Tag: M.W:100-200

Lv, Jian; Zhu, Jia-Jia; Liu, Yu; Dong, Hai published the article 《Regioselective Sulfonylation/Acylation of Carbohydrates Catalyzed by FeCl3 Combined with Benzoyltrifluoroacetone and Its Mechanism Study》. Keywords: catalyst regioselective benzoylation sulfonylation acylation benzoyltrifluoroacetone iron chloride.They researched the compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol( cas:1824-94-8 ).Reference of (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1824-94-8) here.

A catalytic amount of FeCl3 combined with benzoyl trifluoroacetone (Hbtfa) (FeCl3/Hbtfa = 1/2) was used to catalyze sulfonylation/acylation of diols and polyols using diisopropylethylamine (DIPEA) or potassium carbonate (K2CO3) as a base. The catalytic system exhibited high catalytic activity, leading to excellent isolated yields of sulfonylation/acylation products with high regioselectivities. Mechanism studies indicated that FeCl3 initially formed [Fe(btfa)3] (btfa = benzoyl trifluoroacetonate) with twice the amount of Hbtfa under basic conditions in the solvent acetonitrile at room temperature All key intermediates were captured in the high-resolution mass spectrometry assay, therefore demonstrating this mechanism for the first time.

Here is just a brief introduction to this compound(1824-94-8)Reference of (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, more information about the compound((2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Category: chiral-phosphine-ligands. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists. Author is Wilson, Robert J.; Jecs, Edgars; Miller, Eric J.; Nguyen, Huy H.; Tahirovic, Yesim A.; Truax, Valarie M.; Kim, Michelle B.; Kuo, Katie M.; Wang, Tao; Sum, Chi Shing; Cvijic, Mary E.; Paiva, Anthony A.; Schroeder, Gretchen M.; Wilson, Lawrence J.; Liotta, Dennis C..

CXCR4 is the most common chemokine receptor expressed on the surface of many cancer cell types. In comparison to normal cells, cancer cells overexpress CXCR4, which correlates with cancer cell metastasis, angiogenesis, and tumor growth. CXCR4 antagonists can potentially diminish the viability of cancer cells by interfering with CXCL12-mediated pro-survival signaling and by inhibiting chemotaxis. Herein, a series of CXCR4 antagonists, i.e. I, are described that are derived from (S)-5,6,7,8-tetrahydroquinolin-8-amine that has prevailed in the literature. This series removes the rigidity and chirality of the tetrahydroquinoline providing 2-(aminomethyl)pyridine analogs, which are more readily accessible and exhibit improved liver microsomal stability. The medicinal chem. strategy and biol. properties are described.

Here is just a brief introduction to this compound(31181-89-2)Category: chiral-phosphine-ligands, more information about the compound(5-Chloropicolinaldehyde) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 31181-89-2, is researched, Molecular C6H4ClNO, about Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation-Deuteration of Heterobenzylic Methylenes, the main research direction is secondary alc preparation chemoselective hydroxylation deuteration heterobenzylic methylenes.Application In Synthesis of 5-Chloropicolinaldehyde.

We developed an approach for direct selective hydroxylation of heterobenzylic methylenes to secondary alcs. avoiding overoxidn. to ketones by using a KOBu-t/DMSO/air system. Most reactions could reach completion in several minutes to give hydroxylated products in 41-76% yields. Using DMSO-d6, this protocol resulted in difunctionalization of heterobenzylic methylenes to afford α-deuterated secondary alcs. (>93% incorporation). By employing this method, active pharmaceutical ingredients carbinoxamine and doxylamine were synthesized in two steps in moderate yields.

Here is just a brief introduction to this compound(31181-89-2)Application In Synthesis of 5-Chloropicolinaldehyde, more information about the compound(5-Chloropicolinaldehyde) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Chai, Hongxin; Cao, Qun; Dornan, Laura M.; Hughes, N. Louise; Brown, Clare L.; Nockemann, Peter; Li, Jiarong; Muldoon, Mark J. published the article 《Cationic Palladium(II) Complexes for Catalytic Wacker-Type Oxidation of Styrenes to Ketones Using O2 as the Sole Oxidant》. Keywords: styrene palladium complex oxygen Wacker oxidation catalyst; ketone preparation.They researched the compound: 5-Chloropicolinaldehyde( cas:31181-89-2 ).SDS of cas: 31181-89-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:31181-89-2) here.

A series of new cationic palladium(II) complexes were prepared and studied for their ability to catalyze the Wacker-type oxidation of styrenes to their corresponding acetophenones using O2 as the sole oxidant. Catalysts are active at room temperature and the study highlights the importance of solvent choice and the need for ligand development in improving catalyst performance.

Here is just a brief introduction to this compound(31181-89-2)SDS of cas: 31181-89-2, more information about the compound(5-Chloropicolinaldehyde) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Electric Literature of C6H4ClNO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Nonacidic Farnesoid X Receptor Modulators. Author is Flesch, Daniel; Cheung, Sun-Yee; Schmidt, Jurema; Gabler, Matthias; Heitel, Pascal; Kramer, Jan; Kaiser, Astrid; Hartmann, Markus; Lindner, Mara; Lueddens-Daemgen, Kerstin; Heering, Jan; Lamers, Christina; Lueddens, Hartmut; Wurglics, Mario; Proschak, Ewgenij; Schubert-Zsilavecz, Manfred; Merk, Daniel.

As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. Clin. results have validated FXR as therapeutic target in hepatic and metabolic diseases. To date, potent FXR agonists share a neg. ionizable function that might compromise their pharmacokinetic distribution and behavior. Here the authors report the development and characterization of a high-affinity FXR modulator not comprising an acidic residue.

Here is just a brief introduction to this compound(31181-89-2)Electric Literature of C6H4ClNO, more information about the compound(5-Chloropicolinaldehyde) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Holmstroem, Thomas; Pedersen, Christian Marcus published an article about the compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol( cas:1824-94-8,SMILESS:O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC ).Reference of (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1824-94-8) through the article.

Novozym 435 (N435) is an immobilized lipase (Candida antarctica lipase B) capable of catalyzing transesterfications in organic media. This paper describes how this enzyme can be used for regioselective acetylation of unprotected carbohydrates providing protected monosaccharide building blocks in only one step. Unprotected thiogylcosides with both gluco, xylo, and manno stereochem. were tolerated by the enzyme and afforded the acetylated products in high yields. The regioselective acetylation was easily scaled up to a 5.0 g scale and in most cases, no purification was needed. Several other glycosides, including 2-azido-2-deoxy glucosides, galactosides, and gluconolactones, were also acetylated and the scope and limitations using N435 has been uncovered.

Here is just a brief introduction to this compound(1824-94-8)Reference of (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, more information about the compound((2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol) is in the article, you can click the link below.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 49609-84-9, is researched, Molecular C6H3Cl2NO, about Synthesis and Pharmacological Activity of 3-Phenoxybenzoic Acid Derivatives, the main research direction is phenoxybenzoic acid derivative preparation glucokinase protein glycation PPAR.SDS of cas: 49609-84-9.

3-Phenoxybenzoic acid derivatives were synthesized. Their pharmacol. activity was studied. Several compounds, in particular 2-cyanoprop-2-yl 3-phenoxybenzoate, were found to exhibit peroxisome proliferator-activated receptor γ agonist activity and to be capable of activating glucokinase and inhibiting protein glycation. The studied compounds did not influence dipeptidyl peptidase-4 activity.

Compound(49609-84-9)SDS of cas: 49609-84-9 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Chloronicotinoyl chloride), if you are interested, you can check out my other related articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Name: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol, is researched, Molecular C7H14O6, CAS is 1824-94-8, about Catalytic Site-Selective Carbamoylation of Pyranosides.

Carbamate-bearing carbohydrates contribute to the pharmacol. properties of various natural glycosides. The catalytic site-selective carbamoylation of minimally protected pyranosides was achieved for the first time to bypass protection/deprotection sequences. 1-Carbamoylimidazoles were used as the carbamoylation reagents to circumvent the harmful and unstable phosgene and isocyanates. This boronic acid catalyzed transformation granted an expedient access to the tumor cell-binding carbamoylmannoside moiety of bleomycins and analogs in yields of 56% to 89%.

Compound(1824-94-8)Name: (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol), if you are interested, you can check out my other related articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Bioconjugate Chemistry called Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis, Author is Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas, which mentions a compound: 31181-89-2, SMILESS is O=CC1=NC=C(Cl)C=C1, Molecular C6H4ClNO, SDS of cas: 31181-89-2.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Compound(31181-89-2)SDS of cas: 31181-89-2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Chloropicolinaldehyde), if you are interested, you can check out my other related articles.

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloropicolinaldehyde, is researched, Molecular C6H4ClNO, CAS is 31181-89-2, about Design, synthesis and biological activity evaluation of a new class of 2,4-thiazolidinedione compounds as insulin enhancers.Synthetic Route of C6H4ClNO.

Diabetes mellitus (DM) is a global disease with a high incidence of type 2 diabetes. Current studies have shown that insulin enhancers play an important role in the treatment of type 2 diabetes and have great importance in the improvement of type 2 diabetes. In this research, Rosiglitazone was taken as the lead compound, and the structure was modified by using the bioisostere principle, and a new class of 2,4-thiazolanedione compound was designed and synthesized. The novel series of compounds were studied for their biol. activities in vitro and in vivo. In vitro tests, the biol. activities showed that the target compounds have good selective activation of peroxisome-proliferator-activated receptor γ (PPARγ), such as the compounds , , , and , especially the compound to PPARγ was EC50 = 0.03 ± 0.01 μmol/L in vitro. Then, in vivo biol. activities’ test results showed that the tendency of increasing in blood sugar had an obvious inhibiting effect, and had a significant insulin hypoglycemic effect of enhancing and extending the exogenous. In addition, the results of cytotoxicity tests and acute toxicity tests (LD50) showed that these compounds belong to the low toxicity compounds

From this literature《Design, synthesis and biological activity evaluation of a new class of 2,4-thiazolidinedione compounds as insulin enhancers》,we know some information about this compound(31181-89-2)Synthetic Route of C6H4ClNO, but this is not all information, there are many literatures related to this compound(31181-89-2).

Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate