Tag: 498.5321

Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Investigations of Intramolecular Heck Reactions of (E)-α,β-Unsaturated 2-Haloanilides and Analogs To Form Enantioenriched Spirocyclic Products. [Erratum to document cited in CA129:161471] was written by Ashimori, Atsuyuki;Bachand, Benoit;Overman, Larry E.;Poon, Daniel J.. And the article was included in Journal of the American Chemical Society in 2000.SDS of cas: 37002-48-5 This article mentions the following:

In Table 5, the conversion associated with several table entries is ambiguous. The original version of the table, which is clearer and incorporates chem. structures for all conversions, is now available as Supporting Information: “Supporting Information Available: Table 5 showing the scope of asym. Heck cyclizations of (E)-α,β-unsaturated 2-haloanilides with Pd(R)-BINAP (PDF). This material is available free of charge via the Internet at http://pubs.acs.organic”. In the experiment, the researchers used many compounds, for example, (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5SDS of cas: 37002-48-5).

(((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.SDS of cas: 37002-48-5

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Catalytic asymmetric cyclocarbonylation of o-isopropenylphenols: Enantioselective synthesis of six-membered ring lactones was written by Dong, Chune;Alper, Howard. And the article was included in Journal of Organic Chemistry in 2004.Name: (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) This article mentions the following:

Cyclocarbonylation of o-isopropenylphenols with CO and H₂, using Pd(OAc)₂ and (+)-DIOP as the chiral catalyst, in CH₂Cl₂ afforded 3,4-dihydro-4-methylcoumarins, e.g., I, in good yields and enantiomeric excess. The stereoselectivity was influenced by the structure of the chiral phosphine ligands and substrates, as well as by the reaction conditions. In the experiment, the researchers used many compounds, for example, (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5Name: (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)).

(((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Most of these phosphines are acyclic, usually possess low nucleophilic activity, and generally display poor enantioselectivities for phosphine organocatalysis. Name: (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis