Tag: 855-38-9

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

EXAMPLE 14 N-(4-Fluorophenyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide The procedure was as described in Example 4. 4.92 g of crude product was obtained in the form of a light yellow solid from 3.47 g (12.5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine, 2.08 g (18.7 mmol) of 4-fluoroaniline, 1.46 g (13.8 mmol) of sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 0.13 g (375 mumol) of tris(4-methoxyphenyl)phosphine in 12.5 ml of xylene after 21 hours at 150 C. under a CO pressure of 19 bar (GC: complete conversion). It was purified by recrystallization from methylcyclohexane. The yield was 3.97 g (84.4 percent) of light beige crystals. Other data concerning the product was: M.p.: 138-139 C. 1 H NMR (CDCl3): delta=3.85 (s, 3H); 6.41 (s, 1H); 7.06 (m, 2H); 7.29 (d, J=8.1 Hz, 1H); 7.59 (m, 2H); 8.05 (t, J=8.1 Hz, 1H); 8.14 (d, J=8.1 Hz, 1H); 9.28 (bs, 1H).

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

A mixture of 0.23 g (0.6 mmol) of iodo aminoester (S)-2-(t-butyloxycarbonylamino)allyl-4-iodobutanoate (III’) and 0.42 g (1.2 mmol) of [tri-(4- methoxyphenyl)]phosphine in 0.5 mL of dry THF was stirred under argon at 80C. After three hours, 3 mL of toluene followed by 30 mL of diethyl ether were added to the mixture at room temperature. The white precipitate was washed with 2 x 25 mL of diethyl ether and purified by chromatography with a mixture of acetone / petroleum ether (3 : 7) as eluent. The phosphonium salt (II’c) was isolated in 70% yield. Pale yellow solid 31P NMR (121 MHz, CDCl3) : 5(ppm) = +21 (s).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE BOURGOGNE; JUGE, Sylvain; BAYARDON, Jerome; REMOND, Emmanuelle; ONDEL-EYMIN, Marie-Joelle; WO2013/30193; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 50 mL four-necked round-bottom flask, a magnetic stirrer bar, a Claisen distillation apparatus, a condenser, a thermometer, and a three-way stopcock were attached, and the inside was purged with nitrogen. Then, [RuCl2(p-cymene)]2 (459 mg, 0.75 mmol, 1.0 equivalents), tris(4-methoxyphenyl)phosphine (11-6) (581 mg, 1.65 mmol, 2.2 equivalents), and anhydrous THF (5 mL) were introduced sequentially, and the obtained dark red suspension was stirred at room temperature for 5 minutes. Subsequently, 2-diphenylphosphino-N-[2-(methylthio)ethyl]ethylamine (1D-1) (500 mg, 1.65 mmol, 2.2 equivalents) obtained in Example 1/Example 2 and 3M1B (10 mL) were added, and THF was removed by distillation at normal pressure using the Claisen distillation apparatus, followed by stirring for 1 hour under reflux in 3M1B.The reaction liquid was cooled to 5 C., and MeOH (20 mL) was added to the obtained yellowish orange suspension, followed by filtration by suction. Then, the crystals obtained by filtration were washed with MeOH, and dried by heating under reduced pressure to obtain 922 mg of title compound (8S-10) as a yellowish orange powder. Isolated yield: 73.5%, Purity: 99.0% by weight. Note that the major impurity was 3M1B.1H NMR (400 MHz, CD2Cl2): 31P NMR (161 MHz, CD2Cl2): delta=47.0-45.6 (m, 1P), 40.1-39.4 (m, 1P).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; NAKAYAMA, Yuji; OGATA, Osamu; (72 pag.)US2017/233418; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.30 methyl 2-phenyl-5-(4-methoxylphenyl)oxazole-4-carboxylate (4j) A suspension of Pd(OAc)2 (10 mol %), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 72 mg (47%). White solid, mp 131-132.5 C; 1H NMR (300 MHz, CDCl3) delta 3.87 (s, 3H), 3.97 (s, 3H), 7.01 (d, J=8.9 Hz, 2H), 7.46-7.48 (m, 3H), 8.12-8.15 (m, 4H) ppm; 13C NMR (75 MHz, CDCl3) delta 162.4, 160.7, 158.6, 155.1, 130.4, 129.7, 128.3, 126.2, 126.0, 119.0, 113.4, 54.9, 51.8 ppm; IR (KBr) 2962, 2926, 2855, 1729, 1465, 1330, 1261, 1108, 1069, 1020, 802, 761, 686 cm-1; HRMS (ESI) calcd for [C18H15NO4+H]+ 310.1074, found 310.1066.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of methyl iodide (1.14 g, 8 mmol) was added dropwise for 1 min to the stirringmixture of tertiary phosphine (4 mmol) in anhydrous tetrahydrofuran (16 mL) at roomtemperature. After the mixture was stirred at room temperature for 12 h, the mixture wasevaporated in vacuo. The residue was washed with ether, and the precipitate was dried invacuo for 12 h at 40 C to give corresponding quaternary phosphonium iodide as a whitepowder.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Aoyagi, Naoto; Furusho, Yoshio; Endo, Takeshi; Tetrahedron Letters; vol. 54; 51; (2013); p. 7031 – 7034;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate