Tag: M.W:100-200

Computed Properties of C7H14O6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, is researched, Molecular C7H14O6, CAS is 1824-94-8, about Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes. Author is Cosgrove, Sebastian C.; Mattey, Ashley P.; Riese, Michel; Chapman, Michael R.; Birmingham, William R.; Blacker, A. John; Kapur, Nikil; Turner, Nicholas J.; Flitsch, Sabine L..

Galactose Oxidase (GOase) has been used for the scalable and selective C-6′ oxidation of lactose, a waste material from the dairy industry. Generation of the 6′-oxo lactose was achieved with full conversion in batch mode at milligram scale, but further scale-up to gram quantities proved to be challenging because of requirements for high enzyme concentrations and limitation in oxygen cosubstrate availability. To overcome these issues, a continuous-flow system was developed for the bio-oxidation of lactose yielding multigram quantities of product. Using the variant GOase F2, terminal selective oxidations were also observed on a range of oligoglucosides such as maltose. The carbohydrate dialdehydes that were obtained by this highly selective oxidation were chem. further functionalized, establishing the biooxidation as a route to valorize cheap carbohydrates, including waste materials, for building blocks of polymers.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloronicotinoyl chloride( cas:49609-84-9 ) is researched.Electric Literature of C6H3Cl2NO.Takale, Balaram S.; Thakore, Ruchita R.; Mallarapu, Rushil; Gallou, Fabrice; Lipshutz, Bruce H. published the article 《A sustainable 1-pot, 3-step synthesis of boscalid using ppm level Pd catalysis in water》 about this compound( cas:49609-84-9 ) in Organic Process Research & Development. Keywords: boscalid preparation; reduction Suzuki Miyaura cross coupling acylation. Let’s learn more about this compound (cas:49609-84-9).

Herein is disclosed a 1-pot, 3-step route for the synthesis of boscalid using nanomicelles in water as the reaction medium, and a very low loading (700 ppm or 0.07 mol %) of costly and endangered Pd. The developed sequence involves an initial Suzuki-Miyaura cross-coupling, the product from which is not isolated. The second step relies on a carbonyl iron powder (CIP) reduction of the aryl nitro group, followed by the third and final step involving an acylation with the required chloronicotinyl chloride. The overall isolated yield for these three steps is 83%.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

SDS of cas: 1824-94-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, is researched, Molecular C7H14O6, CAS is 1824-94-8, about Evaluation of MIC, MBC, MFC and anticancer activities of acylated methyl β-D-galactopyranoside esters. Author is Misbah, M. H. Md; Ferdous, Jannatul; Bulbul, Z. H. Md; Chowdhury, Tasneem S.; Dey, Sujan; Hasan, Imtiaj; Kawsar, Sarkar M. A..

A bacterial resistance gained by microorganisms to classical antimicrobials is current challenges. Searching of antimicrobial agents with new structure and mode of action is an essential strategy of research. Therefore, some acylated derivatives of Me β-D-galactopyranoside were employed as test compounds for in vitro antimicrobial functionality test against five human pathogenic bacteria and two phytopathogenic fungi.For comparative studies, biol. activity of standard antibiotics, Azithromycin and Nystatin were also carried out against these microorganisms. The study revealed that the tested samples exhibited moderate to good antibacterial and antifungal activities. It was also observed that the test substances were more effective against fungal phytopathogens than those of the bacterial strains. Encouragingly, a good number of test compounds exhibited better antimicrobial activity than the standard antibiotics employed. Min. Inhibition Concentration (MIC) and MBC test of Me 2,3,4-tri-O-(3-chlorobenzoyl)-6-O-pivaloyl-β-D-galactopyranoside 12 was conducted good result against S. aureus and MIC, MBC were found to be 312.5 μg/disk and 625 μg/disk, resp. In addition, MFC was invented to be 1250 μg/disk against Candida albicans. In vitro MTT assays revealed that compound 8 was effective against Ehrlich′s ascites carcinoma (EAC) cells, resulting in 12.72% and 2.11% cell growth inhibition at concentrations of 200 and 6.25 μg/mL, resp. So the acylated derivatives of D-galactopyranoside (2-14) may be considered as a potential source for developing new and better antimicrobial agents against a number of pathogenic organisms.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: 5-Chloropicolinaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Facile One Pot Multi-Component Solvent-Free Synthesis of 2,4,5-Trisubstituted Imidazoles Using “”Green”” and Expeditious Ionic Liquid Catalyst under Microwave Irradiation. Author is Sonyanaik, B.; Ashok, K.; Rambabu, S.; Ravi, D.; Kurumanna, A.; Madhu, P.; Sakram, B..

Acetic acid functionalized poly(4-vinylpyridinium) bromide is a highly efficient and recyclable catalyst for the construction of 2,4,5-trisubstituted imidazole derivatives I (Ar = Ph, 3-indolyl, 5-methylpyridin-2-yl, etc.) by a three-component condensation of benzyl with various aldehydes ArCHO and ammonium acetate under solventless conditions. The microwave initiated process leads to anal. pure compounds within 2-5 min. The advantages of this “”green”” methodol. are cost-effectiveness, simple procedure, low energy consumption, no involvement of organic solvents, safe operation, clean reaction profile, high yields, and recyclability of the catalyst.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical & Pharmaceutical Bulletin called Synthesis and pharmacological evaluation of 3-[(4-oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile derivatives as orally active AMPA receptor antagonists, Author is Inami, Hiroshi; Shishikura, Jun-ichi; Yasunaga, Tomoyuki; Hirano, Masaaki; Kimura, Takenori; Yamashita, Hiroshi; Ohno, Kazushige; Sakamoto, Shuichi, which mentions a compound: 49609-84-9, SMILESS is O=C(Cl)C1=CC=CN=C1Cl, Molecular C6H3Cl2NO, Computed Properties of C6H3Cl2NO.

3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile derivatives I [R = 4-Me, 4-F, 4-Br, etc.] were synthesized and administered them to mice to evaluate their anticonvulsant activity in maximal electroshock (MES)- and pentylenetetrazol (PTZ)-induced seizure tests, and their effects on motor coordination in a rotarod test. compounds I [R = 4-trifluoromethoxy, 2,2-difluoro-2H-1,3-benzodioxol-5-yl] exhibited potent anticonvulsant activity in both seizure tests and induced minor motor disturbances as indicated in the rotarod test. The protective index values of I [R = 4-trifluoromethoxy, 2,2-difluoro-2H-1,3-benzodioxol-5-yl] for MES-induced seizures (10.7 and 12.0, resp.) and PTZ-induced seizures (6.0 and 5.6, resp.) were considerably higher compared with those of YM928 and talampanel.

If you want to learn more about this compound(2-Chloronicotinoyl chloride)Computed Properties of C6H3Cl2NO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(49609-84-9).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Category: chiral-phosphine-ligands. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin. Author is Jin, Yan; Ding, Yin-hao; Dong, Jing-jing; Wei, Yan; Hao, Shuang-hong; Feng, Bai-cheng.

This study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds have been characterized by 1H NMR, 13C NMR, ESI-MS and elemental anal. Meanwhile, their agricultural activity have been evaluated in two weeds (Amaranth and Crabgrass) and four widespread noxious pathogens (V. mali, B. cinerea, F. oxysporium and C. bacteria). The herbicidal activity results showed that almost all synthetic mols. have a greater impact on the stem system than on the root. Excellent inhibition rates were discovered from compounds and against Amaranth on stems, which were above 58%(20 mg/L), 68%(100 mg/L) resp. Compounds and also exhibited striking inhibition on stems growth of both weeds. Anti-pathogenic activity showed that all the compounds exerted a better inhibitory activity on B. cinerea at 20 ppm compared to control carbendazim. All the heterocyclic substituted compounds (>57%) made a better influence than the control (54.1%) at the100 ppm. This research provides promising herbicidal and anti-pathogenic agents that have the better effects and can be potential for further development.

If you want to learn more about this compound(2-Chloronicotinoyl chloride)Category: chiral-phosphine-ligands, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(49609-84-9).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloronicotinoyl chloride(SMILESS: O=C(Cl)C1=CC=CN=C1Cl,cas:49609-84-9) is researched.Synthetic Route of C10H12ClIN2O2. The article 《Synthesis and evaluation of biological properties of 2-(2-(phenoxy)pyridin-3-yl)quinazolin-4(3H)-one derivatives》 in relation to this compound, is published in Heterocycles. Let’s take a look at the latest research on this compound (cas:49609-84-9).

A series of novel title compounds I (R = 3,5-(Me)2, 2-F, 4-I, etc.) was designed and synthesized as antitumor agents. The antitumor activities of target compounds I were evaluated and compared with pos. drug Gefitinib employing standard MTT assay against A549 (human lung adenocarcinoma cell), PC-3 (prostate cancer cells), K562 (human chronic myeloid leukemia cells), HepG2 (human liver cancer cell) cancer cell lines in vitro. The pharmacol. screening results revealed that many compounds exhibited moderate levels of antitumor activities against four cancer cell lines, especially compound I (R = 3,5-(Me)2) displayed promising activities against A549 (IC50 = 12.47±2.86μM) than Gefitinib (IC50 = 17.37±6.01μM). The mechanism and the apoptosis inducing effect of I (R = 3,5-(Me)2) against A549 cell line were studied. The results showed that I (R = 3,5-(Me)2) could inhibit migration and motility of cancer cells, induce cell apoptosis and exhibit the typical apoptotic morphol.

If you want to learn more about this compound(2-Chloronicotinoyl chloride)Category: chiral-phosphine-ligands, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(49609-84-9).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Recommanded Product: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, is researched, Molecular C7H14O6, CAS is 1824-94-8, about Carbohydrate recognition of C3-symmetrical tripodal receptor-type 2,4,6-trisubstituted 1,3,5-triazine derivatives with antiviral activities. Author is Mibu, Nobuko; Ohata, Tomonori; Sano, Marina; Zhou, Jian-Rong; Yokomizo, Kazumi; Aki, Hatsumi; Sumoto, Kunihiro.

In our search for new bioactive compounds that interfere with the sugar recognition process, we have designed and synthesized C3- and Cs-sym. tripodal receptor-type mols. Among the synthesized C3-sym. 2,4,6-trisubstituted 1,3,5-triazine (TAZ) derivatives, compounds A [2,4,6-tris(2-propoxy)-TAZ] and B [2,4,6-tris(3,4-dimethoxyphenyl)-TAZ] showed high levels of anti-HSV-1 activity. We carried out isothermal titration calorimetry on compound B·HCl in aqueous 25% 2-PrOH solution with some sugar derivatives including Me α/β-D-galactopyranoside (MeO-α/β-Gal), Me α/β-D-mannopyranoside (MeO-α/β-Man) and Me α/β-D-glucopyranoside (MeO-α/β-Glc). The reactions of compound B·HCl with MeO-β-Gal and MeO-α-Man were exothermic, and the obtained thermodn. profiles indicated that both reactions are spontaneous and that there is a considerably large enthalpic contribution (ΔH) in total Gibbs free energy change (ΔG), indicating favorable hydrogen bonding interactions. The reaction of compound B·HCl showed a thermodn. signature different from that of the entropically driven reaction of compound A.

If you want to learn more about this compound((2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol)Recommanded Product: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1824-94-8).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Safety of 2-Chloronicotinoyl chloride. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloronicotinoyl chloride, is researched, Molecular C6H3Cl2NO, CAS is 49609-84-9, about α-Arylation of (hetero)aryl ketones in aqueous surfactant media. Author is Wood, Alex B.; Roa, Daniel E.; Gallou, Fabrice; Lipshutz, Bruce H..

The α-arylation reactions can be performed in water and enabled by a designer surfactant under mild conditions and in the absence of organic co-solvents. Multitude of aryl and heteroaryl ketones such as propiophenone, 6,7-dihydro-4-benzo[b]thiophenone, 1-thiazol-2-yl-propan-1-one, 2-(1-benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one, etc. are amenable to coupling with functionalized aryl halides ArBr (Ar = naphthalen-2-yl, 4-(morpholin-4-yl)benzen-1-yl, pyridin-3-yl, 1-benzyl-1H,2H,3H-pyrrolo[2,3-b]pyridin-5-yl, etc.). Use of a lipophilic base that can gain entry to the micellar inner cores mediates enolization. In some cases, palladium loadings as low as 2500 ppm (0.25 mol%) are sufficient for coupling in a completely recyclable medium, exemplifying chem. in water.

If you want to learn more about this compound(2-Chloronicotinoyl chloride)Safety of 2-Chloronicotinoyl chloride, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(49609-84-9).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

He, Zhangxu; Qiao, Hui; Yang, Feifei; Zhou, Wenjuan; Gong, Yunpeng; Zhang, Xinhui; Wang, Haojie; Zhao, Bing; Ma, Liying; Liu, Hong-min; Zhao, Wen published the article 《Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent》. Keywords: thiosemicarbazone diastereoselective preparation antitumor activity SAR cytotoxicity apoptosis; Apoptosis; Migration; Proliferation; Selectivity; Thiosemicarbazone.They researched the compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ).HPLC of Formula: 31181-89-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:31181-89-2) here.

A series of novel thiosemicarbazone derivatives I [R1 = Ph, benzyl, phenylethyl,etc.; R2 = 2-pyridyl, 3-methyl-2-pyridyl, 4-methyl-2-pyridyl,etc.; R3 = H, Me] containing indole fragment were designed and synthesized. Most compounds exhibited excellent antiproliferative activity against PC3, MGC803 and EC109 cell lines with low micromolar IC50 (0.14-12μM). Especially, compound I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] can selectively inhibit PC3 cells in three tested tumor cells with IC50 value of 0.14 μM, which was attributed to a synergistic effect after introducing indole fragment into the TSC structure. Meanwhile, compound I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] displayed more selectivity in PC3 cells toward two normal WPMY-1 and GES-1 cell lines, compared to those of 3-AP and DPC. It was also found that I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] can effectively inhibit PC3 cell proliferation, colonization and induce apoptosis. Compound I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] may significantly suppress migration and invasion by blocking the EMT process but had no effect on cell cycle. Collectively, this findings indicated that I [R1 = 2-(5-chloro-1H-indol-3-yl)ethyl; R2 = 5-methyl-2-pyridyl; R3 = H] with structure of thiosemicarbazone containing indole may serve as a useful anticancer lead for further optimization and development.

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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate