Tag: 300-400

CpCo(I) precatalysts for [2 + 2 + 2] cycloaddition reactions: synthesis and reactivity was written by Fischer, Fabian;Pientka, Tobias;Jiao, Haijun;Spannenberg, Anke;Hapke, Marko. And the article was included in Catalysis Science & Technology in 2020.HPLC of Formula: 252288-04-3 This article mentions the following:

The efficient synthesis and structural characterization of a series of novel CpCo(I)-olefin-phosphite/phosphoramidite complexes and their evaluation in catalytic cyclotrimerization reactions are reported. The protocol for precatalyst synthesis is widely applicable to different P-containing ligands, especially phosphites and phosphoramidites, as well as acyclic and cyclic olefins. A selection of the prepared complexes was investigated towards their catalytic performance in [2 + 2 + 2] cycloaddition reactions of diynes and nitriles, as well as triynes. While revealing significant differences in reactivity, the most reactive precatalysts work even already at 75°. One of these precatalysts also proved its potential in exemplary (co)cyclotrimerizations towards functionalized pyridines and benzenes. The energetics of complex formation and exemplary ligand exchange with a substrate diyne were elucidated by theor. calculations and compared with the catalytic reactivity. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3HPLC of Formula: 252288-04-3).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Generally, the efficiency of nucleophilic phosphine catalysis often depends on the nature of the tertiary phosphine. Asymmetric catalytic performance is determined not only by the metal center but also by the chiral ligand selected.HPLC of Formula: 252288-04-3

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Asymmetric Synthesis of Planar Chiral Ferrocenes by Enantioselective Intramolecular C-H Arylation of N-(2-Haloaryl)ferrocenecarboxamides was written by Liu, Lantao;Zhang, An-An;Zhao, Rui-Juan;Li, Feng;Meng, Tuan-Jie;Ishida, Naoki;Murakami, Masahiro;Zhao, Wen-Xian. And the article was included in Organic Letters in 2014.HPLC of Formula: 252288-04-3 This article mentions the following:

The palladium-catalyzed intramol. C-H arylation reaction of N-(2-bromoaryl)ferrocenecarboxamides furnishes planar chiral ferrocene derivatives TADDOL-derived phosphoramide ligands induce enantioselectivities ranging from 91:9 to 98:2 er. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3HPLC of Formula: 252288-04-3).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. At present, the synthesis of new chiral phosphines designed specifically for nucleophilic organocatalysis remains a significant challenge. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.HPLC of Formula: 252288-04-3

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Towards a Zinc-Catalyzed Asymmetric Hydrogenation/Transfer Hydrogenation of Imines was written by Werkmeister, Svenja;Fleischer, Steffen;Junge, Kathrin;Beller, Matthias. And the article was included in Chemistry – An Asian Journal in 2012.Related Products of 252288-04-3 This article mentions the following:

The first asym. hydrogenation/transfer hydrogenation of imines to amines using zinc(II) triflate in combination with chiral ligands is described. The monodentate binaphthophosphepine ligand provided the highest enantioselectivities. Using different imines, the corresponding amines were obtained in moderate yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Related Products of 252288-04-3).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.Related Products of 252288-04-3

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Platinum(II) Catalyzed Enantioselective Cycloisomerizations of 3-Hydroxylated 1,5-Enynes was written by Zhang, Yang;Jullien, Helene;Brissy, Delphine;Retailleau, Pascal;Voituriez, Arnaud;Marinetti, Angela. And the article was included in ChemCatChem in 2013.Computed Properties of C24H22NO2P This article mentions the following:

The enantioselective cycloisomerization of 3-hydroxylated 1,5-enynes into bicyclo[3.1.0]hexanones was investigated by using cyclometalated NHC-platinum phosphoramidite complexes as precatalysts. Several new complexes were prepared They generate cationic, electrophilic Pt^II species that efficiently promote the cycloisomerization process. Enantiomeric excesses up to 81% were obtained in the reactions of enynes with aryl-substituted alkyne functions (8 examples, 70-81% ee). In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Computed Properties of C24H22NO2P).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Although many reactions require more nucleophilic trialkylphosphines as catalysts, only a few chiral trialkylphosphines are available. Indeed, very little research on chiral tertiary phosphine-catalyzed asymmetric reactions occurred prior to the year 2000.Computed Properties of C24H22NO2P

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

The long-arm effect: influence of axially chiral phosphoramidite ligands on the diastereo- and enantioselectivity of the tandem 1,4-addition/fluorination was written by Wang, Lian;Meng, Wei;Zhu, Chuan-Le;Zheng, Yan;Nie, Jing;Ma, Jun-An. And the article was included in Angewandte Chemie, International Edition in 2011.Name: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine This article mentions the following:

Alkylidene-substituted β-aryl β-ketoesters undergo asym. tandem Michael addition and electrophilic fluorination in reaction with dialkylzinc compounds and N-fluorobenzenesulfonimide, catalyzed by copper(II) triflate, modified with axial chiral 1,1′-binaphthalene 2,2′-phosphoramidite monodentate ligands QO₂PNR³₂ (1a–r, Q = 3,3′-diaryl-1,1′-binaphthalene-2,2-diyl, R³ = Me, Et, ⁱPr, Bu), yielding α-fluoro-β-ketoesters I (3a–v, R = H, 4-MeO, 3-Me, 2-Me, 4-Cl, 4-Br; R¹ = Et, Me, n-Pr, Bu; R² = Ph, 2-MeOC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 4-CF₃C₆H₄, 2-naphthyl, 2-furyl, 2-thienyl)with high yields and >85% ee. The variety of 3,3′-disubstituted chiral phosphoramidites were evaluated, the 4-biphenylyl and 4-(2-naphthyl)phenyl substituents provided optimal chiral induction, 75-90%. N-Substituents of the phosphoramidites 1 play a minor role in induction, the diethylamino group as NR³₂ being optimal. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Name: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.Name: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Rhodium-catalyzed asymmetric addition of aryl- and alkenylboronic acids to isatins was written by Shintani, Ryo;Inoue, Mitsunori;Hayashi, Tamio. And the article was included in Angewandte Chemie, International Edition in 2006.COA of Formula: C24H22NO2P This article mentions the following:

A rhodium-catalyzed asym. addition of arylboronic acids to isatins has been developed to produce biol. relevant 3-aryl-3-hydroxy-2-oxindoles in high yield (mopping up rhodium). The most efficient catalyst discovered in this study was (R)-MeO-mop [i.e., [(1R)-2′-methoxy[1,1′-binaphthalen]-2-yl]diphenylphosphine, (R)=(+)-MOP]. High enantioselectivity was observed with (R)-MeO-mop as a ligand, and the reaction could be extended to the addition of alkenyl groups. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3COA of Formula: C24H22NO2P).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. The synthesis of novel trialkylphosphines can be quite difficult, thereby limiting the scope of their chiral variants. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.COA of Formula: C24H22NO2P

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Catalytic asymmetric induction of planar chirality: palladium catalyzed intramolecular Mizoroki-Heck reaction of prochiral (arene)chromium complexes was written by Kamikawa, Ken;Harada, Kenji;Uemura, Motokazu. And the article was included in Tetrahedron: Asymmetry in 2005.Category: chiral-phosphine-ligands This article mentions the following:

The asym. intramol. Mizoroki-Heck reaction of prochiral tricarbonyl(2,6-dibutenylchlorobenzene)chromium in the presence of a chiral phosphine-palladium catalyst gave the corresponding bicyclic chromium complex up to 73% ee. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Category: chiral-phosphine-ligands).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Generally, the efficiency of nucleophilic phosphine catalysis often depends on the nature of the tertiary phosphine. Indeed, very little research on chiral tertiary phosphine-catalyzed asymmetric reactions occurred prior to the year 2000.Category: chiral-phosphine-ligands

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Influence of copper salts, solvents, and ligands on the structures of precatalytic phosphoramidite copper complexes for conjugate addition reactions was written by Zhang, Hongxia;Gschwind, Ruth M.. And the article was included in Chemistry – A European Journal in 2007.Name: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine This article mentions the following:

For Cu-catalyzed enantioselective conjugate addition reactions of organozinc reagents, the available knowledge about the mechanism and the structures involved is still insufficient to understand in detail the strong influences of solvent, salt, and ligand size, or to enable a rational control of this reaction. Screening with three phosphoramidite ligands and four Cu(I) salts using NMR spectroscopy revealed a binuclear Cu complex with mixed trigonal/tetrahedral stereochem. as the basic structural motif of the ground state of precatalysts with highly stereoselective ligands. Ligands with smaller amine moieties allow higher coordination numbers and higher aggregation levels, leading to reduced ee values. Since the ESI mass spectra of several precatalytic Cu halide complexes show a striking correlation with the structures observed in solution, ESI-MS may be used as a fast tool to determine the maximum number of phosphoramidite ligands attached to Cu. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Name: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Many phosphine-catalyzed reactions have been developed for the syntheses of various biologically important acyclic and cyclic molecules. Asymmetric variants of these reactions have evolved relatively slowly. Chiral phosphine catalysts: Nucleophilic phosphine catalysis often involves the formation of Lewis adducts, namely phosphonium (di)enolate zwitterions, as reaction intermediates.Name: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Catalytic Asymmetric Conjugate Addition of a Borylalkyl Copper Complex for Chiral Organoboronate Synthesis was written by Jang, Won Jun;Yun, Jaesook. And the article was included in Angewandte Chemie, International Edition in 2019.Product Details of 252288-04-3 This article mentions the following:

The authors report the catalytic enantioselective conjugate addition of a borylalkyl Cu nucleophile generated in situ from a 1,1-diborylmethane derivative to α,β-unsaturated diesters. In the presence of a chiral N-heterocyclic carbene (NHC)-Cu catalyst, this method facilitated the enantioselective incorporation of a CH₂Bpin moiety at the β-position of the diesters to yield β-chiral alkyl boronates in up to 86% yield with high enantioselectivity. The alkylboron moiety in the resulting chiral diester products was converted into various functional groups by organic transformation of the C-B bond. In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Product Details of 252288-04-3).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Generally, the efficiency of nucleophilic phosphine catalysis often depends on the nature of the tertiary phosphine. Trivalent phosphorus compounds called phosphines have a tetrahedral electron-group geometry which makes them structurally analogous to amines.Product Details of 252288-04-3

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis

Palladium-catalyzed asymmetric [3 + 3] cycloaddition of trimethylenemethane derivatives with nitrones was written by Shintani, Ryo;Park, Soyoung;Duan, Wei-Liang;Hayashi, Tamio. And the article was included in Angewandte Chemie, International Edition in 2007.Recommanded Product: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine This article mentions the following:

Functionalized 1,2-oxazines can be obtained in high yield by a palladium-catalyzed asym. [3 + 3] cycloaddition of trimethylenemethane derivatives with nitrones. The use of a modified phosphoramidite ligand has led to the formation of these compounds with high stereoselectivity (see scheme, Cp = cyclopentadienyl). In the experiment, the researchers used many compounds, for example, (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3Recommanded Product: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine).

(11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine (cas: 252288-04-3) belongs to chiral phosphine ligands. Generally, the efficiency of nucleophilic phosphine catalysis often depends on the nature of the tertiary phosphine. Chiral ligands coordinate to metal centers to create an asymmetric environment around the reaction centers, which eventually affects enantioselectivity and reaction rate.Recommanded Product: (11bS)-N,N-Diethyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine

Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis