Tag: M.W:200-300

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

Solid silver thiocyanate (0.0604 g, 0.36 mmol) was added to the solution of cyclohexyldiphenylphosphine(0.1922 g, 0.72 mmol) in ethanol (40 mL) and DMSO (30 mL). The reaction mixturewas placed under reux for 5.5 h followed by ltration. The ethanol was removed byevaporation. The ltrate was placed in the freezer which resulted in the solution freezing andupon melting small white crystals were isolated (0.0751 g, 30%), m.p. 190-193 C. Anal. Calcdfor C37H42Ag1N1S1P2: C, 63.25; H, 6.03; N, 1.99; S, 4.56%. Found: C, 62.91; H, 5.99; N, 1.74%. SolidFTIR (nu, in cm-1): 3050(w) nu(=C-H); 2929, 2845(m) nu(C-H); 2069(m) nu(SCN); 1480, 1432(m) nu(C=C);1328 (w); 1174 (w); 1095(w) nu(P-C); 1025, 998(s) deltaasym (C-H); 915, 886, 848, 733, 692(m) delta(C-H).1H NMR (400 MHz, CDCl3) (delta, in ppm): 1.19 (m, 10H, cyclohexyl); 1.62 (m, 12H, cyclohexyl); 2.40(d, 3J(H-H) = 9.2 Hz, cyclohexyl); 7.30 (t, 3 J(H-H) = 7.2 Hz, H-aromatic); 7.36 (t, 3J(H-H) = 7.2 Hz,H-aromatic); 7.49 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz, CDCl3) (delta, in ppm):25.72 (para C); 26.69 (d, 2J(P-C) = 9.7 Hz, cyclohexyl, C2); 29.16 (d, 3J(P-C) = 6.0 Hz, cyclohexyl,C3); 35.60 (d, 1J(P-C) = 11.2 Hz, cyclohexyl, C1); 128.80 (d, 3J(P-C) = 9.0 Hz, meta C, phenyl);130.17 (s, para C, phenyl); 131.23 (d, 1J(P-C) = 23.0 Hz, ipso C, phenyl); 133.69 (d, 2J(P-C) = 15.0 Hz, ortho C, phenyl). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 16.25.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, A 100 mL round-bottomed flask was charged with 2.4 g of benzyl diphenyl phosphine, 1.4 g of benzylpyridine iridium(III) dichloro bridge dimer, 1.83 g of sodium carbonate and 100 mL of 2-ethoxyethanol. The reaction was stirred and heated at 135 C. for 6 h under nitrogen while protected from light with aluminum foil. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure(20 mmHg). A light brown solution was obtained and further purified by flash column chromatography on silica gel using dichloromethane and hexanes mixture as the eluent yielding 2 g (78%) of pure mer isomer was obtained.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Tsai, Yui-Yi; Barone, Michael S.; Tamayo, Arnold; Thompson, Mark E.; US2005/258742; (2005); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: To a flame dried two-neck round-bottom flask containing CsF (5.50 equiv.) was added o-silyl aryl triflate (II) (1.00 equiv.) in acetonitrile, followed by addition of phosphorous compound of formula (III) (4.00 equiv.) in acetonitrile under argon atmosphere. The reaction mixture was stirred at room temperature and the progress was monitored by TLC. After completion of the reaction, acetonitrile was removed on rotary evaporator and the crude product was dried under high vacuum and purified by flash silica gel column using a gradient of ethyl acetate-petroleum ether to afford corresponding aryl-phosphorous compounds of formula (I) in good to excellent yields. 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (25 mg, 0.083 mmol), Cesium Fluoride (70 mg, 0.461 mmol), Ethoxydiphenylphosphane (78 mg, 0.33 mmol), Acetonitrile (1 ml): Reaction Time: 16 h; Rf: 0.3 (1:3 EtOAc:Pet Ether); White Solid; 17.5 mg, 75%; 1H NMR (400 MHz, CDCl3, TMS) delta 7.74-7.63 (m, 6H), 7.59-7.51 (m, 3H), 7.50-7.40 (m, 6H); 13C NMR (100 MHz, CDCl3, TMS) delta 132.5 (d, J=104.0 Hz), 132.1 (d, J=10.0 Hz), 131.9 (d, J=2.3 Hz); 128.5 (d, J=12.4 Hz); 31P NMR (162 MHz, CDCl3) delta 29.2; Mass (M+Na)+ 301; Known Compound, Lit. K. Prokop, D. Goldberg, J. Am. Chem. Soc. 2012, 134, 8014

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Mhaske, Santosh Baburao; Dhokale, Ranjeet Ashokrao; US2015/210725; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: A mixture of AgBr (0.018g, 0.1mmol), diphenyl(p-tolyl) phosphine (P5) 0.028g (0.1mmol) and thiosemicarbazide (L1) 0.018g (0.2mmol) in 20ml of acetone/ methanol (1:1) was refluxed with continuous mechanical stirring overnight at 70C. The light yellow transparent solution obtained was filtered to avoid any impurity and slow addition of water resulted precipitation of final product. The product was collected by filtration, washed with water and dried. Again in situ transformation of L1 to L2 had taken place. Yield 0.078g, 89%. Anal. Calc. for C42H43AgBrN3P2S: C, 57.8; H, 4.9; N, 4.8. Found: C, 57.8; H, 4.9; N, 4.8%. IR cm-1: 3531 (w), 3479 (m), 3413 (m), 3119 (s), 2926 (s), 2842 (s), 1633 (s), 1608 (s), 1546 (m), 1456 (s), 1384 (s), 1148 (m), 1058 (s), 989 (ms), 819 (m), 767 (m), 666 (s), 521 (m).

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Altaf, Muhammad; Stoeckli-Evans, Helen; Cuin, Alexandre; Sato, Daisy Nakamura; Pavan, Fernando Rogerio; Leite, Clarice Queico Fujimura; Ahmad, Saeed; Bouakka, Mohammed; Mimouni, Mostafa; Khardli, Fatima Zahra; Hadda, Taibi Ben; Polyhedron; vol. 62; (2013); p. 138 – 147;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: (S)-2-{[4-(Methoxycarbonylpropyl]phenyl)aminocarbonyl}indoline (3; 676 mg, 2 mmol) and 2-(diphenylphosphino)benzaldehyde (2a;1.16 g, 4 mmol) were dissolved in MeOH (5 mL). The reaction mixture was heated to 80 ¡ãC in a sealed tube for 48 h. After cooling to r.t., the mixture was extracted with EtOAc and concentrated. The resulting residue was chromatographed on silica gel (eluent:acetone/hexane = 1:2) to give colorless fine prisms; yield: 840 (69percent); mp 115?117 ¡ãC; [alpha]D21 ?169 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 7.71 (d, J = 6.5 Hz, 1 H), 7.43?7.13 (m,18 H), 6.97?6.91 (m, 3 H), 4.37 (d, J = 8.5 Hz, 1 H), 3.64 (s, 3 H), 3.53 (d,J = 16.5 Hz, 1 H), 3.09 (dd, J = 8.5, 16.5 Hz, 1 H), 2.52 (t, J = 7.5 Hz, 2 H),2.26 (t, J = 7.5 Hz, 2 H), 1.85 (quin, J = 7.5 Hz, 2 H).13C NMR (126 MHz, CDCl3): delta = 174.1, 173.6, 142.3?113.5 (Carom, overlapped), 81.4 (d, JC,P = 25.9 Hz), 64.1, 51.3, 34.3, 33.1, 31.4, 26.1. 31P{1H} NMR (202 MHz, CDCl3): delta = ?18.9 (s).MS (ESI-TOF): m/z = 633 [M + Na]+.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uozumi, Yasuhiro; Matsuura, Yutaka; Suzuka, Toshimasa; Arakawa, Takayasu; Yamada, Yoichi M. A.; Synthesis; vol. 49; 1; (2017); p. 59 – 68;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-(tert-butyl)-1H-1,2,4-triaz ol-5-yl)pyridine (59 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of EA and n-hexane (EA:n-hexane=1:2 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E3 (44% yield; 73 mg). The reaction scheme for producing the complex E3 is represented as follows: The spectrum analysis for the complex E3 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 8.97 (d, J=7.2 Hz, 1H), 8.05 (s, 1H), 7.84-7.89 (m, 4H), 7.52-7.56 (m, 3H), 7.46-7.50 (m, 4H), 7.17 (d, J=6.8 Hz, 1H), 6.97-6.79 (m, 2H), 6.78 (dd, J=2.2, 6 Hz, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.48 (s, 9H), 1.31 (s, 9H), 31P NMR (200 MHz, CD2Cl2, 298 K) delta 36.32, FAB-MS m/z 728.1 [M+1]+, 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, To a solution of complex Re1 (40 mg, 0.098 mmol) in hexane (1 mL), Ph2P(OEt) (25 mg, 0.109 mmol) was added. The reaction mixture was stirred for 2 h. The precipitate formed was filtered off and dried in oil-pump vacuum to yield 48 mg (77%) of product Re4 as light-yellow powder. Calculated for C29H26O3PRe, %: C, 54.45; H, 4.10. Found: C, 54.40; H, 4.12. IR (hexane), nu/cm-1: 1902s, 1835s (CO). 1H NMR (C6D6), delta: 0.89 (t, 3H, 3JHH = 7.0 Hz, OCH2CH3), 3.43 (dq, 2H, 3JHH ? 3JPH ? 6.4 Hz, POCH2CH3), 4.44 (s, 5H, Cp), 7.11-7.23 (Hpara Ph; Hmeta and Hpara PPh), 7.39 (dd, 2H, 3JHH = 7.6 Hz, Hmeta Ph), 8.02 (d, 2H, 3JHH = 7.9 Hz, Hortho PPh), 8.06 (d, 2H, 3JHH = 7.2 Hz, Hortho PPh), 8.37 (d, 2H, 3JHH = 7.7 Hz, Horhto Ph), 8.75 (d, 1?, 3JPH = 39.0 Hz, =CHPh). 31P{H} NMR (C6D6), delta: 32.28 (s, P+Ph2(OEt)).

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Utegenov, Kamil I.; Krivykh, Vasily V.; Chudin, Oleg S.; Smol’yakov, Alexander F.; Dolgushin, Fedor M.; Semeikin, Oleg V.; Shteltser, Nikolai A.; Ustynyuk, Nikolai A.; Journal of Organometallic Chemistry; vol. 867; (2018); p. 113 – 124;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, To a stirred solution of CsF (63 mg, 0.42 mmol) in anhydrous acetonitrile 1 mL was consecutively added 2,5 dimethyl -(o-trimethyl silyl)phenyl triflate (25 mg, 0.077 mmol) and ethoxydiphenylphosphine (60 mg, 0.31 mmol). Reaction mixture was allowed to stir at room temperature (30 C) for 30 hrs. The reaction mixture’ was concentrated and directly loaded on silica gel column and purified by using solvent gradient of Pet. EthenEthyl Acetate (1 : 1) to yield a white solid phosphine oxide (19 mg, 81%). Reaction Time: 30 h; Rf: 0.3 (1 : 1 EtOAc:Pet Ether); White Solid; mp 157-159 C; 19.0 mg, 81 %; 1 H NMR (400 MHz, GDC13, TMS) delta 7.75-7.60 (m, 4H), 7.59-7.52 (m, 2H), 7.51-7.43 (m, 4H), 7.26-7.20 (m, 1H), 7.19-7.13 (m, 1H), 6.88 (d, J = 14.4 Hz, 1H), 2.37 (s, 3H), 2.21 (s, 3H); 13C NMR ( 100 MHz, CDCI3, TMS) 5 140.0 (d, J = 7.7 Hz), 134.7 (d, J = 13.1 Hz), 133.9 (d, J = 12.3 Hz), 132.9 (d, J = 103.3 Hz), 132.8 (d, J = 2.3 Hz), 13 .9 (d, J = 10.0 Hz), 131.8, 131.7 (d, J = 3.1 Hz), 130.4(d, J= 103.3 Hz), .128.5 (d, J = 11.6 Hz), 21.2 (d, J = 4.6 Hz), 21.0; 31P NMR ( 162 MHz, CDCI3) delta 31.7; HRMS-ESI (m/z) calcd (C20H19OP + H)+ : 307.1246 found: 307.1244.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; MHASKE, Santosh Baburao; DHOKALE, Ranjeet Ashokrao; WO2014/24212; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13360-92-4, Phenoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 20 Diphenyl[1-(morpholinosulfonylamino)ethyl]phosphine oxide STR28 When a mixture of equimolar quantities of phenyl diphenylphosphinite, acetaldehyde, and morpholinosulfonylamine in chlorobenzene is treated by the procedure used in the preceding experiment, the product is a white solid, mp 215-217 C., 31 P nmr (DMSO-d6) -30.9 ppm., 13360-92-4

13360-92-4 Phenoxydiphenylphosphine 11543680, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Monsanto Company; US4036913; (1977); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate