Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.Recommanded Product: 2-Chloronicotinoyl chloride.

Twenty [1,2,4]triazolo[4,3-a]pyridines I (R = C6H5, 2-ClC6H4, 2-Cl,4-FC6H3, etc,) were designed, synthesized and screened as Smoothened (Smo) inhibitors. Four of these novel compounds exhibited directly bound to Smo protein with stronger binding affinity than Vismodegib (VIS). The new compounds exhibited broad anti-proliferative activity against cancer cell lines in vitro, especially triple-neg. breast cancer cells. Mechanistic studies demonstrated that I (R = 2,6-di-Cl-pyridine) markedly induced cell cycle arrest and apoptosis in MDA-MB-468 cells. Compound I (R = 2,6-di-Cl-pyridine) blocked Smo translocation into the cilia and reduced Smo protein and mRNA expression. Furthermore, the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1) was significantly inhibited. Finally, I (R = 2,6-di-Cl-pyridine) demonstrated greater anti-tumor activity in authors’ animal models than VIS with lower toxicity. Hence, these results support further optimization of this novel scaffold to develop improved Smo antagonists.

The article 《Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo》 also mentions many details about this compound(49609-84-9)Recommanded Product: 2-Chloronicotinoyl chloride, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]) to get more information.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 49609-84-9, is researched, SMILESS is O=C(Cl)C1=CC=CN=C1Cl, Molecular C6H3Cl2NOJournal, Article, Scientific Reports called Dual-active antifungal agents containing strobilurin and SDHI-based pharmacophores, Author is Zuccolo, Marco; Kunova, Andrea; Musso, Loana; Forlani, Fabio; Pinto, Andrea; Vistoli, Giulio; Gervasoni, Silvia; Cortesi, Paolo; Dallavalle, Sabrina, the main research direction is Pyricularia Sclerotinia strobilurin SDHi pharmacophore antifungal.Recommanded Product: 2-Chloronicotinoyl chloride.

Crop disease management often implies repeated application of fungicides. However, the increasing emergence of fungicide-resistant pathogens requires their rotation or combined use. Tank-mix combinations using fungicides with different modes of action are often hard to manage by farmers. An alternative and unexploited strategy are bifunctional fungicides, i.e. compounds resulting from conjugation of the pharmacophores of fungicides with different mechanisms of action. In this paper we describe a new approach to antifungal treatments based on the synthesis of dual agents, obtained by merging the strobilurin and succinate dehydrogenase inhibitor pharmacophores into a new entity. The compounds were tested against important fungal plant pathogens and showed good inhibition of Pyricularia oryzae and Sclerotinia sclerotiorum with activity comparable to com. fungicides. The inhibition of the cytochrome bc1 and the succinate dehydrogenase enzyme activity confirmed that the new mols. are endowed with a dual mechanism of action. These results were further supported by mol. modeling which showed that selected compounds form stable complexes with both cytochrome b subunit and succinate dehydrogenase enzyme. This work can be considered an important first step towards the development of novel dual-action agents with optimized structure and improved interaction with the targets.

Different reactions of this compound(2-Chloronicotinoyl chloride)Recommanded Product: 2-Chloronicotinoyl chloride require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Application In Synthesis of 5-Chloropicolinaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents. Author is Dong, Shiyang; Liu, Yanhua; Xu, Jun; Hu, Yue; Huang, Limin; Wang, Zengtao.

Background: Epilepsy is a serious and common neurol. disorder threatening the health of humans. Despite enormous progress in epileptic research, the anti-epileptic drugs present many limitations. These limitations prompted the development of more safer and effective AEDs. Methods: A series of N-substituted (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)- 2-thioxothiazolidin-4- one derivatives and 5-substituted-thioxothiazolidindione derivatives were designed, synthesized and tested for anticonvulsant activity against maximal electroshock (MES) and s.c. pentylenetetrazole (scPTZ). Neurotoxicity was determined by the rotarod test. Results: Among them, the most potent 4e displayed high protection against MES-induced seizures with an ED50 value of 9.7 mg/kg and TD50 value of 263.3 mg/kg, which provided 4e with a high protective index (TD50/ED50) of 27.1 comparable to reference antiepileptic drugs. 4e clearly inhibits the NaV1.1 channel in vitro. The mol. docking study was conducted to exploit the results. Conclusion: Stiripentol is a good lead compound for further structural modification. Compound 4e was synthesized, which displayed remarkable anticonvulsant activities, and the NaV1.1 channel inhibition was involved in the mechanism of action of 4e.

Different reactions of this compound(5-Chloropicolinaldehyde)Application In Synthesis of 5-Chloropicolinaldehyde require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Formula: C6H3Cl2NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by ZnO.

An efficient method for the synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by nano-ZnO under solvent-free condition at room temperature was described. The method is compatible with a range of ethers including tricyclic ethers, tetracyclic ethers, pentacyclic ethers and hexacyclic ethers and have afforded the products with moderate to good yields. The ZnO could be reused up to three times and the product yield after three cycles is 87%.

Different reactions of this compound(2-Chloronicotinoyl chloride)Formula: C6H3Cl2NO require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Electric Literature of C6H3Cl2NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Copper-catalyzed synthesis of 2-aminopyridylbenzoxazoles via domino reactions of intermolecular N-arylation and intramolecular O-arylation. Author is Lu, Ju-You.

A simple and general approach to nitrogen-containing heterocycles via copper-catalyzed domino reaction has been developed, and the corresponding 2-aminopyridylbenzoxazole derivatives I (Z = W = CH, N; R = Me, Et, Ph, etc.; R1 = H, 4-Me, 5-CF3, etc.; R2 = H, 4-Cl) were obtained in good to excellent yields using the readily available starting materials II ( X = Y= Br, Cl; Z = W = CH, N; R1 = H, 4-Me, 5-CF3, etc; R2 = H, 5-Cl) and amines RNH2 (R = Me, Et, Ph, etc.). This method possesses unique step economy features, and is of high tolerance towards various functional groups in the substrates.

Different reactions of this compound(2-Chloronicotinoyl chloride)Electric Literature of C6H3Cl2NO require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Vieira Dos Santos, Maria Clara; Horta, Joana; Moura, Luisa; Pires, David V.; Conceicao, Isabel; Abrantes, Isabel; Costa, Soiia R. researched the compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol( cas:1824-94-8 ).Electric Literature of C7H14O6.They published the article 《An integrative approach for the selection of Pochonia chlamydosporia isolates for biocontrol of potato cyst and root knot nematodes》 about this compound( cas:1824-94-8 ) in Phytopathologia Mediterranea. Keywords: Pochonia chlamydosporia Meloidogyne Globodera potato cyst root knot biocontrol. We’ll tell you more about this compound (cas:1824-94-8).

The nematophagous fungus Pochonia chlamydosporia, a natural enemy of plant parasitic nematodes (PPN) , has been exploited in the development of sustain-able management strategies for PPN control. The intrinsic variation among P. chlamydosporia isolates affects biocontrol potential, so sound characterization is required. Biol., mol. and metabolic analyses can be determinant in the screening and selection of these potential biol. control agents. This study aimed to provide integrative characterization of P. chlamydosporia isolates that can support isolate selection for biol. control purposes. Eight Portuguese isolates, associated with Meloidogyne spp., were used as a case study. Isolates were identified and characterised:i at the biol. level through standard bioassays to evaluate their ability for rhizosphere colonisation, to produce chlamydospores, and to parasitise Globodera pallida and Meloidogyne incognita eggs; ii at the mol. level, examining genetic variation using ERIC-PCR; and iii at the metabolic level, assessing their metabolic profiles using Biolog FF MicroPlates, with concurrent reads of fungal utilization of 95 different carbon sources. Mol. data and metabolic characterization were reduced using Principal Component Anal. and compared with the biol. characteristics. Mol. profiles could only be related to isolate geog. origin, but the original substrate (eggs or roots), parasitism of M. incognita eggs and ability for rhizosphere colonisation were correlated with metabolic profiles, indicative of utilization of specific carbon sources. Meloidogyne egg parasitism and rhizosphere colonisation were related to each other. This integrative characterization offers novel perspectives on the biol. and biocontrol potential of P. chlamydosporia, and, once tested on a broader set of isolates, could be used to assist rapid isolate selection.

Different reactions of this compound((2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol)Electric Literature of C7H14O6 require different conditions, so the reaction conditions are very important.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Category: chiral-phosphine-ligands. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Photoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones. Author is Yang, De-Yong; Liu, Liang; Gu, Jia-Yi; He, Yan-Hong; Guan, Zhi.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

The article 《Photoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones》 also mentions many details about this compound(49609-84-9)Category: chiral-phosphine-ligands, you can pay attention to it, because details determine success or failure

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1824-94-8, is researched, SMILESS is O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC, Molecular C7H14O6Journal, Aquaculture called Growth and metabolomic responses of Pacific white shrimp (Litopenaeus vannamei) to different dietary fatty acid sources and salinity levels, Author is Chen, Ke; Li, Erchao; Xu, Chang; Wang, Xiaodan; Li, Huifeng; Qin, Jian G.; Chen, Liqiao, the main research direction is Litopenaeus dietary fatty acid salinity growth metabolomic analysis.Quality Control of (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol.

The outstanding benefits of and strong interest in the inland low-salinity culture of penaeid shrimp have led to the growth of this industry worldwide. This study aimed to explore the effects of dietary fatty acids on shrimp in low-salinity culture. Individuals of the marine white shrimp Litopenaeus vannamei were fed one of three diets (coconut oil, fish oil, or an equal mixture of both) of differing fatty acid profiles for eight weeks while being maintained at two different salinities (3 or 30 psu). Then, a GC-TOF/MS-based metabolomics anal. was performed to reveal the regulatory roles of fatty acids in shrimp growth, survival and osmoregulation at two salinities. The shrimp fed the mixed oil diet had higher weight gain and survival, and those fed the diet with only fish oil added exhibited higher unsaturated fatty acid levels in the gills and hepatopancreas irresp. of salinity. Na+/K+-ATPase and total ATPase activities were lowest in the shrimp fed the mixed oil diet at both salinities. When coconut oil was the only lipid source, shrimp tissues contained higher tyrosine, lysine and serine levels at 3 psu than at 30 psu. In contrast, the shrimp fed fish oil as the sole lipid source had higher glucose at 3 psu than at 30 psu. This study indicates that appropriate supplementation of dietary unsaturated and saturated fatty acids can improve shrimp osmoregulation capacity and thus promote shrimp growth and survival in low-salinity water.

The article 《Growth and metabolomic responses of Pacific white shrimp (Litopenaeus vannamei) to different dietary fatty acid sources and salinity levels》 also mentions many details about this compound(1824-94-8)Quality Control of (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, you can pay attention to it, because details determine success or failure

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Related Products of 1824-94-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, is researched, Molecular C7H14O6, CAS is 1824-94-8, about Gas phase dynamics, conformational transitions and spectroscopy of charged saccharides: the oxocarbenium ion, protonated anhydrogalactose and protonated methyl galactopyranoside. Author is Dvores, M. P.; Carcabal, P.; Maitre, P.; Simons, J. P.; Gerber, R. B..

Protonated intermediates are postulated to be involved in the rate determining step of many sugar reactions. This paper presents a study of protonated sugar species, isolated in the gas phase, using a combination of IR multiple photon dissociation (IRMPD) spectroscopy, classical ab initio mol. dynamics (AIMD) and quantum mech. vibrational SCF (VSCF) calculations It provides a likely identification of the reactive intermediate oxocarbenium ion structure in a D-galactosyl system as well as the saccharide pyrolysis product anhydrogalactose (that suggests oxocarbenium ion stabilization), along with the spectrum of the protonated parent species: Me D-galactopyranoside-H+. Its vibrational fingerprint indicates intramol. proton sharing. Classical AIMD simulations for galactosyl oxocarbenium ions, conducted in the temperature range ∼300-350 K (using B3LYP potentials on-the-fly) reveal efficient transitions on the picosecond timescale. Multiple conformers are likely to exist under the exptl. conditions and along with static VSCF calculations, they have facilitated the identification of the individual structural motifs of the galactosyl oxocarbenium ion and protonated anhydrogalactose ion conformers that contribute to the observed exptl. spectra. These results demonstrate the power of exptl. IRMPD spectroscopy combined with dynamics simulations and with computational spectroscopy at the anharmonic level to unravel conformer structures of protonated saccharides, and to provide information on their lifetimes.

After consulting a lot of data, we found that this compound(1824-94-8)Related Products of 1824-94-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Ye, Xin; Chen, Jiani; Hu, Chaoyang; Xu, Nianjun; Sun, Xue published the article 《Promotion of the Rapid Growth in Haematococcus pluvialis Under 0.16% CO2 Condition Revealed by Transcriptome and Metabolomic Analysis》. Keywords: Haematococcus growth transcriptomics metabolomics carbondioxide.They researched the compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol( cas:1824-94-8 ).Computed Properties of C7H14O6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1824-94-8) here.

The unicellular green alga Haematococcus pluvialis is considered the optimal natural source of astaxanthin, a strong antioxidant in nature. In the present study, transcriptome and metabolic profiling of H. pluvialis under 0.16% and 0.04% CO2 levels were performed to explore the underlying mechanism by which CO2 affects growth at the vegetative stage of this alga. Approx. 1665 differentially expressed unigenes were screened in response to different CO2 conditions by transcriptome anal. The genes related to photosynthesis, the tricarboxylic acid (TCA) cycle, glycolysis, pentose phosphate pathway, and nitrogen metabolism, were mostly up-regulated by 0.16% CO2. A total of 36 differential metabolites were identified in metabolic profiling, of them, citric acid and ribose were accumulated; however, 12 common amino acids and stress-resistant related substrates such as ornithine and putrescine were decreased at 0.16% CO2 level. Combing the results of the algal growth, the elevated CO2 promoted photosynthesis, and carbon utilization including TCA cycle and glycolysis, together with the stimulated nitrogen metabolism, protein synthesis, and energy metabolism, which resulted in rapid growth of H. pluvialis.

After consulting a lot of data, we found that this compound(1824-94-8)Computed Properties of C7H14O6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate