, H9), 7.52 (t, JHH=7.8Hz, 1H, H4), 7.46-7.33 (m, 7H, H10,11 and H3 or H5), 7.18 (d, JHH=7.8Hz, 1H, H3 or H5), 4.42 (s, 2H, H7), 3.89 (d, JHP=14.4Hz, 2H, H1). 13C{1H} NMR (75.4 MHz, CDCl3): delta=155.9 (C6), 152.4 (d, JCP=7.0Hz, C2), 137.4 (C4), 132.3 (d, JCP=100.4Hz, C8), 131.8 (C11), 131.1 (d, JCP=9.5Hz, C9), 128.4 (d, JCP=11.9Hz, C10), 124.2 (d, JCP=3.2Hz, C5), 120.8 (C3), 46.5 (C7), 40.9 (d, JCP=64.0Hz, C1). IR (KBr, cm-1): nu = 3057, 2923, 1612, 1589, 1575, 1483, 1455, 1433, 1397, 1293, 1268, 1249, 1225, 1200 (nuP=O), 1161, 1118, 1084, 1066, 1024, 992, 963, 858, 827, 813, 753, 734, 714, 699, 690, 618, 575, 543, 519, 490, 452, 435, 410. HRMS (ESI): m/z (%) = 342.0826 (100) [M+H+]. C19H18NOPCl requires 342.0815; 364.0635 (40) [M+Na+]. C19H17NOPClNa requires 364.0634. Anal. Calc. for C19H17ClNOP: C, 66.77; H, 5.01; N, 4.10. Found: C, 66.66; H, 4.86; N, 3.50 %

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ouizem, Sabrina; Rosario Amorin, Daniel; Dickie, Diane A.; Cramer, Roger E.; Campana, Charles F.; Hay, Benjamin P.; Podair, Julien; Delmau, Laetitia H.; Paine, Robert T.; Polyhedron; vol. 97; (2015); p. 20 – 29;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

An acetonitrile solution (5 mL) of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) was slowly added to a dichloromethane solution (5 mL) of cyclohexyldiphenylphosphine (0.027 g, 0.10 mmol) and compound 1 (0.040 g, 0.10 mmol). The resulting mixture was immediately turned from red to dark brown. After 1 h, the solvent was concentrated on an evaporator. The brown residue was purified by TLC (petroleum ether: CH2Cl2 = 4: 1) to give compound 2 (0.046 g, yield 72%) from the main red band. IR (KBr disc, cm-1): nuC?O 2044 (vs), 1983 (vs), 1973 (vs), 1925 (m). 1H NMR (500 MHz, CDCl3): 7.71 (s, 2H, PhH), 7.62 (s, 2H, PhH), 7.47, 7.45 (2s, 6H, PhH), 2.31 (s, 2H, CyH), 2.18 (s, 2H, CyH), 1.84 (s, 2H, SCH2), 1.70 (s, 1H, SCH), 1.39 (s, 2H, CyH), 1.28 (m, 2H, CyH), 1.14-1.03 (m, 3H, CyH), 0.79 (s, 3H, CH3) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85% H3PO4): 65.14 (s) ppm. 13C{1H} NMR (125 MHz, CDCl3): 216.18 (d, JP-C = 9 Hz, PFeCO), 215.94 (d, JP-C = 8.5 Hz, PFeCO), 210.45 (FeCO), 135.29 (d, JP-C = 33.9Hz, i-PhC), 133.40 (d, JP-C = 9.6Hz, o-PhC), 132.86 (d, JP-C = 10 Hz, o-PhC), 130.08 (s, p-PhC), 128.20 (t, JP-C = 8.9 Hz, m-PhC), 54.32 (SCH), 41.12 (SCH2), 40.95, 40.85, 28.90, 27.43, 27.35, 25.99 (CyC), 29.58 (CH2CH3), 14.05 (CH3) ppm. Anal. Calcd. for C27H29Fe2O5PS2: C, 50.65; H, 4.57. Found:C, 50.79; H, 4.34%.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Zhong-Qing; Li, Yu-Long; Liu, Xing-Hai; Liu, Xu-Feng; Yan, Lin; Yang, Jun; Journal of Sulfur Chemistry; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, l-(trimethylsilyl)naphthalen-2-yl trifluoromethanesulfonate (25 mg, 0.071 mmol), Cesium Fluoride (60 mg, 0.395 mmol), Ethoxydiphenylphosphane (68 mg, 0.287 mmol), Acetonitrile (1 ml): Reaction Time: 16 h; Rf. 0.4 (1 :3 EtOAc:Pet Ether); Thick oil; 19.5 mg, 83 %; NMR (400 MHz, CDCI3, TMS) delta 8.28 ( d, J = 13.8 Hz, 1H), 7.95-7.84 (m, 3H), 7.79-7.40 (m, 13 H); 13C NMR (100 MHz, CDC13, TMS) delta 134.7 (d, J= 2.3 Hz), 134.0 (d, J= 9.3 Hz), 133.0, 132.3, 132.1 (d, J =10.0 Hz), 132.0 (d, J = 1.5 Hz), 131.3 (d, 7 = 243.5 Hz), 128.9, 128.5 (d, J = 12.3 Hz), 128.4, 128.2, 127.4 (d, J = 87.9 Hz), 126.8 (d, J= 10.8 Hz); 3IP NMR (162 MHz, CDC13) delta 29.3; HRMS-ESI (m/z) calcd (C22H17OP + H)+ : 329.1090 found: 329.1086; Known compound, Lit. Y.-L. Zhao, G.-J. Wu, Y. Li, L.-X. Gao, F.-S. Han, Chem. Eur. J. 2012, 18, 9622.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; MHASKE, Santosh Baburao; DHOKALE, Ranjeet Ashokrao; WO2014/24212; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

A solution prepared by dissolving 0.86 g (3.1 mmol) of diphenyl (2-toluyl) phosphine in 5 ml of chloroform was charged into a 30 mL eggplant flask equipped with a stirrer, cooled in an ice bath, and filtered dropwise. 6.1 g (62 mmol) of 34.5% aqueous hydrogen peroxide was dropped from the funnel and stirred for 40 minutes. After separating the organic layer with a separatory funnel, the aqueous layer was washed 5 times with 5 ml of chloroform. The obtained organic layer was dried over magnesium sulfate, and then chloroform was distilled off, followed by vacuum drying to obtain crude diphenyl (2-toluyl) phosphine oxide as a yellow solid. The obtained crude diphenyl (2-toluyl) phosphine oxide was dissolved in ethyl acetate / n-hexane and recrystallized and purified to give a white solid of diphenyl (2-toluyl) phosphine oxide.0. 91 g (3.1 mmol) were obtained.

As the paragraph descriping shows that 5931-53-3 is playing an increasingly important role.

Reference£º
Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

As shown in Figure 1 Wittig reagent between methoxy benzyldiphenyloxy phosphate synthesis route.In a 1000 ml reaction flask, 108 g was added(0.5 mol) of diphenylmethoxyphosphine(Purity & gt; 99.5%) and 120 g (0.7 mol)M-methoxybenzyl chloride (content ? 99.2%),Stirring temperature conditions to 55 , and at this temperature for 8 hours, Paul finished cooling to 10 , directly into the next step reaction.

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Taicang Kastem New Material Co., Ltd; Li, Ruiqing; (5 pag.)CN105440075; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 3-(4-(tert-butyl)pyridin-2-yl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-2H-4,7-methanoindazole (70 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of ethyl acetate (hereinafter referred as EA) and n-hexane (EA:n-hexane=1:3 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a white crystalline product, referred to as complex E1 (77.4% yield; 137 mg). The reaction scheme for producing the complex E1 is represented as follows: The spectrum analysis for the complex E1 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 8.97 (d, J=8.1 Hz, 1H), 7.84 (dd, J=10.4, 18.3 Hz, 4H), 7.38-7.51 (m, 8H), 7.06-7.07 (m, 2H), 6.94 (t, J=7.2 Hz, 1H), 6.47 (dd, J=1.8, 6 Hz, 1H), 3.73 (d, J=11.2 Hz, 2H), 2.97 (d, J=3.7 Hz, 1H), 2.08-2.14 (m, 1H), 1.80-1.86 (m, 1H), 1.43-1.47 (m, 1H), 1.41 (s, 3H), 1.25 (s, 9H), 0.97 (s, 3H), 0.84-0.88 (m, 1H), 0.81 (s, 3H) ppm, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.38 ppm, FAB-MS m/z 779.7 [M+1]+, 7650-91-1

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-(tert-butyl)-1H-pyrazol-5-yl)pyridine (59 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:hexane=1:1 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E2 (59.9% yield; 98.9 mg). The reaction scheme for producing the complex E2 is represented as follows: The spectrum analysis for the complex E2 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 9.05 (d, J=7.6 Hz, 1H), 7.86-7.91 (m, 3H), 7.62 (d, J=2.0 Hz, 1H), 7.46-7.54 (m, 5H), 7.26-7.31 (m, 2H), 7.17 (d, J=7.0 Hz, 1H), 6.98-7.11 (m, 4H), 6.60 (s, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.44 (s, 9H), 1.28 (s, 9H) ppm, 31P NMR (200 MHz, CD2Cl2, 298 K) delta 36.68 ppm, FAB-MS m/z 727.7 [M+1]+

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

cis-RuC12(slMes)(t-butylvinylidene)(Ph2P(OMe)), cis-C777v: trans-C 71 9v (5.0 g, 7.0 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed CH2C12 was added (40 mL). Phosphinite Ph2P(OMe) (2.26 g, 10.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The reaction was stirred under N2 for 60 mm at ambient temperature (20 – 25 C) yielding a yellow crystalline solid. The crude material was filtered, washed with heptanes and dried under high vacuum to provide a crude yellow solid (3.6 g). The crude yellow solid (1.6 g) was dissolved in degassed CH2C12 (2000 mL) and filtered through Celite. The filtrate was concentrated under high vacuum and the resulting solid was recrystallized in CH2C12/heptanes. The crystals were filtered and washed with heptanes and dried under high vacuum to yield a yellow solid. Yield: 1.3g. ?H NMR (400 IVIHz, CD2C12, ppm): oe 7.46 -7.41 (m, 1H), 7.39- 7.28 (m, 5H), 7.18 – 7.14 (m, 3H), 7.000 (s, 1H), 6.95 (s, 1H), 6.90 – 6.85 (m, 2H), 6.64 (s, 1H), 4.06 – 3.85 (m, 4H), 3.35 (d, J= 11 Hz, 3H), 2.80 (s, 3H), 2.77 (s, 3H) 2.40 (s, 6H), 2.33 (s, 3H), 2.09 (s, 3H), 1.93 (d, J= 5 Hz, 1H), 0.33 (s, 9H). 3?P NIVIR (161.8 IVIHz, C6D6, ppm): oe 135.15 (s)., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate