Tag: 6737-42-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6737-42-4,1,3-Bis(diphenylphosphino)propane,as a common compound, the synthetic route is as follows.

6737-42-4, 4-[Isopropyl-(7-isopropyl-3,3,6-trimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid methyl ester (Compound 67) Following general procedure O and using 7-isopropyl-5-[isopropyl-(4-trifluoromethanesulfonyloxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 63, 0.052 g, 0. 107 mmol), triethyl amine (0.4 mL, 0.28 mmol), palladium(II)acetate (0.030 g, 0.13 mmol) and 1,3-bis(diphenylphosphino)propane (0.041 g, 0.1 mmol) in a mixture of 3 mL of methanol, 2 mL of dimethylsulfoxide and 1 mL of 1,2-dichloroethane, the title compound (0.037 g, 84%) was obtained as a brown oil. 1 H NMR (300 MHz, CDCl3): delta 7.81 (d, 2H, J=9.2 Hz), 6.59 (s, 1H), 6.40 (d, 2H, J=9.2 Hz), 4.32 (heptet, 1H, J=6.6 Hz), 4.24 (s, 2H), 3.83 (s, 3H), 3.19 (heptet, 1H, J=7.0 Hz), 2.00 (s, 3H), 1.36-1.26 (m, 15H), 0.98 (d, 3H, J=6.6 Hz).

The synthetic route of 6737-42-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan Sales, Inc.; US6093838; (2000); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. 4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-1-benzoic acid methyl ester To a solution of trifluoro-methanesulfonic acid 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-phenyl ester (10.0 g, 19.8 mmol) in a Parr pressure bottle in MeOH (69 mL) were added DMSO (62 mL) and triethylamine (21.8 mL, 157 mmol). To the reaction mixture were added palladium acetate (2.2 g, 9.1 mmol) and 1,3-bis(diphenylphosphino)propane(3.75 g, 9.1 mmol). The mixture was shaken under 40 psi of CO at 70 C. for 4 hours. The reaction mixture was cooled to room temperature and was diluted with diethyl ether (600 mL). The ether layer was washed with water (5*60 mL), dried (MgSO4) and concentrated. The crude residue was purified by flash chromatography with hexanes/EtOAc (1:1) to afford 6.9 g (85% yield) of 4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester. 1H-NMR (400 MHz, CDCl3) delta 7.91 (d, 2H), 7.32 (d, 2H), 7.28-7.16 (comp, 6H),), 6.82 (d,, 1H), 6.79 (s, 1 H), 6.68 (dd, 1H), 3.86 (s, 3H), 3.74 (s, 3H), 3.38 (s, 2H), 2.47-2.44 (comp, 8H); MS (M+1) 416.2.

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Liras, Spiros; US2002/13321; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl-2,2,4,4-tetramethyl chroman-6-carboxylate (Compound 23) A solution of 6-bromo-2,2,4,4-tetramethylchroman (synthesis is described in U.S. Pat. No. 6,252,090)(2.2 g, 8.08 mmol), palladium acetate (0.145 g, 0.65 mmol) and 1,3-bis(diphenylphosphino)propane (0.267 g, 0.65 mmol) in a mixture of N,N-dimethylformamide (25 mL), ethanol (20 mL) and triethyl amine (7 mL) was heated at 90 C. under an atmosphere of carbon monoxide overnight. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with ethyl acetate. The combined organic extract was washed with brine (*1), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to an oil which was subjected to flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent to afford the title compound (1.9 g, 90%). 1H NMR (300 MHz, CDCl3): delta8.00 (d, 1H, J=2.3 Hz), 7.76 (dd, 1H, J=2.1,8.5 Hz), 6.79 (d, 1H, J=8.5 Hz), 4.33(q, 2H, J=7.1 Hz), 1.85 (s, 2H), 1.36(s, 6H), 1.37 (s, 6H), 1.39-1.33(m, 3H).

As the paragraph descriping shows that 6737-42-4 is playing an increasingly important role.

Reference£º
Patent; Yuan, Yang-Dar; Vasudevan, Jayasree; Thacher, Scott; Chandraratna, Roshantha A.; US2004/77721; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate