Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, Under inert gas protection,50mLSchlenk reaction tube added2,9-dimethyl-4,7-bis (3,5-di (n-hexyl) phenyl) 1,10-phenanthroline (0.350g, 0.5mmol),2- (diphenylphosphino) benzaldehyde (0.291 g, 1 mmol)And potassium phosphate (1 mmol),A deoxygenated tetrahydrofuran (20 mL) was added,Room temperature reaction 48h,After completion of the reaction, the mixture was cooled to room temperature,50 mL of water was added to the reaction solution, the solid was precipitated and filtered, and the filtered solid was recrystallized from 1 mL of a crystalline solvent methanol,To give the title product 416 mg, yield 67percent

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang University of Technology; Luo Shuping; Yu Zhejian; Chen Hao; Xia Liangmin; Wang Mingming; Wu Qingan; (8 pag.)CN106749411; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

fac-[Re(Benzac)(CO)3(H2O)] (45mg; 0.1mmol) was dissolved in methanol (3ml), and PPh2Cy (27mg; 0.1mmol) dissolved in methanol (2ml) was added. The solution was then stirred for 7h at room temperature and the bright yellow precipitate was filtered off and dried. The filtrate was left to crystallize and bright yellow crystals suitable for the collection with X-ray diffraction formed. Yield=55mg, 77%. IR (KBr, cm-1): nuCO=2021, 1927, 1909. 1H NMR (600MHz, CD2Cl2): delta 7.63 (d, J=7.8Hz, 2H), 7.56-7.24 (m, 13H), 5.88 (s, 1H), 2.34-2.18 (m, 2H), 2.11 (d, J=16.0Hz, 1H), 1.68 (dt, J=30.3, 16.3Hz, 2H), 1.58 (s, 3H), 1.55 (d, J=7.6Hz, 1H), 1.29-1.14 (m, 2H), 1.03-0.79 (m, 3H). 13C NMR (600MHz, CD2Cl2): delta 197.38, 189.99, 180.18, 138.06, 134.49, 134.2, 131.03, 130.16, 128.77, 128.48, 128.20, 128.08, 126.96, 98.33, 34.63, 30.67, 28.59, 28.19, 28.02, 27.35, 27.19, 27.11, 26.06. 31P NMR (300MHz, CD2Cl2): delta 32.00. UV-Vis: epsilon (lambdamax=370nm)=2343M-1cm-1. Anal. Calc. for C31H30O5PRe: C, 52.98; H, 4.73. Found: C, 52.95; H, 4.70.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Manicum, Amanda-Lee E.; Schutte-Smith, Marietjie; Visser, Hendrik G.; Polyhedron; vol. 145; (2018); p. 80 – 87;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.224311-51-7,2-(Di-tert-Butylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

Under nitrogen atmosphere, a mixture of 4-[[4-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]phenyl trifluoromethanesulfonate (265 mg), palladium(II)acetate (5 mg), 2-[bis(tert-butyl)phosphino]biphenyl (12 mg), and powdered potassium phosphate (177 mg) in toluene (2.6 ml) was heated to 100¡ã C. for 10 hours.After being allowed to cool to room temperature, the mixture was concentrated and the residue was purified by column chromatography (silica gel, hexane/ethyl acetate) to give ethyl 4-[4-[[4-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino]ethyl]phenyl]sulfonyl]phenoxy]benzoate (93 mg) as a white amorphous. NMR (CDCl3, delta): 1.36 (9H, br s), 1.40 (3H, t, J=7 Hz), 2.60-3.05 (2H, m), 3.05-3.60 (4H, m), 4.27 (1H, br s, OH), 4.38 (2H, q, J=7 Hz), 4.86 (1H, m), 6.90-7.45 (10H, m), 7.86 (2H, d, J=8 Hz), 7.90 (2H, d, J=8 Hz), 8.07 (2H, d, J=8 Hz) (+)ESI-MS (m/z): 702 (M+Na)+

224311-51-7, The synthetic route of 224311-51-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; US2004/106653; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: To a solution of [mu-SC6H3(CH3)S-mu]Fe2(CO)6 (0.086 g, 0.2 mmol) and tris(2-furyl)phosphine (0.046 g, 0.2 mmol) in CH2Cl2 was added a solution of Me3NO¡¤2H2O (0.022 g, 0.2 mmol) in MeCN. The mixture was stirred at room temperature for 1 h, then the solvent was reduced on a rotary evaporator and the residue was subjected to TLC separation using CH2Cl2/petroleum ether = 1:3 (v/v) as the eluent. From the first red band, 0.110 g (86%) of complex 2 was obtained as a red solid. From the second red band, 0.016 g (10%) of 3 was obtained as a red solid.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 128; (2017); p. 126 – 132;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: The phosphine ligand (PPh2R and PPhR2; R=Me or Et) (0.5mmol) was directly added to the solution of the starting complex [PtCl(sac)(COD)] (COD=1,5-cyclooctadiene) (0.25mmol, 0.13g) in the mixture of MeCN and MeOH (1:1, 10mL). The reaction mixture was refluxed for 24h. Then, the solvents were removed by a rotary evaporator and the white solids were washed with diethyl ether and a small amount of cold EtOH. The solids were dissolved in a mixture containing water, MeCN and MeOH (1:1:1). The crystals of 2, 3 and 4 were obtained from the evaporation of the solutions after three or four weeks at r.t., 607-01-2

Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Icsel, Ceyda; Yilmaz, Veysel T.; Cevatemre, Buse; Aygun, Muhittin; Ulukaya, Engin; Journal of Inorganic Biochemistry; vol. 195; (2019); p. 39 – 50;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: 1a (70.5 mg, 0.20 mmol), 4-phenylthioxanthone (3 mg, 0.01 mmol), CH3OH (30 mL) were added to a pyrex reaction flash which was equipped with a magnetic stirrer. The mixture was irradiated by a 23 W household lamp at rt under air atmosphere. The photoreaction was completed after 40 minutes as monitored by TLC (eluent: petroleum ether). The solvent was removed and the residue was purified by flash column chromatography on silica gel (eluent: petroleum ether/ethyl acetate = 10/1?EA) to afford 2a as a solid (74 mg, 100%); 1H NMR (400 MHz, CDCl3) delta 7.56 (dd, J = 11.6, 8.8 Hz, 6 H), 6.95 (dd, J = 8.8, 2.0 Hz, 6 H), 3.83 (s, 9 H).

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Ding, Aishun; Li, Shijie; Chen, Yang; Jin, Ruiwen; Ye, Cong; Hu, Jianhua; Guo, Hao; Tetrahedron Letters; vol. 59; 43; (2018); p. 3880 – 3883;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

Potassium tetrachloropalladate(II) was prepared by the procedure described in [26]. Potassium chloride, 2 equiv, was added to a solution of palladium(II) chloride in 25 mL of distilled water with stirring over a period of 30 min. The mixture was cooled with ice, and yellowish-brown crystals of potassium tetrachloropalladate(II) separated in a few minutes. The crystals were collected by filtration and recrystallized from water containing a few drops of aqueous HCl. The complexes were prepared by adding 2 equiv of the corresponding phosphine in 15 mL of acetonitrile to a solution of 0.326 g of K2[PdCl4] in15 mL of water, followed by stirring. After 30 min, a solution of 2 equiv of N,N-dimethylthiourea in 15 mL of methanol was added, and the mixture was stirred for one hour. The resulting yellow or red solution was filtered, and the filtrate was kept at room temperature for three to five days. Slow evaporation of the acetonitrile-methanol solution afforded solid complex 1-3. The overall reaction is shown in Scheme 1.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Aziz; Sirajuddin; Munir; Tirmizi; Nadeem; Tahir; Sajjad; Russian Journal of General Chemistry; vol. 88; 3; (2018); p. 551 – 559;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In 1000 ml by adding reaction bottle 99.5g (0.46mol) diphenyl methoxy phosphorus (? 99.5% purity) and 72g m-methoxybenzyl chloride (0.42mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 10 hours, and cooled to the end of the 10 C, directly enters the reaction of the next., 4020-99-9

4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Suzhou Chenghe Pharmaceutical & Chemical Co., Ltd.; Xia, qiujing; (5 pag.)CN105503954; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Accurately weighed ethyl diphenylphosphine (123 muL, 0.6 mmol),1,10-Phenanthroline (0.4698 g, 2.4 mmol) was added to a 25 mL Schlenk reaction flask.Then 3,5-dimethyl iodobenzene (144 muL, 0.9 mmol) was added and the solvent was dichloromethane (2 mL).The reaction was carried out at 75 C for 30 h. After the reaction,Extract with ethyl acetate/water and dry the organic phase with anhydrous sodium sulfate.The solvent was removed under reduced pressure.Separation of silica gel column using petroleum ether/ethyl acetate as eluentThe yield of the product was 40%., 607-01-2

The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: By analogy with 18a from solution alpha-chloroether 16a (1.25 g, 3.8 mmol) in Et2O (1mL) and ethyl diphenylphosphinite 17(0.87 g, 3.8 mmol) compound 18b in 77 % yield (1.44 g) was obtained, m.p. 146-148 C((isooctane).1H NMR (400 MHz, CDCl3, 20 C): delta 3.37(s, 3H, OMe), 5.02 (d, 2JPH= 13.3 Hz, 1H, PCH), 6.56 (s, 1H, CHBr2), 7.15-8.05 (m, 14H, C6H4, 2Ph) ppm. 13C NMR (100.61 MHz, CDCl3, 20 C): delta 40.7 (CHBr2), 59.0 (d, 3JPC= 12.48 Hz, OMe), 83.1 (d, 1JPC= 86.52 Hz, PCH), 128.4, 128.5, 128.6, 128.7, 129.4, 130.3, 130.6, 131.7, 131.8 (CH-aromatic), 128.8, 128.9, 132.3, 132.5, 132.6, 133.2, 135.4, 135.5, 135.6,135.7, 142.5, 142.6 (C-aromatic). 31P NMR (162 MHz, CCl4,20 C): delta 28.2 ppm. Anal. Calcd for C21H19Br2O2P: C, 51.04; H, 3.88; Br, 32.34; P, 6.27. Found: C, 50.81; H, 3.77; Br, 32.18; P, 6.14.

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Gazizov, Mukattis B.; Ivanova, Svetlana Yu.; Bagauva, Liliya R.; Khairullin, Rafail A.; Musin, Rashid Z.; Tetrahedron Letters; vol. 57; 2; (2016); p. 210 – 212;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate