Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: Phosphorus triamides 10a, 10b (5.2 mmol) in 5 cm3 of dryTHF were added in one portion to a mixture of 0.8 g azide1 (3.9 mmol) and 2 cm3 dil. EtOH (1:1) in 10 cm3 THF.The reaction mixture was stirred at r.t. for &6 h (TLC).The solvent was evaporated to dryness; the residue waswashed several times with light petroleum (40-60 C), andcrystallized from the proper solvent to give 13a and 13b,respectively.N00-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N,N,N?,N?-tetramethylphosphoric triamide(13a, C13H21N4OPS)Pale yellow crystals; yield: 0.97 g (79.6 %); m.p.: 165 C(MeCN); IR (KBr): v = 3325 (NH), 2205 (CN), 1232 (P=O,bonded) cm-1; 1H NMR (500.7 MHz, CDCl3): d = 1.91,2.32 (2 m, 4 9 2H, 4 H2C-hexyl), 2.45 (d, 3JPH = 9.4 Hz,2 9 6H, (Me2N)2P), 11.21 (br, 1H, HN) ppm; 13C NMR(125.4 MHz, CDCl3): d = 150.6 (d, 2JPC = 28.3 Hz, C-NH), 136.1, 130.2 (C=C-hexyl), 113.7 (CN), 87.3 (C-CN),35.5 (d, 2JPC = 13.5 Hz, (Me2N)2P), 26.4, 26.2, 23.5, 21.8(CH2-hexyl) ppm; 31P NMR (200.7 MHz, CDCl3):d = 34.7 ppm; MS (EI, 70 eV): m/z (%) = 311 (45)[M?-1], 285 (34) [M?-27 (H ? CN)], 150 (100) [M?-162 (H ? CN ? C4H12N2OP)]., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Abdou, Wafaa M.; Ganoub, Neven A.; Sabry, Eman; Monatshefte fur Chemie; vol. 147; 3; (2016); p. 619 – 626;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Trisdimethylaminophosphine 1 (1 mmol)was added to a solution of isatin imine 2a (1 mmol) in dry toluene (30mL), and the resulting mixture was stirring at room temperature for 4 h (TLC) in the presence of atmospheric moisture.[24] After evaporation of the volatile material under reduced pressure, the residue was subjected to silica-gel column chromatography to give the product 4a., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arsanious, Mona Hizkial Nasr; Maigali, Soher Said; Synthetic Communications; vol. 44; 2; (2014); p. 202 – 214;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: Ligand 7 (263.3mg, 0.50mmol) [or 10 (249.3mg, 0.50mmol)] was dissolved in 10mL of anhydrous toluene and cooled to 0C. After the addition of P(NMe2)3 or P(NEt2)3 (0.65mmol), the resulting solution mixture was stirred at 0C for 10min. Next, the reaction mixture was gently warmed to 110C for 6h, and then filtered, concentrated, and purified by preparative TLC on silica gel plates to give the pure product 8a-b [or 11a-b]. Characterization data of new ligand 8a: Yield: 80%; mp: 46-48C. [alpha]D20=+352 (c 0.2, CHCl3). 1H NMR (400MHz, CDCl3) delta 8.12 (s, 2H), 7.92 (dd, J=18.9, 13.6Hz, 2H), 7.50 (t, J=8.5Hz, 4H), 7.44-7.21 (m, 12H), 4.90 (dd, J=27.3, 13.3Hz, 4H), 4.80-4.68 (m, 4H), 2.43-2.28 (m, 6H). 13C NMR (100MHz, CDCl3) delta 147.6, 147.5, 138.4, 138.3, 132.4, 132.0, 131.0, 130.6, 130.5, 130.3, 128.6, 128.5, 128.4, 128.3, 127.8, 127.7, 127.6, 127.5, 126.9, 126.8, 125.8, 125.7, 124.9, 124.7, 124.0, 123.9, 122.7, 73.1, 72.8, 68.12, 68.10, 67.7, 35.6, 35.4. 31P NMR (162MHz, CDCl3) delta 148.62. IR(KBr) nu 3056, 2968, 2963, 2857, 1450, 1350, 1108, 1018, 900, 742, 965cm-1. HRMS (ESI) m/z: Calcd for C38H34NO4P [M+H]+: 600.2304 found: 600.2306, 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Wenxian; Wang, Tao; Zhao, Ruijuan; Xie, Huanping; Liu, Lantao; Tetrahedron Asymmetry; vol. 27; 4-5; (2016); p. 157 – 162;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ligand 7 (263.3mg, 0.50mmol) [or 10 (249.3mg, 0.50mmol)] was dissolved in 10mL of anhydrous toluene and cooled to 0C. After the addition of P(NMe2)3 or P(NEt2)3 (0.65mmol), the resulting solution mixture was stirred at 0C for 10min. Next, the reaction mixture was gently warmed to 110C for 6h, and then filtered, concentrated, and purified by preparative TLC on silica gel plates to give the pure product 8a-b [or 11a-b]. Ligand 11a: Yield: 82%; mp: 91-92C. [alpha]D20=+415 (c 0.1, CHCl3). 1H NMR (400MHz, CDCl3) delta 7.79 (dd, J=18.7, 8.1Hz, 2H), 7.60 (dd, J=15.2, 7.6Hz, 4H), 7.48-7.27 (m, 12H), 7.19-7.10 (m, 2H), 5.42 (s, 2H), 5.34 (dd, J=31.4, 11.8Hz, 2H), 2.53 (d, J=9.3Hz, 6H). 13C NMR (100MHz, CDCl3) delta 160.2, 160.1, 148.0, 147.9, 147.7, 140.93, 140.92, 136.94, 136.90, 132.4, 132.1, 131.0, 130.6, 130.44, 130.42, 128.7, 128.6, 128.3, 128.2, 128.0, 127.9, 127.6, 127.5, 127.4, 127.0, 126.9, 125.8, 125.7, 124.9, 124.6, 124.0, 123.9, 122.2, 122.1, 106.7, 106.6, 101.5, 101.4, 72.9, 72.8, 70.1, 68.2, 68.1, 67.9, 39.0, 38.8, 15.0, 14.9. 31P NMR (162MHz, CDCl3) delta 149.30. IR(KBr) nu 3030, 2883, 1592, 1442, 1245, 973, 911, 742, 690cm-1. HRMS (ESI) m/z: Calcd for C36H30NO4P [M+H] +: 572.1985 found: 572.1987, 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Zhao, Wenxian; Wang, Tao; Zhao, Ruijuan; Xie, Huanping; Liu, Lantao; Tetrahedron Asymmetry; vol. 27; 4-5; (2016); p. 157 – 162;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of phosphoresorcinarene 2a (0.06 mmol) in0.7 mL of dioxane was added hexamethyltriamidophosphite(0.590 mmol). The reaction mixture was heated for 60 h at 85-95C and then for 40 h at 110-115C. The precipitate was separated by fltration, washed with dioxane, and dried for 4 h at80C/1 mm Hg. White powder; yield 0.066 g (67%); m.p. >360C. 1H NMR (CDCl3, 25C): delta = 0.54 (s, 12H, C(CH3)2),0.75 (s, 12H, C(CH3)2), 2.15 (dd, 2JHH = 10.2 Hz, 3JPH =19.2 Hz, 4H, O-CH2e), 2.21 (s, 6H, C5CH3), 2.22 (s, 6H, C5CH3),2.50 (d, 3JPH = 9.2 Hz, 24H, NCH3), 2.62 (d, 3JPH = 8.4 Hz, 24H,NCH3), 3.24 (dd, 2JHH = 4.1 Hz, 3JPH = 2.3 Hz, 4H, O-CH2a),3.60 (dd, 2JHH = 11.9 Hz, 3JPH = 19.2 Hz, 4H, O-CH2e), 3.89(dd, 2JHH = 8.3 Hz, 3JPH = 2.7 Hz, 4H, O-CH2a), 5.14 (s, 2H,H3h), 6.16 (s, 2H, H3v), 6.33 (s, 4H, H1), 6.59 (d, 3JHH = 6.8 Hz,4H, H2-Naph), 6.74 (dd, 3JHH = 8.2 Hz, 3JHH = 7.3 Hz, 4H, H7-Naph), 6.89 (dd, 3JHH = 8.2 Hz, 3JHH = 6.8 Hz, 4H, H3-Naph),7.00 (dd, 3JHH = 8.2 Hz, 3JHH = 7.3 Hz, 4H, H6-Naph), 7.26 (d,3JHH = 8.2 Hz, 4H, H4-Naph), 7.35 (d, 3JHH = 8.2 Hz, 4H, H8-Naph), 7.38 (d, 3JHH = 8.2 Hz, 4H, H5-Naph). 13C NMR (CDCl3,25C): delta = 11.9 (C5CH3), 12.5 (C5CH3), 20.1 (C(CH3)2), 31.4(s, C(CH3)2), 31.5 (s, C(CH3)2), 36.8 (d, 2JPC = 3.7 Hz, NCH3),36.9 (d, 2JPC = 3.7 Hz, NCH3), 42.5 (C1), 77.5 (O-CH2), 122.6(C5), 123.7 (C5), 124.2 (C6,7,8-Naph), 124.9 (C3-Naph), 126.7(C4-Naph), 127.2 (C2-Naph), 128.2 (C5-Naph), 129.4 (C2), 130.4(C2), 131.5 (C3, C9-Naph), 131.7 (C3), 133.0 (C10-Naph), 137.5(C1-Naph), 147.2 (d, 2JPC = 9.6 Hz, C4OPO), 150.6 (d, 2JPC =7.7 Hz, C4OPN). 31P NMR (CDCl3, 25C): delta = 130.5 (4P),-14.0(4P). Anal. Calcd. for C108H136N8O20P8 (%): C 61.36, H 6.48, N5.38. Found (%): C 61.34, H 6.43, N 5.38.

1608-26-0, As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Glushko, Valentina V.; Serkova, Olga S.; Smoyan, Gavaz N.; Vasyanina, Larisa K.; Maslennikova, Vera I.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 9; (2017); p. 1054 – 1060;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 816 mg (5 mmol) of tris (dimethylamino) phosphine in 10 mL of dry tetrahydrofuran was stirred at room temperature,1.42 g (10 mmol) of methyl iodide was added to the solution,And the mixture was further stirred at room temperature for 6 hours.After completion of the reaction,The residue obtained by distilling off the solvent was vacuum-dried at 40 C. for 12 hours to obtain 1.54 g (100% yield) of methyltris (dimethylamino) phosphonium iodide as a white powder., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WAKO PURE CHEMICAL INDUSTRIES LIMITED; AOYAGI, NAOTO; ENDO, TAKESHI; (41 pag.)JP6210065; (2017); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred suspension of Ph3P (12.5 mmol, 3280 mg) in dry MeCN (25 mL) solid N-aryl-2-nitrosoaniline 5 (5 mmol) was added portionwise during 30 min under external cooling with coldwater, and the mixture was stirred at r.t. overnight. The precipitated solid was filtered off, the filtrate was concentrated under vacuum and the residue was chromatographed using hexane-EtOAc gradient elution (9:1 to 2:1). An analytically pure sample of the product was obtained by recrystallization from EtOAc-hexane.

1608-26-0, 1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; ?ukasik, Emilia; Wrobel, Zbigniew; Synthesis; vol. 48; 8; (2016); p. 1159 – 1166;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the aminobenzamidine 1 (5.0 mmol) and tris (dimthylamino) phosphine (5.0 mmol) dissolved in anhydrous toluene (10 mL) were heated under reflux for 48 h. After evaporating the solvent in vacuum, the resulting solid product was recrystallized from CCl4 (2b, 2d) or alternatively the obtained oil (2a, 2c) was purified by column chromatography using silica gel (60-120 mesh) with ethyl acetate: petroleum ether (4 : 6) as eluant., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hichri, Sarra; Abderrahim, Raoudha; Letters in Organic Chemistry; vol. 13; 4; (2016); p. 289 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tris(dimethylamino)phosphine (2.29 g, 14 mmol) was added drop-wise to a stirred solution of 2-methylprop-2-en-1-ol (1 g, 14 mmol) and CCl4 (2.46 g, 16 mmol) in dry CH2Cl2 (30 mL) cooled at -30 C. Then, 15 mL of distilled water was added and the reaction mixture was allowed to proceed at room temperature for 2 h. Organic phase was decanted and extracted with water (2 * 40 mL). Aqueous phases were collected, washed with Et2O and decanted to give an aqueous solution of methallyloxyphosphonium chloride. After the addition of KPF6 (3.68 g, 20 mmol) in 10 mL of water, an immediate precipitate was formed. The mixture was filtered and the crude product was washed with Et2O and dried under vacuum. Recrystallization from a mixture of chloroform: Et2O solution afforded salt 2 as a white solid., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Dridi, Sana; Mechria, Ali; Sgarbossa, Paolo; Bertani, Roberta; Msaddek, Moncef; Journal of Organometallic Chemistry; vol. 819; (2016); p. 255 – 259;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EMBODIMENT I (1R,cis)-2-[2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropyl]ethanal dimethyl acetal Tri(dimethylamino)phosphine (168.3 mmol) was added over a period of 12 minutes to a stirred solution of carbon tetrachloride (167.4 mmol) in pentane (360 ml) kept at 0 C. under nitrogen in a 1-liter flask. Then, the mixture in the flask was stirred for 30 minutes at 0 C. This finished the first step. At 0 C. (1R,cis)-2-(2,2-dimethoxyethyl)-3,3-dimethylcyclopropanecarbaldehyde (66.4 mmol) was added dropwise to the suspension in the flask over a period of nine minutes. The temperature was increased to 12 C. over a period of 15 minutes and stirring was continued at the temperature for a further 15 minutes. This finished the second step. Then water (75 ml) was added at 12 C. and–after removal of the aqueous phase–the organic phase was washed with two 35-ml portions of water. The washed organic phase was dried over anhydrous magnesium sulphate and the solvent was evaporated from the dried solution to give a residue (17.4 g) containing the desired product (100% (1R,cis), purity 88%, yield 91.1%). The NMR spectrum of the desired product showed the following absorptions: delta=1.00 ppm singlet H3 C–C–CH3 delta=3.33 ppm singlet C–(O–CH3)2 delta=5.59 ppm doublet C=CH delta=1.13 ppm singlet H3 C–C–CH3 delta=4.33 ppm triplet (H3 C–O)2 –CH– multiplets for the two H atoms bound to the ring and for HC–CH2 –CH., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shell Oil Company; US4298757; (1981); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate