Tag: 1608-26-0

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Embodiment 1 Synthesis of Compounds 8 and 9 Ammonium chloride (0.01 g) and Compound 7 (1 mmol) were charged to a 30 mL flask. The mixture was dissolved in toluene (10 mL), hexamethyl phosphorus triamide was added, and the mixture was refluxed for 12 hours. After allowing the mixture to cool to room temperature, the solvent was distilled off. The residue was recrystallized from methylene chloride/pentane (yield 75 percent, R=Me).

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Patent; Japan Science and Technology Agency; EP1854802; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Tris(dimethylamino)phosphine (2.29g, 14mmol) was added drop-wise to a stirred solution of 2-methylprop-2-en-1-ol (1g, 14mmol) and CCl4 (2.46g, 16mmol) in dry CH2Cl2 (30mL) cooled at-30C. Then, 15mL of distilled water was added and the reaction mixture was allowed to proceed at room temperature for 2h. Organic phase was decanted and extracted with water (2¡Á40mL). Aqueous phases were collected, washed with Et2O and decanted to give an aqueous solution of methallyloxyphosphonium chloride. After the addition of KPF6 (3.68g, 20mmol) in 10mL of water, an immediate precipitate was formed. The mixture was filtered and the crude product was washed with Et2O and dried under vacuum. Recrystallization from a mixture of chloroform: Et2O solution afforded salt 2 as a white solid. Yield: 4.15g (78%). IR [nu cm-1]: 836 (PF6-). 1H NMR (300MHz, CDCl3): 1.78 (s, 3H, CH3-allyl); 2.76 (d, 18H, (CH3)2N); 4.54 (d, 2H, CH2-O); 5.01 (s, 1H, CH2); 5.08 (s, 1H, CH2). 13C NMR (75.47MHz, CDCl3): 18.7 (CH3-allyl); 36.7 (CH3-N); 71.9 (CH2-O); 114.3 (CH2); 137.7 (C).

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Dridi, Sana; Mechria, Ali; Msaddek, Moncef; Journal of Organometallic Chemistry; vol. 772-773; (2014); p. 217 – 221;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 6 (526.211 eq) was added to the Schlenk tube,After evacuation of nitrogen,The system was cooled to 0 C,And the reaction vessel was added at this temperatureP (NMe2) 3 (1.3 eq),Reaction at 0 C for 10 min,Then rose to 110 C,TLC detection to complete reaction,Separation by column chromatography to give a white solid,The yield was 80%

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shangqiu Teachers College; Zhengzhou University; Zhao, Wenxian; Chao, Ruiqing; Li, Gaowei; Xu, Kai; Wang, Tao; Wang, Xiaojuan; Zhao, Ruijuan; Liu, Lantao; (16 pag.)CN104530122; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate