Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: In a sealed tube containing a solution of the phosphine oxide derivative (5 mmol) in anhydrous toluene (1 M) was added InBr3 (1 mol %, 0.05 mmol) and the TMDS (1.5 equiv, 7.5 mmol) under an argon atmosphere. The reaction mixture was stirred at 100 C during 7-40 h depending on the substrate (the reaction was monitored by 31P NMR). After complete consumption of the reagent the mixture was kept under argon in the sealed tube and cooled to 0 C. A solution of BH3.SMe2 (2 M in THF, 1 equiv) was then slowly added. After 1 h at room temperature, 31P NMR analysis of an aliquot indicates complete conversion to phosphine borane adduct. The crude was poured in an erlenmeyer flask and silica gel was carefully added while stirring. When silica gel was added in the reaction mixture, a slightly exothermic reaction was observed. The reaction mixture was then filtered on silica gel and washed several times with ethyl acetate. After evaporation of the ethyl acetate, the residue was purified by flash chromatography on silica gel with pure cyclohexane to afford the desired phosphine-borane., 13689-20-8

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc; Tetrahedron; vol. 68; 15; (2012); p. 3151 – 3155;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

932710-63-9, The procedure used to prepare 1a was modified to replace the HgCl2 addition with 0.045 g (0.1 mmol) HgI2. After 1 week, yellow crystals suitable for X-ray analysis were obtained. Yield: 0.052 g,70% based on Hg(SePh)2.Properties: yellow crystalline substance. Melting point: 187-189C. Anal. Calc. for C44H66Hg2I2N2P2Se2 (1497.83): Hg, 26.78;Se, 10.54; C, 35.28; H, 4.44; N, 1.87. Found: Hg, 26.91; Se, 10.62;C, 35.19; H, 4.47; N, 1.84%. IR (KBr): 3051 [vs(CAH)]; 2952[vas(CH3)]; 2872 [vs(CH3)]; 1599, 1472, 1432 [vs(CC)]; 1366[v(CAN)]; 1067, 1022 [dip(CCAH)]; 737, 691 [dop(CCAH)]; 507[v(PAC)]; 466 cm1 [dop(CCAC)] (dip and dop = in-plane and outof-plane bending motions, respectively).

The synthetic route of 932710-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz; Journal of Molecular Structure; vol. 1079; (2014); p. 9 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5931-53-3,5931-53-3, Diphenyl(o-tolyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar amounts of KSeCN (5.8 mg, 0.04 mmol) andeither diphenyl(ortho-tolyl)phosphane (11.1 mg, 0.04 mmol)or dicyclohexyl(ortho-tolyl)phosphane (11.5 mg, 0.04 mmol)were dissolved in the minimum amount of MeOH (10 ml). TheKSeCN solution was added dropwise (over a period of 5 min)to the phosphane solution with stirring at room temperature.Slow evaporation of the solvent afforded the title compoundsas colourless crystals suitable for single-crystal X-ray studies.Analytical data for I, 31P {H} NMR (CDCl3, 161.99 MHz):32.03 [t, 1J(31P-77Se) = 714 Hz]

The synthetic route of 5931-53-3 has been constantly updated, and we look forward to future research findings.

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Article; Davis, Wade L.; Muller, Alfred; Acta Crystallographica Section C: Structural Chemistry; vol. 75; (2019); p. 1310 – 1318;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

If the process is carried out in such a manner that the mixture is brought to room temperature after completion of the dropwise addition of chloro(diphenyl)phosphine, then kept under reflux for 12 hours and then worked up as above after cooling, 195 g of ethyl diphenylphosphinite are obtained. This corresponds to a yield of 94% of theory.

1079-66-9, As the paragraph descriping shows that 1079-66-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5705669; (1998); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 2-(Diphenylphosphino)benzaldehyde (2.09 g, 7.20 mmol, 1.0 equiv.) and mesitylamine (1.01 g,7.44 mmol, 1.03 mmol) were dissolved in 40 mL toluene. The orange solution was heated to 135 for 20 h under a dropping funnel filled with molecular sieves. Evaporating the solvent in vacuo yielded the product as a yellow solid, which was used in following syntheses without further purication (2.60 g, 6.38 mmol, 89 percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vasilenko, Vladislav; Roth, Torsten; Blasius, Clemens K.; Intorp, Sebastian N.; Wadepohl, Hubert; Gade, Lutz H.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 846 – 853;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50 mL three-necked flask equipped with a reflux condenser and a stirrer, 0.32 g (13 mmol) of metal magnesium powder and 3.3 mg (0.013 mmol) of iodine were charged under an argon stream.Stir for 8 hours. ThenA solution prepared by dissolving 1.9 g (11 mmol) of 2-bromotoluene in 10 ml of tetrahydrofuran (THF) was dropped from a dropping funnel.After completion of dropping, the mixture was stirred for 3 hours under reflux of THF. *The obtained 2-toluylmagnesium bromide in THF was cooled to -78 C.,ChlorodiphenylphosphineAfter adding a solution of 3.3 g (15 mmol) dissolved in 2 ml of THF, the temperature was raised to room temperature,Stir for 8 hours.The chloromagnesium bromide precipitated from the obtained reaction mixture was filtered off with a glass filter and washed with 5 ml of pure water and 5 ml of saturated saline. This crude diphenyl (2-toluyl) phosphine solution was dried over magnesium sulfate, and then THF was distilled off, followed by vacuum drying to obtain yellow oily crude diphenyl (2-toluyl) phosphine. The resulting crude diphenyl (2-tolyl) phosphine was purified by flash silica gel chromatography (ethyl acetate / n-hexane)Diphenyl (2-toluyl) phosphine0.88 g (3.2 mmol) was obtained.

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various fields.

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Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2., 719-80-2

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, 2.90 grams (12 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzaldehyde (prepared according to Stokker, Jour. Med. Chem. Vol. 29 p.170, 1986) was reduced with 0.454 grams (12 mmol) of sodium borohydride in ethanol (20 mL) at 0 C. The reaction was stirred 1 hr, quenched with aqueous ammonium chloride and the mixture extracted with ether. The organic portion was dried (MgSO4) and concentrated to give 2.90 grams of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl alcohol as an oil which solidified on standing. The crude solid was treated with 1.31 mL of thionyl chloride and heated on a steam bath for 1 hour. After cooling to room temperature, the crude mixture was taken up in water and extracted with ether. The ether was washed with water and dried(MgSO4), and concentrated to give an oily residue which was purified by silica gel chromatography (25% methylene chloride/ 75% hexane) to give 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride as a solid. 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150C for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111C).

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; EP948335; (2007); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of 1-imidoalkyltriarylphosphonium salt 2 (0.25 mmol, 1.0 equiv.) in CHCl3(2 cm3) placed in a glass vial sealed with a screw-cap a phosphorus nucleophile (2.5 mmol, 10 equiv.)and, in the case of a catalytic reaction, methyltriphenylphosphonium iodide (25.3 mg, 0.0625 mmol,0.25 equiv.) was added. The reaction was carried out under conditions given in Table 1. Then,the solvent was evaporated to dryness under reduced pressure and the product was isolated bycolumn chromatography using 50 cm3 of hexane and then ethyl acetate as the eluent. If necessary,purication can be repeated using acetonitrile or toluene:ethyl acetate (5:1,v/v) as the eluent (this isparticularly useful during the separation of diastereoisomers 1h and 1i). The crystalline compoundswere recrystallized from toluene.

4020-99-9, The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adamek, Jakub; egrzyk-Schlieter, Anna W.; Ste?, Klaudia; Walczak, Krzysztof; Erfurt, Karol; Molecules; vol. 24; 18; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate