Tag: 700-800

《Development of a Large-Scale Synthetic Route to Manufacture (-)-Huperzine A》 was written by Tudhope, Stephen R.; Bellamy, Julie A.; Ball, Anthony; Rajasekar, Dewakar; Azadi-Ardakani, Manouchehr; Meera, Harihara Subramanian; Gnanadeepam, Jesudoss Mercy; Saiganesh, Ramanathan; Gibson, Frank; He, Linli; Behrens, Carl H.; Underiner, Gail; Marfurt, Judith; Favre, Nathalie. Synthetic Route of C43H63FeNP2 And the article was included in Organic Process Research & Development on April 20 ,2012. The article conveys some information:

A safe, practical and scalable process for manufacture of (-)-huperzine A has been developed and scaled up to manufacture several hundred grams of (-)-huperzine A with chem. and optical purity of >99%. The process consists of 11 chem. stages starting from com. available materials with only nine isolation steps and no chromatog. purification This process provides a reliable and cost-effective source of synthetic (-)-huperzine A and its derivatives for pharmaceutical and nutraceutical markets. A hazard evaluation assessment indicated that the safety margin for DPPA thermal decomposition onset is sufficient for conducting reaction at intended scale. In the experiment, the researchers used (1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene(cas: 1156547-61-3Synthetic Route of C43H63FeNP2)

(1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene(cas: 1156547-61-3) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds. Synthetic Route of C43H63FeNP2

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Category: chiral-phosphine-ligandsOn October 4, 2017 ,《Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts》 was published in Journal of the American Chemical Society. The article was written by Garcia-Morales, Cristina; Ranieri, Beatrice; Escofet, Imma; Lopez-Suarez, Laura; Obradors, Carla; Konovalov, Andrey I.; Echavarren, Antonio M.. The article contains the following contents:

The enantioselective intermol. gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes was achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach was applied to the enantioselective total synthesis of rumphellaone A. After reading the article, we found that the author used (R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8Category: chiral-phosphine-ligands)

(R)-1-{(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl}-ethylbis(2-methylphenyl)phosphine(cas: 849924-49-8) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Category: chiral-phosphine-ligands These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

《The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes》 was written by Kanda, Kazumasa; Koike, Tamami; Endo, Kohei; Shibata, Takanori. Application In Synthesis of (1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene And the article was included in Chemical Communications (Cambridge, United Kingdom) on April 14 ,2009. The article conveys some information:

The double Sonogashira coupling of diiodoparacyclophanes with alkynes proceeded to give planar chiral dialkynylparacyclophanes. A chiral Pd catalyst, which was prepared in situ from PdCl2(CH3CN)2 and Taniaphos, realized the first asym. Sonogashira coupling with up to ca. 80% ee. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene(cas: 1156547-61-3Application In Synthesis of (1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene)

(1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene(cas: 1156547-61-3) belongs to chiral phosphine ligands. Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates. Application In Synthesis of (1S)-1-(Dicyclohexylphosphino)-2-[(R)-[2-(dicyclohexylphosphino)phenyl](dimethylamino)methyl]ferrocene These intermediates are formed through nucleophilic attack of the phosphine catalysts at electron-poor nuclei (normally carbon atoms) and then proceed through several steps to form new chemical bonds.

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis