Tag: M.W:200-300

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: In a Schlenk tube under nitrogen, alpha-D-pyranose 5-8 (2.1 mmol) and 2-(diphenylphosphino)benzaldehyde (621 mg, 2.1mmol) were stirred in toluene (40 mL) at 60 ¡ãC for 12 h. After concentration, the residue was purified by flash column chromatography on silica gel.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Szulc, Izabela; Ko?odziuk, Robert; Zawisza, Anna; Tetrahedron; vol. 74; 13; (2018); p. 1476 – 1485;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

fac-[Re(Hfaa)(CO)3(H2O)] (51mg; 0.1mmol) was dissolved in methanol (3ml) and PPh2Cy (27mg; 0.1mmol) dissolved in 2ml methanol was added. The solution was stirred for 6h at room temperature and the orange solution was left to crystallize. Crystals suitable for the collection with X-ray diffraction formed. Yield=48mg, 64%. IR (KBr, cm-1): nuCO=2024, 1949, 1907. 1H NMR (600MHz, CD2Cl2): delta 7.50-7.47 (m, 2H), 7.46-7.41 (m, 8H), 5.83 (s, 1H), 2.39 (tq, J=12.2, 2.8Hz, 1H), 2.13 (d, J=11.1Hz, 2H), 1.81-1.76 (m, 2H), 1.65 (d, J=13.3Hz, 1H), 1.41-1.31 (m, 2H), 1.03-0.92 (m, 3H). 13C NMR (600MHz, CD2Cl2): delta 195.41, 192.55, 177.60, 168.02, 134.07, 130.88, 128.60, 127.09, 116.98, 93.10, 35.39, 28.15, 26.99, 25.95. 31P NMR (300MHz, CD2Cl2): delta 32.18. UV-Vis: epsilon (lambdamax=350nm)=2783M-1cm-1. Anal. Calc. for C26H22F6O5PRe: C, 41.71; H, 3.37. Found: C, 41.75; H, 3.35.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Manicum, Amanda-Lee E.; Schutte-Smith, Marietjie; Visser, Hendrik G.; Polyhedron; vol. 145; (2018); p. 80 – 87;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150 C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111 C.).

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US5969017; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

158.6 g (332.8 mmol in terms of sulfur trioxide) of fuming sulfuric acid containing 16.8% by mass of sulfur trioxide was placed in a 3-neck flask having an internal capacity of 300 mL, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line, and 35.03 g (130.54 mmol) of diphenylcyclohexylphosphine (hereinafter referred to as DPCHxP) was introduced thereinto for 1 hour. Further, the liquid temperature was controlled to a range of 25 C. to 30 C. After completion of the addition, the reaction was carried out at 50 C. for 7 hours. (0225) While controlling the liquid temperature to a range of 25 C. to 30 C., the reaction solution was diluted with 480 g of ion exchange water, and then transferred to a separatory funnel, and 250 g of toluene and 60 g of triisooctylamine were added thereto, followed by thoroughly mixing, thereby acquiring an organic phase. The organic phase was separated by adding 330 g of an aqueous 5%-by-mass sodium hydroxide solution to the organic phase. A lower phase was acquired and 76 g of an aqueous 20%-by-mass sulfuric acid solution was added dropwise thereto. Then, 70 g of toluene and 70 g of tetrahydrofuran were added thereto, followed by sufficiently mixing, thereby acquiring an organic phase. To the organic phase was added 15.85 g (156.63 mmol) of triethylamine, followed by stirring in the range of 20 C. to 30 C. for 1 hour. This liquid was concentrated until the liquid amount reached 50 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration through natural filtering, thereby acquiring 5.68 g of a white solid. (0226) 31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) delta: a (3-sulfonatophenyl)phenylcyclohexylphosphine triethylammonium salt as a mono-form showed a peak at -4.49 and an oxide formed by oxidation of the phosphorous atoms showed a peak at 32.76. (0227) The acquisition was a mixture including 5.32 g (11.83 mmol, 93.81% by mole) of a (3-sulfonatophenyl)phenylcyclohexylphosphine triethylammonium salt and 0.36 g (0.78 mmol, 6.19% by mole) of an oxide formed by oxidation of the phosphorous atoms. From the viewpoint that 5.68 g (12.61 mmol in terms of phosphorous atoms) of a desired product could be acquired using 35.03 g (130.54 mmol) of DPCHxP, the yield based on phosphorous atoms was 9.7%. This phosphorous compound was referred to as a ligand L.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; KURARAY CO., LTD.; YOSHIKAWA, Tatsuya; TSUJI, Tomoaki; (30 pag.)US2016/46549; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

Ce(NO3)4(Cy3PO)2 An excess of CAN (0.45 g 0.82 mmol) in2.5 mL water were stirred with a solution of Cy3PO (0.24 g0.81 mmol) in 1.8 mL of chloroform for 10 minutes. The orangechloroform layer was separated, dried (MgSO4), filtered and mixedwith an equal volume of diethylether. Cooling to -30 C gave yellowneedles suitable for X-ray crystallography (0.19 g 46% based onCy3PO). Analysis (%) Expected (found): C 44.08 (44.92) H6.78 (6.73)N 5.71 (5.69).

13689-19-5, 13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Coles, Simon J.; Fieldhouse, Sarah J.; Klooster, Wim T.; Platt, Andrew W.G.; Polyhedron; vol. 161; (2019); p. 346 – 351;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OMe)), trans-C763: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OMe) (0.556 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from dichloromethane/pentane at room temperature affording trans-C763 (1.35 g, 62.2%, >95% purity). ?H NMR (400 IVIFIz, CD2C12, ppm): oe18.37 (d, J= 11.2 Hz, 1H), 7.36-7.29 (m, 2H), 7.27 -7.15 (m, 8H), 7.06 -7.000 (m, 1H), 6.88 (s, 2H), 6.79 (s, 2H), 4.13 -3.87 (m,4H), 3.15 (d, J= 12.8 Hz, 3H), 2.56 (s, 6H), 2.37 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.10 (s, 3H),1.03 (s, 3H). 3?PNIVIR(161.8 IVIFIz, CD2C12, ppm): oe 134.4 (s)., 4020-99-9

4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5518-52-5, Tri(furan-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5518-52-5, A solution of 10-bromomethyl-10-desmethyl- erythralosamine N-oxide (4) (0.196 g, 0.310 mmol) in NMP (3 ml) was degassed and tris (2-furyl) phosphine (0.018 g, 0.077 mmol) and PD2DBA3. CHC13 (0.010 G, 0.010 mmol) added. The reaction mixture was heated at 50 C for 10 min and more tris (2-furyl) phosphine (0.12 ml, 0.372 mmol) added. The reaction mixture was heated at 80C for 22 h. The product was extracted with ethyl acetate, the organic phase washed with aqueous sodium hydrogen carbonate, brine and dried (MGSOG). The NMP was removed under reduced pressure and the residual material subjected to flash chromatography on silica gel using CH2C12 : MEOH : NH3 90: 4: 1, yield 0.096 g (51%) of a white crystalline solid. HRMS: [M+1] 606.3654. Calc. for C33HS1NO9 : 606.3636.

As the paragraph descriping shows that 5518-52-5 is playing an increasingly important role.

Reference£º
Patent; ALPHARMA APS; COCKBAIN, Julian; WO2004/56843; (2004); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

cis-RuC12(slMes)(phenylindenylidene)(Ph2P(OMe)), cis-C885: trans-C748? 2Py (27.18 g, 30 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed heptanes were added (5000 mL). Phosphinite Ph2P(OMe) (6.8 g, 31.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The mixture was stirred under N2 for 1 hr at ambient temperature (20 – 25 C). because there was some undissolved starting material, degassed CH2C12 (250 mL) was added and all solids were dissolved. The solution was passed through a silica plug (2.5? x 1.5?, D X H) and CH2C12 was used as eluent to remove the first red band of material, which was trans-C885. Then EtOAc was used as eluent to remove a second band that was concentrated and filtered providing brown crystals of cis-C885 (8.49 g). ?H NMR (400 MHz, CD2C12, ppm): oe 8.78 (dd, J = 8 Hz, J = 1 Hz, 1H), 7.52-7.24 (m, 8H), 7.13 – 6.89 (m, 9H), 6.75 (m, 2H), 6.43 (s, 1H), 6.40 (s, 1H), 6.24 (s, 1H), 6.11 (s, 1H), 3.98-3.63 (m, 4H), 3.66 (d, J = 10 Hz, 3H), 2.79 (s, 3H), 2.56 (s, 3H), 2.54 (s, 3H), 2.21 (s, 3H), 1.95 (s, 3H),1.66 (s, 3H). 3?P NIVIR (161.8 MHz, CD2C12, ppm): oe 133.3 (s), 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: To a solution of [Fe2(CO)6{mu-SCH2CH(CH2O2CCH3)S}] (0.044?g, 0.1?mmol) and tris(2-furyl)phosphine (0.023?g, 0.1?mmol) in CH2Cl2 (5?mL) was added a solution of Me3NO¡¤2H2O (0.011?g, 0.1?mmol) in MeCN (5?mL). The mixture was stirred at room temperature for 1?h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC separation using CH2Cl2/petroleum ether?=?1:1 (v/v) as eluent. From the main red band, 0.062?g (95%) of complex 2 was obtained as a red solid.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Chen, Fei-Yan; He, Jiao; Mu, Chao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Polyhedron; vol. 160; (2019); p. 74 – 82;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuC12(slMes)(CHPh)(Ph2P(OMe)), trans-C785: trans-C727 (4.35 g, 6.0 mmol) was dissolved in degassed CH2C12 (50 mL) with a magnetic stir bar under nitrogen in a round-bottomed flask. The flask was capped with a gas adaptor. Methyl diphenylphosphinite (2.6 g, 12 mmol) was syringed to the flask under nitrogen flow. The green solution turned brown immediately, which was continued to stir at room temperature for lh. The lights were removed under high vacuum, yielding a mixture of black oil and brown crystalline material. The flask was chilled by liquid nitrogen and the resulting solid was broken into small pieces with a spatula. Hexanes (50 mL) was added and the solvent was reduced by a rotary evaporator. The pink solid was collected by a frit funnel with vacuum filtration and washed with hexanes twice (2 x 25 mL). The solid was dried under high vacuum for 16h. Yield: 2.91g (62%). ?H NIVIR (400 IVIHz, C6D6, ppm): oe 19.33 (s, 1H, Ru=CH), 7.86 (d, J = 8 Hz, 2H), 7.33 (m, 4H), 7.13 (t, J = 8 Hz, 1H), 7.10 – 6.88 (m, 6H), 6.83 (s, 2H), 6.80 (m, 2H), 6.32 (s, 2H), 3.46 – 3.38 (m, 2H), 3.34 – 3.25 (m, 2H),3.29 (d, J = 12Hz, 3H), 2.79 (s, 6H), 2.39 (s, 6H), 2.17 (s, 3H), 1.90 (s, 3H). 3?P NIVIR (162 IVIHz, C6D6, ppm): oe 132.5 (s).

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate