Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

A solution of silver thiocyanate (0.1146 g, 0.691 mmol) in pyridine (5 mL) was added to asolution of cyclohexyldiphenylphosphine (0.1854 g, 0.691 mmol) in acetonitrile (100 mL).The reaction was heated under reux for 2.5 h. The ltered solution was left to crystallizewhich resulted in an oily product. The oil was dissolved in acetonitrile followed by the removalof the excess of pyridine using a rotary evaporator. Again, an oily product was obtained afterthe acetonitrile evaporated to dryness. Small white crystals were obtained by placing theproduct on the rotary evaporator for 2 h at 95 C. The product yielded 0.2423 g (81%) witha m.p. of 161-164 C. Anal. Calcd for C38H42Ag2N2S2P2: C, 52.55; H, 4.87; N, 3.23; S, 7.38%.Found: C, 52.52; H, 4.96; N, 3.24; S, 7.06%. Solid FTIR (nu, in cm-1): 3045(w) nu(=C-H); 3002(w)nu(C-H); 2089(s) nu(SCN); 1477, 1433(m) nu(C=C); 1384(w); 1326, 1306(w); 1182, 1157(w); 1093(w)nu(P-C); 1025, 996(m) deltaasym (C-H); 848(w) delta(C-H)para; 742, 692(s) delta(C-H)meta. 1H NMR (400 MHz,CDCl3), (delta, in ppm): 1.25 (m, cyclohexyl); 1.51 (m, cyclohexyl); 2.30 (d, 3J(H-H) = 11.6 Hz,cyclohexyl); 7.30 (m, H-aromatic); 7.62 (t, 3J(H-H) = 8.6 Hz, H-aromatic). 13C{H} NMR (100 MHz,CDCl3) (delta, in ppm): 25.73 (para C, cyclohexyl); 26.50 (d, 2J(P-C) = 13.9 Hz, cyclohexyl, ortho C); 28.88 (d, 3 J(P-C) = 6.9 Hz, cyclohexyl, meta C); 35.43 (d, 1J(P-C) = 17.7 Hz, cyclohexyl, ipsoC). 31P{H} NMR (161 MHz, CDCl3) (delta, in ppm): 9.07.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, In the Ar atmosphere,1.0 mmol of the compound represented by the formula (3) was obtained(Wherein R1 is methyl and R2 is hydrogen; the synthesis is by the method of Organometallics 2008, 27, 88-99)Was dissolved in 10 mL of anhydrous THF,Then, 1.2 mmol of the azide compound of the structure represented by the formula (4) was added(R3 is 2,4,6-trimethylphenyl, synthesized by the method described in Organometallics 2013, 32, 2300-2308)The reaction was stirred at 25 for 24 hours.The resulting reaction solution was concentrated to about 10 ml,2 mL of n-hexane was added (keeping the solution clear).The mixture was stored at -30 overnight,Precipitation ligand.The resulting solid was filtered,Washed with a small amount of n-hexane,And dried in vacuo to obtain ligand L6.The ligand L6 was analyzed and the results were as follows

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sinopec China Petroleum & Chemical Corporation; Sinopec Beijing Research Institute of Chemical Industry; Sun, Wei; Xin, Yishuang; Shao, Mingbo; Li, Chuanqing; Wang, Xue; Zhao, Jiangwei; (18 pag.)CN105985382; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

To a mixture of o-(diphenylphosphino)benzaldehyde (0.86 g, 3.0 mmol) and anhydrous Na2SO4 (10.0 g, 70.0 mmol) in CH2Cl2 (25 mL) was added (R,R)-2-(2,5-dimethyl-pyrrol-1-yl)-cyclohexylamine (0.68 g, 3.5 mmol). The mixture was stirred at room temperature for 3 days. The resulting solution was filtrated and the solvent was removed under vacuum to obtain a yellow solid (R,R)-1 (1.30 g, 93percent yield). Anal. for C31H33N2P: 464.58 g/mol; [alpha]D20 = -36.0 (c 1.0, CH2Cl2)., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Zeng, Li; Wu, Fang; Li, Yan-Yun; Dong, Zhen-Rong; Gao, Jing-Xing; Journal of Organometallic Chemistry; vol. 762; (2014); p. 34 – 39;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The selenides of the phosphines 1-8 were prepared by heating (60 C) each phosphine in CDCl3 (0.5 mL) with a three-fold excess of selenium in an NMR tube under nitrogen for 3 hours. Upon cooling to room temperature, the 31P{1H} NMR spectrum of each solution was recorded, and in each case revealed quantitative conversion to the corresponding phosphine selenide. The 31P{1H} NMR chemical shifts and 1JPSe coupling constants of the selenides are provided in Table 1., 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

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Article; Tassone, Joseph P.; Mawhinney, Robert C.; Spivak, Gregory J.; Journal of Organometallic Chemistry; vol. 776; (2015); p. 153 – 156;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

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Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, 1. “A”reaction. Benzyldiphenylphosphine (approximately 2.0 g or 13 mmol from Strem Chemicals, Inc. of Newburyport, Massachusetts (“Strem”) ) and platinum (II) chloride (approximately 1.8 g or 12 mmol ; Strem) can be combined in the presence of tetrabutylammonium chloride (approximately 330 mg or 0.12 mmol from Sigma-Aldrich Corp. of St. Louis, Missouri (“Aldrich”)) in chlorobenzene (approximately 100 mL; ALDRICH) and can be stirred at approximately 130 C for approximately 10 minutes under nitrogen, after which time the volatile components can be removed in vacuo. The solid residue may be suspended in methanol, and the resulting solid can be isolated via filtration, washed with ether, and allowed to dry in vacuo. The yield of this resulting solid can be approximately 3.5 g. 2. “B”reaction. The entire yield of the resulting solid from the A reaction can be combined with 2,2, 6,[6-TETRAMETHYL-3, 5-HEPTANEDIONE, sodium salt (approximately 1.8 g or 8.7 mmol that can be prepared from the corresponding acid and sodium hydride (both from ALDRICH)) and 2- ethoxyethanol (approximately 50 mL; ALDRICH). The contents may be stirred under nitrogen at approximately 120 C for approximately 45 minutes. The volatile components can then be removed in vacuo. The desired product can be purified from a resulting crude dark brown solid via silica gel flash chromatography with hexanes/ethyl acetate (at a ratio of approximately 20: 1) as the eluting solvent (product Rf = 0.7). The desired product (approximately 250 mg or 0.38 mmol, 3.2% from PtCI2) can be isolated as a colorless foamy solid that exhibits blue luminescence under 254 and 365 nm illumination. 1H NMR (300 MHz, CD2CI2, 296 K): 7.76-7. 83 (4H, m), 7.38-7. 46 (4H, m), 7.13-7. 25 (2H, m), 6.90-7. 13 (3H, m), 5.86 (1H, s), 3.71 (2H, d, J = 11.6 Hz), 1.29 (9H, s), 1.09 (9H, s) ppm.

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; E.I. du Pont de Nemours and Company; WO2004/16710; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 1000 ml by adding reaction bottle 99.5g (0.46mol) diphenyl methoxy phosphorus (? 99.5% purity) and 87.4g (0.51mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 10 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; Suzhou Chenghe Medical Company Chemistry Limited Company; Xia, Qiujing; (6 pag.)CN105439828; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate