Tag: M.W:200-300

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(2,6-diisopropylphenyl)-2-(3-trifluoromethyl-1H-pyrazol-5-yl)pyridine (84 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:n-hexane 1:1). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E6 (44.3% yield; 85 mg). The reaction scheme for producing the complex E6 is represented as follows: The spectrum analysis for the complex E6 is: 1H NMR (400 MHz, CDCl3, 298 K) delta 8.85 (d, J=8.3 Hz, 1H), 7.85-7.90 (m, 4H), 7.63 (d, J=5.7 Hz, 1H), 7.42-7.51 (m, 7H), 7.35 (t, J=7.8 Hz, 1H), 7.18 (d, J=7.8 Hz, 2H), 7.13-7.16 (m, 2H), 7.00 (t, J=7.4 Hz, 1H), 6.88 (s, 1H), 6.47 (dd, J=1.7, 5.7 Hz, 1H), 3.82 (d, J=11.4 Hz, 2H), 2.41 (hept, J=6.8 Hz, 2H), 1.10 (d, J=6.8 Hz, 6H), 0.99 (d, J=6.8 Hz, 6H), 19F NMR (400 MHz, CDCl3, 298 K) delta -60.7, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.81, FAB-MS m/z 842.9 M+

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-51-7,2-(Di-tert-Butylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

Example 9 A mixture of 5-(3-bromophenoxy)isophthalonitrile (75 mg), 3-hydroxybenzotrifluoride (61 mg), palladium(II) acetate (11 mg), tripotassium phosphate (0.106 g) and 2-(di-tert-butylphosphino)biphenyl (18 mg) in dry toluene was heated at reflux under a nitrogen atmosphere for 24 hours. Water and ethyl acetate were added to the cooled mixture, followed by acidification with aqueous hydrochloric acid (2M). The phases were separated and the organic layer dried over magnesium sulphate, concentrated and purified by flash chromatography. Elution with 5percent ethyl acetate/i-hexane gave 5-[3-(3-trifluoromethylphenoxy)phenoxy]isophthalonitrile (Compound 77, 32 mg), NMR 7.62 (1H, s); 7.52-7.37 (5H, m); 7.31 (1H, s); 7.25 (1H, d); 6.92 (1H, dd); 6.82 (1H, dd); 6.73 (1H, t).

224311-51-7, As the paragraph descriping shows that 224311-51-7 is playing an increasingly important role.

Reference£º
Patent; Cornell, Clive; Cramp, Michael Colin; Gingell, Michael; Westaway, Susan; US2003/181334; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

932710-63-9, 4-(Di-tert-butylphosphino)-N,N-dimethylaniline is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

932710-63-9, The procedure used to prepare 1a was modified to replace the HgCl2 addition with 0.032 g (0.1 mmol) Hg(SCN)2. After 3 days,white crystals suitable for X-ray analysis were obtained. Yield:0.046 g, 68% based on Hg(SePh)2.Properties: white crystalline substance. Melting point: 195-197 C. Anal. Calc. for C46H66Hg2N4P2S2Se2 (1360.18): Hg, 29.49;Se, 11.61; C, 40.62; H, 4.89; N, 4.12. Found: Hg, 29,40; Se, 11.58;C, 40.81; H, 4.83; N, 4.11%. IR (KBr): 3064 [vs(CAH)]; 2951[vas(CH3)]; 2874 [vs(CH3)]; 2101 [v(SCN)]; 1595, 1472, 1435[vs(CC)]; 1370 [v(CAN)]; 1066, 1021 [dip(CCAH)]; 744, 692[dop(CCAH)]; 507 [v(PAC)]; 465 cm1 [dop(CCAC)] (dip anddop = in-plane and out-of-plane bending motions, respectively).

932710-63-9 4-(Di-tert-butylphosphino)-N,N-dimethylaniline 11714598, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz; Journal of Molecular Structure; vol. 1079; (2014); p. 9 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 9 Preparation of 1,2-Bis[2-(diphenylphosphino)-2-phenyl ethyl]-benzene A 500-mL three-necked flask was equipped with a mechanical stirrer, pressure equalizing dropping funnel, thermometer, and a nitrogen atmosphere. This was charged with 75 mL of THF and diphenylbenzylphosphine (6.0 grams, 21.7 mmole), and the mixture was then cooled to -5 C. N-Butyl lithium (1.55 molar in hexane, 14 mL, 21.7 mmole) was added dropwise to the cold mixture. The resulting dark red solution was stirred at -5 C. for an additional hour. The mixture was then cooled to -78 C. A solution of alpha,alpha’-dichloro-o-xylene (1.75 grams, 10 mmole) in 50 mL of THF was added dropwise to the cold anion solution over 40 minutes. The mixture was stirred at -78 C. for an additional 2 hours, and then it was warmed to 25 C. for 2 more hours. The mixture was quenched with 2 mL of water. The crude mixture was warmed to 70 C. and swept with argon to remove solvent. The residue was treated with a mixture of 200 mL of toluene and 75 ml of 5 percent aqueous hydrochloric acid. The aqueous phase was separated from the toluene layer and discarded. The toluene layer was washed once with 100 mL of water. The toluene solvent was removed by heating to 70 C. at 100 torr under an argon stream. The residue was purified by removing the volatile impurities by distillation with the base temperature reaching 210 C. at 1 torr. The base product (2.6 grams) was an amorphous yellow solid analyzing as follows: 1 H NMR (CDCl3)delta: 2.37-2.93 (multiplet 14H); 3.33-3.78 (multiplet, 2H); 6.33-8.00 (multiplet 34H); 31 P NMR (CDCl3): Two peaks at 0 ppm (Relative to 85 Percent H3 PO4 diasteriomeric pair)., 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; Eastmank Kodak Company; US4774362; (1988); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, EXAMPLE 7 Diphenyl(1-ureidobutyl)phosphine oxide STR15 When a mixture of 0.50 mole of ethyl diphenylphosphinite 0.55 mole of n-butyraldehyde, and 0.25 mole of urea in 150 ml of chlorobenzene is warmed at 110 C. for 3 hr, there is only a slow reaction. The mixture is cooled to room temperature and 0.25 mole of acetic acid is added dropwise in ~10 minutes. The temperature increases to 65 during this addition; the urea dissolves and then a white solid product separates. The addition of another 0.25 mole of acetic acid causes no additional heat of reaction. The reaction mixture is warmed at 65-80 for 9.5 hr and filtered, giving 44.4g. Recrystallization from ethylene glycol gives 26.5g of a white solid: mp 241-244; 31 P nmr (CF3 CO2 H) -44.4 ppm; ms M+ = 316 (theory 316). Anal. Calcd for C17 H21 N2 O2 P: N, 8.85; P, 9.79. Found: N, 8.62; P, 9.94.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Monsanto Company; US4036913; (1977); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5518-52-5,Tri(furan-2-yl)phosphine,as a common compound, the synthetic route is as follows.

5518-52-5, a 4-Nitrobenzyl (1S,5R,6S)-2-[7-(2-t-butyldimethylsilyloxyethyl)thioimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate N,N-Diisopropylethylamine (0.574 ml) was added dropwise to a solution of 791 mg of 4-nitrobenzyl (1R,3R,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-oxo-1-carbapenam-3-carboxylate in 20 ml of dry acetonitrile at -30 C. under an argon atmosphere, followed by the dropwise addition of 0.367 ml of trifluoromethanesulfonic anhydride under the same conditions. The mixture was stirred at that temperature for 30 min. Ethyl acetate (40 ml) was then added thereto, and the mixture was washed with semi-saturated brine, a mixed solution composed of semi-saturated brine with a 1 N aqueous hydrochloric acid solution (pH 1.1), a mixed solution composed of semi-saturated brine with a saturated aqueous sodium hydrogencarbonate solution (pH 8.9), and semi-saturated brine in that order, dried over anhydrous magnesium sulfate, and then filtered. The solvent was removed by distillation under the reduced pressure. The residue was dissolved in 10 ml of dry N-methylpyrrolidinone. Tri-2-furylphosphine (11 mg), 104 mg of zinc chloride, 11 mg of tris(dibenzylideneacetone)dipalladium(0), and 1.433 g of 7-(2-t-butyldimethylsilyloxyethyl)thio-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole were added to the solution. The mixture was stirred at 50 C. under an argon atmosphere for 1.5 hr. Ethyl acetate (30 ml) and 15 ml of a semi-saturated aqueous sodium hydrogencarbonate solution were added to the reaction solution. The mixture was stirred, and the insolubles were removed by filtration. The organic layer was separated from the filtrate, washed with 20 ml of semi-saturated brine three times, and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography on silica gel (dichloromethane:methanol =20:1) to prepare 573 mg of 4-nitrobenzyl (1S,5R,6S)-2-[7-(2-t-butyldimethylsilyloxyethyl)thioimidazo[5,1-b]thiazole-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate. NMR (CDCl3) delta: 0.02 (6H, s), 0.86 (9H, s), 1.31 (3H, d, J=7.3 Hz), 1.40 (3H, d, J=6.3 Hz), 2.9-3.0 (2H, m), 3.37 (1H, dd, J1=6.6 Hz, J2=2.8 Hz), 3.4-3.5 (1H, m), 3.75-3.85 (2H, m), 4.25-4.35 (1H, m), 4.38 (1H, dd, J1=9.6 Hz, J22.8 Hz), 5.28 (1H, d, J=13.7 Hz), 5.53 (1H, d, J=13.7 Hz), 7.68 (2H, d, J=8.9 Hz), 8.00 (1H, s), 8.25 (2H, d, J=8.9 Hz), 8.32 (1H, s)

The synthetic route of 5518-52-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kano, Yuko; Maruyama, Takahisa; Sambongi, Yumiko; Aihara, Kazuhiro; Atsumi, Kunio; Iwamatsu, Kastuyoshi; Ida, Takashi; US2003/27809; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, The synthesis of the iminophosphine ligand carryingalkoxylsilane moiety A was performed through the reactive distillation of 2-(diphenylphosphino)benzaldehyde(0.500 g) with 3-(aminopropyl)trimethoxysilane (0.250 g)in dry toluene (25 mL). After 5 h, we obtained a yellowoily liquid by careful removal of toluene under vacuum(85 percent yield).1H NMR (400 MHz, CD2Cl2): d = 8.8 (s, 1H), 8.02 (s,1H), 7.45?7.27 (m, 12 H), 6.91 (s, 1 H), 3.53 (s, 9 H), 3.46(m, 2 H), 1.68?1.60 (m, 2 H), 0.58?0.52 (m, 2 H); 13CNMR (100 MHz, CD2Cl2): d = 158.57, 134.14, 128.79,65.13, 50.82, 24.62, 8.73 ppm; 31P NMR: (300 MHz,CD2Cl2, ppm) d = -13.07 ppm.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Upadhyay, Praveenkumar Ramprakash; Srivastava, Vivek; Catalysis Letters; vol. 146; 8; (2016); p. 1478 – 1486;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

The reaction flask was evacuated to -0.098 MPa using a vacuum pump.Under this condition will be 23.02gDiphenylethoxyphosphine and 18.26g2,4,6-trimethylbenzoyl chloride was added to the reaction flask, and the reaction was started at a temperature of 40 C.During the reaction, the temperature was raised by 10 C every 20 minutes until the temperature was raised to 90 C.Then react at a constant temperature of 90 C for 8 h.The exhaust gas generated during the reaction is removed by vacuum to the ethyl chloride recovery system and used.After the reaction, 50% ethanol was added to crystallize.33.13 g of the target product TPO were obtained. The purity of the product was 99.2% and the yield was 95.1%., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Shaoxing Shangyu Yirui Chemical Co., Ltd.; Li Kunwu; (6 pag.)CN109336925; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

932710-63-9, To a solution of 0.051 g (0.1 mmol) Hg(SePh)2 in 6 mL DMFwere added 0.026 g (0.1 mmol) of PR2R’ (R = tert-butyl; R’ = 4-N,N-dimethylaniline), and the solution was stirred for 1 h. Thesolution was then filtered over Celite, and 6 mL isopropanol waslayered over the mother liqour. After 3 days, yellow crystals suitablefor X-ray analysis were obtained. Yield: 0.047 g, 61% basedon Hg(SePh)2.Properties: yellow crystalline substance. Melting point: 190-192 C. Anal. Calc. for C56H76Hg2N2P2Se4 (1556,14): Hg, 25.78; Se,20.30; C, 43.22; H, 4.92; N, 1.80. Found: Hg, 25.73; Se, 20.26; C,43.15; H, 4.86; N, 1.71%. IR (KBr): 3040 [vs(CAH)]; 2945 [vas(CH3)];2868 [vs(CH3)]; 1596, 1471, 1435 [vs(CC)]; 1361 [v(CAN)]; 1068,1019 [dip(CCAH)]; 735, 694 [dop(CCAH)]; 505 [v(PAC)];460 cm1 [dop(CCAC)] (dip and dop = in-plane and out-of-planebending motions, respectively).

932710-63-9 4-(Di-tert-butylphosphino)-N,N-dimethylaniline 11714598, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz; Journal of Molecular Structure; vol. 1079; (2014); p. 9 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate