Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Under nitrogen protection, Weigh 2g of compound 5 in a 50mL dry two-necked bottle, Add 15 mL of dry toluene, Slowly add 0.7 mL of tris(dimethylamino)phosphine, Reflux for 4 h. The solvent was removed under reduced pressure. The crude product is separated by a column, I got 1.96g of compound J, Yield 86%, 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Jiao Tong University; Cui Yong; Chen Xu; Liu Yan; (21 pag.)CN108586529; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trisdimethylaminophosphine (1 mmol) was added to a solution of methyl-isatin (1 mmol) in dry toluene with stirring for 1-2 h at room temperature. After evaporation of the volatile material under reduced pressure, the residue was subjected to silica-gel column chromatography to give the isoindigo 6 as red crystals., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Arsanious, Mona Hizkial Nasr; Maigali, Soher Said; Synthetic Communications; vol. 44; 2; (2014); p. 202 – 214;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: To a well-stirred solution of compounds (2a-2b) (2mmol) in anhydrous toluene (15 mL) was added hexamethylphosphoroustriamide (2mmol). The mixture was heated under reflux for 12 h. Silica gel TLC indicated the completion of the reaction. The solvent was evaporated under reduced pressure, and the residue was purified on silica gel preparative TLC using ethyl acetate as eluent. A mixture of compounds (3a-3b) (1mmol), S8 (5 mmol) and anhydrous toluene (10mL) was refluxed for 4h, and then cooled. The sulfur excess was filtered off, and the solvent was removed under reduced pressure. Flash column chromatography on silica gelusing petroleum ether as eluant affords (4a-4b)., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Balti, Monaem; Efrit, Mohamed Lotfi; Journal of Sulfur Chemistry; vol. 37; 4; (2016); p. 466 – 475;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

The compound was synthesized with some minor changes to the published procedure [37]. Thus, freshly distilled tris(dimethy-lamino) phosphine (11.1 g, 0.068 mol) was placed in a round bottom flask equipped with thermometer, flushed with argon and 1-bromohexane (10.0 mL, 0.071 mol) was added dropwise at r.t. with gentle stirring. The stirring was continued at 25 C for 13 h, whereupon the reaction mixture was slowly heated to 105 C, at which temperature an exothermic effect was evident. External heating was then discontinued and the reaction temperature was maintained at 105 C for 30 min by air-cooling (Caution: the reaction is very exothermic and the sharp temperature jump ispossible, thus requiring constant temperature monitoring). Finally heating was resumed and stirring was continued for 15 min at110 C. Upon cooling to r.t. the reaction mass solidified. Unreacted reagents were partially removed by heating to 80 C/10-12 mm Hg for 2 hours. The obtained solid mass was consequently washed with anhydrous ethyl acetate and hexane. After evaporation of residual solvents at 60 C/10-12 mm Hg, the product was dissolved in anhydrous dichloromethane and boiled with charcoal. The charcoal was then filtered off and dichloromethane was stripped off under reduced pressure at 30 C. The product was obtained as white crystalline solid, which was finally dried at 60 C/1 mm Hg for 5 h (hereinafter with a special flask filled with P2O5 and introduced into the vacuum line). Yield: 14.5 g (66%); mp = 67-68 C; 1H NMR (400 MHz, CDCl3): 2.86-2.84 (d, 18H, CNE=3), 2.60-2.56 (m, 2=, CE=2), 1.61-1.51 (m, 4=, E=2E=2(E=2)2E=3), 1.33-1.30 (m, 4=, E=2E=2E=3), 0.91-0.87 (m, 3=, E=2E=3); IR (KBrpellet): 3006 (w, nE-=), 2929 (s, nE-=), 2856 (s, nE-=), 2816 (m,nE-=), 2732 (w, nE-=), 1488 (m), 1468 (w), 1306 (s), 1262 (w), 1169(m), 1071 (m), 998 (vs, nP-N), 962 (vs, nP-N), 812 (m), 791 (m), 737(w), 622 (w) cm1., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Shaplov, Alexander S.; Lozinskaya, Elena I.; Vlasov, Petr S.; Morozova, Sofia M.; Antonov, Dmitrii Y.; Aubert, Pierre-Henri; Armand, Michel; Vygodskii, Yakov S.; Electrochimica Acta; vol. 175; (2015); p. 254 – 260;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Example 4; (g) Preparation of tri(dimethylamino) butylphosphonium butylsulfate; In an eggplant-shaped two-neck flask equipped with a reflux condenser, a dropping funnel and a magnetic stirrer, 37.4 g (178 mmol) of diethylsulfate were added dropwise to 24.2 g (149 mmol) of hexamethylphosphorous triamide at room temperature in a nitrogen gas atmosphere. After 3-day stirring at room temperature, a white solid salt was obtained. The salt was washed sufficiently with ether and vacuum-dried at 50C for 5 hours to obtain tri(dimethylamino) butylphosphonium butylsulfate with 94% yield. The resulting compound was identified with a nuclear magnetic resonance spectrometer (BRUKER Ultra Shield 300 NMR Spectrometer, supplied by BRUKER Corp.). The spectrum data are shown below. 1H-NMR (300 MHz, solvent: acetone-d6, reference material: tetramethylsilane) delta 3.83 (t, 2H) 2.85 (d, 18H) 2.73-2.63 (m, 2H) 1.70-1.33 (m, 8H) 0.97 (t, 3H) 0.90 (t, 3H) The structural formula is shown below (a dashed line in the formula represents a conjugated structure)., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kanto Denka Kogyo CO., LTD.; EP1876181; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate