Ming-Phos/Gold(I)-Catalyzed Stereodivergent Synthesis of Highly Substituted Furo[3,4-d][1,2]oxazines was written by Zhou, Lujia;Xu, Bing;Ji, Danting;Zhang, Zhan-Ming;Zhang, Junliang. And the article was included in Chinese Journal of Chemistry in 2020.Product Details of 1595319-95-1 This article mentions the following:
A gold(I)-catalyzed asym. intermol. tandem [3+3]-cyclization reaction of 2-(1-alkynyl)-2- alken-1-ones R1CCC(=CHR3)(C(O)R2) (R1 = Bu, Ph, 1-naphthyl, etc.; R2 = Me, Ph; R3 = Ph, 4-methylphenyl, 4-methoxyphenyl, 4-chlorophenyl, 4-bromophenyl) with nitrones R4N(=O)=CHR5 (R4 = Ph, 4-methylphenyl, 4-methoxyphenyl, 3-chlorophenyl; R5 = Ph, styryl, furan-2-yl, etc.) has been developed by using Ming-Phos as a chiral ligand. This method enables access to the stereodivergent synthesis of highly substituted furo[3,4-d][1,2]oxazines I and II in excellent efficiency and stereoselectivity (up to 99% yield, 99% ee, >20 : 1 dr). In the experiment, the researchers used many compounds, for example, (R)-N-((S)-(2-(diphenylphosphaneyl)phenyl)(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide (cas: 1595319-95-1Product Details of 1595319-95-1).
(R)-N-((S)-(2-(diphenylphosphaneyl)phenyl)(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide (cas: 1595319-95-1) belongs to chiral phosphine ligands. During the past two decades, tertiary phosphine catalysts have been applied extensively in a wide range of carbon–carbon and carbon–heteroatom bond-forming transformations. Trivalent phosphorus compounds called phosphines have a tetrahedral electron-group geometry which makes them structurally analogous to amines.Product Details of 1595319-95-1
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis