Tag: 719-80-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Ethyl diphenylphosphinite (5.7 g, 0.025 mol) and diethyl ether (30 ml) were combined in a 100 ml round bottom flask equipped with a water condensor topped by a glass tee leading to a source of dry nitrogen and a mineral oil bubbler. After cooling the flask in an ice bath, 1 (7.35 g, 0.035 mol) was added. The reaction mixture was then heated at reflux for 18 h. The ether was removed by rotary evaporation at aspirator pressure to yield a clear oil which crystallized on the addition of fresh ether. The crystals were filtered and washed once with a smal portion of ice cold ether to give 5.7 g (69%) 17 (mp = 66-69 C). After recrystallization from benzene and again from Skelly B, the melting point was 68.5-69.5 C. 19F NMR (CDCl3) (ppm): delta = -59.2 (d, 2JPF = 71 Hz); 31P NMR (CDCl3) (ppm): delta = 27.5 (t, 2JPF = 71 Hz); 13C NMR (CDCl3) (ppm): delta = 123.0 (td, 1JCF = 336 Hz, 1JCP = 101 Hz), d = 125.5 (d, 1JCP = 106 Hz, a-carbon of ring), [d = 129.0 (d, JCP = 13.2 Hz) and d = 132.4 (d, JCP = 10.3 Hz) (o- and m-ring carbons)], d = 133.8 (d, 4JCP = 2.9 Hz, p-ring carbon); 1H NMR (CDCl3) (ppm): delta = 7.5-8.2 (multiplet). GC-MS, m/z (relative intensity): 201 (15), 77 (13), 39 (100); molecular ion 330, 332; intensity very low: IR (P=O) 1222 cm-1:Anal. Calcd. for C12H10OPCF2Br: C, 47.13%; H, 3.02%. Found C, 47.18%; H, 3.02%.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Flynn, Richard M.; Burton, Donald J.; Journal of Fluorine Chemistry; vol. 132; 10; (2011); p. 815 – 828;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (25 mg, 0.083 mmol), Cesium Fluoride (70 mg, 0.461 mmol), Ethoxydiphenylphosphane (78 mg, 0.33 mmol), Acetonitrile (1 ml): Reaction Time: 16 h; Rf: 0.3 (1 :3 EtOAc:Pet Ether); White Solid; 17.5 mg, 75 %; NMR (400 MHz, CDC13, TMS) delta 7.74-7.63 (m, 6H), 7.59-7.51 (m, 3H), 7.50-7.40 (m, 6H); 13C NMR (100 MHz, CDCI3, TMS) delta 132.5 (d, J = 104.0 Hz), 132.1 (d, J = 10.0 Hz), 131.9 (d, J= 2.3 Hz); 128.5 (d, J = 12.4 Hz); 31P NMR (162 MHz, CDC13) delta 29.2; Mass (M + Na)+ 301; Known Compound, Lit. K. Prokop, D. Goldberg, J. Am. Chem. Soc. 2012, 134, 8014.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; MHASKE, Santosh Baburao; DHOKALE, Ranjeet Ashokrao; WO2014/24212; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, A mixed solution of Compound 558-4 (10.0 g, 0.023 mol), nickel(II) chloride (1.79 g, 0.0138 mol), and benzonitrile was heated to 180 C. and stirred for 1 hour in a two neck round bottom flask (two neck r.b.f) under nitrogen. Ph2POEt (ethyl diphenylphosphinite) (8.48 g, 0.0368 mol) was slowly added dropwise to the above mixture and then stirred for 2 hours. The reaction mixture cooled to room temperature was extracted with MC (methylene chloride)/H2O and dried using MgSO4 and then filtered. After being concentrated, the resultant reaction product was separated by column chromatography (SiO2, hexane_MC=2:1). As a result, a white solid compound 571 (6.4 g, 58%) was obtained.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HEESUNG MATERIAL LTD.; JANG, SO HYUN; KIM, KEE YONG; HONG, JANG MI; CHOI, JIN SEOK; CHOI, DAE HYUK; EUM, SUNG JIN; LEE, JOO DONG; (114 pag.)KR101558495; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, REFERENCE EXAMPLE 1 Synthesis of o-(diphenylphosphinylmethyl)phenol In a reactor equipped with a thermometer, a stirrer and a condenser were placed 99.2 g of o-(hydroxymethyl)phenol and 400 ml of tetrahydrofuran. They were made into a uniform solution. Thereto was added 184 g of ethyldiphenylphosphinite. The resulting mixture was subjected to reaction for 3 hr with heating and stirring. The reaction mixture was cooled and the resulting white crystal precipitate was separated by filtration and then dried to obtain 180 g of o-(diphenylphosphinylmethyl)phenol. Yield: 73% Melting point: 179 C.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; US4621123; (1986); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A (the ratio of 2 : 1 in a hexane solution). Theaddition of compound 2 (0.63 g, 2.5 mmol) to a solution of ester 1b(1.15 g, 5 mmol) in hexane (3 mL) was accompanied by warmingup and deepening of the color. Trituration of the reaction mixtureled to the restructuring of the crystals. The reaction mixture wasallowed to stand at 20-25 C for 24 h, thus obtaining (3,5bistertbutyl4hydroxyphenyl)diphenylphosphoryl(diphenyl)ethoxyphosphoniomethyl ylide (3b) (0.95 g, 59%), m.p. 212-215 C(toluene-heptane, 4 : 1). Found (%): C, 75.35; H, 7.18; P, 9.45.C41H46O3P2. Calculated (%): C, 75.92; H, 7.09; P, 9.57. 31P NMR(CDCl3), delta: deltaP(1) 27.82 (2JP,P = 49.40 Hz, phosphine oxide), deltaP(2)50.49 (2J = 49.4 Hz, ylide). 1H NMR (CDCl3), delta: 1.30 (s, 18 H,CMe3); 1.70 (t, 3 H, CH3, 3JH,H = 7 Hz); 4.80 (q, 2 H, CH2,3JP,H = 3JH,H = 7 Hz); 4.95 (s, 1 H, OH); 6.92 (d, 2 H, C6H2,2JH,H = 2 Hz); 7.40-8.10 (m, 20 H, C6H5). The concentration ofthe toluene-heptane mother liquor gave (3,5bistertbutyl4hydroxyphenyl)bis(diphenylphosphoryl)methane (5b) (0.26 g,16.8%), m.p. 260-263 C (toluene; cf. Ref. 12: 262-264 C).1H NMR (CDCl3), delta: 1.25 (s, 18 H, CMe3); 4.72 (t, 1 H, CH,3JP,H = 12 Hz); 5.10 (s, 1 H, OH); 6.95 (s, 2 H, C6H2); 7.20-8.30(m, 20 H, C6H5)., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Gazizov; Ismagilov; Shamsutdinova; Tarakanova; Karimova; Russian Chemical Bulletin; vol. 65; 12; (2016); p. 2943 – 2947; Izv. Akad. Nauk, Ser. Khim.; vol. 65; 12; (2016); p. 2943 – 2947,5;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: To a solution of [Fe2(CO)6(m-SCH2CH2CH2S)] (0.039 g, 0.10 mmol) and methyl diphenylphosphinite(0.022 g, 0.10 mmol) in CH2Cl2 (5 mL) was added a solution ofMe3NO2H2O (0.011 g, 0.10 mmol) in MeCN (5 mL). The mixture was stirred at roomtemperature for 1 h and then the solvent was reduced on a rotary evaporator. Theresidue was subjected to TLC using CH2Cl2/petroleum ether 1:5 (v/v) as eluent.From the main red band, 0.045 g (78%) of 2 was obtained as a red solid. IR (CH2Cl2,cm1): mCO 2045 (vs), 1983 (vs), 1933 (m). 1H NMR (500 MHz, CDCl3): 7.78 (s, 4H, PhH),7.45 (s, 6H, PhH), 3.61 (d, J12.5 Hz, 3H, CH3), 1.88 (s, 2H, CH2), 1.63 (s, 4H, 2SCH2)ppm. 31Pf1Hg NMR (200 MHz, CDCl3, 85% H3PO4): 167.75 (s) ppm. 13Cf1Hg NMR(125 MHz, CDCl3): 213.67 (d, JP-C 13.7 Hz, PFeCO), 209.61 (s, FeCO), 139.22 (d, JP-C 42.9 Hz, i-PhC), 131.07 (d, JP-C 12.2 Hz, o-PhC), 130.73 (s, p-PhC), 128.43 (d, JP-C 9.7 Hz, m-PhC), 53.16 (s, CH3), 30.09 (s, SCH2), 22.01 (s, CH2) ppm. Anal. Calcd. forC21H19Fe2O6PS2: C, 43.93; H, 3.34. Found: C, 44.06; H, 3.52%.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yan, Lin; Hu, Meng-Yuan; Mu, Chao; Li, Ao; Liu, Xu-Feng; Zhao, Pei-Hua; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 72; 15; (2019); p. 2499 – 2516;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, To a stirred solution of CsF (64 mg, 0.42 mmol) in anhydrous acetonitrile was consecutively added 2-methoxy (o-trimethyl silyl) phenyl triflate (25 mg, 0.077 mmol) and ethoxydiphenylphosphine (61 mg, 0.31 mmol). Reaction mixture was allowed to stir at room temperature (30 C.) for 20 hrs. The reaction mixture was concentrated and directly loaded on silica gel column and purified by using solvent gradient of Pet. Ether: Ethyl Acetate (1:1) to yield a white sticky solid phosphine oxide (16 mg, 68%). Reaction Time: 20 h; Rf: 0.3 (1:1 EtOAc:Pet Ether); Thick oil; 16.0 mg, 68%; 1H NMR (400 MHz, CDCl3, TMS) delta 7.71-7.63 (m, 4H), 7.59-7.52 (m, 2H), 7.50-7.43 (m, 4H), 7.40-7.29 (m, 2H), 7.18-7.05 (m, 2H), 3.80 (s, 3H); 13C NMR (100 MHz, CDCl3, TMS) delta 159.6 (d, J=15.4 Hz), 133.8 (d, J=103.3 Hz), 132.4 (d, J=104.0 Hz), 132.1 (d, J=10.0 Hz), 131.9 (d, J=3.1 Hz), 129.6 (d, J=14.6 Hz), 128.5 (d, J=12.3 Hz), 124.4 (d, J=10.0 Hz), 118.2 (d, J=3.1 Hz), 116.7 (d, J=10.8 Hz), 55.4; 31P NMR (162 MHz, CDCl3) delta 29.5; HRMS-ESI (m/z) calcd (C19H17O2P+H)+: 309.1039 found: 309.1034; Known compound, Lit. X. Zhang, H. Liu, X. Hu, G. Tang, J. Zhu, Y. Zhao, Org. Lett. 2011, 13, 3478

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Patent; Mhaske, Santosh Baburao; Dhokale, Ranjeet Ashokrao; US2015/210725; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Example 1 Diphenyl(phthalimidomethyl)phosphine oxide IV Toluene (25 ml) was added to a mixture of ethyl diphenylphosphinite (5 g, 21.71 mmole) and the N-(bromomethy)phthalimide III (5.21 g, 21.70 mmole) at room temperature. The reaction mixture was heated to 90 C. and maintained at this temperature for 48 h when the reaction was complete as indicated from the TLC of the reaction mixture. The reaction mixture was concentrated under reduced pressure, triturated with toluene and filtered to furnish the phosphine oxide compound IV as a solid; yield: 6 g, 76.5%.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; HELVETICA INDUSTRIES (P) LIMITED; US2011/263870; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The crude solid was treated with 1.31 mL of thionyl chloride and heated on a steam bath for 1 hour. After cooling to room temperature, the crude mixture was taken up in water and extracted with ether. The ether was washed with water and dried(MgSO4), and concentrated to give an oily residue which was purified by silica gel chromatography (25% methylene chloride/75% hexane) to give 2.70 grams (85.6%) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride as a solid. 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150 C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography (10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the above-titled compound. MP 109-111 C.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US5935945; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OEt)), trans-C777: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OEt) (0.607 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from toluene/pentane at -35 C affording trans-C777 (1.48 g, 67.2%, >95% purity). ?H NMR (400 MHz, CD2C12, ppm): oe18.39 (d, J= 11.2 Hz, 1H), 7.34 – 7.26 (m, 2H), 7.24 – 7.14 (m, 8H), 7.03 – 6.95 (m, 1H), 6.89 (s, 2H), 6.79 (s, 2H), 4.08 – 3.88 (m, 4H), 3.36 (pseudo pentet, J= 6.9 Hz, 2H), 2.56 (s, 6H), 2.36 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.11 (s, 3H), 1.07 (t, J= 6.9 Hz, 3H), 1.03 (s, 3H). 3?PNIVIR(161.8 IVIHz, CD2C12, ppm): oe 129.8 (s).

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate