Tag: 591.4477

An Enantioselective Total Synthesis of (-)-Isoschizogamine was written by Xu, Zhengren;Bao, Xu;Wang, Qian;Zhu, Jieping. And the article was included in Angewandte Chemie, International Edition in 2015.Product Details of 1006708-91-3 This article mentions the following:

A concise enantioselective total synthesis of (-)-isoschizogamine, a complex bridged polycyclic monoterpene indole alkaloid, was accomplished. N-Alkylation of an enantio-enriched imine with an alkyl iodide afforded an iminium salt, which, upon heating by microwave irradiation in the presence of pivalic acid, was converted into the hexacyclic structure of natural product by a complex but ordered domino sequence. The one-pot process leading to the formation of one C-C bond and three C-N bonds created three rings and three contiguous stereogenic centers with complete control of both the relative and absolute stereochem. In the experiment, the researchers used many compounds, for example, (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3Product Details of 1006708-91-3).

(R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.Product Details of 1006708-91-3

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

A general enantioselective route to the chamigrene natural product family was written by White, David E.;Stewart, Ian C.;Seashore-Ludlow, Brinton A.;Grubbs, Robert H.;Stoltz, Brian M.. And the article was included in Tetrahedron in 2010.Recommanded Product: (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole This article mentions the following:

Described in this report is an enantioselective route toward the chamigrene natural product family. The key disconnections in our synthetic approach include sequential enantioselective decarboxylative allylation and ring-closing olefin metathesis to form the all-carbon quaternary stereocenter and spirocyclic core present in all members of this class of compounds The generality of this strategy is demonstrated by the first total syntheses of elatol (I) and the proposed structure of laurencenone B, as well as the first enantioselective total syntheses of laurencenone C and α-chamigrene. A brief exploration of the substrate scope of the enantioselective decarboxylative allylation/ring-closing metathesis sequence with fully substituted vinyl chlorides is also presented. In the experiment, the researchers used many compounds, for example, (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3Recommanded Product: (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole).

(R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole (cas: 1006708-91-3) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Over the last decade, however, and especially since 2005, considerable progress has been made in asymmetric phosphine catalysis.Recommanded Product: (R)-2-(2-(Bis(4-(trifluoromethyl)phenyl)phosphino)-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis