Tag: 17261-28-8

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound NF-OH (50 mg, 0.16 mmol) and 2-(diphenylphosphino)benzoic acid (161.7 mg, 0.528 mmol) were dissolved in dichloromethane and then added4-(Dimethylamino)-pyridine-4-toluenesulfonate (141.3 mg, 0.48 mmol) and N,N’-diisopropylcarbodiimide (60.6 mg, 0.48 mmol). The reaction system was stirred at room temperature for 5 hours under argon gas. It is then extracted with ethyl acetate and the organic phase is separated.Drying over anhydrous sodium sulfate and column chromatography gave the product: NF-P., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Hubei University; Wang Feiyi; Yang Guichun; Chai Yun; Chen Zuxing; Lu Cuifen; Nie Junqi; Ma Chao; (12 pag.)CN109608495; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, (2)Compound 2 (156 mg, 0.5 mmol), diphenyl phthalic acid (184 mg, 0.6 mmol), dicyclohexylcarbodiimide (288 mg, 1.4 mmol),4-Dimethylaminopyridine (61.1 mg, 0.5 mmol) was mixed with dichloromethane (anhydrous grade).The reaction was stirred at room temperature, and monitored by TCL plate until Compound 2 disappeared, and the reaction was carried out for 12 h;The resulting product is subjected to suction filtration,Wash with saturated brine and extract three times with dichloromethane.Purified by silica gel column chromatography,The eluent used was dichloromethane and methanol (mound ratio of dichloromethane to methanol was 15:1).A brownish green solid of 195 mg was obtained.The calculated yield is 65%;

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Inner Mongolia University; Wang Jianguo; Jiang Guoyu; Zhu Wenping; (19 pag.)CN109796493; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, (R, R) -cyclohexanediamine (1.26 g, 11.0 mmol), 2-diphenylphosphine benzoic acid (6.74 g), DCM (100.0 mL) were added successively under nitrogen, followed by sequential EDCI (4.22 g, 22.0 mmol) and DMAP (1.34 g, 11.0 mmol) were stirred at room temperature for 6 hours, quenched with 1 N aqueous hydrochloric acid and extracted with DCM (3 x 50.0 mL). The organic phases were combined, Dried over magnesium sulfate and spin-dried to give the indicated product Trostligand;(17.4 mL, 35percent w / w) was added at 0 ¡ã C, stirred at 0 ¡ã C for 4 hours, diluted with water (100.0 mL), and the mixture was stirred at 0 ¡ã C, The aqueous phase was extracted with DCM (3 x 50.0 mL) and the combined organic phases were dried over anhydrous magnesium sulphate and spin-dried to give the indicated product as a white solid, 4.34 g, 86percent yield.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES; SHI, YIAN; HUANG, HU; PAN, HONGJIE; CAI, YUDONG; LIU, MAO; TIAN, HUA; (24 pag.)CN104447606; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (1R,5S)-(?)-cytisine (571mg, 3.00mmol) in CH3OH (10mL) was added platinum (IV) oxide hydrate (80percent Pt) (82mg, 0.30mmol) and the mixture was stirred at room temperature under a hydrogen atmosphere (balloon) for 48h. The solids were removed by filtration through Celite and the filter cake was washed with CH2Cl2/CH3OH (9:1). The filtrate was evaporated under reduced pressure to give the crude product. Purification by flash column chromatography (silica gel, CH2Cl2/CH3OH/Et3N=20:1:0.5) gave lactam 4 (314mg, 54percent) as a white solid [8b]. To a mixture of 2-diphenylphosphinobenzoic acid (76mg, 0.25mmol), N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide (58mg, 0.30mmol) and hydroxybenzotriazole (41mg, 0.30mmol) in dry CH2Cl2 (5mL) under an argon atmosphere lactam 4 (63mg, 0.32mmol) was added at room temperature. The mixture was stirred at room temperature for 24h and then was directly subjected to flash column chromatography (silica gel, CH2Cl2/CH3OH=50:1) to give 116mg (97percent yield) of 5 as a white solid; m.p. 194?196¡ãC. [alpha]D20=?18.2 (c 0.31, CHCl3). 1H NMR (600MHz, CDCl3, 293K): delta=7.42 (t, JH,H=7.4Hz, 1H, Har), 7.35?7.30 (m, 6H, Har), 7.29?7.28 (m, 3H, Har), 7.25 (dt, JH,H=7.7Hz, 1H, Har), 7.23?7.21 (m, 2H, Har), 7.02 (dd, JH,H=7.3, 4.0Hz, 1H, Har), 5.06 (d, JH,H=13.9Hz, 1H, 2-Heq), 4.60 (d, JH,H=13.8Hz, 1H, 4-Heq), 3.50?3.46 (m, 1H, 12-H), 3.44 (d, JH,H=12.5Hz, 1H, 6-H), 2.98 (d, JH,H=12.5Hz, 1H, 6-H), 2.81 (d, JH,H=14.0Hz, 1H, 4-Hax), 2.78 (d, JH,H=14.0Hz, 1H, 2-Hax), 2.52?2.43 (m, 2H, 9-H, 10-H), 2.22 (dq, JH,H=13.0, 3.0Hz, 1H, 11-H), 1.96?1.85 (m, 4H, 9-H, 10-H, 11-H, 13-H), 1.80 (brs, 2H, 1-H, 5-H), 1.70?1.63 (m, 1H, 13-H) ppm. 13C NMR (150.9MHz, CDCl3, 293K): delta=170.32 (Cq, C=O, lactam), 170.12 (Cq, C=O, amide), 142.65 (d, J31P,13C=32.6Hz, Cq, Car), 136.55 (d, J31P,13C=9.9Hz, Cq, Car), 136.14 (d, J31P,13C=10.1Hz, Cq, Car), 133.99 (d J31P,13C=20.3Hz, 2 CH, Car), 133.73 (CH, Car), 133.28 (d, J31P,13C=19.6Hz, 2 CH, Car), 131.67 (Cq, CCO), 129.79 (CH, Car), 128.82 (CH, Car), 128.70 (CH, Car), 128.50 (CH, Car), 128.49 (d, J31P,13C=6.5Hz, 2 CH, Car), 128.32 (d, J31P,13C=6.9Hz, 2 CH, Car), 127.52 (d, J31P,13C=7.1Hz, CH, Car), 59.53 (CH, 12-C), 51.80 (CH2, 6-C), 45.72 (CH2, 4-C), 41.63 (CH2, 2-C), 33.02 (2 CH2, 9-C, 10-C), 32.70 (CH, 1-C), 28.15 (CH, 5-C), 28.10 (CH2, 11-C), 20.16 (CH2, 13-C) ppm. 31P{1H} NMR (242.92MHz, CDCl3, 293K): delta=?12.20ppm. IR(KBr): nu=3058, 2922, 2861, 1624, 1584, 1439, 1422, 1254, 1182, 779, 692cm?1. MS (ESI): m/z=483 (100, [M+1]+), 289 (52). C30H31N2O2P (482.55): calcd. C 74.67, H 6.48, N 5.81, found C 74.58, H 6.71, N 5.89., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Philipova, Irena; Stavrakov, Georgi; Vassilev, Nikolay; Nikolova, Rositsa; Shivachev, Boris; Dimitrov, Vladimir; Journal of Organometallic Chemistry; vol. 778; (2015); p. 10 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

After dissolving 3-amino-2-naphthol (0.159 g, 1.0 mmol), 2 (diphenylphosphino) benzoic acid (0.306 g, 1.0 mmol) and paratoluenesulfonicacid (0.190 g, 1.0 mmol) in 30 ml of toluene,The mixture was stirred at 150 under N2 (g) air flow for 15 hours.The product was separated into H2O and toluene layers using H2O,after toluene layer only collected separately dissolved in minimum amount of CHCl3 and the solvent evaporated in evaporator was performed by a silica gel column (Merck 60, 70-230 mesh).The column was prepared using a solution of CHCl3: ethyl acetate in a volume ratio of 5: 1 (v: v),The extracted product was recrystallized with CHCl3 and ethyl acetate in a volume ratio of 5: 2. The recrystallized product was dissolved in 10 ml of CH2Cl2,While stirring, 2 ml of H2O2 (30percent) was slowly added dropwise and the reaction was allowed to proceed overnight.The product was separated into a H2O layer and a CH2Cl2 layer using H2O,The CH2Cl2 layer alone was collected and the solvent was evaporated by evaporator and 2- (2-diphenylphosphoryl) phenyl) naphtho [2,3-d] oxazole (2-PPN),obtained.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Inje university industry-academic cooperation foundation; Lee, Bum-Jong; Kim, Ik-Hwan; Kang, Eun-Guk; Kim, Kyung-Hyun; (23 pag.)KR101581821; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: To a diethyl ether solution (20 mL) of AgCF3SO3 (51 mg,0.2 mmol) was added the corresponding phosphinobenzoic acid(61 mg, 0.2 mmol), and the reaction stirred for 2 h protected fromthe light. The insoluble compounds were filtered off, washed anddried. A second fraction was obtained by evaporation ca. 2 ml and addition of hexane. Compounds 1?2 were obtained as whitesolids. Yield of 1: 78 mg, 70percent. Anal. Calc. for C40H30Ag2F6O10P2S2:C, 42.65; H, 2.68; N, 0. Found: C, 42.37; H, 2.75; N, 0percent. 1H NMR(d6-acetone): d 8.37 (d, JHH = 7.6 Hz, 1H, H6), 7.76 (td, JHH = 7.6 Hz,JHP = 1.4 Hz, 1H, H5), 7.70 (td, JHH = 7.6 Hz, JHP = 1.4 Hz, 1H, H4),7.59?7.45 (m, 10H, Ph), 7.04 (t, JHP = JHH = 7.8 Hz, 1H, H3). 1HNMR (50 C, d6-acetone): d 12.49 (brs, 1H, COOH), 8.40 (ddd,JHH = 7.5 and 1.5 Hz, JHP = 4.4 Hz, 1H, H6), 7.82 (t, JHH = 7.5 Hz, 1H,H5), 7.77 (t, JHH = 7.5 Hz, 1H, H4), 7.60?7.43 (m, 10H, Ph),6.94 (ddd, JHP = 9.2 and 1.2 Hz, JHH = 7.5 Hz, 1H, H3). 19F NMR(d6-acetone): 77.58 (s). 31P NMR (d6-acetone): 15.6 (brs).31P NMR (50 C, d6-acetone): 15.5 (d, 1J107Ag?31P = 736 and1J109Ag?31P = 849 Hz). IR (KBr): 3060 m(O?H), 1673 m(CO), 1257,1223, 1209, 635 (CF3SO3) cm?1. Yield of 2: 91 mg, 81percent. Anal. Calc.for C20H15AgF3O5PS: C, 42.65; H, 2.68; N, 0. Found: C, 42.60; H,2.84; N, 0percent. 1H NMR (d6-acetone): d 11.5 (brs, 1H, COOH), 8.13(d, JHH = 8.0 Hz, 2H, H2), 7.68?7.55 (m, 12H, H3+Ph). 1H NMR(50 C, d6-acetone): d 12.54 (brs, 1H, COOH), 8.15 (dd, JHP =1.6 Hz, JHH = 8.4 Hz, 2H, H2), 7.68?7.53 (m, 12H, H3+Ph). 19F NMR(d6-acetone): 77.6 (s). 31P NMR (d6-acetone): 14.5 (d, 1JAg?P =721 Hz). 31P NMR (50 C, d6-acetone): 13.8 (d, 1J107Ag-31P = 690and 1J109Ag-31P = 795 Hz). IR (KBr): 3054 m(O?H), 1687 m(CO),1223, 635 (CF3SO3) cm1.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Miguel-Coello, Ana B.; Bardaji, Manuel; Inorganica Chimica Acta; vol. 423; PA; (2014); p. 219 – 224;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate