Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Under nitrogen gas protection, 344 mg of Fe2S2(CO)6 (1 mmol) and 20 mL of tetrahydrofuran solvent were added to a flask equipped with a stirrer magnet.A dark red solution was obtained and the resulting solution was cooled down to -80C in a liquid nitrogen bath.2.2 mL of lithium triethylborohydride (1M in THF) was added slowly with stirring.After 15 minutes of reaction, 0.2 mL of trifluoroacetic acid was added and the reaction was continued for 10 minutes.Add 0.2 mL of formaldehyde solution (37%wt) and raise the reaction to room temperature.After stirring the reaction for 2 h, 235 mg of Ph2PCH2CH3 (1.1 mmol) was added.After stirring for 11h at room temperature, the tetrahydrofuran solvent was removed by rotary evaporation.Add 20 mL of methylene chloride and 1 mL of concentrated sulfuric acid and continue stirring for 20 h.20 mL of water was added and the layers were separated. The dichloromethane in the organic layer was removed by rotary evaporation.The residue was extracted with methylene chloride, and then thin layer chromatography was performed using a developing solvent having a methylene chloride/petroleum ether volume ratio of 1:3. The main red band was collected to obtain a model 3 with a yield of 24%.

607-01-2, As the paragraph descriping shows that 607-01-2 is playing an increasingly important role.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; Zou Like; Mu Chao; Deng Chenglong; Wu Yu; Zhao Peihua; Xie Bin; Luo Qiang; (10 pag.)CN106674288; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

Under nitrogen protection,1L three bottles,From 29.3 g of 2-bromotoluene,5 g of magnesium turnings and 400 mlOf anhydrous methyl tetrahydrofuran to produce a Grignard reagent,Refluxed for 6 hours,To the room temperature, 2 g of tetrakis (triphenylphosphine) palladium was added,Stirred for 10 minutes,40 g of diphenylphosphonium chloride was added dropwise at room temperature,The reaction was refluxed for 6 hours.To the reaction solution was added dropwise 200 mL of an ice-water bathThe saturated aqueous ammonium chloride solution was quenched,Liquid separation,The organic phase is dissolved,Add methanol crystallization,Filtration gave 45 g of white 2-diphenylphosphine toluene,Yield 95%.

1079-66-9, The synthetic route of 1079-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Panjin Gelin Kaimo Technology Co., Ltd.; Rao, Zhihua; Gong, Ningrui; (12 pag.)CN105859774; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: Equimolar mixture of chloride 2a and respective phosphite or phosphinite 3 in benzene was kept at room temperature for 12 h. Solvent was evaporated in vacuo, solid residue was triturated with petroleum ether. In case of reaction of 2a with phosphinite 3c the precipitated phosphine oxide 4c was separated by filtration and washed with benzene. 4.5.3. [1-(Benzyloxycarbonylamino)-2,2,3,3-tetrafluoropropyl](dipheny)phosphine oxide 4c. Yield 59%; mp 177-179 C. 1H NMR (CDCl3): delta = 4.96 (d, 1H, 2JHH = 12 Hz, PhCHA), 5.03 (d, 1H, 2JHH = 12 Hz, PhCHB), 5.34 (m, 1H, CHP), 5.53 (d, 1H, 3JHH = 10 Hz, NH), 6.27 (tt, 1H, 2JHF = 54, 3JHF = 5 Hz, HCF2), 7.2-7.9 (m, 15H, Ph) ppm. 19F NMR (CDCl3): delta = -120.4 (m, 1F, CFAFB), -120.6 (m, 1F, CFAFB), -139.2 (d, 1F, 2JFH = 54 Hz, HCFAFB), -139.5 (d, 1F, 2JFH = 54 Hz, HCFAFB) ppm. 31P NMR (CDCl3): delta = 29.1 ppm. 13? NMR (CDCl3) (selected signals): delta = 51.81 (dt, 1JCP = 74, 2JCF = 24 Hz, CHP), 66.50 (CH2), 109.43 (dt, 1JCF = 252, 2JCF = 30 Hz, HCF2), 156.34 (C=O) ppm. Anal. calcd for C23H20F4NO3P: C, 59.36; H, 4.33; N, 3.01. Found: C, 59.67; H, 4.43; N, 3.17., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Onys’ko, Petro P.; Zamulko, Kateryna A.; Kyselyova, Olena I.; Yelenich, Ivanna P.; Rassukana, Yuliya V.; Journal of Fluorine Chemistry; vol. 185; (2016); p. 191 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: 2-Chloromethylbenzothiazole (1) (0.183 g, 0.001 mol) andpotassium iodide (KI) (0.166 g, 0.001 mol) were taken intoa round bottomed flask containing 20 mL of THF. Thereaction mixture was stirred for 3 h at 40C. After completionof the reaction as checked by TLC, cooled the reactionmass to RT and then filtered to remove the salt (KCl),resulted in iodo compound, 2-(iodomethyl) benzo[d]thiazole(2). The filtrate was transferred into a flask and sodiumazide (NaN3) (0.065 g, 0.001 mol) was added. The reactionmixture was stirred at 25-30C for 3 h to form an intermediate,2-azidomethylbenzothiazole (3). The reaction mixturewas filtered to remove the salt, NaI, and filtrate was takenfor the next step.Triphenylphosphine (4a) (0.262 g, 0.001mol) was added to 3under N2 atmosphere. The reaction mixture was stirred at 65-70C for 4 h and the progress of the reaction was monitored byTLC using ethylacetate: n-hexane (2:3) as an eluent. After completionof the reaction, the solvent was removed from the reactionmixture in a rotaevaporator to get the crude product and itwas purified by column chromatography using ethylacetate:nhexane(1:4) to obtain pure product, N-(1,3-Benzothiazol-2-ylmethyl)-N-(1,1,1-triphenyl-lambda5-phosphanylidene) amine (5a).The same procedure was adopted for the synthesis of remainingtitle compounds and the physical data of these compounds aresummarized in Table 1.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Madhava; Subramanyam; Thaslim Basha; Jawahar Babu; Naga Raju; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 16 – 21;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, Preparation Example 206,7,8-Trifluoro-4-thiophenyl-3 (diphenylphosphorylmethyl)-quinoline (B13); A solution of G13 (5.2 g, 13.4 mmol) and ethyl diphenylphosphinite (6.2 ml, 27 mmol) in toluene (25 ml) was refluxed for 2 h during which time the precipitated solid developed. After cooling to room temperature, the solid was isolated by filtration and washed with toluene. The product was then dried to obtain the title compound (6.6 g, 96.9% yield), mp: 244-245 C.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY; US2011/46379; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-51-7,2-(Di-tert-Butylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

Example 123A 4-(5-Bromo-pyridin-3-yl)-piperazine-1-carboxylic Acid Tert-Butyl Ester A solution of the 3,5-dibromo-pyridine (12.8 g, 68.8 mmol) and piperazine-1-carboxylic acid tert butyl ester (10 g, 42.4 mmol) in 200 mL of dioxane was treated with Pd2(dba)3 (5 g, 5.5 mmol), 2-(di-tbutyl-phosphino)biphenyl (4 g, 13.4 mmol), and sodium t-butoxide (7.2 g, 75 mmol). The reaction was heated to 95¡ã C. for 8 h then cooled and filtered through celite. The mixture was evaporated and the residue was purified by flash column chromatography on silica gel, eluding with a solvent gradient of 1:4 ethyl acetate/hexane to 100percent ethyl acetate. Recovered 2.9 g of product (20percent). MS (ESI) m/z 344 (M+H)+., 224311-51-7

224311-51-7 2-(Di-tert-Butylphosphino)biphenyl 2734215, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert; Dinges, Jurgen; Hutchins, Charles; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L.; US2003/187026; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9,50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In 1000 ml by adding reaction bottle 108g (0.5mol) diphenyl methoxy phosphorus (? 99.5% purity) and 86g (0.5mol) (content ? 99.2%) making between, to elevate temperature under stirring condition 50 C, and at this temperature thermal insulation 8 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Chenghe Medical Company Chemistry Limited Company; Xia, Qiujing; (5 pag.)CN105418677; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-20-8, Cyclohexyldiphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add cyclohexyldiphenylphosphine (28.4 mg, 0.1 mmol), copper triflate (3.6 mg, 0.01 mmol),Tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), the mixture was stirred at 80oC;TLC follows the reaction to completion;The crude product obtained after the reaction was recrystallized from toluene to obtain the target product (yield 82%). The analytical data of the product are as follows:, 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, Fluorene (16.62 g, 0.1 mol) was added to a solution of (3.9 g, 0.17 mol) sodium in 200-mL ethanol, the mixture was kept at 60 ¡ãC then a solution of (29 g, 0.1 mol) 2-diphenylphosphino benzaldehyde in 40-mLethanol was added dropwise. The mixture turned red after 2 h then the reaction was cooled and the solids were crystallized from dichloromethane?hexane. Yield: 85percent, m.p.:153 ¡ãC.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Nemati Kharat, Ali; Rajabi Kouchi, Fereshteh; Tamaddoni Jahromi, Bahareh; Journal of Coordination Chemistry; vol. 69; 1; (2016); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate