Tag: 15929-43-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15929-43-8,Bis(4-(trifluoromethyl)phenyl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: To an 10mL oven-dried Schlenk tube under argon atmosphere were added R1R2P(O)H (1.0 mmol) and THF (2.0 mL), stirring the solution until all the solid was totally dissolved, and then MeC(O)Cl (2.0 mmol) was added to the solution and the mixture was stirred at room temperature or 50oC for overnight. After reaction, the excessive MeC(O)Cl, byproduct AcOH and solvent THF were removed under vacuum to afford pure R1R2PCl., 15929-43-8

As the paragraph descriping shows that 15929-43-8 is playing an increasingly important role.

Reference£º
Article; Zhang, Jian-Qiu; Yang, Shangdong; Han, Li-Biao; Tetrahedron Letters; vol. 61; 10; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15929-43-8,Bis(4-(trifluoromethyl)phenyl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 2-iodophenol (21c) (1.32 g, 6.00 mmol) and bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide (22) (2.85 g, 6.01 mmol) dissolved in CCl4 (30 mL) was added triethylamine (1.67 mL, 12.0 mmol) at 0 C. After stirring for 15 min at the same temperature, to the mixture was added an aqueous saturated solution of NH4Cl (40mL). The mixture was extracted with CH2Cl2 (50 mL ¡Á 3), and the combined organicextract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel100 g, n-hexane/EtOAc = 19/1 to 9/1) to give 2-iodophenyl bis(3,5-bis(trifluoromethyl)-phenyl)phosphinate (23c) (3.67 g, 5.30 mmol, 88.4%) as a colorless solid.

The synthetic route of 15929-43-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nishiyama, Yoshitake; Kamada, Shuhei; Yoshida, Suguru; Hosoya, Takamitsu; Chemistry Letters; vol. 47; 9; (2018); p. 1216 – 1219;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate