Tag: 13440-07-8

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 2-methoxyphenylacetylene (0.066 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuCl (0.01 g, 0.1 mmol), di-tert-butyl peroxide(0.45 g, 3 mmol),And N-methylpyrrolidone (2 mL),70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the reaction is separated by column chromatography(Ethyl acetate: petroleum ether = 1:1) gave the desired product (yield: 73%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Example 3 Dinaphthylphosphine-borane complex Under an argon atmosphere, 4 mL of toluene was added to dinaphthylphosphine oxide synthesised in Reference Example 2 (0.6061 g, 2.00 mmol) at a room temperature (25C) and the mixture was stirred to obtain a suspension. Then, to the suspension was added 1.02 mol/L of a borane-tetrahydrofuran complex (5 mL, 2.55 equivalents). The reaction mixture was purified by silica gel column chromatography (silica gel 15 g, toluene) and the desired fraction was concentrated under reduced pressure. The residue was dried (under reduced pressure at 40C) to obtain the titled compound (0.4577 g, white powder). The yield was 76.2%. 1H-NMR (300 MHz, CDCl3, TMS) delta: 0.60-1.85 (m, 3 H), 6.56 (dq, 1 H, JH-P= 378.7 Hz, J = 6.9 Hz), 7.52-8.31 (m, 14H). 13C-NMR (75 MHz, CDCl3, CDCl3) delta: 124.40, 125.16, 128.53, 129.22, 129.31, 129.61, 129.96, 130.30, 130.43, 134.20, 134.36, 135.91, 135.94, 135.99, 136.14. 31P-NMR (121 MHz, CDCl3, 85% H3PO4) delta: 1.10-2.21 (m), 3.92-4.95 (m).

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1626052; (2006); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 2-ethynylpyridine (0.052 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuI (0.019 g, 0.1 mmol), di-tert-butyl peroxide(0.30 g, 2 mmol), and acetone (2 mL),50oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product. (Yield 63%).

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate